GREMLIN Database
Q9HQF7 - Heme biosynthesis protein
UniProt: Q9HQF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (261)
Sequences: 5943 (4644)
Seq/√Len: 287.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_P67_D5.3991.00
57_D64_G3.4651.00
211_N225_N3.4231.00
31_A75_N3.3231.00
35_A79_A3.0421.00
74_E107_V2.8911.00
66_F103_L2.8561.00
211_N222_S2.6231.00
50_D60_R2.5811.00
197_D215_T2.5401.00
230_S233_D2.5131.00
96_D99_E2.4451.00
52_L55_R2.3791.00
98_P142_T2.3181.00
7_E36_A2.3001.00
31_A78_D2.2391.00
215_T270_S2.1941.00
229_R233_D2.1801.00
52_L96_D2.1621.00
31_A79_A2.0401.00
75_N78_D2.0311.00
225_N228_D2.0291.00
12_Y15_D2.0261.00
26_G47_I1.9991.00
47_I73_I1.9611.00
35_A39_D1.9541.00
102_D146_L1.9521.00
30_T33_R1.9331.00
55_R96_D1.9211.00
36_A40_A1.9121.00
207_D211_N1.8221.00
91_E135_D1.7971.00
53_P57_D1.7561.00
102_D106_D1.7471.00
58_E92_A1.7471.00
85_L104_L1.7441.00
34_A75_N1.7341.00
38_K79_A1.7141.00
7_E33_R1.7011.00
68_A71_R1.6941.00
74_E78_D1.6761.00
132_S135_D1.6701.00
70_V107_V1.6681.00
12_Y16_N1.6551.00
29_I34_A1.6431.00
87_Y100_V1.6421.00
56_N65_A1.6351.00
71_R74_E1.6171.00
53_P66_F1.6071.00
99_E102_D1.6031.00
11_A36_A1.6021.00
233_D237_D1.5891.00
212_V234_I1.5891.00
45_A76_S1.5751.00
11_A15_D1.5741.00
69_A72_G1.5641.00
103_L107_V1.5631.00
47_I72_G1.5601.00
197_D270_S1.5601.00
71_R75_N1.4771.00
74_E77_L1.4691.00
138_T142_T1.4661.00
235_W247_R1.4541.00
67_D71_R1.4411.00
85_L109_L1.4341.00
87_Y112_F1.4311.00
207_D213_H1.4211.00
23_S46_G1.4111.00
254_T280_P1.3801.00
59_F90_T1.3731.00
13_A20_P1.3711.00
77_L108_G1.3701.00
22_L37_M1.3671.00
141_R145_D1.3651.00
57_D60_R1.3611.00
33_R37_M1.3491.00
51_G66_F1.3471.00
137_R141_R1.3371.00
34_A72_G1.3031.00
213_H222_S1.2921.00
68_A72_G1.2861.00
51_G55_R1.2791.00
52_L99_E1.2731.00
34_A79_A1.2631.00
155_K159_T1.2541.00
98_P146_L1.2501.00
232_G236_S1.2481.00
49_V85_L1.2421.00
56_N66_F1.2331.00
27_T72_G1.2291.00
146_L149_E1.2271.00
138_T141_R1.2171.00
255_G258_A1.2151.00
46_G86_R1.2061.00
70_V103_L1.2001.00
256_R283_P1.1911.00
75_N79_A1.1861.00
56_N64_G1.1851.00
70_V74_E1.1841.00
36_A39_D1.1821.00
32_E35_A1.1661.00
72_G75_N1.1641.00
56_N69_A1.1591.00
66_F70_V1.1591.00
8_E11_A1.1591.00
48_S88_T1.1571.00
194_N197_D1.1541.00
241_P245_G1.1501.00
51_G60_R1.1431.00
204_A231_F1.1421.00
142_T145_D1.1341.00
25_N28_L1.1311.00
29_I72_G1.1261.00
33_R36_A1.1161.00
134_A138_T1.1101.00
6_L10_I1.1011.00
11_A40_A1.0921.00
229_R237_D1.0861.00
14_D40_A1.0851.00
8_E12_Y1.0821.00
135_D138_T1.0761.00
10_I42_L1.0741.00
223_L243_L1.0721.00
38_K80_G1.0711.00
159_T163_G1.0671.00
47_I76_S1.0661.00
57_D65_A1.0631.00
224_G234_I1.0631.00
104_L109_L1.0461.00
31_A35_A1.0401.00
52_L103_L1.0201.00
242_L245_G1.0151.00
76_S81_L0.9871.00
102_D105_H0.9841.00
