GREMLIN Database
Q9HQG4 - Archaeal nucleolar protein homolog
UniProt: Q9HQG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (254)
Sequences: 924 (552)
Seq/√Len: 34.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_V244_T6.4281.00
84_G174_R4.9011.00
156_A172_A4.2881.00
249_V260_L3.9931.00
166_L239_L3.8581.00
228_H231_Q3.6901.00
238_A268_M3.2631.00
87_S145_R2.6011.00
112_I115_A2.3770.99
98_V109_D2.3500.99
266_A270_R2.3230.99
265_D269_E2.3060.99
178_L217_V2.2760.99
267_R271_I2.2560.99
108_V112_I2.2060.99
166_L268_M2.1760.99
163_L243_L2.1660.99
227_T272_R2.1110.99
235_A268_M2.0780.99
190_S241_G1.9830.98
190_S244_T1.9740.98
271_I274_R1.9320.98
31_E34_P1.9310.98
107_G120_G1.9280.98
153_E169_P1.9040.97
261_E265_D1.8830.97
24_N27_A1.8800.97
107_G118_V1.8800.97
87_S173_A1.8720.97
136_E139_T1.8600.97
271_I275_E1.8080.97
213_P236_A1.7850.96
40_D43_V1.7000.95
105_F108_V1.6900.95
238_A243_L1.6720.95
96_R100_W1.6670.94
267_R270_R1.6560.94
220_T225_R1.6200.94
164_S169_P1.5950.93
176_I185_L1.5810.93
194_Q214_K1.5770.93
103_T121_R1.5640.92
76_L156_A1.5620.92
212_S215_H1.5270.91
235_A272_R1.5250.91
37_A41_G1.5130.91
28_D31_E1.5010.91
165_M258_P1.4850.90
113_A116_R1.4770.90
183_D187_K1.4660.90
111_G114_G1.4470.89
272_R275_E1.4460.89
190_S245_I1.4380.89
163_L248_R1.4200.88
188_L244_T1.4110.88
265_D272_R1.3890.87
80_V86_L1.3760.86
194_Q213_P1.3750.86
101_A106_D1.3680.86
199_E215_H1.3670.86
263_E267_R1.3640.86
166_L243_L1.3370.85
115_A120_G1.3340.85
115_A118_V1.3330.85
22_V28_D1.3310.84
22_V27_A1.3300.84
239_L268_M1.3270.84
49_Y53_L1.3270.84
95_E99_E1.3270.84
262_A270_R1.3200.84
176_I182_L1.3200.84
202_L214_K1.3170.84
101_A108_V1.3070.83
225_R232_R1.2970.83
97_A138_A1.2910.83
60_A253_S1.2860.82
194_Q199_E1.2800.82
244_T268_M1.2770.82
194_Q233_G1.2770.82
68_R71_A1.2760.82
136_E140_D1.2680.81
24_N28_D1.2680.81
101_A105_F1.2500.81
246_A264_L1.2470.80
86_L123_A1.2380.80
72_D159_V1.2360.80
86_L270_R1.2360.80
114_G118_V1.2330.80
198_A237_R1.2210.79
22_V25_G1.2150.79
80_V222_E1.2000.78
98_V124_N1.1860.77
75_Q82_T1.1710.76
267_R274_R1.1710.76
38_V41_G1.1570.75
263_E266_A1.1560.75
193_V247_A1.1540.75
242_K245_I1.1390.74
117_D154_T1.1170.72
214_K233_G1.1100.72
194_Q236_A1.1090.72
203_F214_K1.1060.72
203_F213_P1.1060.72
195_V214_K1.1020.71
96_R201_A1.0930.71
129_E133_A1.0870.70
89_A117_D1.0780.70
156_A160_A1.0760.70
91_N213_P1.0630.69
22_V39_E1.0580.68
223_Y265_D1.0500.68
214_K236_A1.0390.67
23_R28_D1.0320.66
229_P232_R1.0280.66
115_A179_A1.0260.66
59_A63_A1.0170.65
238_A264_L1.0160.65
150_G154_T1.0140.65
194_Q203_F1.0140.65
90_A147_R1.0050.64
112_I165_M1.0020.64
23_R27_A0.9960.63
73_D201_A0.9850.63
65_V68_R0.9780.62
93_V134_L0.9710.61
238_A274_R0.9670.61
