GREMLIN Database
Q9HQF5 - Coenzyme PQQ synthesis protein
UniProt: Q9HQF5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (300)
Sequences: 10397 (8087)
Seq/√Len: 466.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_L96_T4.1471.00
47_K81_H3.5681.00
123_T138_E3.3071.00
145_R178_L3.1641.00
101_P146_A3.0201.00
105_E150_L2.9691.00
51_T81_H2.8551.00
42_S45_E2.6691.00
128_D135_G2.5471.00
22_A94_S2.5391.00
45_E279_R2.5001.00
264_A277_N2.4741.00
48_Q52_D2.4361.00
76_V106_A2.4351.00
146_A149_E2.3341.00
43_T77_E2.2611.00
105_E109_D2.2281.00
120_D131_R2.1931.00
264_A274_S2.1911.00
137_F174_L2.1651.00
250_V268_S2.1591.00
13_L53_A2.1391.00
83_T113_A2.1051.00
126_T167_A2.0801.00
173_D215_V2.0591.00
282_S285_D2.0441.00
167_A170_A2.0421.00
20_A40_E1.9311.00
122_A126_T1.9211.00
81_H84_D1.8691.00
169_P211_W1.8621.00
158_T171_I1.8541.00
95_G117_V1.8341.00
122_A167_A1.8251.00
46_G78_L1.8231.00
50_L82_G1.7841.00
43_T74_D1.7841.00
76_V103_A1.7721.00
260_S264_A1.7531.00
156_V175_V1.7381.00
137_F141_L1.7161.00
142_R145_R1.7001.00
101_P149_E1.7001.00
22_A97_A1.6871.00
277_N280_E1.6871.00
260_S266_Y1.6841.00
77_E80_E1.6771.00
106_A110_A1.6741.00
145_R149_E1.6691.00
27_H120_D1.6631.00
146_A150_L1.6591.00
281_R285_D1.6571.00
51_T85_C1.6381.00
117_V144_A1.6331.00
139_R142_R1.6311.00
145_R148_R1.6221.00
70_L91_V1.6211.00
174_L178_L1.6201.00
80_E106_A1.6101.00
138_E142_R1.6051.00
43_T47_K1.5991.00
173_D177_E1.5951.00
45_E48_Q1.5951.00
80_E84_D1.5931.00
74_D77_E1.5831.00
64_L82_G1.5791.00
129_E163_D1.5601.00
100_T103_A1.5531.00
47_K77_E1.5491.00
108_A150_L1.5281.00
106_A109_D1.5021.00
47_K51_T1.4821.00
17_V64_L1.4791.00
170_A173_D1.4671.00
201_S204_R1.4431.00
26_D129_E1.4191.00
62_V82_G1.4141.00
104_I146_A1.4121.00
121_G126_T1.4011.00
103_A106_A1.4001.00
117_V143_A1.4001.00
142_R146_A1.3981.00
104_I143_A1.3921.00
54_A85_C1.3881.00
73_P76_V1.3751.00
207_E211_W1.3541.00
101_P150_L1.3501.00
83_T89_M1.3291.00
115_F147_I1.3281.00
140_T143_A1.3231.00
127_H136_S1.3161.00
173_D176_A1.3151.00
79_V112_V1.3111.00
123_T167_A1.3071.00
82_G89_M1.3071.00
41_L45_E1.2861.00
70_L97_A1.2841.00
80_E110_A1.2831.00
162_A204_R1.2791.00
92_T116_A1.2661.00
64_L89_M1.2591.00
148_R179_G1.2541.00
83_T110_A1.2451.00
79_V110_A1.2391.00
284_V288_R1.2371.00
40_E72_R1.2361.00
204_R207_E1.2311.00
72_R78_L1.2231.00
212_L216_A1.2191.00
141_L178_L1.2131.00
