Q9HQF0 - HALSA - GREMLIN Contacts

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Q9HQF0 - Acyl-CoA dehydrogenase

UniProt:	Q9HQF0	Sequences: MDKAADAGLLGPGIPMAYGGAGYSPVEVAIIVEELFAADPGIGLCVASAGFGAEAITAFGTDDQKRRFLEPVTAGDAIMGSAISEPDTGSDVASVSATAEKDGDEWIIDGNKMWITNGSVGDYFVVLCRTDPDASGRYEGFSQIVVESDRDGFTAEKITGKLGIRASDTAELVLDAVRVPEENLIGTRGGGFLQLMQFFDETRTTVAAQGVGIARGATERALAYAQEREQFGQPVADFQAIQHKLAEMQTKTEAARTLTRKSAWSVDHRDDQLTALASMAKSFASRIAVEVADEAVQIHGGAGYVNDFDVERFYRDAKITQLYEGTTEIQKNVIAREMMD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	340 (329)
Sequences:	32284 (17578)
Seq/√Len:	969.1

ECOLI - CAIA YDIO AIDB FADE
BACSU - ACDA FADE ACDC ACDB YDBM
HALSA - Q9HQF0 Q9HS75 Q9HRI6 Q9HPT2 Q9HRB3 Q9HMK7
SULSO - Q97UW6 Q97V73 Q97U78 Q97XW3 Q97WQ8 Q97VU6 Q97YZ6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
105_E	178_R	4.215	1.00
251_K	290_E	3.394	1.00
109_D	176_A	3.340	1.00
101_K	181_E	3.209	1.00
71_P	76_D	2.907	1.00
71_P	77_A	2.864	1.00
154_T	175_D	2.732	1.00
24_S	27_E	2.680	1.00
244_K	294_E	2.658	1.00
62_D	66_R	2.631	1.00
111_N	173_V	2.566	1.00
102_D	178_R	2.491	1.00
215_R	256_R	2.274	1.00
223_A	227_E	2.228	1.00
142_S	184_L	2.174	1.00
102_D	107_I	2.137	1.00
111_N	171_E	2.091	1.00
190_G	193_L	2.036	1.00
124_F	148_S	1.995	1.00
306_N	311_E	1.935	1.00
15_P	57_T	1.917	1.00
218_T	252_T	1.902	1.00
187_T	190_G	1.900	1.00
234_P	237_D	1.898	1.00
240_A	243_H	1.897	1.00
154_T	173_V	1.874	1.00
156_E	173_V	1.836	1.00
128_C	144_I	1.836	1.00
311_E	315_R	1.828	1.00
62_D	65_K	1.803	1.00
265_S	276_L	1.799	1.00
229_E	234_P	1.797	1.00
107_I	178_R	1.793	1.00
220_R	309_D	1.793	1.00
33_E	256_R	1.781	1.00
37_A	219_E	1.769	1.00
118_G	170_A	1.762	1.00
261_K	265_S	1.761	1.00
107_I	176_A	1.758	1.00
255_A	284_A	1.740	1.00
102_D	105_E	1.736	1.00
233_Q	237_D	1.733	1.00
150_R	177_V	1.732	1.00
80_G	124_F	1.722	1.00
16_M	22_G	1.711	1.00
290_E	294_E	1.706	1.00
225_A	298_I	1.700	1.00
286_R	327_T	1.688	1.00
61_T	64_Q	1.669	1.00
289_V	321_Q	1.661	1.00
100_E	109_D	1.617	1.00
34_E	37_A	1.616	1.00
67_R	71_P	1.610	1.00
106_W	144_I	1.605	1.00
26_V	264_W	1.601	1.00
67_R	182_E	1.576	1.00
215_R	219_E	1.571	1.00
156_E	171_E	1.567	1.00
119_S	170_A	1.558	1.00
147_E	183_N	1.552	1.00
66_R	70_E	1.550	1.00
254_A	283_F	1.550	1.00
217_A	292_A	1.544	1.00
222_L	226_Q	1.541	1.00
101_K	188_R	1.537	1.00
248_M	291_V	1.532	1.00
216_G	220_R	1.518	1.00
160_G	306_N	1.505	1.00
39_D	42_I	1.499	1.00
302_A	308_F	1.483	1.00
221_A	295_A	1.475	1.00
225_A	241_I	1.469	1.00
220_R	223_A	1.467	1.00
70_E	74_A	1.466	1.00
59_F	197_Q	1.462	1.00
249_Q	253_E	1.458	1.00
184_L	188_R	1.457	1.00
131_D	134_A	1.456	1.00
264_W	268_H	1.448	1.00
214_A	252_T	1.417	1.00
37_A	215_R	1.416	1.00
180_P	183_N	1.408	1.00
109_D	175_D	1.406	1.00
63_D	67_R	1.404	1.00
241_I	298_I	1.397	1.00
101_K	105_E	1.393	1.00
71_P	74_A	1.390	1.00
181_E	184_L	1.383	1.00
289_V	293_D	1.374	1.00
