GREMLIN Database
Q9HQH0 - Uncharacterized protein
UniProt: Q9HQH0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (178)
Sequences: 186 (137)
Seq/√Len: 10.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_V162_V5.2291.00
47_V195_A4.0830.99
49_T70_R4.0420.99
46_A57_L3.4610.97
104_V108_V3.1700.95
22_A125_I2.9640.93
72_Q78_E2.9060.92
117_D121_D2.7910.90
111_N114_R2.5630.86
28_L31_G2.5510.86
160_A164_E2.4820.84
69_D80_G2.4200.82
124_P147_L2.3450.80
74_R78_E2.1020.72
147_L178_E2.0680.71
81_I176_I2.0320.70
43_V148_E1.9320.66
109_D176_I1.9250.65
44_G59_L1.9140.65
21_S49_T1.8610.62
99_E102_Y1.8540.62
31_G42_A1.8350.61
112_E116_V1.7210.56
158_S162_V1.7200.56
113_R117_D1.7130.56
161_D164_E1.6990.55
101_D119_Y1.6450.53
42_A93_S1.5770.50
73_V78_E1.5540.48
147_L160_A1.5480.48
122_A166_V1.4980.46
31_G190_K1.4940.46
59_L65_I1.4840.45
119_Y133_N1.4400.43
136_P190_K1.4330.43
59_L119_Y1.3760.40
108_V177_V1.3630.40
67_I149_E1.3280.38
27_F108_V1.3170.38
46_A81_I1.2890.36
108_V162_V1.2760.36
122_A174_E1.2720.36
23_V49_T1.2660.35
115_F193_N1.2560.35
41_G55_Y1.2540.35
121_D128_R1.2480.35
59_L81_I1.2370.34
24_V193_N1.2300.34
30_H53_T1.2270.34
39_G187_P1.2200.34
129_L191_Y1.2190.34
101_D152_R1.2050.33
125_I180_I1.2020.33
184_I187_P1.1990.33
134_L158_S1.1940.32
126_S149_E1.1900.32
163_S170_H1.1840.32
147_L177_V1.1800.32
31_G136_P1.1790.32
24_V36_R1.1740.32
45_Y87_V1.1710.32
33_S38_Y1.1690.31
171_T184_I1.1610.31
60_S71_V1.1520.31
67_I95_G1.1490.31
23_V83_R1.1480.31
88_E100_L1.1480.31
177_V181_L1.1430.30
127_L144_D1.1320.30
39_G186_D1.1160.29
124_P168_G1.1080.29
149_E152_R1.1060.29
45_Y93_S1.0950.29
74_R80_G1.0920.28
159_F177_V1.0840.28
127_L143_R1.0840.28
25_L147_L1.0730.28
60_S78_E1.0650.27
155_P159_F1.0620.27
113_R121_D1.0570.27
133_N142_L1.0540.27
133_N141_K1.0400.27
71_V176_I1.0320.26
127_L151_K1.0320.26
104_V127_L1.0180.26
23_V185_R1.0170.26
125_I191_Y1.0140.26
126_S168_G1.0120.26
19_S48_S1.0100.25
29_A125_I1.0060.25
173_Q184_I1.0030.25
31_G43_V0.9890.25
163_S171_T0.9850.25
57_L162_V0.9830.25
42_A118_F0.9790.24
71_V94_D0.9760.24
56_E143_R0.9610.24
34_D62_D0.9570.24
105_E192_Y0.9550.24
65_I146_I0.9520.23
106_D110_A0.9510.23
90_D124_P0.9460.23
49_T163_S0.9420.23
43_V146_I0.9390.23
24_V71_V0.9370.23
119_Y141_K0.9340.23
27_F136_P0.9330.23
71_V146_I0.9230.23
28_L42_A0.9120.22
89_Y92_L0.9120.22
45_Y97_R0.9100.22
107_V111_N0.9090.22
66_G69_D0.9020.22
82_D195_A0.8990.22
115_F124_P0.8860.21
18_D75_P0.8860.21
160_A184_I0.8810.21
35_G38_Y0.8800.21
98_S106_D0.8760.21
125_I174_E0.8720.21
124_P158_S0.8700.21
55_Y86_E0.8670.21
60_S72_Q0.8640.21
49_T83_R0.8640.21
55_Y121_D0.8530.20
184_I195_A0.8480.20
105_E174_E0.8480.20
18_D87_V0.8460.20
89_Y97_R0.8360.20
32_R66_G0.8350.20
22_A99_E0.8340.20
70_R110_A0.8330.20
82_D89_Y0.8310.20
129_L166_V0.8310.20
67_I129_L0.8270.20
72_Q86_E0.8120.19
40_D144_D0.8090.19
43_V135_L0.8070.19
80_G161_D0.8050.19
135_L187_P0.8030.19
45_Y138_I0.8000.19