71_A219_Y0.9660.61
47_D50_Y0.9650.61
188_L193_V0.9620.61
178_L208_G0.9580.60
258_P261_E0.9580.60
215_H233_G0.9570.60
128_E132_I0.9560.60
76_L166_L0.9530.60
221_H272_R0.9500.60
194_Q201_A0.9470.60
85_D218_I0.9460.59
100_W233_G0.9420.59
58_R61_T0.9420.59
38_V46_A0.9400.59
198_A203_F0.9320.58
118_V205_H0.9260.58
25_G30_P0.9250.58
26_H31_E0.9230.58
135_C139_T0.9210.57
27_A39_E0.9180.57
203_F207_R0.9160.57
23_R30_P0.9120.57
72_D75_Q0.9100.56
249_V253_S0.9100.56
159_V236_A0.9100.56
93_V135_C0.9090.56
75_Q251_H0.9010.56
105_F120_G0.8990.56
246_A267_R0.8970.55
80_V84_G0.8960.55
165_M261_E0.8890.55
231_Q275_E0.8870.54
79_A151_F0.8800.54
39_E47_D0.8790.54
125_S128_E0.8790.54
23_R29_A0.8780.54
23_R45_D0.8770.54
29_A32_N0.8760.54
108_V247_A0.8730.53
26_H32_N0.8720.53
128_E135_C0.8710.53
38_V45_D0.8700.53
89_A155_H0.8660.53
135_C222_E0.8590.52
129_E132_I0.8580.52
217_V226_G0.8570.52
201_A207_R0.8570.52
29_A39_E0.8520.52
132_I136_E0.8490.51
148_A187_K0.8460.51
233_G236_A0.8450.51
56_A59_A0.8420.51
73_D214_K0.8410.51
32_N36_A0.8360.50
78_H200_D0.8310.50
213_P219_Y0.8280.49
166_L231_Q0.8250.49
226_G252_Y0.8240.49
73_D203_F0.8230.49
124_N261_E0.8220.49
36_A51_D0.8180.49
82_T89_A0.8170.49
201_A214_K0.8150.48
192_T199_E0.8100.48
179_A188_L0.8100.48
100_W213_P0.8100.48
140_D150_G0.8100.48
153_E236_A0.8080.48
178_L269_E0.8040.47
212_S220_T0.8010.47
212_S232_R0.8000.47
206_L240_A0.7930.46
227_T232_R0.7920.46
36_A41_G0.7910.46
81_R195_V0.7880.46
130_R133_A0.7880.46
85_D89_A0.7870.46
209_H230_D0.7840.46
130_R143_D0.7840.46
199_E214_K0.7830.46
208_G224_V0.7800.45
108_V261_E0.7750.45
36_A42_V0.7720.45
213_P252_Y0.7720.45
203_F212_S0.7660.44
255_D258_P0.7650.44
30_P35_A0.7650.44
47_D97_A0.7630.44
31_E36_A0.7630.44
143_D151_F0.7630.44
50_Y200_D0.7600.44
120_G200_D0.7560.43
100_W203_F0.7550.43
30_P33_W0.7540.43
221_H261_E0.7520.43
136_E167_A0.7520.43
22_V32_N0.7520.43
198_A213_P0.7480.43
166_L261_E0.7470.43
131_A193_V0.7410.42
86_L224_V0.7390.42
213_P233_G0.7280.41
125_S163_L0.7280.41
68_R74_Q0.7240.41
183_D186_A0.7230.41
195_V213_P0.7230.41
106_D118_V0.7210.40
26_H33_W0.7210.40
203_F233_G0.7200.40
194_Q202_L0.7200.40
174_R207_R0.7180.40
96_R134_L0.7160.40
26_H39_E0.7120.40
239_L243_L0.7100.40
65_V131_A0.7020.39
36_A39_E0.6990.39
259_D263_E0.6940.38
140_D267_R0.6920.38
65_V218_I0.6920.38
203_F206_L0.6920.38
36_A43_V0.6910.38
198_A214_K0.6860.38
194_Q216_G0.6840.37
74_Q155_H0.6820.37
222_E235_A0.6820.37
101_A107_G0.6810.37
238_A275_E0.6810.37
85_D274_R0.6800.37
96_R221_H0.6790.37
45_D50_Y0.6790.37
160_A176_I0.6790.37
95_E205_H0.6770.37
142_A149_Q0.6720.36
82_T148_A0.6710.36
37_A43_V0.6710.36
135_C208_G0.6710.36
27_A50_Y0.6700.36
191_G199_E0.6680.36
98_V111_G0.6680.36
