Q9HQF4 - HALSA - GREMLIN Contacts

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Q9HQF4 - Membrane protein

UniProt:	Q9HQF4	Sequences: MTDQIGAPGLGISRRDFVAATAGVGTAAIAGCTAPDGGESVTDTTTAAKQSGLPTTSPPEVVDATEQGNQVTLKSVPAVHDVHPLDSMGGPVKLPRVWAFATEDGDPSVPGPIVRTEEGQDIEVTLDNTDGKRPHTLHFHGSQTAWEDDGVPTTTGIRVGPGEKHTYTIPANVPGTHLYHCHYQTQRHIDMGMYGIFRIDPKGYEPADKEYFMTVKDWDSRLNRSMAGEDVDYSPRTRNPDVFTVNGKSAPRTLHPEDGSPIIVEQGDTVRLHLVNGGYMNHPLHIHNHRFRMVEKDGGQIPAAAQHTMDITDMAPAERHTIEFQADADPGIYLMHCHKVNHVMNGTFYPGGMLSGIVYKDAMDSDIFGKLMDFAGYDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	379 (314)
Sequences:	2002 (1526)
Seq/√Len:	86.1

ECOLI - FTSP CUEO
BACSU - COTA
HALSA - Q9HQF4 Q9HPH3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
123_E	168_T	5.712	1.00
115_R	200_D	5.264	1.00
209_K	268_D	4.200	1.00
127_D	164_K	3.594	1.00
121_D	168_T	3.515	1.00
29_I	32_C	2.972	1.00
179_Y	195_G	2.798	1.00
337_C	342_H	2.782	1.00
314_M	320_H	2.723	1.00
86_D	129_T	2.706	1.00
315_A	318_E	2.654	1.00
204_Y	207_A	2.642	1.00
30_A	33_T	2.612	1.00
84_P	125_T	2.521	1.00
269_T	323_E	2.511	1.00
200_D	210_E	2.509	1.00
118_E	201_P	2.504	1.00
81_D	123_E	2.503	1.00
274_L	322_I	2.501	1.00
196_I	275_V	2.455	1.00
171_A	197_F	2.447	1.00
115_R	210_E	2.403	1.00
59_P	62_V	2.338	1.00
148_D	165_H	2.277	1.00
125_T	166_T	2.241	1.00
93_K	96_R	2.212	1.00
286_I	335_M	2.199	1.00
211_Y	262_I	2.196	1.00
160_G	163_E	2.192	1.00
291_F	322_I	2.189	1.00
269_T	325_Q	2.115	1.00
84_P	127_D	2.110	1.00
138_H	182_H	2.084	1.00
116_T	122_I	2.073	1.00
140_H	180_H	2.031	1.00
126_L	159_V	2.005	1.00
211_Y	272_L	1.985	1.00
93_K	97_V	1.980	1.00
194_Y	216_K	1.894	1.00
237_T	240_P	1.877	1.00
278_G	282_H	1.874	1.00
273_H	321_T	1.856	1.00
282_H	287_H	1.842	1.00
113_I	196_I	1.825	1.00
126_L	137_L	1.802	1.00
69_N	72_T	1.785	1.00
287_H	336_H	1.748	1.00
265_E	268_D	1.717	1.00
196_I	214_T	1.692	1.00
91_P	101_A	1.688	1.00
91_P	99_A	1.684	1.00
295_E	321_T	1.663	1.00
286_I	324_F	1.655	1.00
89_G	101_A	1.624	1.00
286_I	291_F	1.605	1.00
118_E	202_K	1.585	1.00
121_D	170_P	1.585	1.00
22_A	31_G	1.582	1.00
181_C	188_H	1.578	1.00
285_H	338_H	1.527	1.00
44_T	47_A	1.491	0.99
282_H	337_C	1.463	0.99
116_T	171_A	1.462	0.99
285_H	291_F	1.444	0.99
93_K	99_A	1.417	0.99
57_S	60_E	1.403	0.99
213_M	245_V	1.403	0.99
26_T	30_A	1.394	0.99
43_D	46_T	1.363	0.99
243_F	282_H	1.357	0.99
32_C	35_P	1.349	0.99