22_A46_A0.7940.19
99_E143_R0.7800.18
47_V104_V0.7690.18
71_V175_V0.7650.18
122_A172_P0.7650.18
29_A105_E0.7630.18
91_D113_R0.7620.18
27_F182_D0.7540.18
20_E64_D0.7510.17
116_V158_S0.7490.17
97_R159_F0.7460.17
69_D131_Q0.7460.17
80_G93_S0.7410.17
143_R174_E0.7390.17
128_R170_H0.7340.17
23_V75_P0.7310.17
147_L185_R0.7290.17
64_D81_I0.7260.17
52_F158_S0.7220.17
19_S73_V0.7210.17
129_L181_L0.7130.16
158_S166_V0.7130.16
131_Q168_G0.7110.16
43_V151_K0.7100.16
61_S69_D0.7090.16
49_T121_D0.7060.16
43_V96_A0.7050.16
65_I186_D0.7040.16
124_P182_D0.7020.16
138_I142_L0.7010.16
62_D106_D0.7000.16
45_Y53_T0.6990.16
20_E74_R0.6960.16
70_R193_N0.6900.16
67_I103_V0.6900.16
72_Q80_G0.6840.16
69_D123_Q0.6780.16
138_I168_G0.6750.15
61_S93_S0.6710.15
162_V193_N0.6690.15
51_D133_N0.6680.15
76_E79_T0.6680.15
70_R146_I0.6610.15
152_R188_D0.6600.15
70_R104_V0.6570.15
129_L190_K0.6570.15
70_R105_E0.6520.15
16_D49_T0.6510.15
171_T177_V0.6470.15
121_D162_V0.6420.15
144_D176_I0.6370.15
151_K170_H0.6340.15
19_S193_N0.6340.15
46_A99_E0.6300.14
44_G160_A0.6300.14
44_G107_V0.6300.14
70_R124_P0.6260.14
82_D108_V0.6250.14
147_L155_P0.6230.14
18_D55_Y0.6210.14
103_V192_Y0.6200.14
22_A155_P0.6170.14
94_D176_I0.6140.14
181_L186_D0.6140.14
35_G190_K0.6130.14
86_E107_V0.6100.14
119_Y172_P0.6060.14
20_E40_D0.6020.14
67_I102_Y0.6020.14
28_L40_D0.6020.14
91_D181_L0.6010.14
53_T87_V0.5990.14
52_F141_K0.5960.14
147_L188_D0.5950.14
26_D56_E0.5940.14
23_V70_R0.5940.14
152_R157_E0.5940.14
126_S140_E0.5930.14
38_Y142_L0.5930.14
127_L188_D0.5890.14
92_L191_Y0.5850.13
96_A150_R0.5810.13
116_V134_L0.5800.13
38_Y44_G0.5800.13
35_G40_D0.5760.13
24_V44_G0.5750.13
62_D157_E0.5750.13
55_Y74_R0.5730.13
28_L190_K0.5730.13
31_G135_L0.5710.13
141_K191_Y0.5690.13
27_F50_I0.5640.13
21_S74_R0.5630.13
159_F167_D0.5630.13
48_S184_I0.5620.13
137_G182_D0.5550.13
33_S61_S0.5540.13
46_A51_D0.5510.13
36_R164_E0.5500.13
136_P141_K0.5460.13
28_L135_L0.5440.13
44_G151_K0.5440.13
103_V131_Q0.5430.13
38_Y175_V0.5420.13
146_I162_V0.5400.12
78_E81_I0.5370.12
113_R148_E0.5350.12
15_A21_S0.5340.12
30_H55_Y0.5340.12
176_I182_D0.5330.12
132_L180_I0.5290.12
120_N140_E0.5270.12
114_R169_L0.5270.12
61_S148_E0.5260.12
102_Y143_R0.5240.12
79_T171_T0.5210.12
77_F116_V0.5200.12
82_D117_D0.5190.12
49_T110_A0.5160.12
128_R192_Y0.5140.12
38_Y51_D0.5130.12
20_E81_I0.5130.12
123_Q195_A0.5110.12
101_D172_P0.5080.12
35_G91_D0.5050.12
160_A163_S0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i5hA 1 0.8883 100 0.379 Contact Map
2eduA 1 0.4873 96.6 0.917 Contact Map
3wu2U 1 0.4061 95.8 0.924 Contact Map
2duyA 1 0.3249 90.6 0.938 Contact Map
3f2bA 1 0.6802 89.3 0.939 Contact Map
3b0xA 1 0.8934 88.5 0.94 Contact Map
1ixrA 4 0.6802 85.9 0.942 Contact Map
2hnhA 1 0.8579 84.3 0.944 Contact Map
4pj0U 1 0.3756 84 0.944 Contact Map
2hpiA 2 0.8274 81.9 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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