141_L145_R1.2051.00
220_A223_V1.2031.00
52_D282_S1.1821.00
15_W46_G1.1681.00
123_T128_D1.1661.00
206_E210_A1.1531.00
285_D289_N1.1521.00
207_E210_A1.1431.00
200_V204_R1.1411.00
88_R114_Q1.1351.00
265_V286_S1.1281.00
19_Q261_H1.1211.00
54_A87_L1.1131.00
127_H140_T1.1081.00
104_I150_L1.1061.00
169_P173_D1.1051.00
103_A107_L1.1041.00
130_F161_C1.1001.00
81_H85_C1.0891.00
101_P142_R1.0871.00
49_L259_V1.0831.00
77_E81_H1.0821.00
203_A207_E1.0721.00
291_E295_R1.0671.00
158_T183_W1.0671.00
200_V203_A1.0661.00
78_L82_G1.0641.00
141_L174_L1.0631.00
104_I108_A1.0581.00
108_A152_V1.0531.00
128_D136_S1.0521.00
11_V59_G1.0521.00
121_G137_F1.0481.00
125_T129_E1.0471.00
148_R178_L1.0461.00
211_W214_G1.0391.00
102_T105_E1.0371.00
23_L136_S1.0341.00
91_V107_L1.0251.00
211_W215_V1.0241.00
122_A174_L1.0131.00
22_A68_D1.0101.00
291_E294_Q1.0061.00
41_L46_G1.0041.00
210_A214_G1.0031.00
43_T81_H1.0011.00
116_A157_N0.9971.00
148_R154_L0.9881.00
117_V147_I0.9801.00
70_L103_A0.9781.00
156_V180_V0.9781.00
223_V226_T0.9751.00
126_T129_E0.9741.00
215_V219_E0.9711.00
126_T166_E0.9711.00
221_F225_T0.9651.00
169_P215_V0.9601.00
48_Q51_T0.9541.00
128_D131_R0.9471.00
64_L79_V0.9461.00
48_Q279_R0.9451.00
17_V75_T0.9381.00
139_R143_A0.9351.00
147_I152_V0.9341.00
22_A96_T0.9341.00
122_A170_A0.9321.00
52_D56_F0.9311.00
215_V218_S0.9311.00
119_I156_V0.9251.00
70_L75_T0.9221.00
99_L104_I0.9221.00
304_G307_G0.9211.00
18_T40_E0.9191.00
143_A146_A0.9181.00
27_H130_F0.9161.00
292_L295_R0.9091.00
171_I175_V0.9091.00
144_A154_L0.9001.00
115_F152_V0.9001.00
281_R289_N0.8991.00
39_S262_T0.8941.00
53_A62_V0.8941.00
175_V180_V0.8941.00
50_L62_V0.8901.00
29_R65_S0.8901.00
118_S159_T0.8811.00
147_I154_L0.8771.00
51_T55_A0.8711.00
127_H131_R0.8701.00
287_Y297_R0.8691.00
266_Y274_S0.8671.00
306_C315_C0.8651.00
276_G279_R0.8651.00
75_T79_V0.8641.00
148_R180_V0.8571.00
26_D130_F0.8571.00
13_L257_A0.8571.00
17_V78_L0.8561.00
144_A156_V0.8531.00
91_V115_F0.8521.00
94_S97_A0.8521.00
210_A213_D0.8511.00
11_V255_G0.8491.00
188_L194_G0.8481.00
156_V183_W0.8441.00
276_G286_S0.8431.00
68_D94_S0.8391.00
17_V72_R0.8381.00
70_L143_A0.8301.00
52_D55_A0.8231.00
205_A208_V0.8191.00
16_E258_F0.8171.00
105_E108_A0.8161.00
47_K84_D0.8151.00
50_L85_C0.8121.00
274_S277_N0.8111.00
50_L87_L0.8081.00
44_A47_K0.8071.00
102_T106_A0.8011.00
15_W49_L0.8011.00
281_R286_S0.7981.00