24_V	28_A	1.344	0.99
283_P	311_I	1.341	0.99
64_A	67_Q	1.338	0.99
138_H	141_G	1.337	0.99
89_G	132_K	1.334	0.99
92_V	102_T	1.333	0.99
289_H	327_D	1.321	0.99
25_G	30_A	1.321	0.99
135_H	181_C	1.315	0.99
56_T	59_P	1.306	0.99
25_G	29_I	1.305	0.99
213_M	262_I	1.299	0.99
116_T	199_I	1.293	0.99
31_G	35_P	1.289	0.98
140_H	182_H	1.287	0.98
117_E	120_Q	1.286	0.98
215_V	243_F	1.265	0.98
293_M	320_H	1.263	0.98
59_P	65_T	1.260	0.98
26_T	29_I	1.260	0.98
35_P	38_G	1.248	0.98
312_T	320_H	1.245	0.98
211_Y	264_V	1.243	0.98
111_G	179_Y	1.236	0.98
22_A	26_T	1.230	0.98
329_D	333_Y	1.229	0.98
105_G	193_M	1.223	0.98
223_N	226_M	1.221	0.98
106_D	112_P	1.213	0.98
55_T	59_P	1.204	0.98
81_D	125_T	1.194	0.97
113_I	179_Y	1.186	0.97
171_A	199_I	1.183	0.97
80_H	120_Q	1.180	0.97
285_H	311_I	1.171	0.97
196_I	212_F	1.166	0.97
20_A	24_V	1.163	0.97
117_E	200_D	1.154	0.97
176_T	273_H	1.153	0.97
62_V	70_Q	1.146	0.97
138_H	180_H	1.146	0.97
45_T	48_A	1.142	0.97
65_T	70_Q	1.142	0.97
55_T	60_E	1.142	0.97
287_H	291_F	1.137	0.97
59_P	64_A	1.135	0.97
176_T	275_V	1.131	0.97
42_T	45_T	1.125	0.96
286_I	289_H	1.123	0.96
173_V	199_I	1.112	0.96
336_H	342_H	1.100	0.96
126_L	139_F	1.099	0.96
333_Y	336_H	1.093	0.96
123_E	166_T	1.093	0.96
34_A	39_E	1.090	0.96
342_H	345_N	1.090	0.96
39_E	47_A	1.089	0.96
330_P	333_Y	1.087	0.96
69_N	73_L	1.087	0.96
104_D	107_P	1.083	0.96
33_T	36_D	1.082	0.95
139_F	169_I	1.069	0.95
139_F	142_S	1.063	0.95
43_D	48_A	1.062	0.95
178_L	277_G	1.061	0.95
221_R	225_S	1.059	0.95
274_L	314_M	1.055	0.95
94_L	98_W	1.042	0.94
176_T	210_E	1.042	0.94
60_E	65_T	1.039	0.94
213_M	274_L	1.031	0.94
244_T	249_S	1.031	0.94
264_V	326_A	1.029	0.94
272_L	324_F	1.029	0.94
209_K	270_V	1.029	0.94
116_T	197_F	1.026	0.94
182_H	319_R	1.025	0.94
68_G	71_V	1.015	0.94
43_D	47_A	1.011	0.94
264_V	270_V	1.004	0.93
34_A	38_G	1.002	0.93
41_V	48_A	1.002	0.93
135_H	188_H	1.001	0.93
79_V	123_E	0.996	0.93
37_G	40_S	0.996	0.93
90_G	104_D	0.993	0.93
94_L	97_V	0.992	0.93
88_M	129_T	0.992	0.93
28_A	33_T	0.991	0.93
327_D	330_P	0.989	0.93
27_A	30_A	0.988	0.93
72_T	80_H	0.976	0.92
301_I	306_Q	0.976	0.92
107_P	110_P	0.970	0.92
67_Q	71_V	0.969	0.92
55_T	64_A	0.966	0.92
296_K	299_G	0.962	0.92
57_S	62_V	0.957	0.92
53_L	59_P	0.953	0.91
53_L	57_S	0.951	0.91
62_V	65_T	0.945	0.91
105_G	137_L	0.945	0.91
29_I	35_P	0.940	0.91
26_T	36_D	0.936	0.91
341_N	345_N	0.936	0.91
