GREMLIN Database
Q9HQF4 - Membrane protein
UniProt: Q9HQF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (314)
Sequences: 2002 (1526)
Seq/√Len: 86.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_E168_T5.7121.00
115_R200_D5.2641.00
209_K268_D4.2001.00
127_D164_K3.5941.00
121_D168_T3.5151.00
29_I32_C2.9721.00
179_Y195_G2.7981.00
337_C342_H2.7821.00
314_M320_H2.7231.00
86_D129_T2.7061.00
315_A318_E2.6541.00
204_Y207_A2.6421.00
30_A33_T2.6121.00
84_P125_T2.5211.00
269_T323_E2.5111.00
200_D210_E2.5091.00
118_E201_P2.5041.00
81_D123_E2.5031.00
274_L322_I2.5011.00
196_I275_V2.4551.00
171_A197_F2.4471.00
115_R210_E2.4031.00
59_P62_V2.3381.00
148_D165_H2.2771.00
125_T166_T2.2411.00
93_K96_R2.2121.00
286_I335_M2.1991.00
211_Y262_I2.1961.00
160_G163_E2.1921.00
291_F322_I2.1891.00
269_T325_Q2.1151.00
84_P127_D2.1101.00
138_H182_H2.0841.00
116_T122_I2.0731.00
140_H180_H2.0311.00
126_L159_V2.0051.00
211_Y272_L1.9851.00
93_K97_V1.9801.00
194_Y216_K1.8941.00
237_T240_P1.8771.00
278_G282_H1.8741.00
273_H321_T1.8561.00
282_H287_H1.8421.00
113_I196_I1.8251.00
126_L137_L1.8021.00
69_N72_T1.7851.00
287_H336_H1.7481.00
265_E268_D1.7171.00
196_I214_T1.6921.00
91_P101_A1.6881.00
91_P99_A1.6841.00
295_E321_T1.6631.00
286_I324_F1.6551.00
89_G101_A1.6241.00
286_I291_F1.6051.00
118_E202_K1.5851.00
121_D170_P1.5851.00
22_A31_G1.5821.00
181_C188_H1.5781.00
285_H338_H1.5271.00
44_T47_A1.4910.99
282_H337_C1.4630.99
116_T171_A1.4620.99
285_H291_F1.4440.99
93_K99_A1.4170.99
57_S60_E1.4030.99
213_M245_V1.4030.99
26_T30_A1.3940.99
43_D46_T1.3630.99
243_F282_H1.3570.99
32_C35_P1.3490.99
24_V28_A1.3440.99
283_P311_I1.3410.99
64_A67_Q1.3380.99
138_H141_G1.3370.99
89_G132_K1.3340.99
92_V102_T1.3330.99
289_H327_D1.3210.99
25_G30_A1.3210.99
135_H181_C1.3150.99
56_T59_P1.3060.99
25_G29_I1.3050.99
213_M262_I1.2990.99
116_T199_I1.2930.99
31_G35_P1.2890.98
140_H182_H1.2870.98
117_E120_Q1.2860.98
215_V243_F1.2650.98
293_M320_H1.2630.98
59_P65_T1.2600.98
26_T29_I1.2600.98
35_P38_G1.2480.98
312_T320_H1.2450.98
211_Y264_V1.2430.98
111_G179_Y1.2360.98
22_A26_T1.2300.98
329_D333_Y1.2290.98
105_G193_M1.2230.98
223_N226_M1.2210.98
106_D112_P1.2130.98
55_T59_P1.2040.98
81_D125_T1.1940.97
113_I179_Y1.1860.97
171_A199_I1.1830.97
80_H120_Q1.1800.97
285_H311_I1.1710.97
196_I212_F1.1660.97
20_A24_V1.1630.97
117_E200_D1.1540.97
176_T273_H1.1530.97
62_V70_Q1.1460.97
138_H180_H1.1460.97
45_T48_A1.1420.97
65_T70_Q1.1420.97
