Q9HQG4 - HALSA - GREMLIN Contacts

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Q9HQG4 - Archaeal nucleolar protein homolog

UniProt:	Q9HQG4	Sequences: MTTHGWFADTAVRDADAAADAVRNGHADAPENWPAAAVEDGVVDDADEYYDRLRDATRAATRAAVRERERADDQQLVHAVRTIGDLSDAANEVAERAVEWARTLFDGVDDGIAGARDVAGRSANSPTEERAIALCERATDLADERDRAQGFVETHAPTVAPNLSMLAGPVLAARLIALAGGLDDLAKLPSGTVQVLGAEDALFAHLRGHAPSPKHGVIYTHEYVRGTHPDQRGSAARALAGKLTIAARVDHYSGDRRPDLEAELDARMERIRARETE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	277 (254)
Sequences:	924 (552)
Seq/√Len:	34.6

HALSA - Q9HQG4
SULSO - Q97ZH3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_V	244_T	6.428	1.00
84_G	174_R	4.901	1.00
156_A	172_A	4.288	1.00
249_V	260_L	3.993	1.00
166_L	239_L	3.858	1.00
228_H	231_Q	3.690	1.00
238_A	268_M	3.263	1.00
87_S	145_R	2.601	1.00
112_I	115_A	2.377	0.99
98_V	109_D	2.350	0.99
266_A	270_R	2.323	0.99
265_D	269_E	2.306	0.99
178_L	217_V	2.276	0.99
267_R	271_I	2.256	0.99
108_V	112_I	2.206	0.99
166_L	268_M	2.176	0.99
163_L	243_L	2.166	0.99
227_T	272_R	2.111	0.99
235_A	268_M	2.078	0.99
190_S	241_G	1.983	0.98
190_S	244_T	1.974	0.98
271_I	274_R	1.932	0.98
31_E	34_P	1.931	0.98
107_G	120_G	1.928	0.98
153_E	169_P	1.904	0.97
261_E	265_D	1.883	0.97
24_N	27_A	1.880	0.97
107_G	118_V	1.880	0.97
87_S	173_A	1.872	0.97
136_E	139_T	1.860	0.97
271_I	275_E	1.808	0.97
213_P	236_A	1.785	0.96
40_D	43_V	1.700	0.95
105_F	108_V	1.690	0.95
238_A	243_L	1.672	0.95
96_R	100_W	1.667	0.94
267_R	270_R	1.656	0.94
220_T	225_R	1.620	0.94
164_S	169_P	1.595	0.93
176_I	185_L	1.581	0.93
194_Q	214_K	1.577	0.93
103_T	121_R	1.564	0.92
76_L	156_A	1.562	0.92
212_S	215_H	1.527	0.91
235_A	272_R	1.525	0.91
37_A	41_G	1.513	0.91
28_D	31_E	1.501	0.91
165_M	258_P	1.485	0.90
113_A	116_R	1.477	0.90
183_D	187_K	1.466	0.90
111_G	114_G	1.447	0.89
272_R	275_E	1.446	0.89
190_S	245_I	1.438	0.89
163_L	248_R	1.420	0.88
188_L	244_T	1.411	0.88
265_D	272_R	1.389	0.87
80_V	86_L	1.376	0.86
194_Q	213_P	1.375	0.86
101_A	106_D	1.368	0.86
199_E	215_H	1.367	0.86
263_E	267_R	1.364	0.86
166_L	243_L	1.337	0.85
115_A	120_G	1.334	0.85
115_A	118_V	1.333	0.85
22_V	28_D	1.331	0.84
22_V	27_A	1.330	0.84
239_L	268_M	1.327	0.84
49_Y	53_L	1.327	0.84
95_E	99_E	1.327	0.84
262_A	270_R	1.320	0.84
176_I	182_L	1.320	0.84
202_L	214_K	1.317	0.84
101_A	108_V	1.307	0.83
225_R	232_R	1.297	0.83
97_A	138_A	1.291	0.83
60_A	253_S	1.286	0.82
194_Q	199_E	1.280	0.82
244_T	268_M	1.277	0.82
194_Q	233_G	1.277	0.82