126_L	135_H	0.934	0.91
52_G	59_P	0.932	0.90
215_V	284_L	0.931	0.90
21_T	31_G	0.930	0.90
75_S	78_A	0.927	0.90
40_S	43_D	0.924	0.90
339_K	342_H	0.922	0.90
145_A	148_D	0.918	0.90
46_T	49_K	0.912	0.89
38_G	49_K	0.911	0.89
27_A	32_C	0.906	0.89
28_A	32_C	0.903	0.89
31_G	43_D	0.902	0.89
41_V	47_A	0.899	0.89
60_E	64_A	0.899	0.89
214_T	277_G	0.893	0.88
55_T	58_P	0.891	0.88
61_V	64_A	0.889	0.88
217_D	281_N	0.889	0.88
295_E	299_G	0.889	0.88
20_A	25_G	0.886	0.88
28_A	34_A	0.885	0.88
31_G	34_A	0.884	0.88
60_E	67_Q	0.879	0.88
159_V	165_H	0.875	0.87
64_A	68_G	0.868	0.87
146_W	149_D	0.866	0.87
340_V	343_V	0.866	0.87
215_V	282_H	0.861	0.87
232_D	236_R	0.857	0.86
25_G	28_A	0.856	0.86
341_N	344_M	0.854	0.86
178_L	182_H	0.851	0.86
190_D	216_K	0.848	0.86
234_S	238_R	0.844	0.85
139_F	181_C	0.843	0.85
337_C	341_N	0.841	0.85
122_I	169_I	0.840	0.85
211_Y	270_V	0.835	0.85
29_I	33_T	0.834	0.85
41_V	45_T	0.833	0.85
78_A	81_D	0.827	0.84
135_H	138_H	0.826	0.84
50_Q	57_S	0.825	0.84
221_R	228_G	0.819	0.84
34_A	41_V	0.818	0.84
61_V	66_E	0.816	0.84
126_L	197_F	0.812	0.83
142_S	171_A	0.811	0.83
138_H	149_D	0.810	0.83
62_V	69_N	0.809	0.83
81_D	163_E	0.808	0.83
55_T	61_V	0.808	0.83
53_L	56_T	0.807	0.83
24_V	32_C	0.807	0.83
63_D	67_Q	0.806	0.83
287_H	338_H	0.805	0.83
68_G	74_K	0.803	0.83
77_P	80_H	0.802	0.82
243_F	281_N	0.802	0.82
55_T	63_D	0.800	0.82
40_S	44_T	0.800	0.82
125_T	164_K	0.797	0.82
38_G	46_T	0.796	0.82
285_H	289_H	0.796	0.82
45_T	49_K	0.790	0.81
58_P	63_D	0.789	0.81
318_E	321_T	0.788	0.81
122_I	197_F	0.785	0.81
297_D	319_R	0.780	0.81
104_D	109_V	0.780	0.81
39_E	49_K	0.778	0.80
25_G	31_G	0.777	0.80
296_K	313_D	0.777	0.80
290_R	308_T	0.776	0.80
153_T	167_Y	0.775	0.80
282_H	342_H	0.774	0.80
210_E	295_E	0.771	0.80
69_N	77_P	0.771	0.80
297_D	317_A	0.770	0.80
111_G	247_G	0.770	0.80
209_K	264_V	0.762	0.79
52_G	57_S	0.753	0.78
130_D	135_H	0.750	0.78
32_C	36_D	0.747	0.78
136_T	149_D	0.747	0.78
135_H	141_G	0.746	0.78
138_H	319_R	0.742	0.77
87_S	126_L	0.741	0.77
29_I	39_E	0.740	0.77
149_D	153_T	0.738	0.77
158_R	183_Y	0.734	0.76
37_G	43_D	0.729	0.76
336_H	339_K	0.728	0.76
21_T	25_G	0.728	0.76
37_G	42_T	0.727	0.76
334_L	338_H	0.727	0.76
25_G	33_T	0.722	0.75
234_S	237_T	0.721	0.75
42_T	48_A	0.720	0.75
33_T	48_A	0.720	0.75
51_S	59_P	0.716	0.75
58_P	61_V	0.715	0.75
36_D	40_S	0.714	0.75
208_D	269_T	0.714	0.75
