GREMLIN Database
EF1B - Elongation factor 1-beta
UniProt: Q9HQG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 88 (87)
Sequences: 155 (112)
Seq/√Len: 12.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_S22_L3.6110.99
11_M79_S3.4560.98
23_E41_T2.5290.90
18_D21_G2.4990.89
15_P49_T2.3870.87
82_V87_R2.1530.80
21_G25_D2.1130.79
45_A63_G1.9230.72
33_G87_R1.8520.69
2_S59_D1.7850.66
10_V28_E1.6880.61
19_L26_L1.6720.60
20_D23_E1.6230.58
6_A64_T1.6230.58
39_T53_T1.6220.58
32_D45_A1.6000.57
42_E61_S1.5600.55
52_L83_E1.5120.53
41_T49_T1.4680.50
72_G80_V1.4620.50
11_M78_E1.4360.49
8_L73_A1.3800.46
17_I65_E1.3790.46
7_V10_V1.3730.46
24_A28_E1.3350.44
6_A63_G1.3330.44
4_V57_V1.3030.42
28_E73_A1.2980.42
43_E81_S1.2890.41
61_S87_R1.2860.41
71_F74_V1.2480.39
30_L53_T1.2450.39
30_L68_E1.2190.38
37_N56_I1.2080.38
6_A57_V1.2070.37
56_I59_D1.1740.36
35_E40_D1.1600.35
55_V59_D1.1490.35
11_M15_P1.1210.34
22_L74_V1.0570.31
44_V50_A1.0250.29
78_E84_E1.0140.29
13_D17_I1.0130.29
66_A69_D1.0060.29
5_A11_M0.9760.27
5_A68_E0.9670.27
28_E66_A0.9550.27
58_P86_G0.9450.26
17_I22_L0.9410.26
29_S44_V0.9410.26
45_A82_V0.9080.25
4_V64_T0.9060.25
14_S17_I0.9060.25
27_S44_V0.8960.24
64_T68_E0.8900.24
16_D22_L0.8880.24
65_E85_V0.8880.24
49_T61_S0.8750.24
14_S21_G0.8700.23
29_S79_S0.8700.23
2_S69_D0.8590.23
55_V67_V0.8550.23
38_G54_T0.8460.22
26_L71_F0.8430.22
29_S32_D0.8240.22
43_E67_V0.8130.21
48_L62_G0.8020.21
16_D81_S0.7970.21
26_L33_G0.7950.21
19_L87_R0.7920.21
31_P82_V0.7880.21
6_A68_E0.7840.20
55_V82_V0.7810.20
2_S61_S0.7800.20
30_L36_I0.7780.20
15_P41_T0.7560.19
6_A34_A0.7490.19
3_K18_D0.7330.19
60_D83_E0.7250.19
9_K25_D0.7250.19
26_L78_E0.7250.19
37_N45_A0.7230.18
22_L25_D0.7070.18
20_D41_T0.6940.18
29_S74_V0.6930.18
24_A77_V0.6880.17
29_S36_I0.6870.17
4_V63_G0.6840.17
35_E51_L0.6780.17
63_G68_E0.6680.17
25_D60_D0.6650.17
24_A32_D0.6600.17
8_L71_F0.6580.17
34_A59_D0.6540.16
10_V80_V0.6490.16
36_I74_V0.6390.16
41_T53_T0.6330.16
45_A77_V0.6300.16
34_A52_L0.6240.16
9_K83_E0.6220.16
6_A32_D0.6210.16
16_D66_A0.6180.15
28_E72_G0.6150.15
2_S49_T0.6060.15
39_T71_F0.6040.15
7_V57_V0.6030.15
42_E75_D0.6020.15
13_D37_N0.5870.15
10_V39_T0.5820.15
60_D81_S0.5780.14
15_P71_F0.5760.14
22_L71_F0.5720.14
59_D70_A0.5710.14
3_K24_A0.5690.14
43_E54_T0.5570.14
67_V71_F0.5550.14
25_D28_E0.5520.14
32_D69_D0.5490.14
28_E60_D0.5470.14
10_V58_P0.5420.14
34_A81_S0.5340.13
24_A27_S0.5300.13
67_V79_S0.5290.13
19_L59_D0.5190.13
31_P64_T0.5160.13
37_N41_T0.5120.13
2_S84_E0.5110.13
43_E61_S0.5100.13
9_K75_D0.5070.13
1_M12_P0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gh8A 1 1 99.9 0.274 Contact Map
2yy3A 1 1 99.9 0.277 Contact Map
1b64A 1 1 99.9 0.291 Contact Map
1f60B 1 1 99.9 0.297 Contact Map
4r86A 1 0.9659 30.2 0.902 Contact Map
4q2lA 1 0.4318 29.3 0.902 Contact Map
2djwA 6 0.875 25.6 0.905 Contact Map
3w9iA 3 0.9318 22.3 0.908 Contact Map
4mt1A 3 0.9205 21.4 0.909 Contact Map
2zbcA 6 0.8636 20.7 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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