GREMLIN Database
RL21 - 50S ribosomal protein L21e
UniProt: Q9HQG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 99 (96)
Sequences: 489 (271)
Seq/√Len: 27.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_P10_N2.9361.00
2_P5_N2.8271.00
3_N9_S2.6480.99
17_N45_D2.6010.99
72_F92_L2.2570.98
12_G88_G2.1640.98
32_A94_T2.1560.98
79_G82_D2.1280.97
29_R45_D2.0860.97
8_L62_G2.0090.96
43_T58_S1.9910.96
2_P9_S1.8860.95
34_Y94_T1.8580.94
40_V59_G1.7340.92
5_N9_S1.7240.92
65_V86_I1.6930.91
10_N13_G1.6500.90
39_S94_T1.6400.89
9_S63_T1.6140.89
59_G62_G1.5560.87
39_S63_T1.5470.86
66_G86_I1.5240.86
17_N46_P1.4890.84
41_H61_T1.4810.84
18_D21_D1.4760.84
4_S71_A1.4720.84
42_L60_L1.4000.80
4_S9_S1.3970.80
75_E86_I1.3810.79
3_N44_L1.3430.77
15_L62_G1.3340.77
66_G92_L1.2850.74
3_N49_Q1.2490.72
36_D70_D1.2300.71
60_L63_T1.1970.69
23_G74_V1.1830.68
30_A89_A1.1820.68
73_K86_I1.1330.64
71_A77_N1.1110.63
23_G37_G1.1020.62
46_P63_T1.1000.62
40_V91_H1.0930.61
41_H95_Q1.0910.61
70_D84_T1.0780.60
43_T93_R1.0590.59
80_G84_T1.0480.58
35_D38_E1.0480.58
14_K55_P1.0410.58
17_N53_F1.0200.56
37_G40_V1.0130.56
39_S49_Q0.9970.54
25_S48_V0.9910.54
25_S28_Q0.9740.53
88_G91_H0.9610.52
1_M6_G0.9590.51
26_P48_V0.9560.51
20_R23_G0.9270.49
47_S74_V0.9210.49
21_D33_D0.9170.48
1_M4_S0.9080.48
11_S58_S0.9040.47
68_Q86_I0.8930.46
5_N10_N0.8830.46
59_G91_H0.8790.45
68_Q92_L0.8700.45
50_D91_H0.8670.44
3_N10_N0.8610.44
29_R93_R0.8580.44
35_D75_E0.8530.43
25_S46_P0.8520.43
21_D24_T0.8510.43
17_N26_P0.8440.43
45_D56_R0.8070.40
21_D72_F0.8060.40
8_L42_L0.7850.38
37_G88_G0.7790.38
14_K96_R0.7740.38
40_V52_R0.7600.37
36_D69_G0.7600.37
35_D60_L0.7530.36
3_N55_P0.7470.36
18_D75_E0.7460.36
16_Q72_F0.7420.35
19_P88_G0.7330.35
14_K76_V0.7330.35
36_D44_L0.7240.34
78_D83_K0.7220.34
12_G74_V0.7220.34
66_G83_K0.7220.34
43_T57_F0.7170.34
12_G47_S0.7150.33
25_S31_I0.7110.33
40_V87_V0.7020.33
56_R79_G0.6970.32
29_R55_P0.6950.32
11_S15_L0.6900.32
77_N85_L0.6820.31
42_L50_D0.6810.31
73_K84_T0.6640.30
29_R32_A0.6590.30
28_Q36_D0.6470.29
48_V70_D0.6460.29
78_D95_Q0.6420.29
41_H50_D0.6390.29
51_G59_G0.6300.28
2_P50_D0.6270.28
5_N82_D0.6250.28
33_D36_D0.6230.28
17_N29_R0.6210.27
36_D63_T0.6200.27
52_R57_F0.6190.27
33_D46_P0.6180.27
90_A95_Q0.6160.27
28_Q31_I0.6110.27
39_S96_R0.6100.27
40_V53_F0.6060.27
15_L72_F0.6000.26
68_Q73_K0.5980.26
44_L94_T0.5980.26
13_G85_L0.5950.26
33_D79_G0.5800.25
22_R79_G0.5790.25
18_D67_T0.5780.25
39_S67_T0.5740.25
80_G87_V0.5670.24
70_D77_N0.5670.24
51_G61_T0.5490.23
78_D87_V0.5490.23
10_N38_E0.5460.23
15_L64_V0.5440.23
57_F78_D0.5430.23
8_L59_G0.5380.23
40_V51_G0.5360.23
53_F58_S0.5360.23
12_G83_K0.5330.22
52_R91_H0.5300.22
11_S61_T0.5300.22
7_P47_S0.5290.22
2_P14_K0.5290.22
64_V70_D0.5180.22
25_S30_A0.5130.21
73_K80_G0.5110.21
50_D82_D0.5100.21
22_R64_V0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zf7U 1 0.9899 100 0.04 Contact Map
3j61T 1 1 100 0.046 Contact Map
1vq8Q 1 0.9596 100 0.049 Contact Map
4w20T 1 0.9899 100 0.051 Contact Map
4a17P 1 0.9899 100 0.051 Contact Map
1vx7V 1 0.9798 100 0.059 Contact Map
3j21R 1 0.9596 100 0.062 Contact Map
3jywQ 1 0.9899 100 0.065 Contact Map
4ujrG 1 0.9899 100 0.066 Contact Map
2do3A 1 0.697 47.6 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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