Q9HQH0 - HALSA - GREMLIN Contacts

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Q9HQH0 - Uncharacterized protein

UniProt:	Q9HQH0	Sequences: MSDTSTTDANSDSGADGDSESAVVLDFLAHGRSDGRSYGDGAVGYAVSTIDFTLYELSLSSDADIGILDRVQVRPEFETGIDRGREVEYDDLSDGARSELDYVVEDVVDANERRFVDFYNDAQPISLRLHQLNLLPGIGEKLRDNILEERKRRGPFESFADVSERVDGLHTPQEVIVERILDEIRDPDLKYYNFAAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	197 (178)
Sequences:	186 (137)
Seq/√Len:	10.3

HALSA - Q9HQH0
SULSO - Q7LXK5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
116_V	162_V	5.229	1.00
47_V	195_A	4.083	0.99
49_T	70_R	4.042	0.99
46_A	57_L	3.461	0.97
104_V	108_V	3.170	0.95
22_A	125_I	2.964	0.93
72_Q	78_E	2.906	0.92
117_D	121_D	2.791	0.90
111_N	114_R	2.563	0.86
28_L	31_G	2.551	0.86
160_A	164_E	2.482	0.84
69_D	80_G	2.420	0.82
124_P	147_L	2.345	0.80
74_R	78_E	2.102	0.72
147_L	178_E	2.068	0.71
81_I	176_I	2.032	0.70
43_V	148_E	1.932	0.66
109_D	176_I	1.925	0.65
44_G	59_L	1.914	0.65
21_S	49_T	1.861	0.62
99_E	102_Y	1.854	0.62
31_G	42_A	1.835	0.61
112_E	116_V	1.721	0.56
158_S	162_V	1.720	0.56
113_R	117_D	1.713	0.56
161_D	164_E	1.699	0.55
101_D	119_Y	1.645	0.53
42_A	93_S	1.577	0.50
73_V	78_E	1.554	0.48
147_L	160_A	1.548	0.48
122_A	166_V	1.498	0.46
31_G	190_K	1.494	0.46
59_L	65_I	1.484	0.45
119_Y	133_N	1.440	0.43
136_P	190_K	1.433	0.43
59_L	119_Y	1.376	0.40
108_V	177_V	1.363	0.40
67_I	149_E	1.328	0.38
27_F	108_V	1.317	0.38
46_A	81_I	1.289	0.36
108_V	162_V	1.276	0.36
122_A	174_E	1.272	0.36
23_V	49_T	1.266	0.35
115_F	193_N	1.256	0.35
41_G	55_Y	1.254	0.35
121_D	128_R	1.248	0.35
59_L	81_I	1.237	0.34
24_V	193_N	1.230	0.34
30_H	53_T	1.227	0.34
39_G	187_P	1.220	0.34
129_L	191_Y	1.219	0.34
101_D	152_R	1.205	0.33
125_I	180_I	1.202	0.33
184_I	187_P	1.199	0.33
134_L	158_S	1.194	0.32
126_S	149_E	1.190	0.32
163_S	170_H	1.184	0.32
147_L	177_V	1.180	0.32
31_G	136_P	1.179	0.32
24_V	36_R	1.174	0.32
45_Y	87_V	1.171	0.32
33_S	38_Y	1.169	0.31
171_T	184_I	1.161	0.31
60_S	71_V	1.152	0.31
67_I	95_G	1.149	0.31
23_V	83_R	1.148	0.31
88_E	100_L	1.148	0.31
177_V	181_L	1.143	0.30
127_L	144_D	1.132	0.30
39_G	186_D	1.116	0.29
124_P	168_G	1.108	0.29
149_E	152_R	1.106	0.29
45_Y	93_S	1.095	0.29
74_R	80_G	1.092	0.28
159_F	177_V	1.084	0.28
127_L	143_R	1.084	0.28
25_L	147_L	1.073	0.28
60_S	78_E	1.065	0.27
155_P	159_F	1.062	0.27
113_R	121_D	1.057	0.27