68_R	71_A	1.276	0.82
136_E	140_D	1.268	0.81
24_N	28_D	1.268	0.81
101_A	105_F	1.250	0.81
246_A	264_L	1.247	0.80
86_L	123_A	1.238	0.80
72_D	159_V	1.236	0.80
86_L	270_R	1.236	0.80
114_G	118_V	1.233	0.80
198_A	237_R	1.221	0.79
22_V	25_G	1.215	0.79
80_V	222_E	1.200	0.78
98_V	124_N	1.186	0.77
75_Q	82_T	1.171	0.76
267_R	274_R	1.171	0.76
38_V	41_G	1.157	0.75
263_E	266_A	1.156	0.75
193_V	247_A	1.154	0.75
242_K	245_I	1.139	0.74
117_D	154_T	1.117	0.72
214_K	233_G	1.110	0.72
194_Q	236_A	1.109	0.72
203_F	214_K	1.106	0.72
203_F	213_P	1.106	0.72
195_V	214_K	1.102	0.71
96_R	201_A	1.093	0.71
129_E	133_A	1.087	0.70
89_A	117_D	1.078	0.70
156_A	160_A	1.076	0.70
91_N	213_P	1.063	0.69
22_V	39_E	1.058	0.68
223_Y	265_D	1.050	0.68
214_K	236_A	1.039	0.67
23_R	28_D	1.032	0.66
229_P	232_R	1.028	0.66
115_A	179_A	1.026	0.66
59_A	63_A	1.017	0.65
238_A	264_L	1.016	0.65
150_G	154_T	1.014	0.65
194_Q	203_F	1.014	0.65
90_A	147_R	1.005	0.64
112_I	165_M	1.002	0.64
23_R	27_A	0.996	0.63
73_D	201_A	0.985	0.63
65_V	68_R	0.978	0.62
93_V	134_L	0.971	0.61
238_A	274_R	0.967	0.61
71_A	219_Y	0.966	0.61
47_D	50_Y	0.965	0.61
188_L	193_V	0.962	0.61
178_L	208_G	0.958	0.60
258_P	261_E	0.958	0.60
215_H	233_G	0.957	0.60
128_E	132_I	0.956	0.60
76_L	166_L	0.953	0.60
221_H	272_R	0.950	0.60
194_Q	201_A	0.947	0.60
85_D	218_I	0.946	0.59
100_W	233_G	0.942	0.59
58_R	61_T	0.942	0.59
38_V	46_A	0.940	0.59
198_A	203_F	0.932	0.58
118_V	205_H	0.926	0.58
25_G	30_P	0.925	0.58
26_H	31_E	0.923	0.58
135_C	139_T	0.921	0.57
27_A	39_E	0.918	0.57
203_F	207_R	0.916	0.57
23_R	30_P	0.912	0.57
72_D	75_Q	0.910	0.56
249_V	253_S	0.910	0.56
159_V	236_A	0.910	0.56
93_V	135_C	0.909	0.56
75_Q	251_H	0.901	0.56
105_F	120_G	0.899	0.56
246_A	267_R	0.897	0.55
80_V	84_G	0.896	0.55
165_M	261_E	0.889	0.55
231_Q	275_E	0.887	0.54
79_A	151_F	0.880	0.54
39_E	47_D	0.879	0.54
125_S	128_E	0.879	0.54
23_R	29_A	0.878	0.54
23_R	45_D	0.877	0.54
29_A	32_N	0.876	0.54
108_V	247_A	0.873	0.53
26_H	32_N	0.872	0.53
128_E	135_C	0.871	0.53
38_V	45_D	0.870	0.53
89_A	155_H	0.866	0.53
135_C	222_E	0.859	0.52
129_E	132_I	0.858	0.52
217_V	226_G	0.857	0.52
201_A	207_R	0.857	0.52
29_A	39_E	0.852	0.52
132_I	136_E	0.849	0.51
148_A	187_K	0.846	0.51
233_G	236_A	0.845	0.51
56_A	59_A	0.842	0.51
73_D	214_K	0.841	0.51
32_N	36_A	0.836	0.50
78_H	200_D	0.831	0.50
213_P	219_Y	0.828	0.49
166_L	231_Q	0.825	0.49
226_G	252_Y	0.824	0.49
73_D	203_F	0.823	0.49
124_N	261_E	0.822	0.49
36_A	51_D	0.818	0.49
82_T	89_A	0.817	0.49