55_T60_E1.1420.97
287_H291_F1.1370.97
59_P64_A1.1350.97
176_T275_V1.1310.97
42_T45_T1.1250.96
286_I289_H1.1230.96
173_V199_I1.1120.96
336_H342_H1.1000.96
126_L139_F1.0990.96
333_Y336_H1.0930.96
123_E166_T1.0930.96
34_A39_E1.0900.96
342_H345_N1.0900.96
39_E47_A1.0890.96
330_P333_Y1.0870.96
69_N73_L1.0870.96
104_D107_P1.0830.96
33_T36_D1.0820.95
139_F169_I1.0690.95
139_F142_S1.0630.95
43_D48_A1.0620.95
178_L277_G1.0610.95
221_R225_S1.0590.95
274_L314_M1.0550.95
94_L98_W1.0420.94
176_T210_E1.0420.94
60_E65_T1.0390.94
213_M274_L1.0310.94
244_T249_S1.0310.94
264_V326_A1.0290.94
272_L324_F1.0290.94
209_K270_V1.0290.94
116_T197_F1.0260.94
182_H319_R1.0250.94
68_G71_V1.0150.94
43_D47_A1.0110.94
264_V270_V1.0040.93
34_A38_G1.0020.93
41_V48_A1.0020.93
135_H188_H1.0010.93
79_V123_E0.9960.93
37_G40_S0.9960.93
90_G104_D0.9930.93
94_L97_V0.9920.93
88_M129_T0.9920.93
28_A33_T0.9910.93
327_D330_P0.9890.93
27_A30_A0.9880.93
72_T80_H0.9760.92
301_I306_Q0.9760.92
107_P110_P0.9700.92
67_Q71_V0.9690.92
55_T64_A0.9660.92
296_K299_G0.9620.92
57_S62_V0.9570.92
53_L59_P0.9530.91
53_L57_S0.9510.91
62_V65_T0.9450.91
105_G137_L0.9450.91
29_I35_P0.9400.91
26_T36_D0.9360.91
341_N345_N0.9360.91
126_L135_H0.9340.91
52_G59_P0.9320.90
215_V284_L0.9310.90
21_T31_G0.9300.90
75_S78_A0.9270.90
40_S43_D0.9240.90
339_K342_H0.9220.90
145_A148_D0.9180.90
46_T49_K0.9120.89
38_G49_K0.9110.89
27_A32_C0.9060.89
28_A32_C0.9030.89
31_G43_D0.9020.89
41_V47_A0.8990.89
60_E64_A0.8990.89
214_T277_G0.8930.88
55_T58_P0.8910.88
61_V64_A0.8890.88
217_D281_N0.8890.88
295_E299_G0.8890.88
20_A25_G0.8860.88
28_A34_A0.8850.88
31_G34_A0.8840.88
60_E67_Q0.8790.88
159_V165_H0.8750.87
64_A68_G0.8680.87
146_W149_D0.8660.87
340_V343_V0.8660.87
215_V282_H0.8610.87
232_D236_R0.8570.86
25_G28_A0.8560.86
341_N344_M0.8540.86
178_L182_H0.8510.86
190_D216_K0.8480.86
234_S238_R0.8440.85
139_F181_C0.8430.85
337_C341_N0.8410.85
122_I169_I0.8400.85
211_Y270_V0.8350.85
29_I33_T0.8340.85
41_V45_T0.8330.85
78_A81_D0.8270.84
135_H138_H0.8260.84
50_Q57_S0.8250.84
221_R228_G0.8190.84
34_A41_V0.8180.84
61_V66_E0.8160.84
126_L197_F0.8120.83
142_S171_A0.8110.83
138_H149_D0.8100.83
62_V69_N0.8090.83
81_D163_E0.8080.83
55_T61_V0.8080.83
53_L56_T0.8070.83
24_V32_C0.8070.83
63_D67_Q0.8060.83
287_H338_H0.8050.83
68_G74_K0.8030.83
77_P80_H0.8020.82
243_F281_N0.8020.82
55_T63_D0.8000.82
40_S44_T0.8000.82
125_T164_K0.7970.82
38_G46_T0.7960.82
285_H289_H0.7960.82
45_T49_K0.7900.81