243_L247_R0.9831.00
146_L150_Y0.9811.00
271_R274_A0.9811.00
29_I37_M0.9801.00
73_I83_T0.9791.00
10_I40_A0.9781.00
34_A38_K0.9741.00
45_A81_L0.9681.00
97_L142_T0.9651.00
23_S216_Q0.9621.00
32_E36_A0.9611.00
218_W272_L0.9591.00
245_G248_D0.9591.00
23_S86_R0.9541.00
101_V105_H0.9521.00
54_E58_E0.9511.00
241_P244_A0.9491.00
257_C260_C0.9491.00
256_R284_D0.9431.00
30_T72_G0.9401.00
20_P42_L0.9311.00
77_L110_D0.9261.00
73_I85_L0.9261.00
212_V231_F0.9231.00
51_G96_D0.9191.00
76_S83_T0.9131.00
231_F235_W0.9101.00
204_A235_W0.9061.00
254_T283_P0.9041.00
77_L109_L0.9031.00
95_P135_D0.9021.00
224_G229_R0.9011.00
255_G259_S0.9001.00
105_H150_Y0.8991.00
206_V212_V0.8891.00
157_I161_L0.8831.00
56_N60_R0.8821.00
46_G84_G0.8731.00
14_D20_P0.8711.00
48_S60_R0.8681.00
77_L83_T0.8531.00
210_G226_V0.8501.00
22_L45_A0.8451.00
244_A248_D0.8431.00
28_L72_G0.8371.00
254_T282_D0.8351.00
253_L263_R0.8241.00
88_T117_L0.8221.00
51_G56_N0.8201.00
100_V104_L0.8191.00
86_R115_Y0.8151.00
205_D216_Q0.8151.00
38_K81_L0.8090.99
222_S225_N0.8090.99
82_K110_D0.8090.99
50_D56_N0.8080.99
86_R216_Q0.8060.99
29_I76_S0.8050.99
269_G284_D0.8030.99
17_G20_P0.7990.99
98_P145_D0.7980.99
49_V70_V0.7960.99
262_Y291_E0.7950.99
65_A69_A0.7940.99
44_Y84_G0.7930.99
60_R64_G0.7930.99
13_A16_N0.7910.99
282_D285_P0.7890.99
101_V112_F0.7850.99
53_P64_G0.7830.99
257_C266_C0.7780.99
103_L106_D0.7780.99
34_A76_S0.7730.99
142_T146_L0.7630.99
237_D241_P0.7580.99
101_V150_Y0.7560.99
97_L114_F0.7560.99
104_L112_F0.7550.99
123_G126_I0.7530.99
161_L164_N0.7470.99
91_E132_S0.7460.99
49_V69_A0.7460.99
117_L123_G0.7460.99
219_Q222_S0.7460.99
60_R65_A0.7450.99
83_T109_L0.7450.99
191_L197_D0.7450.99
7_E10_I0.7450.99
94_A135_D0.7440.99
136_T140_V0.7430.99
34_A81_L0.7380.99
23_S217_F0.7370.99
278_G282_D0.7310.99
157_I163_G0.7310.99
49_V66_F0.7310.99
73_I109_L0.7300.99
27_T68_A0.7290.99
7_E40_A0.7290.99
263_R267_R0.7240.99
67_D70_V0.7230.99
221_Y275_L0.7220.99
193_A196_G0.7200.99
55_R58_E0.7190.99
120_G123_G0.7180.99
261_Q291_E0.7180.99
156_E159_T0.7140.99
278_G283_P0.7100.99
87_Y104_L0.7070.99
48_S86_R0.7070.99
90_T93_N0.7070.99
230_S234_I0.7060.99
260_C287_C0.7050.99
158_E162_V0.7040.99
85_L112_F0.7020.99
9_L13_A0.7020.99
210_G225_N0.7010.99
257_C287_C0.6990.99
197_D200_G0.6980.99
214_M223_L0.6970.98
145_D148_R0.6870.98
144_C148_R0.6870.98
10_I20_P0.6820.98
151_H155_K0.6790.98
77_L107_V0.6790.98
95_P138_T0.6770.98
260_C266_C0.6740.98
31_A34_A0.6720.98
144_C147_T0.6710.98
95_P98_P0.6670.98
89_I97_L0.6670.98
157_I160_L0.6630.98
191_L194_N0.6590.98
145_D149_E0.6560.98
156_E160_L0.6520.98
143_V147_T0.6520.98
256_R291_E0.6510.98
34_A37_M0.6510.98
229_R234_I0.6490.98
37_M40_A0.6490.98
184_A187_I0.6440.97
121_G124_A0.6420.97
72_G76_S0.6410.97
57_D66_F0.6400.97
