GREMLIN Database
FLPA - Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
UniProt: Q9HQG3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (196)
Sequences: 387 (197)
Seq/√Len: 14.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_V86_A4.7841.00
77_V84_T3.3470.99
161_L179_L3.2750.99
151_L155_G3.1090.98
63_V77_V3.1020.98
115_R139_G3.0430.98
139_G142_D3.0310.98
179_L182_R2.9830.97
180_L192_T2.6470.94
131_I147_N2.6350.94
164_R201_D2.6020.94
158_V206_V2.5490.93
48_T204_A2.5440.93
100_V107_L2.5420.93
157_L207_A2.5380.93
180_L205_V2.4910.92
92_R95_T2.3910.91
163_A176_F2.3780.90
112_K119_T2.3160.89
132_V160_A2.2940.89
161_L205_V2.2370.87
57_L130_A2.2080.87
144_A147_N2.1070.84
68_A86_A2.0360.82
144_A157_L1.9640.79
48_T53_L1.9580.79
80_F166_E1.8530.75
116_A119_T1.7370.70
46_G132_V1.7340.70
167_D172_P1.7280.70
86_A107_L1.7060.69
19_L31_V1.6890.68
22_R31_V1.6320.65
90_A94_V1.6080.64
40_A198_F1.5320.60
16_D37_R1.5320.60
166_E182_R1.5190.59
19_L34_G1.5190.59
112_K195_M1.5020.58
68_A74_V1.4320.55
137_T143_V1.4230.54
77_V130_A1.4200.54
49_F131_I1.4170.54
57_L61_D1.4100.53
81_A84_T1.4010.53
181_G184_R1.3970.53
78_A107_L1.3930.53
70_N166_E1.3900.52
68_A97_L1.3880.52
172_P201_D1.3660.51
74_V107_L1.3660.51
23_G34_G1.3530.50
190_R208_T1.3330.49
22_R34_G1.3200.49
141_A161_L1.3090.48
139_G143_V1.2990.47
163_A205_V1.2670.46
176_F192_T1.2520.45
31_V34_G1.2440.44
166_E179_L1.2420.44
196_E205_V1.2290.44
69_A136_A1.2230.43
50_E198_F1.2150.43
102_D119_T1.2120.43
197_P201_D1.2040.42
80_F187_Y1.1910.42
136_A205_V1.1720.41
90_A100_V1.1650.40
21_T84_T1.1540.40
92_R141_A1.1530.40
131_I160_A1.1440.39
16_D47_A1.1440.39
151_L154_D1.1410.39
110_L143_V1.1380.39
90_A192_T1.1360.39
42_R72_T1.1310.39
19_L23_G1.1210.38
162_K202_H1.1140.38
187_Y207_A1.0990.37
13_G90_A1.0960.37
36_R71_G1.0950.37
157_L205_V1.0910.37
26_A29_E1.0840.36
69_A141_A1.0830.36
176_F203_L1.0800.36
94_V111_L1.0740.36
90_A143_V1.0730.36
195_M201_D1.0700.35
25_P31_V1.0630.35
41_H51_L1.0630.35
170_A174_A1.0530.35
128_V151_L1.0490.34
74_V196_E1.0330.34
80_F193_A1.0320.34
160_A204_A1.0320.34
47_A96_D1.0190.33
65_Y104_R1.0090.32
93_P199_H1.0090.32
85_Y126_S1.0080.32
86_A97_L1.0040.32
17_G34_G1.0000.32
135_V175_V0.9990.32
45_L98_L0.9920.32
77_V173_A0.9910.32
67_G71_G0.9890.32
181_G185_D0.9810.31
53_L158_V0.9800.31
92_R202_H0.9770.31
100_V103_S0.9710.31
33_D180_L0.9610.30
171_D201_D0.9510.30
15_E81_A0.9460.30
21_T103_S0.9360.29
51_L197_P0.9300.29
61_D130_A0.9290.29
63_V130_A0.9150.28
56_G156_R0.9060.28
23_G26_A0.9020.28
90_A93_P0.8980.27
64_L202_H0.8970.27
92_R96_D0.8850.27
42_R75_S0.8820.27
178_D193_A0.8780.27
195_M205_V0.8710.26
86_A101_A0.8710.26
48_T157_L0.8580.26
97_L105_E0.8550.26
73_T78_A0.8390.25
135_V199_H0.8340.25
35_W110_L0.8290.25
63_V81_A0.8210.24
65_Y72_T0.8110.24
109_P162_K0.8080.24
164_R187_Y0.8040.24
67_G72_T0.8030.24
60_G107_L0.7980.23
82_G115_R0.7980.23
99_A171_D0.7940.23
74_V87_V0.7890.23
46_G135_V0.7860.23
33_D83_P0.7840.23
90_A207_A0.7810.23
156_R190_R0.7810.23
70_N160_A0.7770.23
128_V155_G0.7720.22
48_T100_V0.7710.22
165_S202_H0.7690.22
175_V201_D0.7650.22
43_S71_G0.7630.22
15_E19_L0.7610.22
55_T88_E0.7610.22
91_P168_V0.7540.22
78_A177_E0.7450.21
16_D171_D0.7400.21
