GREMLIN Database
Q9HQH2 - Uncharacterized protein
UniProt: Q9HQH2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (254)
Sequences: 11427 (8240)
Seq/√Len: 517.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_K265_D3.6041.00
40_V81_A3.5431.00
199_E262_T3.4671.00
137_Q142_Q3.4161.00
146_T156_Q3.2321.00
202_M258_Q2.9441.00
206_K210_S2.8831.00
227_S234_V2.8281.00
263_A266_D2.7581.00
263_A267_A2.6681.00
200_H267_A2.6631.00
275_Q279_A2.6061.00
212_L255_A2.6031.00
169_V173_S2.5001.00
135_W142_Q2.4881.00
197_D200_H2.4331.00
226_S236_D2.3801.00
229_G234_V2.3111.00
203_D207_D2.2721.00
112_R116_G2.1951.00
200_H203_D2.1601.00
207_D211_D2.1011.00
191_G232_A2.0941.00
189_S236_D2.0811.00
207_D263_A2.0551.00
189_S234_V2.0431.00
147_D154_R1.9711.00
205_A260_V1.9681.00
259_S262_T1.9581.00
200_H204_V1.9571.00
253_Q257_I1.9361.00
135_W144_I1.9281.00
204_V263_A1.9121.00
137_Q178_R1.8201.00
204_V267_A1.7901.00
193_D270_K1.7861.00
192_V201_A1.7651.00
208_A263_A1.7411.00
202_M206_K1.7131.00
255_A259_S1.7091.00
262_T266_D1.7001.00
208_A259_S1.6831.00
196_T270_K1.6451.00
211_D259_S1.6451.00
225_L233_I1.6361.00
137_Q176_V1.6311.00
157_T163_V1.6151.00
146_T162_Y1.5911.00
187_H236_D1.5681.00
52_D70_F1.5631.00
199_E258_Q1.5491.00
127_S151_V1.5371.00
139_G174_E1.5261.00
239_V256_V1.5161.00
209_V237_V1.5131.00
191_G234_V1.5101.00
212_L259_S1.5061.00
137_Q140_D1.4731.00
216_L219_P1.4651.00
264_F269_I1.4631.00
141_K174_E1.4491.00
214_D248_R1.4471.00
113_Q116_G1.4461.00
135_W158_F1.4381.00
48_D74_Q1.3841.00
154_R162_Y1.3821.00
190_V260_V1.3761.00
33_T89_W1.3671.00
163_V176_V1.3541.00
248_R251_R1.3421.00
105_I108_G1.3331.00
136_V145_V1.3301.00
251_R255_A1.3271.00
130_F153_T1.3201.00
161_E176_V1.3181.00
139_G173_S1.3141.00
214_D255_A1.3061.00
201_A235_M1.3011.00
258_Q262_T1.2961.00
134_D180_R1.2761.00
153_T167_N1.2661.00
42_V46_V1.2641.00
209_V212_L1.2631.00
241_I252_A1.2601.00
29_R32_I1.2471.00
37_L41_Y1.2441.00
77_L81_A1.2401.00
210_S217_S1.2391.00
199_E202_M1.2301.00
192_V196_T1.2261.00
40_V44_T1.2231.00
186_V239_V1.2201.00
85_I89_W1.2131.00
211_D263_A1.2001.00
230_D276_R1.1981.00
199_E203_D1.1981.00
33_T85_I1.1891.00
259_S263_A1.1811.00
205_A237_V1.1781.00
249_H253_Q1.1721.00
48_D70_F1.1631.00
204_V207_D1.1511.00
36_F81_A1.1501.00
74_Q78_Y1.1431.00
196_T201_A1.1401.00
162_Y180_R1.1361.00
157_T161_E1.1361.00
131_E180_R1.1351.00
189_S227_S1.1211.00
36_F88_F1.1201.00
138_V170_V1.1171.00
169_V172_S1.1121.00
143_G155_L1.1101.00
169_V174_E1.0981.00
230_D234_V1.0921.00
86_L91_L1.0911.00
99_G102_F1.0701.00
226_S234_V1.0651.00
41_Y45_G1.0631.00
195_E261_K1.0621.00
184_L249_H1.0601.00
41_Y78_Y1.0581.00
195_E273_F1.0451.00
206_K223_V1.0321.00
193_D196_T1.0231.00
28_V32_I1.0221.00
191_G229_G1.0181.00