201_A	214_K	0.815	0.48
192_T	199_E	0.810	0.48
179_A	188_L	0.810	0.48
100_W	213_P	0.810	0.48
140_D	150_G	0.810	0.48
153_E	236_A	0.808	0.48
178_L	269_E	0.804	0.47
212_S	220_T	0.801	0.47
212_S	232_R	0.800	0.47
206_L	240_A	0.793	0.46
227_T	232_R	0.792	0.46
36_A	41_G	0.791	0.46
81_R	195_V	0.788	0.46
130_R	133_A	0.788	0.46
85_D	89_A	0.787	0.46
209_H	230_D	0.784	0.46
130_R	143_D	0.784	0.46
199_E	214_K	0.783	0.46
208_G	224_V	0.780	0.45
108_V	261_E	0.775	0.45
36_A	42_V	0.772	0.45
213_P	252_Y	0.772	0.45
203_F	212_S	0.766	0.44
255_D	258_P	0.765	0.44
30_P	35_A	0.765	0.44
47_D	97_A	0.763	0.44
31_E	36_A	0.763	0.44
143_D	151_F	0.763	0.44
50_Y	200_D	0.760	0.44
120_G	200_D	0.756	0.43
100_W	203_F	0.755	0.43
30_P	33_W	0.754	0.43
221_H	261_E	0.752	0.43
136_E	167_A	0.752	0.43
22_V	32_N	0.752	0.43
198_A	213_P	0.748	0.43
166_L	261_E	0.747	0.43
131_A	193_V	0.741	0.42
86_L	224_V	0.739	0.42
213_P	233_G	0.728	0.41
125_S	163_L	0.728	0.41
68_R	74_Q	0.724	0.41
183_D	186_A	0.723	0.41
195_V	213_P	0.723	0.41
106_D	118_V	0.721	0.40
26_H	33_W	0.721	0.40
203_F	233_G	0.720	0.40
194_Q	202_L	0.720	0.40
174_R	207_R	0.718	0.40
96_R	134_L	0.716	0.40
26_H	39_E	0.712	0.40
239_L	243_L	0.710	0.40
65_V	131_A	0.702	0.39
36_A	39_E	0.699	0.39
259_D	263_E	0.694	0.38
140_D	267_R	0.692	0.38
65_V	218_I	0.692	0.38
203_F	206_L	0.692	0.38
36_A	43_V	0.691	0.38
198_A	214_K	0.686	0.38
194_Q	216_G	0.684	0.37
74_Q	155_H	0.682	0.37
222_E	235_A	0.682	0.37
101_A	107_G	0.681	0.37
238_A	275_E	0.681	0.37
85_D	274_R	0.680	0.37
96_R	221_H	0.679	0.37
45_D	50_Y	0.679	0.37
160_A	176_I	0.679	0.37
95_E	205_H	0.677	0.37
142_A	149_Q	0.672	0.36
82_T	148_A	0.671	0.36
37_A	43_V	0.671	0.36
135_C	208_G	0.671	0.36
27_A	50_Y	0.670	0.36
191_G	199_E	0.668	0.36
98_V	111_G	0.668	0.36
85_D	116_R	0.667	0.36
36_A	40_D	0.664	0.36
54_R	61_T	0.663	0.36
91_N	236_A	0.660	0.36
39_E	45_D	0.659	0.35
109_D	112_I	0.652	0.35
191_G	214_K	0.652	0.35
129_E	136_E	0.650	0.35
199_E	203_F	0.648	0.35
112_I	117_D	0.648	0.35
79_A	152_V	0.648	0.35
98_V	188_L	0.646	0.34
46_A	51_D	0.646	0.34
104_L	151_F	0.645	0.34
247_A	268_M	0.644	0.34
61_T	124_N	0.643	0.34
125_S	235_A	0.643	0.34
186_A	218_I	0.640	0.34
191_G	198_A	0.638	0.34
167_A	172_A	0.636	0.34
73_D	96_R	0.635	0.34
151_F	156_A	0.633	0.33
182_L	240_A	0.633	0.33
54_R	58_R	0.631	0.33
146_D	157_P	0.630	0.33
218_I	233_G	0.628	0.33
77_V	120_G	0.627	0.33
173_A	243_L	0.625	0.33
28_D	59_A	0.624	0.33
182_L	247_A	0.622	0.33