58_P63_D0.7890.81
318_E321_T0.7880.81
122_I197_F0.7850.81
297_D319_R0.7800.81
104_D109_V0.7800.81
39_E49_K0.7780.80
25_G31_G0.7770.80
296_K313_D0.7770.80
290_R308_T0.7760.80
153_T167_Y0.7750.80
282_H342_H0.7740.80
210_E295_E0.7710.80
69_N77_P0.7710.80
297_D317_A0.7700.80
111_G247_G0.7700.80
209_K264_V0.7620.79
52_G57_S0.7530.78
130_D135_H0.7500.78
32_C36_D0.7470.78
136_T149_D0.7470.78
135_H141_G0.7460.78
138_H319_R0.7420.77
87_S126_L0.7410.77
29_I39_E0.7400.77
149_D153_T0.7380.77
158_R183_Y0.7340.76
37_G43_D0.7290.76
336_H339_K0.7280.76
21_T25_G0.7280.76
37_G42_T0.7270.76
334_L338_H0.7270.76
25_G33_T0.7220.75
234_S237_T0.7210.75
42_T48_A0.7200.75
33_T48_A0.7200.75
51_S59_P0.7160.75
58_P61_V0.7150.75
36_D40_S0.7140.75
208_D269_T0.7140.75
19_A24_V0.7130.74
150_G182_H0.7120.74
76_V82_V0.7120.74
62_V66_E0.7070.74
76_V80_H0.7060.74
303_A306_Q0.7060.74
24_V33_T0.7050.74
177_H298_G0.7040.73
30_A45_T0.7030.73
27_A39_E0.7030.73
120_Q197_F0.7020.73
33_T37_G0.6990.73
210_E214_T0.6990.73
57_S63_D0.6980.73
290_R310_D0.6970.73
112_P195_G0.6960.73
39_E42_T0.6950.73
44_T48_A0.6930.72
20_A27_A0.6930.72
66_E70_Q0.6920.72
33_T39_E0.6900.72
72_T77_P0.6890.72
44_T49_K0.6890.72
41_V44_T0.6880.72
333_Y337_C0.6820.71
21_T32_C0.6810.71
65_T72_T0.6800.71
149_D182_H0.6760.70
78_A82_V0.6750.70
137_L193_M0.6730.70
21_T36_D0.6730.70
70_Q73_L0.6720.70
171_A181_C0.6720.70
79_V82_V0.6690.70
103_E191_M0.6640.69
224_R228_G0.6620.69
34_A37_G0.6610.69
36_D44_T0.6600.69
57_S61_V0.6590.68
82_V114_V0.6590.68
42_T46_T0.6560.68
51_S56_T0.6550.68
19_A22_A0.6520.68
36_D51_S0.6520.68
60_E63_D0.6510.68
71_V74_K0.6510.68
59_P63_D0.6510.68
20_A33_T0.6510.68
56_T60_E0.6500.67
210_E273_H0.6490.67
169_I197_F0.6480.67
27_A44_T0.6480.67
235_P238_R0.6460.67
25_G32_C0.6460.67
66_E74_K0.6440.67
198_R212_F0.6440.67
36_D45_T0.6430.67
87_S105_G0.6420.66
28_A31_G0.6410.66
38_G43_D0.6390.66
22_A35_P0.6380.66
289_H326_A0.6370.66
56_T64_A0.6360.66
176_T196_I0.6350.66
296_K301_I0.6350.66
118_E172_N0.6340.66
140_H149_D0.6330.65
153_T183_Y0.6320.65
85_L126_L0.6270.65
74_K77_P0.6260.65
26_T34_A0.6250.64
265_E270_V0.6250.64
292_R308_T0.6240.64
53_L61_V0.6240.64
284_L291_F0.6240.64
190_D279_Y0.6230.64
84_P164_K0.6220.64
32_C199_I0.6180.64
287_H290_R0.6180.64
35_P46_T0.6140.63
58_P62_V0.6140.63
54_P58_P0.6130.63
220_S242_V0.6130.63
50_Q54_P0.6080.62
167_Y175_G0.6050.62
333_Y343_V0.5990.61
284_L287_H0.5990.61
55_T65_T0.5980.61
293_M309_M0.5980.61