185_R240_W1.0101.00
95_G98_I1.0031.00
191_G231_S1.0031.00
207_D210_S0.9991.00
198_V235_M0.9951.00
186_V253_Q0.9781.00
203_D206_K0.9741.00
195_E270_K0.9711.00
194_Y228_F0.9691.00
189_S226_S0.9661.00
44_T74_Q0.9661.00
111_A119_I0.9581.00
40_V77_L0.9531.00
204_V269_I0.9511.00
24_A28_V0.9501.00
242_D248_R0.9501.00
264_F271_I0.9401.00
44_T48_D0.9351.00
149_T154_R0.9351.00
228_F233_I0.9341.00
32_I88_F0.9321.00
214_D251_R0.9221.00
227_S257_I0.9211.00
97_L101_G0.9201.00
187_H238_R0.9201.00
103_A107_L0.9141.00
212_L256_V0.9071.00
116_G168_D0.9061.00
152_N164_M0.9041.00
256_V260_V0.9031.00
190_V205_A0.8921.00
214_D252_A0.8851.00
209_V239_V0.8841.00
192_V235_M0.8841.00
67_E71_R0.8841.00
198_V233_I0.8801.00
206_K221_P0.8771.00
250_W254_T0.8741.00
136_V155_L0.8731.00
156_Q162_Y0.8731.00
191_G230_D0.8691.00
254_T258_Q0.8551.00
223_V237_V0.8551.00
144_I156_Q0.8511.00
196_T200_H0.8401.00
160_G240_W0.8381.00
145_V155_L0.8361.00
47_L73_L0.8321.00
114_T120_A0.8291.00
139_G169_V0.8291.00
224_V254_T0.8281.00
231_S273_F0.8271.00
110_A115_L0.8251.00
31_A35_G0.8171.00
70_F74_Q0.8161.00
212_L215_V0.8141.00
141_K163_V0.8071.00
225_L257_I0.8041.00
192_V264_F0.7991.00
205_A264_F0.7971.00
25_R29_R0.7961.00
44_T81_A0.7961.00
188_V257_I0.7961.00
270_K277_E0.7931.00
192_V269_I0.7911.00
81_A85_I0.7911.00
50_A54_F0.7891.00
208_A256_V0.7871.00
230_D274_P0.7781.00
102_F111_A0.7781.00
120_A171_G0.7771.00
123_V171_G0.7701.00
229_G232_A0.7641.00
194_Y233_I0.7631.00
194_Y271_I0.7611.00
128_R131_E0.7581.00
224_V236_D0.7571.00
186_V241_I0.7511.00
89_W92_D0.7471.00
198_V202_M0.7461.00
198_V261_K0.7461.00
193_D272_P0.7441.00
87_G92_D0.7411.00
79_I83_I0.7381.00
273_F277_E0.7361.00
107_L115_L0.7301.00
255_A258_Q0.7261.00
202_M254_T0.7251.00
231_S276_R0.7241.00
213_D216_L0.7201.00
191_G194_Y0.7121.00
78_Y82_L0.7081.00
162_Y181_K0.7081.00
127_S152_N0.7051.00
38_A42_V0.7041.00
209_V215_V0.7011.00
138_V165_L0.7001.00
44_T77_L0.6981.00
203_D267_A0.6971.00
52_D56_D0.6961.00
228_F257_I0.6921.00
191_G273_F0.6871.00
26_V30_V0.6851.00
226_S253_Q0.6841.00
117_S168_D0.6841.00
216_L242_D0.6841.00
99_G103_A0.6821.00
156_Q160_G0.6821.00
53_R57_G0.6811.00
208_A212_L0.6781.00
99_G104_G0.6751.00
23_R26_V0.6731.00
130_F170_V0.6721.00
44_T78_Y0.6661.00
250_W253_Q0.6651.00
100_A104_G0.6611.00
188_V239_V0.6611.00
103_A106_V0.6611.00
222_Q238_R0.6601.00
231_S274_P0.6591.00
67_E147_D0.6591.00
47_L77_L0.6551.00
27_L30_V0.6541.00
45_G49_D0.6541.00
194_Y273_F0.6541.00
116_G172_S0.6541.00
64_H125_M0.6531.00
81_A84_V0.6491.00
35_G39_V0.6481.00
207_D267_A0.6461.00
204_V208_A0.6451.00
97_L106_V0.6431.00
138_V141_K0.6421.00
107_L119_I0.6421.00
136_V170_V0.6421.00
149_T152_N0.6401.00
198_V262_T0.6401.00
146_T181_K0.6381.00
55_T66_T0.6351.00
