GREMLIN Database
Q9HQF3 - Halocyanin-like
UniProt: Q9HQF3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (160)
Sequences: 259 (234)
Seq/√Len: 18.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_Y150_G3.8651.00
93_F152_V3.6381.00
33_G37_Q3.4101.00
166_G171_N3.1400.99
140_C143_H2.8980.99
100_H143_H2.7800.98
168_D171_N2.6770.98
9_T12_R2.6450.98
140_C148_M2.5750.97
143_H148_M2.5510.97
100_H140_C2.4870.96
100_H148_M2.2620.94
166_G170_G2.2180.93
16_G19_G2.2120.93
167_I171_N2.1170.92
103_A141_S2.0280.90
130_F136_Y2.0260.90
15_Q20_A1.8760.86
9_T13_V1.8750.86
22_A25_A1.8360.84
93_F97_S1.8310.84
84_R155_G1.6960.79
166_G169_W1.6640.78
134_G154_V1.6390.77
44_W48_V1.6160.76
13_V36_A1.5880.74
165_G168_D1.5650.73
95_W101_N1.5620.73
50_N82_A1.5070.70
61_S154_V1.5040.70
59_G67_V1.4900.69
105_E139_F1.4860.69
91_V97_S1.4650.68
8_V12_R1.4620.68
84_R157_A1.4540.67
165_G171_N1.4240.66
93_F102_V1.4210.66
34_G37_Q1.4070.65
164_S167_I1.3990.64
91_V130_F1.3510.62
20_A25_A1.3450.61
41_I48_V1.3350.61
71_A77_G1.3260.60
165_G169_W1.2960.58
28_G82_A1.2920.58
15_Q38_S1.2780.57
101_N142_P1.2760.57
25_A49_S1.2740.57
104_V143_H1.2320.54
90_T129_T1.2210.54
84_R153_V1.2120.53
167_I170_G1.2080.53
116_V120_N1.1970.52
26_G29_G1.1950.52
91_V154_V1.1950.52
150_G154_V1.1940.52
130_F152_V1.1940.52
12_R18_A1.1920.52
83_V93_F1.1900.52
33_G38_S1.1830.51
137_T149_K1.1650.50
56_D59_G1.1610.50
58_T84_R1.1400.49
41_I54_V1.1390.49
86_D155_G1.1230.48
12_R22_A1.1050.46
24_A34_G1.0650.44
101_N141_S1.0630.44
165_G170_G1.0600.44
16_G21_G1.0480.43
83_V152_V1.0480.43
61_S83_V1.0440.43
32_A57_E1.0410.42
128_H135_V1.0400.42
104_V126_D1.0400.42
18_A163_A1.0340.42
41_I45_L1.0330.42
126_D130_F1.0310.42
104_V109_D1.0260.42
117_E120_N1.0250.42
54_V58_T1.0090.41
65_V83_V1.0030.40
106_S109_D1.0030.40
22_A27_I1.0010.40
104_V116_V0.9970.40
19_G29_G0.9770.39
85_V154_V0.9710.38
84_R105_E0.9440.37
47_D152_V0.9390.36
16_G118_E0.9390.36
133_A158_D0.9350.36
25_A126_D0.9310.36
103_A139_F0.9280.36
47_D51_Y0.9220.35
127_S152_V0.9150.35
22_A37_Q0.9110.35
49_S164_S0.9090.35
116_V141_S0.9080.35
16_G38_S0.8980.34
12_R32_A0.8950.34
69_V77_G0.8910.34
137_T151_A0.8890.34
84_R151_A0.8880.34
37_Q40_S0.8830.33
68_G95_W0.8800.33
13_V39_A0.8720.33
113_W126_D0.8640.32
21_G30_F0.8630.32
31_A36_A0.8610.32
61_S89_T0.8560.32
75_A146_M0.8520.32
90_T127_S0.8520.32
76_Y148_M0.8280.30
9_T16_G0.8240.30
105_E144_R0.8230.30
88_G138_Y0.8230.30
94_E99_T0.8100.29
14_L24_A0.8070.29
65_V87_P0.8020.29
142_P148_M0.8000.29
51_Y91_V0.8000.29
144_R152_V0.7950.29
12_R164_S0.7910.28
22_A170_G0.7910.28
38_S49_S0.7880.28
164_S168_D0.7850.28
13_V161_G0.7830.28
40_S49_S0.7810.28