13_A18_I0.6380.97
207_D216_Q0.6340.97
54_E99_E0.6340.97
126_I129_L0.6330.97
159_T162_V0.6320.97
7_E11_A0.6310.97
94_A138_T0.6300.97
274_A285_P0.6290.97
84_G111_R0.6290.97
160_L163_G0.6280.97
131_L135_D0.6280.97
14_D41_G0.6270.97
57_D67_D0.6260.97
115_Y118_D0.6250.97
247_R250_D0.6250.97
183_Q187_I0.6240.97
76_S79_A0.6220.97
227_R230_S0.6210.97
269_G274_A0.6200.97
269_G273_R0.6180.97
214_M218_W0.6160.97
73_I107_V0.6150.97
50_D88_T0.6150.97
203_I216_Q0.6140.97
214_M246_L0.6110.97
266_C287_C0.6110.97
147_T150_Y0.6110.97
237_D243_L0.6080.96
96_D100_V0.6060.96
88_T115_Y0.6030.96
233_D236_S0.5990.96
218_W221_Y0.5980.96
14_D39_D0.5960.96
134_A137_R0.5930.96
72_G79_A0.5920.96
26_G72_G0.5910.96
143_V146_L0.5910.96
284_D290_T0.5870.96
155_K158_E0.5860.96
214_M221_Y0.5810.95
68_A75_N0.5790.95
52_L66_F0.5780.95
60_R88_T0.5770.95
277_A281_F0.5760.95
29_I33_R0.5740.95
49_V100_V0.5720.95
206_V226_V0.5690.95
51_G90_T0.5690.95
246_L250_D0.5680.95
273_R284_D0.5680.95
57_D63_E0.5670.95
38_K41_G0.5620.95
46_G216_Q0.5620.95
121_G125_D0.5610.95
158_E163_G0.5600.94
10_I13_A0.5600.94
24_T47_I0.5590.94
141_R144_C0.5590.94
237_D244_A0.5580.94
31_A71_R0.5580.94
97_L139_A0.5570.94
92_A129_L0.5570.94
214_M217_F0.5540.94
275_L278_G0.5540.94
133_P137_R0.5540.94
87_Y114_F0.5530.94
196_G200_G0.5520.94
101_V143_V0.5510.94
204_A208_Y0.5470.94
50_D69_A0.5460.94
274_A284_D0.5450.94
73_I76_S0.5440.94
119_Y123_G0.5440.94
192_E198_P0.5430.94
133_P288_Y0.5420.93
130_D136_T0.5420.93
190_Y193_A0.5420.93
90_T129_L0.5410.93
97_L101_V0.5410.93
45_A72_G0.5400.93
71_R78_D0.5390.93
278_G281_F0.5390.93
112_F116_H0.5380.93
51_G57_D0.5360.93
98_P101_V0.5350.93
136_T139_A0.5310.93
39_D227_R0.5290.93
237_D242_L0.5280.93
21_V44_Y0.5260.92
147_T151_H0.5220.92
35_A38_K0.5220.92
34_A45_A0.5200.92
23_S203_I0.5200.92
225_N230_S0.5190.92
262_Y265_I0.5170.92
101_V146_L0.5150.92
156_E162_V0.5140.92
56_N59_F0.5140.92
89_I139_A0.5140.92
184_A190_Y0.5120.91
195_G198_P0.5120.91
119_Y122_R0.5110.91
27_T64_G0.5100.91
284_D288_Y0.5090.91
77_L80_G0.5090.91
7_E13_A0.5080.91
214_M243_L0.5080.91
199_T215_T0.5070.91
255_G283_P0.5050.91
221_Y242_L0.5040.91
111_R158_E0.5010.91
76_S80_G0.5010.91
194_N200_G0.5010.91
213_H223_L0.5000.90
26_G45_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9213 100 0.315 Contact Map
1tv8A 2 0.7541 99.9 0.583 Contact Map
4m7tA 1 0.5672 99.9 0.584 Contact Map
4rtbA 2 0.7967 99.9 0.607 Contact Map
4wcxA 1 0.8689 99.8 0.66 Contact Map
3canA 2 0.4623 99.8 0.664 Contact Map
3c8fA 1 0.4885 99.7 0.689 Contact Map
2yx0A 1 0.5738 99.7 0.7 Contact Map
2z2uA 1 0.5016 99.6 0.722 Contact Map
2qgqA 1 0.682 99.5 0.734 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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