GREMLIN Database
Q9HQH3 - Protoporphyrinogen oxidase
UniProt: Q9HQH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 191 (182)
Sequences: 7210 (5251)
Seq/√Len: 389.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_G76_D3.7691.00
50_A63_G2.8711.00
13_D69_F2.4471.00
68_P83_R2.4461.00
66_L118_V2.3701.00
62_V82_V2.3601.00
84_G89_P2.3551.00
50_A61_V2.3531.00
96_D142_A2.3261.00
176_E182_E2.2841.00
40_L95_F2.2011.00
4_L56_E2.1331.00
6_D55_D2.1291.00
62_V95_F2.0951.00
107_R121_S2.0921.00
134_F164_A2.0801.00
137_V147_V2.0301.00
78_G81_V2.0201.00
123_G128_R1.9741.00
44_T74_A1.9261.00
27_A175_S1.9151.00
11_G73_Q1.8901.00
141_L145_G1.8141.00
38_R60_D1.8031.00
149_M164_A1.7971.00
8_R52_T1.7291.00
117_D121_S1.7171.00
86_L129_V1.6531.00
28_A148_I1.6491.00
125_T131_E1.6471.00
6_D56_E1.6341.00
54_R61_V1.6161.00
157_V174_I1.6131.00
20_D23_L1.6051.00
53_V99_V1.6001.00
87_V140_V1.5791.00
71_V81_V1.5641.00
29_V57_T1.5631.00
85_D132_S1.5521.00
31_E148_I1.5441.00
51_A78_G1.5101.00
6_D52_T1.5101.00
4_L26_T1.4821.00
14_V46_S1.4711.00
31_E146_V1.4551.00
157_V182_E1.4181.00
132_S136_A1.4111.00
24_L148_I1.3841.00
71_V83_R1.3751.00
44_T50_A1.3631.00
27_A30_G1.3471.00
154_L181_F1.3331.00
34_D37_A1.3231.00
28_A99_V1.2971.00
162_A166_D1.2911.00
85_D88_A1.2781.00
23_L184_L1.2761.00
106_P155_T1.2751.00
110_D113_D1.2331.00
94_A142_A1.2131.00
21_T49_V1.2011.00
151_V185_T1.2011.00
8_R51_A1.1971.00
161_A165_G1.1921.00
28_A97_A1.1921.00
106_P109_D1.1871.00
23_L178_S1.1861.00
161_A174_I1.1811.00
130_I149_M1.1751.00
64_T84_G1.1721.00
100_F149_M1.1711.00
25_A52_T1.1681.00
60_D80_P1.1671.00
29_V56_E1.1591.00
39_V53_V1.1541.00
67_N118_V1.1531.00
124_D131_E1.1521.00
74_A81_V1.1491.00
136_A139_R1.1471.00
67_N70_A1.1451.00
63_G81_V1.1421.00
42_V133_F1.1401.00
63_G79_V1.1291.00
87_V136_A1.1241.00
38_R62_V1.1121.00
64_T90_F1.1081.00
38_R93_D1.1051.00
134_F163_Y1.0941.00
153_T156_G1.0911.00
127_R159_E1.0891.00
38_R95_F1.0801.00
86_L132_S1.0701.00
27_A184_L1.0691.00
95_F98_V1.0671.00
65_D71_V1.0621.00
4_L52_T1.0591.00
122_G130_I1.0571.00
41_D50_A1.0541.00
174_I185_T1.0531.00
8_R48_Y1.0391.00
62_V80_P1.0351.00
39_V61_V1.0111.00
49_V99_V1.0031.00
50_A54_R1.0031.00
135_D167_R0.9911.00
10_A73_Q0.9911.00
151_V157_V0.9861.00
137_V169_F0.9811.00
42_V86_L0.9811.00
13_D73_Q0.9691.00
16_Q115_W0.9671.00
10_A14_V0.9641.00
11_G76_D0.9501.00
38_R142_A0.9431.00
127_R131_E0.9391.00
39_V59_A0.9381.00
80_P93_D0.9371.00
32_L97_A0.9261.00
122_G126_G0.9181.00
127_R163_Y0.9171.00
175_S184_L0.9161.00
122_G129_V0.9091.00
5_A55_D0.9001.00
157_V161_A0.9001.00
44_T65_D0.8991.00
109_D155_T0.8931.00
151_V160_V0.8821.00
100_F133_F0.8771.00
50_A79_V0.8731.00
174_I182_E0.8671.00
52_T56_E0.8641.00
41_D44_T0.8611.00
98_V140_V0.8451.00
130_I160_V0.8431.00
44_T63_G0.8421.00
27_A31_E0.8411.00
135_D163_Y0.8411.00
176_E180_P0.8321.00
164_A185_T0.8311.00
107_R122_G0.8291.00
91_R140_V0.8251.00
75_A78_G0.8251.00
25_A49_V0.8171.00
162_A165_G0.8091.00
62_V93_D0.8061.00
