GREMLIN Database
MSRA - Peptide methionine sulfoxide reductase MsrA
UniProt: Q9HQG0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (158)
Sequences: 5921 (3708)
Seq/√Len: 295.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_H111_T3.3301.00
6_A68_Y3.2581.00
7_T102_H3.2491.00
5_T58_Q3.0441.00
76_F113_F2.7551.00
34_A56_V2.3061.00
101_P107_H2.2491.00
30_T137_F2.0621.00
114_V131_I2.0501.00
38_T45_D1.9381.00
101_P133_P1.9111.00
76_F114_V1.8861.00
8_L71_V1.8571.00
30_T139_P1.8561.00
9_G56_V1.8181.00
23_L74_V1.8171.00
34_A134_L1.8131.00
84_V128_V1.8051.00
49_G94_Q1.8001.00
54_A96_R1.7851.00
10_G16_T1.7841.00
69_E109_R1.7611.00
24_A65_E1.7581.00
7_T58_Q1.7541.00
4_E103_D1.7191.00
42_S45_D1.7061.00
67_A70_D1.6701.00
3_T27_T1.6621.00
21_E146_N1.6391.00
30_T58_Q1.6261.00
31_S145_Q1.6231.00
4_E106_Q1.5831.00
23_L66_L1.5751.00
99_V110_A1.5561.00
16_T78_V1.5531.00
35_G98_I1.5271.00
104_D107_H1.5221.00
3_T63_T1.5001.00
21_E149_E1.4991.00
54_A132_E1.4811.00
69_E112_A1.4701.00
86_R91_V1.4651.00
108_E112_A1.4471.00
54_A98_I1.4331.00
5_T60_E1.4301.00
83_T86_R1.4141.00
36_G53_H1.3821.00
7_T56_V1.3511.00
79_H97_S1.3451.00
30_T60_E1.3291.00
28_D60_E1.3241.00
73_E113_F1.2861.00
7_T34_A1.2771.00
13_F33_Y1.2571.00
72_L109_R1.2561.00
4_E61_Y1.2431.00
4_E63_T1.2301.00
21_E29_V1.2111.00
9_G98_I1.1921.00
62_D65_E1.1841.00
142_E150_K1.1721.00
52_G93_S1.1651.00
112_A116_E1.1251.00
10_G78_V1.1211.00
17_E21_E1.1211.00
102_H106_Q1.1131.00
98_I132_E1.1091.00
47_C94_Q1.1021.00
69_E116_E1.1001.00
34_A135_E1.0941.00
70_D73_E1.0751.00
98_I130_E1.0721.00
97_S129_T1.0691.00
146_N149_E1.0681.00
41_P138_Y1.0471.00
79_H129_T1.0341.00
3_T60_E1.0301.00
100_L130_E1.0151.00
105_Q108_E1.0121.00
155_A158_T1.0091.00
102_H134_L1.0071.00
123_F126_S1.0011.00
26_V66_L0.9951.00
96_R130_E0.9891.00
93_S96_R0.9861.00
101_P131_I0.9851.00
118_A127_I0.9771.00
19_A78_V0.9721.00
117_L127_I0.9661.00
158_T162_A0.9581.00
8_L72_L0.9581.00
111_T115_D0.9571.00
7_T134_L0.9571.00
158_T161_V0.9531.00
61_Y106_Q0.9511.00
5_T102_H0.9471.00
44_R143_K0.9421.00
18_A21_E0.9401.00
8_L68_Y0.9391.00
39_A136_T0.9381.00
33_Y141_A0.8991.00
54_A100_L0.8921.00
107_H133_P0.8821.00
20_M59_V0.8771.00
38_T41_P0.8771.00
111_T114_V0.8691.00
114_V127_I0.8681.00
155_A159_V0.8661.00
104_D108_E0.8641.00
18_A160_N0.8591.00
108_E111_T0.8581.00
39_A138_Y0.8561.00
72_L99_V0.8461.00
18_A148_F0.8431.00
68_Y110_A0.8381.00
113_F117_L0.8371.00
15_C148_F0.8341.00
160_N163_P0.8321.00
110_A131_I0.8251.00
8_L20_M0.8231.00
46_V51_T0.8201.00
17_E29_V0.8201.00
153_D158_T0.8191.00
73_E116_E0.8081.00
112_A115_D0.7990.99
132_E135_E0.7970.99