276_G281_R0.7941.00
43_T78_L0.7931.00
99_L117_V0.7921.00
206_E209_M0.7921.00
41_L49_L0.7891.00
88_R113_A0.7861.00
108_A151_G0.7841.00
166_E204_R0.7731.00
79_V89_M0.7721.00
27_H131_R0.7721.00
295_R298_D0.7711.00
257_A283_V0.7671.00
60_Q88_R0.7661.00
15_W259_V0.7661.00
16_E65_S0.7641.00
93_P117_V0.7641.00
123_T137_F0.7631.00
16_E261_H0.7611.00
144_A180_V0.7561.00
72_R75_T0.7541.00
89_M112_V0.7521.00
127_H137_F0.7521.00
52_D284_V0.7511.00
127_H135_G0.7491.00
228_A232_R0.7491.00
63_V92_T0.7471.00
123_T170_A0.7461.00
160_V168_L0.7451.00
283_V287_Y0.7451.00
203_A206_E0.7441.00
121_G127_H0.7431.00
65_S92_T0.7421.00
119_I137_F0.7421.00
202_P206_E0.7411.00
104_I147_I0.7401.00
43_T72_R0.7401.00
99_L147_I0.7381.00
13_L259_V0.7371.00
105_E146_A0.7361.00
121_G131_R0.7321.00
172_R176_A0.7321.00
121_G167_A0.7311.00
209_M213_D0.7301.00
276_G280_E0.7281.00
68_D71_A0.7251.00
123_T126_T0.7251.00
114_Q155_Q0.7241.00
128_D137_F0.7231.00
153_P181_A0.7221.00
275_A293_F0.7211.00
143_A147_I0.7191.00
133_E136_S0.7181.00
99_L107_L0.7151.00
46_G49_L0.7141.00
63_V90_T0.7131.00
76_V110_A0.7111.00
99_L143_A0.7101.00
18_T72_R0.7071.00
208_V212_L0.7061.00
97_A100_T0.7051.00
92_T157_N0.7051.00
174_L177_E0.7031.00
136_S139_R0.7011.00
138_E141_L0.7011.00
65_S269_G0.6981.00
101_P105_E0.6961.00
148_R181_A0.6951.00
53_A58_D0.6941.00
175_V178_L0.6931.00
114_Q153_P0.6881.00
79_V82_G0.6861.00
46_G72_R0.6861.00
294_Q298_D0.6831.00
49_L53_A0.6791.00
293_F297_R0.6781.00
119_I141_L0.6771.00
23_L127_H0.6741.00
257_A287_Y0.6731.00
294_Q297_R0.6711.00
62_V89_M0.6711.00
62_V87_L0.6681.00
83_T111_G0.6661.00
55_A284_V0.6651.00
205_A209_M0.6641.00
26_D132_G0.6611.00
70_L107_L0.6571.00
233_R237_Q0.6561.00
72_R77_E0.6541.00
169_P172_R0.6531.00
64_L78_L0.6531.00
265_V283_V0.6531.00
209_M212_L0.6501.00
92_T269_G0.6471.00
158_T175_V0.6471.00
267_P271_L0.6471.00
14_V269_G0.6461.00
30_A65_S0.6441.00
231_Y234_V0.6421.00
282_S286_S0.6421.00
128_D133_E0.6401.00
304_G308_A0.6391.00
168_L208_V0.6391.00
76_V80_E0.6381.00
165_V204_R0.6371.00
22_A71_A0.6361.00
145_R177_E0.6361.00
49_L52_D0.6361.00
234_V237_Q0.6331.00
171_I174_L0.6320.99
231_Y237_Q0.6320.99
279_R282_S0.6300.99
71_A97_A0.6270.99
79_V106_A0.6270.99
116_A155_Q0.6260.99
194_G197_L0.6260.99
229_P232_R0.6250.99
302_L312_R0.6240.99
161_C164_T0.6240.99
21_C25_C0.6240.99
202_P205_A0.6230.99
229_P233_R0.6220.99