133_N	142_L	1.054	0.27
133_N	141_K	1.040	0.27
71_V	176_I	1.032	0.26
127_L	151_K	1.032	0.26
104_V	127_L	1.018	0.26
23_V	185_R	1.017	0.26
125_I	191_Y	1.014	0.26
126_S	168_G	1.012	0.26
19_S	48_S	1.010	0.25
29_A	125_I	1.006	0.25
173_Q	184_I	1.003	0.25
31_G	43_V	0.989	0.25
163_S	171_T	0.985	0.25
57_L	162_V	0.983	0.25
42_A	118_F	0.979	0.24
71_V	94_D	0.976	0.24
56_E	143_R	0.961	0.24
34_D	62_D	0.957	0.24
105_E	192_Y	0.955	0.24
65_I	146_I	0.952	0.23
106_D	110_A	0.951	0.23
90_D	124_P	0.946	0.23
49_T	163_S	0.942	0.23
43_V	146_I	0.939	0.23
24_V	71_V	0.937	0.23
119_Y	141_K	0.934	0.23
27_F	136_P	0.933	0.23
71_V	146_I	0.923	0.23
28_L	42_A	0.912	0.22
89_Y	92_L	0.912	0.22
45_Y	97_R	0.910	0.22
107_V	111_N	0.909	0.22
66_G	69_D	0.902	0.22
82_D	195_A	0.899	0.22
115_F	124_P	0.886	0.21
18_D	75_P	0.886	0.21
160_A	184_I	0.881	0.21
35_G	38_Y	0.880	0.21
98_S	106_D	0.876	0.21
125_I	174_E	0.872	0.21
124_P	158_S	0.870	0.21
55_Y	86_E	0.867	0.21
60_S	72_Q	0.864	0.21
49_T	83_R	0.864	0.21
55_Y	121_D	0.853	0.20
184_I	195_A	0.848	0.20
105_E	174_E	0.848	0.20
18_D	87_V	0.846	0.20
89_Y	97_R	0.836	0.20
32_R	66_G	0.835	0.20
22_A	99_E	0.834	0.20
70_R	110_A	0.833	0.20
82_D	89_Y	0.831	0.20
129_L	166_V	0.831	0.20
67_I	129_L	0.827	0.20
72_Q	86_E	0.812	0.19
40_D	144_D	0.809	0.19
43_V	135_L	0.807	0.19
80_G	161_D	0.805	0.19
135_L	187_P	0.803	0.19
45_Y	138_I	0.800	0.19
22_A	46_A	0.794	0.19
99_E	143_R	0.780	0.18
47_V	104_V	0.769	0.18
71_V	175_V	0.765	0.18
122_A	172_P	0.765	0.18
29_A	105_E	0.763	0.18
91_D	113_R	0.762	0.18
27_F	182_D	0.754	0.18
20_E	64_D	0.751	0.17
116_V	158_S	0.749	0.17
97_R	159_F	0.746	0.17
69_D	131_Q	0.746	0.17
80_G	93_S	0.741	0.17
143_R	174_E	0.739	0.17
128_R	170_H	0.734	0.17
23_V	75_P	0.731	0.17
147_L	185_R	0.729	0.17
64_D	81_I	0.726	0.17
52_F	158_S	0.722	0.17
19_S	73_V	0.721	0.17
129_L	181_L	0.713	0.16
158_S	166_V	0.713	0.16
131_Q	168_G	0.711	0.16
43_V	151_K	0.710	0.16
61_S	69_D	0.709	0.16
49_T	121_D	0.706	0.16
43_V	96_A	0.705	0.16
65_I	186_D	0.704	0.16
124_P	182_D	0.702	0.16
138_I	142_L	0.701	0.16
62_D	106_D	0.700	0.16
45_Y	53_T	0.699	0.16
20_E	74_R	0.696	0.16
70_R	193_N	0.690	0.16
67_I	103_V	0.690	0.16
72_Q	80_G	0.684	0.16
69_D	123_Q	0.678	0.16
138_I	168_G	0.675	0.15
61_S	93_S	0.671	0.15
162_V	193_N	0.669	0.15
51_D	133_N	0.668	0.15
76_E	79_T	0.668	0.15
70_R	146_I	0.661	0.15
152_R	188_D	0.660	0.15
70_R	104_V	0.657	0.15