66_L70_D0.7900.99
27_T30_T0.7860.99
114_V118_A0.7840.99
105_Q109_R0.7760.99
23_L26_V0.7740.99
72_L113_F0.7690.99
38_T51_T0.7640.99
22_E149_E0.7620.99
69_E113_F0.7600.99
40_D138_Y0.7600.99
152_P155_A0.7550.99
89_P159_V0.7510.99
37_D52_G0.7490.99
4_E105_Q0.7490.99
16_T19_A0.7440.99
89_P163_P0.7430.99
117_L122_A0.7420.99
34_A136_T0.7420.99
83_T91_V0.7380.99
118_A126_S0.7350.99
85_D91_V0.7350.99
111_T131_I0.7330.99
85_D93_S0.7290.99
69_E73_E0.7230.99
9_G54_A0.7210.99
18_A22_E0.7180.99
82_T123_F0.7170.99
83_T128_V0.7130.99
74_V77_T0.7120.99
19_A74_V0.7110.99
157_C161_V0.7060.99
148_F162_A0.7040.99
45_D50_T0.7040.99
89_P160_N0.6980.99
113_F116_E0.6980.99
13_F141_A0.6950.99
121_D124_D0.6950.99
38_T53_H0.6880.98
139_P142_E0.6830.98
27_T60_E0.6780.98
46_V94_Q0.6780.98
32_G137_F0.6760.98
8_L59_V0.6750.98
146_N150_K0.6660.98
72_L76_F0.6640.98
26_V59_V0.6640.98
74_V78_V0.6630.98
49_G93_S0.6590.98
58_Q102_H0.6480.98
31_S146_N0.6480.98
35_G53_H0.6480.98
31_S57_V0.6440.98
45_D51_T0.6410.98
143_K151_N0.6270.97
48_S51_T0.6270.97
34_A98_I0.6250.97
68_Y106_Q0.6240.97
18_A149_E0.6230.97
118_A122_A0.6120.97
101_P110_A0.6110.97
75_F97_S0.6030.97
51_T93_S0.6030.97
104_D133_P0.6000.96
29_V57_V0.5980.96
27_T65_E0.5980.96
103_D106_Q0.5980.96
159_V162_A0.5970.96
148_F152_P0.5930.96
75_F79_H0.5880.96
118_A121_D0.5820.96
18_A23_L0.5810.96
34_A100_L0.5790.96
54_A93_S0.5770.96
35_G100_L0.5770.96
109_R112_A0.5760.96
109_R113_F0.5760.96
16_T57_V0.5720.95
115_D118_A0.5680.95
16_T31_S0.5680.95
15_C19_A0.5630.95
33_Y47_C0.5590.95
41_P45_D0.5570.95
147_Y151_N0.5530.94
101_P134_L0.5520.94
28_D139_P0.5490.94
158_T163_P0.5480.94
80_D86_R0.5470.94
54_A97_S0.5470.94
38_T42_S0.5460.94
15_C31_S0.5390.94
8_L99_V0.5380.94
48_S93_S0.5340.93
82_T128_V0.5330.93
33_Y140_A0.5310.93
80_D125_G0.5300.93
26_V29_V0.5280.93
15_C158_T0.5270.93
19_A160_N0.5260.93
99_V114_V0.5250.93
58_Q139_P0.5230.93
148_F157_C0.5220.93
24_A66_L0.5220.93
16_T75_F0.5210.93
30_T145_Q0.5200.92
43_Y141_A0.5190.92
87_E92_G0.5180.92
155_A162_A0.5130.92
84_V93_S0.5130.92
9_G100_L0.5090.92
123_F127_I0.5060.91
100_L132_E0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bqhA 1 0.9153 100 0.046 Contact Map
1ff3A 5 0.9492 100 0.058 Contact Map
1fvgA 1 0.8814 100 0.058 Contact Map
3e0mA 4 0.9661 100 0.06 Contact Map
2j89A 1 0.9605 100 0.064 Contact Map
4d7lA 3 0.9548 100 0.068 Contact Map
1nwaA 1 0.904 100 0.077 Contact Map
3pimA 2 0.887 100 0.082 Contact Map
4gwbA 2 0.9266 100 0.087 Contact Map
4lwlA 1 0.9322 100 0.157 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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