25_C28_C0.6180.99
119_I140_T0.6170.99
91_V112_V0.6170.99
20_A38_P0.6130.99
157_N186_F0.6120.99
78_L81_H0.6120.99
117_V140_T0.6120.99
68_D93_P0.6070.99
232_R238_R0.6070.99
213_D217_R0.6060.99
224_K227_E0.6040.99
222_G226_T0.6010.99
76_V79_V0.5960.99
258_F269_G0.5940.99
47_K85_C0.5910.99
24_A31_S0.5910.99
96_T143_A0.5880.99
213_D216_A0.5870.99
142_R149_E0.5850.99
45_E49_L0.5830.99
14_V256_F0.5820.99
74_D78_L0.5820.99
46_G50_L0.5800.99
186_F189_V0.5790.99
82_G87_L0.5760.99
90_T114_Q0.5760.99
31_S132_G0.5750.99
101_P104_I0.5750.99
10_P287_Y0.5740.99
214_G218_S0.5740.99
21_C28_C0.5730.99
199_P202_P0.5730.99
27_H30_A0.5720.99
50_L64_L0.5710.99
190_P193_R0.5650.99
43_T46_G0.5650.99
44_A48_Q0.5630.99
14_V65_S0.5620.99
175_V179_G0.5600.99
230_M234_V0.5590.99
96_T139_R0.5560.99
193_R196_A0.5550.99
204_R208_V0.5550.99
247_R250_V0.5510.99
51_T54_A0.5510.99
172_R183_W0.5500.99
212_L215_V0.5500.99
169_P214_G0.5490.99
83_T86_G0.5470.99
222_G225_T0.5470.99
16_E30_A0.5460.99
231_Y235_R0.5450.99
259_V265_V0.5430.98
295_R299_T0.5420.98
144_A178_L0.5420.98
29_R315_C0.5380.98
232_R235_R0.5360.98
200_V206_E0.5340.98
37_H40_E0.5330.98
192_G196_A0.5330.98
305_K308_A0.5330.98
167_A171_I0.5330.98
160_V185_V0.5320.98
80_E109_D0.5310.98
214_G217_R0.5300.98
219_E222_G0.5300.98
100_T143_A0.5290.98
201_S209_M0.5290.98
32_A193_R0.5270.98
275_A280_E0.5240.98
311_F314_V0.5240.98
68_D95_G0.5240.98
192_G195_R0.5210.98
190_P194_G0.5210.98
216_A219_E0.5190.98
191_V194_G0.5190.98
235_R238_R0.5170.98
108_A113_A0.5170.98
75_T91_V0.5170.98
248_A251_T0.5170.98
23_L140_T0.5150.98
12_V63_V0.5130.98
15_W50_L0.5130.98
24_A133_E0.5110.98
170_A174_L0.5100.98
166_E169_P0.5090.98
27_H92_T0.5090.98
267_P270_F0.5070.98
92_T270_F0.5070.98
131_R135_G0.5070.98
173_D219_E0.5060.98
122_A137_F0.5050.98
225_T228_A0.5040.98
293_F296_L0.5020.97
125_T128_D0.5010.97
136_S140_T0.5000.97
291_E297_R0.5000.97
96_T136_S0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9522 100 0.311 Contact Map
1tv8A 2 0.8427 100 0.495 Contact Map
4m7tA 1 0.6601 100 0.497 Contact Map
4rtbA 2 0.8876 100 0.535 Contact Map
4wcxA 1 0.941 100 0.563 Contact Map
3c8fA 1 0.618 100 0.594 Contact Map
2yx0A 1 0.6798 100 0.617 Contact Map
2qgqA 1 0.7135 99.9 0.626 Contact Map
2z2uA 1 0.5983 99.9 0.63 Contact Map
4jc0A 1 0.8006 99.9 0.65 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.