19_A	24_V	0.713	0.74
150_G	182_H	0.712	0.74
76_V	82_V	0.712	0.74
62_V	66_E	0.707	0.74
76_V	80_H	0.706	0.74
303_A	306_Q	0.706	0.74
24_V	33_T	0.705	0.74
177_H	298_G	0.704	0.73
30_A	45_T	0.703	0.73
27_A	39_E	0.703	0.73
120_Q	197_F	0.702	0.73
33_T	37_G	0.699	0.73
210_E	214_T	0.699	0.73
57_S	63_D	0.698	0.73
290_R	310_D	0.697	0.73
112_P	195_G	0.696	0.73
39_E	42_T	0.695	0.73
44_T	48_A	0.693	0.72
20_A	27_A	0.693	0.72
66_E	70_Q	0.692	0.72
33_T	39_E	0.690	0.72
72_T	77_P	0.689	0.72
44_T	49_K	0.689	0.72
41_V	44_T	0.688	0.72
333_Y	337_C	0.682	0.71
21_T	32_C	0.681	0.71
65_T	72_T	0.680	0.71
149_D	182_H	0.676	0.70
78_A	82_V	0.675	0.70
137_L	193_M	0.673	0.70
21_T	36_D	0.673	0.70
70_Q	73_L	0.672	0.70
171_A	181_C	0.672	0.70
79_V	82_V	0.669	0.70
103_E	191_M	0.664	0.69
224_R	228_G	0.662	0.69
34_A	37_G	0.661	0.69
36_D	44_T	0.660	0.69
57_S	61_V	0.659	0.68
82_V	114_V	0.659	0.68
42_T	46_T	0.656	0.68
51_S	56_T	0.655	0.68
19_A	22_A	0.652	0.68
36_D	51_S	0.652	0.68
60_E	63_D	0.651	0.68
71_V	74_K	0.651	0.68
59_P	63_D	0.651	0.68
20_A	33_T	0.651	0.68
56_T	60_E	0.650	0.67
210_E	273_H	0.649	0.67
169_I	197_F	0.648	0.67
27_A	44_T	0.648	0.67
235_P	238_R	0.646	0.67
25_G	32_C	0.646	0.67
66_E	74_K	0.644	0.67
198_R	212_F	0.644	0.67
36_D	45_T	0.643	0.67
87_S	105_G	0.642	0.66
28_A	31_G	0.641	0.66
38_G	43_D	0.639	0.66
22_A	35_P	0.638	0.66
289_H	326_A	0.637	0.66
56_T	64_A	0.636	0.66
176_T	196_I	0.635	0.66
296_K	301_I	0.635	0.66
118_E	172_N	0.634	0.66
140_H	149_D	0.633	0.65
153_T	183_Y	0.632	0.65
85_L	126_L	0.627	0.65
74_K	77_P	0.626	0.65
26_T	34_A	0.625	0.64
265_E	270_V	0.625	0.64
292_R	308_T	0.624	0.64
53_L	61_V	0.624	0.64
284_L	291_F	0.624	0.64
190_D	279_Y	0.623	0.64
84_P	164_K	0.622	0.64
32_C	199_I	0.618	0.64
287_H	290_R	0.618	0.64
35_P	46_T	0.614	0.63
58_P	62_V	0.614	0.63
54_P	58_P	0.613	0.63
220_S	242_V	0.613	0.63
50_Q	54_P	0.608	0.62
167_Y	175_G	0.605	0.62
333_Y	343_V	0.599	0.61
284_L	287_H	0.599	0.61
55_T	65_T	0.598	0.61
293_M	309_M	0.598	0.61
189_I	194_Y	0.597	0.61
26_T	39_E	0.595	0.61
189_I	340_V	0.591	0.60
31_G	38_G	0.590	0.60
227_A	230_D	0.589	0.60
274_L	291_F	0.589	0.60
63_D	66_E	0.588	0.60
40_S	48_A	0.587	0.60
27_A	48_A	0.587	0.60
87_S	103_E	0.587	0.60
33_T	43_D	0.584	0.59
56_T	78_A	0.584	0.59
22_A	28_A	0.584	0.59
50_Q	61_V	0.582	0.59
76_V	79_V	0.582	0.59
270_V	326_A	0.580	0.59
35_P	42_T	0.579	0.59
20_A	32_C	0.576	0.58