125_S	129_E	0.620	0.32
58_R	62_R	0.617	0.32
83_I	171_L	0.616	0.32
96_R	233_G	0.613	0.32
191_G	194_Q	0.612	0.32
37_A	51_D	0.607	0.32
26_H	30_P	0.604	0.31
184_D	187_K	0.602	0.31
102_R	151_F	0.601	0.31
53_L	246_A	0.601	0.31
125_S	263_E	0.600	0.31
24_N	266_A	0.599	0.31
92_E	97_A	0.598	0.31
146_D	150_G	0.598	0.31
238_A	249_V	0.594	0.31
75_Q	152_V	0.593	0.31
184_D	188_L	0.593	0.31
55_D	58_R	0.592	0.30
73_D	191_G	0.591	0.30
178_L	237_R	0.590	0.30
267_R	272_R	0.586	0.30
175_L	254_G	0.585	0.30
106_D	120_G	0.581	0.30
199_E	236_A	0.580	0.30
23_R	47_D	0.578	0.29
174_R	213_P	0.577	0.29
73_D	215_H	0.575	0.29
41_G	44_D	0.572	0.29
114_G	117_D	0.572	0.29
76_L	170_V	0.571	0.29
45_D	193_V	0.571	0.29
178_L	200_D	0.567	0.29
31_E	62_R	0.566	0.29
87_S	200_D	0.566	0.29
90_A	115_A	0.565	0.29
72_D	172_A	0.564	0.28
149_Q	153_E	0.563	0.28
98_V	105_F	0.560	0.28
172_A	243_L	0.559	0.28
234_S	267_R	0.558	0.28
41_G	46_A	0.557	0.28
68_R	89_A	0.556	0.28
82_T	153_E	0.555	0.28
236_A	240_A	0.553	0.28
82_T	266_A	0.553	0.28
91_N	198_A	0.553	0.28
117_D	120_G	0.553	0.28
73_D	192_T	0.550	0.27
159_V	188_L	0.548	0.27
140_D	259_D	0.548	0.27
107_G	160_A	0.545	0.27
37_A	44_D	0.544	0.27
101_A	128_E	0.544	0.27
143_D	165_M	0.544	0.27
23_R	26_H	0.541	0.27
86_L	101_A	0.540	0.27
90_A	109_D	0.538	0.27
228_H	274_R	0.537	0.27
76_L	159_V	0.535	0.26
213_P	240_A	0.533	0.26
48_E	51_D	0.533	0.26
175_L	224_V	0.533	0.26
194_Q	252_Y	0.531	0.26
199_E	202_L	0.531	0.26
181_G	187_K	0.529	0.26
117_D	123_A	0.528	0.26
183_D	252_Y	0.526	0.26
42_V	157_P	0.524	0.26
80_V	96_R	0.523	0.26
145_R	177_A	0.522	0.26
125_S	139_T	0.519	0.25
96_R	99_E	0.517	0.25
49_Y	136_E	0.516	0.25
212_S	260_L	0.516	0.25
43_V	53_L	0.514	0.25
172_A	181_G	0.513	0.25
127_T	151_F	0.511	0.25
104_L	119_A	0.509	0.25
98_V	220_T	0.507	0.25
162_N	180_G	0.506	0.25
27_A	33_W	0.504	0.24
149_Q	164_S	0.504	0.24
55_D	59_A	0.504	0.24
67_E	171_L	0.502	0.24
201_A	233_G	0.501	0.24
75_Q	144_E	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3plaA	2	0.9892	100	0.129	Contact Map
2nnwA	2	0.9242	100	0.135	Contact Map
2ozbB	1	0.7256	100	0.138	Contact Map
3icxA	2	0.6679	100	0.176	Contact Map
1nt2B	2	0.8448	100	0.205	Contact Map
3gquA	1	0.4079	100	0.425	Contact Map
3id6A	2	0.5668	100	0.662	Contact Map
1dvpA	2	0.5126	26.4	0.963	Contact Map
1mhqA	1	0.5054	17.7	0.966	Contact Map
3ldzA	1	0.4982	14.6	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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