85_D116_R0.6670.36
36_A40_D0.6640.36
54_R61_T0.6630.36
91_N236_A0.6600.36
39_E45_D0.6590.35
109_D112_I0.6520.35
191_G214_K0.6520.35
129_E136_E0.6500.35
199_E203_F0.6480.35
112_I117_D0.6480.35
79_A152_V0.6480.35
98_V188_L0.6460.34
46_A51_D0.6460.34
104_L151_F0.6450.34
247_A268_M0.6440.34
61_T124_N0.6430.34
125_S235_A0.6430.34
186_A218_I0.6400.34
191_G198_A0.6380.34
167_A172_A0.6360.34
73_D96_R0.6350.34
151_F156_A0.6330.33
182_L240_A0.6330.33
54_R58_R0.6310.33
146_D157_P0.6300.33
218_I233_G0.6280.33
77_V120_G0.6270.33
173_A243_L0.6250.33
28_D59_A0.6240.33
182_L247_A0.6220.33
125_S129_E0.6200.32
58_R62_R0.6170.32
83_I171_L0.6160.32
96_R233_G0.6130.32
191_G194_Q0.6120.32
37_A51_D0.6070.32
26_H30_P0.6040.31
184_D187_K0.6020.31
102_R151_F0.6010.31
53_L246_A0.6010.31
125_S263_E0.6000.31
24_N266_A0.5990.31
92_E97_A0.5980.31
146_D150_G0.5980.31
238_A249_V0.5940.31
75_Q152_V0.5930.31
184_D188_L0.5930.31
55_D58_R0.5920.30
73_D191_G0.5910.30
178_L237_R0.5900.30
267_R272_R0.5860.30
175_L254_G0.5850.30
106_D120_G0.5810.30
199_E236_A0.5800.30
23_R47_D0.5780.29
174_R213_P0.5770.29
73_D215_H0.5750.29
41_G44_D0.5720.29
114_G117_D0.5720.29
76_L170_V0.5710.29
45_D193_V0.5710.29
178_L200_D0.5670.29
31_E62_R0.5660.29
87_S200_D0.5660.29
90_A115_A0.5650.29
72_D172_A0.5640.28
149_Q153_E0.5630.28
98_V105_F0.5600.28
172_A243_L0.5590.28
234_S267_R0.5580.28
41_G46_A0.5570.28
68_R89_A0.5560.28
82_T153_E0.5550.28
236_A240_A0.5530.28
82_T266_A0.5530.28
91_N198_A0.5530.28
117_D120_G0.5530.28
73_D192_T0.5500.27
159_V188_L0.5480.27
140_D259_D0.5480.27
107_G160_A0.5450.27
37_A44_D0.5440.27
101_A128_E0.5440.27
143_D165_M0.5440.27
23_R26_H0.5410.27
86_L101_A0.5400.27
90_A109_D0.5380.27
228_H274_R0.5370.27
76_L159_V0.5350.26
213_P240_A0.5330.26
48_E51_D0.5330.26
175_L224_V0.5330.26
194_Q252_Y0.5310.26
199_E202_L0.5310.26
181_G187_K0.5290.26
117_D123_A0.5280.26
183_D252_Y0.5260.26
42_V157_P0.5240.26
80_V96_R0.5230.26
145_R177_A0.5220.26
125_S139_T0.5190.25
96_R99_E0.5170.25
49_Y136_E0.5160.25
212_S260_L0.5160.25
43_V53_L0.5140.25
172_A181_G0.5130.25
127_T151_F0.5110.25
104_L119_A0.5090.25
98_V220_T0.5070.25
162_N180_G0.5060.25
27_A33_W0.5040.24
149_Q164_S0.5040.24
55_D59_A0.5040.24
67_E171_L0.5020.24
201_A233_G0.5010.24
75_Q144_E0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3plaA 2 0.9892 100 0.129 Contact Map
2nnwA 2 0.9242 100 0.135 Contact Map
2ozbB 1 0.7256 100 0.138 Contact Map
3icxA 2 0.6679 100 0.176 Contact Map
1nt2B 2 0.8448 100 0.205 Contact Map
3gquA 1 0.4079 100 0.425 Contact Map
3id6A 2 0.5668 100 0.662 Contact Map
1dvpA 2 0.5126 26.4 0.963 Contact Map
1mhqA 1 0.5054 17.7 0.966 Contact Map
3ldzA 1 0.4982 14.6 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.