137_Q141_K0.6291.00
228_F261_K0.6271.00
186_V249_H0.6261.00
126_F129_P0.6241.00
84_V88_F0.6211.00
270_K275_Q0.6211.00
156_Q181_K0.6201.00
201_A264_F0.6201.00
114_T171_G0.6191.00
215_V252_A0.6191.00
141_K176_V0.6181.00
48_D52_D0.6151.00
183_R219_P0.6151.00
154_R164_M0.6151.00
42_V45_G0.6121.00
193_D271_I0.6121.00
127_S154_R0.6121.00
101_G104_G0.6121.00
210_S220_R0.6101.00
31_A34_M0.6091.00
112_R168_D0.6071.00
214_D217_S0.6051.00
221_P224_V0.6041.00
197_D262_T0.6021.00
206_K220_R0.6000.99
63_D66_T0.5970.99
205_A209_V0.5930.99
246_S249_H0.5920.99
26_V29_R0.5920.99
273_F276_R0.5910.99
185_R238_R0.5900.99
130_F136_V0.5880.99
208_A211_D0.5880.99
209_V256_V0.5880.99
233_I261_K0.5870.99
63_D67_E0.5870.99
98_I101_G0.5820.99
200_H207_D0.5820.99
94_S98_I0.5820.99
144_I247_R0.5820.99
237_V260_V0.5810.99
33_T37_L0.5790.99
51_L55_T0.5790.99
71_R74_Q0.5770.99
159_D185_R0.5770.99
113_Q172_S0.5770.99
113_Q168_D0.5770.99
206_K209_V0.5770.99
222_Q226_S0.5750.99
39_V43_G0.5740.99
204_V264_F0.5680.99
46_V50_A0.5680.99
192_V198_V0.5670.99
252_A255_A0.5670.99
257_I260_V0.5670.99
242_D247_R0.5660.99
80_G84_V0.5630.99
102_F106_V0.5600.99
97_L102_F0.5580.99
47_L50_A0.5570.99
35_G38_A0.5570.99
46_V49_D0.5550.99
142_Q178_R0.5540.99
276_R279_A0.5530.99
203_D210_S0.5520.99
75_I79_I0.5520.99
92_D95_G0.5510.99
209_V223_V0.5500.99
130_F175_I0.5490.99
165_L174_E0.5490.99
201_A269_I0.5490.99
71_R75_I0.5480.99
142_Q158_F0.5460.99
220_R224_V0.5460.99
120_A168_D0.5450.99
100_A103_A0.5440.99
205_A223_V0.5430.99
27_L31_A0.5430.99
132_I148_I0.5410.99
109_M112_R0.5410.99
225_L228_F0.5380.99
144_I158_F0.5370.99
138_V174_E0.5350.99
124_L130_F0.5330.99
38_A41_Y0.5330.99
183_R242_D0.5330.99
71_R147_D0.5320.99
105_I113_Q0.5310.99
168_D172_S0.5310.99
262_T265_D0.5290.99
201_A204_V0.5290.99
36_F84_V0.5290.99
37_L85_I0.5280.99
25_R28_V0.5270.99
62_T128_R0.5260.99
202_M235_M0.5230.99
64_H68_V0.5230.99
208_A267_A0.5230.99
36_F39_V0.5220.99
224_V250_W0.5200.99
54_F57_G0.5190.99
66_T70_F0.5170.99
196_T233_I0.5140.98
37_L40_V0.5130.98
231_S275_Q0.5130.98
102_F105_I0.5110.98
56_D66_T0.5110.98
34_M38_A0.5090.98
138_V173_S0.5050.98
190_V237_V0.5040.98
157_T176_V0.5030.98
103_A110_A0.5030.98
227_S253_Q0.5020.98
208_A264_F0.5000.98
45_G48_D0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hw9A 3 0.8433 100 0.158 Contact Map
5ajiA 3 0.8767 100 0.164 Contact Map
3udcA 3 0.85 100 0.207 Contact Map
1nz9A 1 0.16 24.7 0.947 Contact Map
3mlqE 1 0.13 16 0.952 Contact Map
2lt1A 1 0.21 15.9 0.952 Contact Map
2mi6A 1 0.1733 14.7 0.953 Contact Map
2e6zA 1 0.17 12.3 0.954 Contact Map
3j1zP 8 0.86 12 0.954 Contact Map
4l5gA 1 0.4533 10.8 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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