334_L	340_V	0.576	0.58
134_P	158_R	0.575	0.58
36_D	42_T	0.573	0.58
172_N	199_I	0.573	0.58
126_L	136_T	0.570	0.57
25_G	37_G	0.570	0.57
37_G	41_V	0.569	0.57
66_E	69_N	0.569	0.57
69_N	78_A	0.568	0.57
185_T	343_V	0.566	0.57
139_F	197_F	0.565	0.57
300_Q	321_T	0.565	0.57
24_V	27_A	0.564	0.57
20_A	28_A	0.564	0.57
103_E	132_K	0.563	0.56
42_T	49_K	0.562	0.56
19_A	34_A	0.561	0.56
120_Q	311_I	0.560	0.56
77_P	81_D	0.559	0.56
46_T	54_P	0.558	0.56
52_G	62_V	0.557	0.56
85_L	105_G	0.557	0.56
219_D	240_P	0.555	0.55
240_P	282_H	0.554	0.55
64_A	69_N	0.554	0.55
31_G	36_D	0.554	0.55
300_Q	306_Q	0.551	0.55
22_A	36_D	0.550	0.55
117_E	202_K	0.549	0.55
41_V	46_T	0.549	0.55
225_S	228_G	0.549	0.55
24_V	41_V	0.549	0.55
74_K	78_A	0.548	0.54
118_E	177_H	0.548	0.54
338_H	342_H	0.548	0.54
294_V	297_D	0.547	0.54
175_G	195_G	0.546	0.54
22_A	29_I	0.546	0.54
319_R	337_C	0.545	0.54
285_H	323_E	0.545	0.54
110_P	286_I	0.544	0.54
39_E	46_T	0.544	0.54
27_A	42_T	0.544	0.54
30_A	46_T	0.544	0.54
286_I	318_E	0.542	0.54
21_T	28_A	0.540	0.53
30_A	39_E	0.540	0.53
293_M	312_T	0.539	0.53
40_S	45_T	0.539	0.53
209_K	269_T	0.538	0.53
59_P	67_Q	0.538	0.53
224_R	227_A	0.538	0.53
177_H	197_F	0.537	0.53
29_I	34_A	0.535	0.53
65_T	68_G	0.533	0.52
45_T	52_G	0.531	0.52
95_P	98_W	0.531	0.52
27_A	38_G	0.529	0.52
124_V	167_Y	0.529	0.52
293_M	322_I	0.527	0.52
85_L	114_V	0.527	0.52
208_D	219_D	0.526	0.52
60_E	70_Q	0.525	0.51
37_G	46_T	0.524	0.51
29_I	42_T	0.523	0.51
136_T	183_Y	0.522	0.51
25_G	45_T	0.521	0.51
81_D	168_T	0.520	0.51
60_E	66_E	0.519	0.51
100_F	103_E	0.518	0.50
56_T	61_V	0.516	0.50
23_G	78_A	0.512	0.50
112_P	179_Y	0.511	0.49
65_T	69_N	0.510	0.49
135_H	186_Q	0.509	0.49
292_R	295_E	0.507	0.49
187_R	210_E	0.505	0.49
20_A	23_G	0.505	0.49
146_W	153_T	0.504	0.49
152_P	177_H	0.504	0.49
296_K	320_H	0.503	0.48
54_P	57_S	0.502	0.48
31_G	50_Q	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3g5wA	4	0.7573	100	0.347	Contact Map
3sqrA	1	0.8391	100	0.351	Contact Map
4e9xA	3	0.7467	100	0.351	Contact Map
2q9oA	2	0.8496	100	0.362	Contact Map
5akrA	3	0.8206	100	0.363	Contact Map
2xu9A	1	0.7573	100	0.367	Contact Map
3ziyA	3	0.8285	100	0.372	Contact Map
2uxtA	1	0.7388	100	0.373	Contact Map
4f7kA	1	0.7177	100	0.374	Contact Map
1kbvA	3	0.7757	100	0.375	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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