189_I194_Y0.5970.61
26_T39_E0.5950.61
189_I340_V0.5910.60
31_G38_G0.5900.60
227_A230_D0.5890.60
274_L291_F0.5890.60
63_D66_E0.5880.60
40_S48_A0.5870.60
27_A48_A0.5870.60
87_S103_E0.5870.60
33_T43_D0.5840.59
56_T78_A0.5840.59
22_A28_A0.5840.59
50_Q61_V0.5820.59
76_V79_V0.5820.59
270_V326_A0.5800.59
35_P42_T0.5790.59
20_A32_C0.5760.58
334_L340_V0.5760.58
134_P158_R0.5750.58
36_D42_T0.5730.58
172_N199_I0.5730.58
126_L136_T0.5700.57
25_G37_G0.5700.57
37_G41_V0.5690.57
66_E69_N0.5690.57
69_N78_A0.5680.57
185_T343_V0.5660.57
139_F197_F0.5650.57
300_Q321_T0.5650.57
24_V27_A0.5640.57
20_A28_A0.5640.57
103_E132_K0.5630.56
42_T49_K0.5620.56
19_A34_A0.5610.56
120_Q311_I0.5600.56
77_P81_D0.5590.56
46_T54_P0.5580.56
52_G62_V0.5570.56
85_L105_G0.5570.56
219_D240_P0.5550.55
240_P282_H0.5540.55
64_A69_N0.5540.55
31_G36_D0.5540.55
300_Q306_Q0.5510.55
22_A36_D0.5500.55
117_E202_K0.5490.55
41_V46_T0.5490.55
225_S228_G0.5490.55
24_V41_V0.5490.55
74_K78_A0.5480.54
118_E177_H0.5480.54
338_H342_H0.5480.54
294_V297_D0.5470.54
175_G195_G0.5460.54
22_A29_I0.5460.54
319_R337_C0.5450.54
285_H323_E0.5450.54
110_P286_I0.5440.54
39_E46_T0.5440.54
27_A42_T0.5440.54
30_A46_T0.5440.54
286_I318_E0.5420.54
21_T28_A0.5400.53
30_A39_E0.5400.53
293_M312_T0.5390.53
40_S45_T0.5390.53
209_K269_T0.5380.53
59_P67_Q0.5380.53
224_R227_A0.5380.53
177_H197_F0.5370.53
29_I34_A0.5350.53
65_T68_G0.5330.52
45_T52_G0.5310.52
95_P98_W0.5310.52
27_A38_G0.5290.52
124_V167_Y0.5290.52
293_M322_I0.5270.52
85_L114_V0.5270.52
208_D219_D0.5260.52
60_E70_Q0.5250.51
37_G46_T0.5240.51
29_I42_T0.5230.51
136_T183_Y0.5220.51
25_G45_T0.5210.51
81_D168_T0.5200.51
60_E66_E0.5190.51
100_F103_E0.5180.50
56_T61_V0.5160.50
23_G78_A0.5120.50
112_P179_Y0.5110.49
65_T69_N0.5100.49
135_H186_Q0.5090.49
292_R295_E0.5070.49
187_R210_E0.5050.49
20_A23_G0.5050.49
146_W153_T0.5040.49
152_P177_H0.5040.49
296_K320_H0.5030.48
54_P57_S0.5020.48
31_G50_Q0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g5wA 4 0.7573 100 0.347 Contact Map
3sqrA 1 0.8391 100 0.351 Contact Map
4e9xA 3 0.7467 100 0.351 Contact Map
2q9oA 2 0.8496 100 0.362 Contact Map
5akrA 3 0.8206 100 0.363 Contact Map
2xu9A 1 0.7573 100 0.367 Contact Map
3ziyA 3 0.8285 100 0.372 Contact Map
2uxtA 1 0.7388 100 0.373 Contact Map
4f7kA 1 0.7177 100 0.374 Contact Map
1kbvA 3 0.7757 100 0.375 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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