48_T199_H0.7310.21
100_V160_A0.7300.21
58_S185_D0.7270.21
78_A166_E0.7250.21
117_P155_G0.7200.20
56_G61_D0.7150.20
28_G111_L0.7140.20
105_E159_A0.7090.20
192_T205_V0.7080.20
36_R43_S0.7050.20
23_G115_R0.7010.20
102_D198_F0.7010.20
159_A206_V0.7000.20
114_A162_K0.6960.20
188_E208_T0.6950.20
44_K47_A0.6940.20
35_W166_E0.6940.20
131_I141_A0.6880.19
72_T162_K0.6870.19
131_I171_D0.6860.19
97_L122_H0.6840.19
167_D175_V0.6830.19
28_G68_A0.6810.19
145_L148_R0.6810.19
92_R161_L0.6810.19
90_A168_V0.6800.19
40_A128_V0.6760.19
18_V40_A0.6740.19
57_L63_V0.6730.19
145_L158_V0.6700.19
131_I182_R0.6690.19
86_A196_E0.6660.19
64_L73_T0.6660.19
31_V93_P0.6630.18
16_D32_V0.6590.18
102_D160_A0.6590.18
108_F158_V0.6550.18
67_G73_T0.6520.18
15_E50_E0.6510.18
33_D53_L0.6510.18
186_G196_E0.6440.18
167_D201_D0.6370.18
184_R208_T0.6350.18
101_A107_L0.6350.18
70_N199_H0.6340.18
25_P90_A0.6330.18
82_G134_D0.6310.17
26_A162_K0.6290.17
36_R67_G0.6280.17
65_Y71_G0.6280.17
118_E154_D0.6260.17
49_F198_F0.6250.17
186_G189_V0.6240.17
74_V170_A0.6240.17
18_V200_E0.6240.17
60_G115_R0.6210.17
183_L202_H0.6170.17
164_R168_V0.6170.17
48_T78_A0.6140.17
145_L186_G0.6130.17
122_H135_V0.6120.17
42_R69_A0.6120.17
50_E80_F0.6110.17
42_R76_H0.6080.17
68_A88_E0.6070.17
62_A128_V0.6050.17
57_L77_V0.6040.17
106_R143_V0.6040.17
103_S187_Y0.6040.17
57_L204_A0.6040.17
43_S65_Y0.6030.17
63_V189_V0.6010.17
92_R138_R0.6000.17
31_V97_L0.6000.17
62_A74_V0.5990.16
70_N96_D0.5970.16
73_T109_P0.5950.16
40_A116_A0.5940.16
35_W106_R0.5900.16
150_F155_G0.5880.16
95_T155_G0.5880.16
136_A162_K0.5870.16
49_F70_N0.5840.16
81_A105_E0.5820.16
157_L188_E0.5820.16
116_A136_A0.5810.16
20_A138_R0.5810.16
164_R172_P0.5800.16
180_L184_R0.5790.16
136_A141_A0.5780.16
86_A142_D0.5770.16
93_P161_L0.5730.16
130_A191_A0.5730.16
142_D182_R0.5730.16
170_A178_D0.5690.16
149_Q205_V0.5680.16
141_A144_A0.5680.16
46_G197_P0.5680.16
84_T110_L0.5610.15
157_L199_H0.5560.15
25_P103_S0.5550.15
96_D169_T0.5550.15
126_S177_E0.5520.15
93_P188_E0.5480.15
37_R154_D0.5470.15
81_A110_L0.5440.15
72_T202_H0.5410.15
156_R208_T0.5410.15
50_E153_D0.5400.15
109_P137_T0.5390.15
64_L109_P0.5380.15
101_A198_F0.5350.15
94_V122_H0.5320.15
187_Y200_E0.5320.15
98_L112_K0.5320.15
191_A199_H0.5310.15
137_T166_E0.5310.15
49_F142_D0.5300.15
43_S67_G0.5290.14
112_K159_A0.5260.14
31_V176_F0.5260.14
90_A116_A0.5250.14
37_R108_F0.5250.14
80_F106_R0.5230.14
69_A147_N0.5220.14
13_G142_D0.5170.14
128_V146_S0.5170.14
40_A63_V0.5110.14
77_V160_A0.5090.14
109_P146_S0.5070.14
19_L198_F0.5070.14
85_Y155_G0.5060.14
65_Y134_D0.5060.14
123_V170_A0.5040.14
183_L206_V0.5040.14
50_E166_E0.5030.14
154_D185_D0.5020.14
159_A169_T0.5020.14
72_T136_A0.5000.14
94_V126_S0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ipxA 1 0.9667 100 0.692 Contact Map
3id6C 1 0.9571 100 0.702 Contact Map
4df3A 1 0.9857 100 0.704 Contact Map
1g8aA 1 0.9952 100 0.711 Contact Map
1fbnA 1 0.9952 99.9 0.724 Contact Map
1nt2A 2 0.9571 99.9 0.757 Contact Map
4k6mA 2 0.8524 98.9 0.877 Contact Map
3a27A 1 0.8619 98.9 0.878 Contact Map
2xyqA 1 0.8238 98.9 0.879 Contact Map
4fzvA 1 0.9143 98.8 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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