GREMLIN Database
Q9HQG9 - Uncharacterized protein
UniProt: Q9HQG9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (114)
Sequences: 112 (82)
Seq/√Len: 7.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_L108_L4.3450.98
65_E117_K3.6590.95
62_F85_L3.3510.92
63_V82_V3.0890.88
81_I115_V3.0150.86
51_F80_K2.5550.75
8_V87_R2.2160.64
18_A117_K2.1140.60
79_Y83_D1.9950.55
16_S62_F1.8370.49
58_E61_E1.8160.48
55_E59_S1.8080.48
37_L79_Y1.7560.46
77_V82_V1.6980.44
58_E85_L1.6950.43
42_S48_A1.6930.43
22_L26_E1.6790.43
73_D80_K1.6140.40
4_F91_E1.6030.40
22_L48_A1.5930.40
3_I51_F1.5880.39
76_A96_F1.5870.39
28_E107_E1.5080.36
54_L85_L1.4860.36
18_A87_R1.4790.35
15_V53_L1.4050.33
43_R91_E1.4040.33
16_S83_D1.4020.32
89_R109_D1.3980.32
96_F106_D1.3820.32
26_E105_G1.3480.31
17_E60_R1.3420.30
46_E107_E1.2810.28
65_E114_V1.2610.28
16_S87_R1.2570.28
82_V115_V1.2530.27
23_S111_I1.2390.27
41_L45_I1.2110.26
61_E65_E1.1990.26
18_A37_L1.1920.26
28_E56_P1.1740.25
94_S101_Y1.1650.25
95_V102_A1.1600.25
110_E113_D1.1600.25
46_E49_N1.1320.24
20_A23_S1.1140.23
75_E79_Y1.1100.23
90_T102_A1.1060.23
37_L118_Y1.1060.23
28_E50_R1.1010.23
11_E36_E1.1000.23
20_A94_S1.0730.22
13_L104_S1.0640.22
16_S85_L1.0610.22
21_L24_E1.0590.22
19_K47_H1.0590.22
42_S98_N1.0520.22
41_L109_D1.0370.21
47_H107_E1.0330.21
36_E79_Y1.0220.21
13_L51_F1.0220.21
2_T53_L0.9980.20
2_T98_N0.9810.20
17_E29_R0.9730.19
41_L108_L0.9480.19
26_E49_N0.9400.19
27_T102_A0.9400.19
91_E103_M0.9390.19
63_V78_A0.9340.19
69_L84_L0.9300.18
7_T52_A0.9070.18
90_T93_R0.9060.18
55_E58_E0.9000.18
17_E93_R0.8680.17
97_A100_R0.8670.17
54_L62_F0.8660.17
70_D103_M0.8580.17
22_L105_G0.8560.17
93_R99_E0.8470.17
85_L104_S0.8450.16
45_I100_R0.8340.16
8_V52_A0.8290.16
56_P113_D0.8220.16
36_E115_V0.8210.16
52_A64_D0.8210.16
95_V98_N0.8180.16
16_S114_V0.7990.15
72_L96_F0.7950.15
24_E64_D0.7950.15
82_V90_T0.7910.15
62_F82_V0.7880.15
20_A56_P0.7720.15
64_D69_L0.7680.15
112_L117_K0.7650.15
19_K52_A0.7540.15
23_S36_E0.7530.15
65_E68_A0.7530.15
29_R103_M0.7440.14
16_S54_L0.7410.14
88_T111_I0.7370.14
63_V115_V0.7320.14
59_S64_D0.7300.14
16_S19_K0.7110.14
34_D88_T0.7100.14
38_R42_S0.7050.14
61_E64_D0.6990.13
6_E41_L0.6940.13
64_D117_K0.6930.13
12_P52_A0.6880.13
61_E67_L0.6830.13
62_F69_L0.6820.13
47_H97_A0.6770.13
4_F103_M0.6740.13
13_L98_N0.6720.13
41_L89_R0.6650.13
53_L95_V0.6600.13
5_K36_E0.6600.13
69_L113_D0.6590.13
44_A112_L0.6510.13
11_E82_V0.6500.13
38_R46_E0.6500.13
7_T45_I0.6470.13
89_R92_L0.6400.12
52_A111_I0.6350.12
8_V55_E0.6330.12
7_T96_F0.6310.12
60_R83_D0.6250.12
54_L118_Y0.6240.12
39_F82_V0.6150.12
22_L97_A0.6090.12
92_L105_G0.6070.12
113_D117_K0.6050.12
88_T91_E0.6010.12
46_E50_R0.5970.12
4_F43_R0.5950.12
42_S104_S0.5940.12
20_A45_I0.5940.12
110_E115_V0.5920.12
22_L107_E0.5890.12
13_L18_A0.5830.11
67_L77_V0.5810.11
39_F97_A0.5800.11
53_L87_R0.5800.11
85_L117_K0.5800.11
80_K116_A0.5770.11
27_T84_L0.5770.11
16_S37_L0.5740.11
66_L80_K0.5730.11
92_L112_L0.5670.11
21_L28_E0.5640.11
16_S47_H0.5620.11
53_L84_L0.5560.11
26_E107_E0.5540.11
8_V27_T0.5460.11
29_R108_L0.5410.11
27_T59_S0.5360.11
25_V29_R0.5330.11
90_T103_M0.5330.11
23_S37_L0.5290.11
52_A106_D0.5290.11
16_S95_V0.5210.10
27_T37_L0.5210.10
19_K34_D0.5210.10
29_R89_R0.5080.10
15_V55_E0.5070.10
61_E101_Y0.5070.10
77_V96_F0.5050.10
14_T17_E0.5050.10
39_F88_T0.5030.10
15_V57_A0.5030.10
71_V103_M0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjfB 1 0.9832 100 0.423 Contact Map
1go3F 1 0.8992 99.9 0.444 Contact Map
2c35A 1 0.9916 99.9 0.545 Contact Map
4aybF 1 0.8739 99.9 0.549 Contact Map
3h0gD 1 0.9832 99.8 0.587 Contact Map
1y14A 1 0.9076 99.8 0.595 Contact Map
3ayhA 1 0.958 99.3 0.708 Contact Map
2ckzA 1 0.9412 98 0.811 Contact Map
2e1fA 2 0.5882 26.2 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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