39_A42_D0.7800.28
67_V90_T0.7800.28
47_D52_D0.7780.28
20_A72_N0.7730.27
29_G166_G0.7710.27
107_Q113_W0.7690.27
31_A127_S0.7650.27
104_V148_M0.7630.27
161_G164_S0.7620.27
139_F149_K0.7610.27
42_D53_G0.7600.27
41_I51_Y0.7580.27
29_G32_A0.7580.27
45_L72_N0.7550.27
17_S21_G0.7470.26
22_A51_Y0.7450.26
45_L51_Y0.7430.26
31_A35_A0.7430.26
14_L17_S0.7350.26
120_N149_K0.7240.25
76_Y142_P0.7230.25
135_V141_S0.7220.25
56_D63_V0.7150.25
42_D46_G0.7100.24
33_G36_A0.7090.24
59_G122_E0.7040.24
107_Q136_Y0.7030.24
12_R15_Q0.7030.24
62_E89_T0.6900.24
19_G62_E0.6880.23
105_E155_G0.6830.23
98_N116_V0.6740.23
108_P156_D0.6720.23
104_V108_P0.6680.23
114_G124_Y0.6670.23
117_E128_H0.6670.23
137_T143_H0.6660.22
102_V127_S0.6650.22
13_V20_A0.6600.22
17_S26_G0.6580.22
93_F138_Y0.6560.22
76_Y146_M0.6520.22
100_H146_M0.6490.22
43_D47_D0.6450.22
103_A106_S0.6430.21
106_S135_V0.6400.21
26_G90_T0.6390.21
9_T17_S0.6360.21
28_G162_A0.6350.21
101_N145_A0.6310.21
25_A62_E0.6280.21
16_G22_A0.6250.21
29_G157_A0.6230.21
76_Y153_V0.6200.21
146_M152_V0.6170.20
75_A79_G0.6150.20
28_G31_A0.6090.20
93_F104_V0.6070.20
77_G139_F0.6060.20
109_D113_W0.6000.20
16_G78_F0.5980.20
107_Q132_T0.5960.20
55_R153_V0.5960.20
121_N125_T0.5950.20
76_Y84_R0.5900.19
79_G83_V0.5900.19
24_A52_D0.5890.19
40_S44_W0.5890.19
64_T94_E0.5890.19
14_L27_I0.5780.19
90_T144_R0.5760.19
25_A32_A0.5760.19
106_S137_T0.5740.19
129_T132_T0.5700.19
100_H104_V0.5690.19
17_S28_G0.5680.18
134_G138_Y0.5620.18
104_V140_C0.5610.18
34_G83_V0.5590.18
18_A154_V0.5560.18
40_S43_D0.5560.18
65_V133_A0.5540.18
26_G124_Y0.5470.18
44_W50_N0.5470.18
46_G53_G0.5460.18
156_D159_V0.5460.18
18_A156_D0.5420.18
40_S45_L0.5420.18
163_A166_G0.5410.17
109_D136_Y0.5350.17
161_G169_W0.5330.17
128_H136_Y0.5330.17
51_Y92_T0.5330.17
116_V119_I0.5320.17
18_A28_G0.5320.17
130_F145_A0.5250.17
91_V95_W0.5250.17
95_W120_N0.5250.17
120_N124_Y0.5220.17
113_W148_M0.5150.17
134_G150_G0.5130.17
121_N124_Y0.5110.16
136_Y146_M0.5090.16
76_Y101_N0.5080.16
117_E144_R0.5060.16
11_R27_I0.5050.16
41_I46_G0.5040.16
40_S91_V0.5020.16
139_F156_D0.5020.16
164_S170_G0.5020.16
59_G63_V0.5010.16
34_G38_S0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c75A 1 0.5122 99.9 0.585 Contact Map
3ef4A 1 0.6 99.8 0.635 Contact Map
5akrA 3 0.7463 99.8 0.641 Contact Map
3erxA 3 0.5951 99.8 0.643 Contact Map
3cvbA 1 0.4585 99.8 0.647 Contact Map
1iuzA 1 0.4488 99.8 0.65 Contact Map
1pcsA 2 0.4537 99.8 0.651 Contact Map
1pmyA 1 0.5951 99.8 0.651 Contact Map
3tu6A 1 0.6146 99.8 0.651 Contact Map
1pazA 1 0.5805 99.8 0.653 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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