122_G128_R0.8021.00
130_I151_V0.7981.00
14_V73_Q0.7971.00
5_A56_E0.7901.00
133_F147_V0.7771.00
54_R78_G0.7741.00
39_V97_A0.7721.00
20_D184_L0.7711.00
37_A59_A0.7691.00
28_A32_L0.7651.00
51_A55_D0.7621.00
105_L120_L0.7611.00
31_E173_A0.7581.00
39_V57_T0.7501.00
43_G129_V0.7481.00
159_E162_A0.7441.00
92_D139_R0.7411.00
25_A29_V0.7351.00
158_D162_A0.7351.00
54_R79_V0.7341.00
30_G175_S0.7331.00
36_Y60_D0.7291.00
132_S135_D0.7261.00
106_P122_G0.7261.00
37_A57_T0.7241.00
27_A148_I0.7171.00
151_V174_I0.7121.00
53_V57_T0.6940.99
125_T128_R0.6930.99
23_L27_A0.6920.99
82_V93_D0.6900.99
157_V181_F0.6900.99
135_D138_G0.6870.99
42_V87_V0.6870.99
64_T82_V0.6850.99
42_V64_T0.6840.99
156_G160_V0.6800.99
32_L57_T0.6790.99
26_T30_G0.6740.99
131_E163_Y0.6720.99
34_D58_G0.6690.99
134_F149_M0.6650.99
102_P160_V0.6630.99
97_A148_I0.6620.99
69_F72_R0.6620.99
61_V79_V0.6590.99
37_A96_D0.6510.99
5_A8_R0.6500.99
11_G69_F0.6490.99
71_V75_A0.6470.99
134_F167_R0.6440.99
20_D179_F0.6440.99
107_R123_G0.6420.99
52_T55_D0.6390.99
161_A172_A0.6390.99
128_R131_E0.6370.99
68_P72_R0.6370.99
43_G86_L0.6320.99
129_V132_S0.6310.99
19_E22_H0.6210.99
159_E163_Y0.6200.99
33_D37_A0.6190.99
84_G90_F0.6140.99
107_R117_D0.6050.99
111_T114_D0.6010.99
165_G172_A0.5980.99
25_A53_V0.5960.98
24_L99_V0.5950.98
38_R96_D0.5930.98
158_D161_A0.5910.98
16_Q119_A0.5910.98
75_A81_V0.5870.98
40_L64_T0.5850.98
33_D36_Y0.5840.98
131_E135_D0.5840.98
136_A140_V0.5820.98
122_G125_T0.5810.98
149_M160_V0.5800.98
161_A182_E0.5790.98
155_T181_F0.5780.98
106_P125_T0.5760.98
25_A48_Y0.5750.98
138_G167_R0.5710.98
67_N71_V0.5710.98
44_T81_V0.5700.98
160_V163_Y0.5680.98
40_L90_F0.5670.98
72_R75_A0.5660.98
40_L87_V0.5630.98
48_Y52_T0.5610.98
51_A79_V0.5610.98
107_R124_D0.5600.98
108_E124_D0.5590.98
23_L26_T0.5530.98
87_V90_F0.5530.98
53_V59_A0.5520.98
137_V141_L0.5500.97
138_G169_F0.5480.97
148_I184_L0.5470.97
38_R94_A0.5470.97
32_L59_A0.5430.97
43_G100_F0.5420.97
177_E183_T0.5420.97
109_D153_T0.5410.97
9_G73_Q0.5380.97
97_A146_V0.5380.97
158_D182_E0.5370.97
133_F137_V0.5350.97
98_V137_V0.5350.97
4_L29_V0.5340.97
82_V89_P0.5330.97
106_P154_L0.5330.97
11_G14_V0.5320.97
130_I134_F0.5310.97
37_A58_G0.5300.97
32_L37_A0.5300.97
87_V98_V0.5290.97
106_P153_T0.5280.97
35_P58_G0.5240.97
160_V185_T0.5220.97
123_G126_G0.5190.96
11_G72_R0.5170.96
36_Y58_G0.5170.96
13_D116_M0.5150.96
105_L112_R0.5060.96
106_P121_S0.5030.96
86_L90_F0.5030.96
28_A31_E0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3tA 1 0.9895 100 0.337 Contact Map
1nv8A 1 0.9529 100 0.348 Contact Map
4dzrA 2 0.7906 100 0.499 Contact Map
3evzA 1 0.8953 100 0.5 Contact Map
3c6kA 2 0.9215 99.9 0.581 Contact Map
3lpmA 2 0.8586 99.9 0.586 Contact Map
3tm4A 1 0.8796 99.9 0.594 Contact Map
4dcmA 1 0.8377 99.9 0.602 Contact Map
3q87B 1 0.8534 99.9 0.603 Contact Map
3dmgA 1 0.8743 99.9 0.608 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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