129_L	190_K	0.657	0.15
70_R	105_E	0.652	0.15
16_D	49_T	0.651	0.15
171_T	177_V	0.647	0.15
121_D	162_V	0.642	0.15
144_D	176_I	0.637	0.15
151_K	170_H	0.634	0.15
19_S	193_N	0.634	0.15
46_A	99_E	0.630	0.14
44_G	160_A	0.630	0.14
44_G	107_V	0.630	0.14
70_R	124_P	0.626	0.14
82_D	108_V	0.625	0.14
147_L	155_P	0.623	0.14
18_D	55_Y	0.621	0.14
103_V	192_Y	0.620	0.14
22_A	155_P	0.617	0.14
94_D	176_I	0.614	0.14
181_L	186_D	0.614	0.14
35_G	190_K	0.613	0.14
86_E	107_V	0.610	0.14
119_Y	172_P	0.606	0.14
20_E	40_D	0.602	0.14
67_I	102_Y	0.602	0.14
28_L	40_D	0.602	0.14
91_D	181_L	0.601	0.14
53_T	87_V	0.599	0.14
52_F	141_K	0.596	0.14
147_L	188_D	0.595	0.14
26_D	56_E	0.594	0.14
23_V	70_R	0.594	0.14
152_R	157_E	0.594	0.14
126_S	140_E	0.593	0.14
38_Y	142_L	0.593	0.14
127_L	188_D	0.589	0.14
92_L	191_Y	0.585	0.13
96_A	150_R	0.581	0.13
116_V	134_L	0.580	0.13
38_Y	44_G	0.580	0.13
35_G	40_D	0.576	0.13
24_V	44_G	0.575	0.13
62_D	157_E	0.575	0.13
55_Y	74_R	0.573	0.13
28_L	190_K	0.573	0.13
31_G	135_L	0.571	0.13
141_K	191_Y	0.569	0.13
27_F	50_I	0.564	0.13
21_S	74_R	0.563	0.13
159_F	167_D	0.563	0.13
48_S	184_I	0.562	0.13
137_G	182_D	0.555	0.13
33_S	61_S	0.554	0.13
46_A	51_D	0.551	0.13
36_R	164_E	0.550	0.13
136_P	141_K	0.546	0.13
28_L	135_L	0.544	0.13
44_G	151_K	0.544	0.13
103_V	131_Q	0.543	0.13
38_Y	175_V	0.542	0.13
146_I	162_V	0.540	0.12
78_E	81_I	0.537	0.12
113_R	148_E	0.535	0.12
15_A	21_S	0.534	0.12
30_H	55_Y	0.534	0.12
176_I	182_D	0.533	0.12
132_L	180_I	0.529	0.12
120_N	140_E	0.527	0.12
114_R	169_L	0.527	0.12
61_S	148_E	0.526	0.12
102_Y	143_R	0.524	0.12
79_T	171_T	0.521	0.12
77_F	116_V	0.520	0.12
82_D	117_D	0.519	0.12
49_T	110_A	0.516	0.12
128_R	192_Y	0.514	0.12
38_Y	51_D	0.513	0.12
20_E	81_I	0.513	0.12
123_Q	195_A	0.511	0.12
101_D	172_P	0.508	0.12
35_G	91_D	0.505	0.12
160_A	163_S	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i5hA	1	0.8883	100	0.379	Contact Map
2eduA	1	0.4873	96.6	0.917	Contact Map
3wu2U	1	0.4061	95.8	0.924	Contact Map
2duyA	1	0.3249	90.6	0.938	Contact Map
3f2bA	1	0.6802	89.3	0.939	Contact Map
3b0xA	1	0.8934	88.5	0.94	Contact Map
1ixrA	4	0.6802	85.9	0.942	Contact Map
2hnhA	1	0.8579	84.3	0.944	Contact Map
4pj0U	1	0.3756	84	0.944	Contact Map
2hpiA	2	0.8274	81.9	0.945	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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