214_A	291_V	1.370	1.00
248_M	294_E	1.361	1.00
77_A	122_D	1.361	1.00
87_D	96_S	1.360	1.00
33_E	215_R	1.360	1.00
251_K	287_I	1.354	1.00
253_E	261_K	1.336	1.00
233_Q	238_F	1.330	1.00
18_Y	65_K	1.327	1.00
63_D	182_E	1.324	1.00
293_D	318_K	1.321	1.00
230_Q	238_F	1.320	1.00
261_K	264_W	1.317	1.00
29_A	263_A	1.317	1.00
104_D	181_E	1.312	1.00
106_W	181_E	1.310	1.00
101_K	106_W	1.310	1.00
147_E	150_R	1.294	1.00
23_Y	27_E	1.286	1.00
25_P	267_D	1.283	1.00
200_D	274_T	1.272	1.00
251_K	294_E	1.271	1.00
288_A	317_A	1.270	1.00
148_S	155_A	1.260	1.00
58_A	197_Q	1.258	1.00
127_L	143_Q	1.255	1.00
265_S	270_D	1.241	1.00
33_E	260_R	1.237	1.00
150_R	183_N	1.235	1.00
257_T	261_K	1.232	1.00
100_E	107_I	1.231	1.00
82_A	115_I	1.231	1.00
79_M	123_Y	1.230	1.00
220_R	299_H	1.229	1.00
12_P	31_I	1.223	1.00
179_V	183_N	1.219	1.00
255_A	287_I	1.219	1.00
99_A	144_I	1.219	1.00
105_E	181_E	1.219	1.00
67_R	183_N	1.209	1.00
130_T	142_S	1.204	1.00
218_T	222_L	1.202	1.00
295_A	310_V	1.192	1.00
29_A	208_A	1.185	1.00
216_G	313_F	1.184	1.00
247_E	331_K	1.179	1.00
282_S	327_T	1.169	1.00
208_A	259_T	1.163	1.00
68_F	123_Y	1.161	1.00
72_V	79_M	1.160	1.00
148_S	153_F	1.156	1.00
287_I	290_E	1.153	1.00
226_Q	236_A	1.146	1.00
84_S	114_W	1.135	1.00
82_A	124_F	1.133	1.00
108_I	144_I	1.128	1.00
293_D	321_Q	1.125	1.00
104_D	178_R	1.124	1.00
14_I	73_T	1.124	1.00
247_E	251_K	1.118	1.00
85_E	112_K	1.118	1.00
5_A	10_L	1.117	1.00
252_T	291_V	1.110	1.00
126_V	146_V	1.103	1.00
65_K	69_L	1.102	1.00
225_A	236_A	1.101	1.00
244_K	328_E	1.095	1.00
126_V	174_L	1.087	1.00
99_A	128_C	1.083	1.00
282_S	331_K	1.083	1.00
59_F	194_Q	1.082	1.00
318_K	321_Q	1.074	1.00
286_R	290_E	1.073	1.00
127_L	141_F	1.064	1.00
113_M	171_E	1.063	1.00
153_F	177_V	1.058	1.00
222_L	245_L	1.058	1.00
82_A	174_L	1.057	1.00
123_Y	147_E	1.057	1.00
30_I	34_E	1.055	1.00
13_G	28_V	1.055	1.00
289_V	314_Y	1.053	1.00
64_Q	68_F	1.051	1.00
278_S	330_Q	1.044	1.00
24_S	267_D	1.042	1.00
124_F	153_F	1.042	1.00
247_E	294_E	1.039	1.00
91_D	94_S	1.038	1.00
98_T	109_D	1.033	1.00
296_V	314_Y	1.033	1.00
292_A	317_A	1.032	1.00
17_A	66_R	1.031	1.00
30_I	260_R	1.024	1.00
26_V	267_D	1.024	1.00
52_G	79_M	1.020	1.00
210_G	320_T	1.019	1.00
100_E	176_A	1.019	1.00
60_G	64_Q	1.009	1.00
192_F	196_M	1.008	1.00
213_I	288_A	1.008	1.00
211_V	252_T	0.999	1.00
211_V	259_T	0.998	1.00
77_A	123_Y	0.994	1.00
63_D	66_R	0.992	1.00
105_E	180_P	0.989	1.00
249_Q	279_M	0.989	1.00
262_S	280_A	0.986	1.00
26_V	260_R	0.981	1.00
97_A	108_I	0.975	1.00
36_F	43_G	0.966	1.00
251_K	283_F	0.959	1.00
243_H	247_E	0.956	1.00
162_L	314_Y	0.953	1.00
26_V	30_I	0.946	1.00
108_I	179_V	0.946	1.00
64_Q	183_N	0.946	1.00
67_R	147_E	0.945	1.00
211_V	255_A	0.943	1.00
321_Q	327_T	0.940	1.00
106_W	130_T	0.937	1.00
125_V	143_Q	0.932	1.00
144_I	184_L	0.930	1.00
283_F	287_I	0.918	1.00
14_I	53_A	0.917	1.00
106_W	188_R	0.916	1.00
129_R	141_F	0.916	1.00
293_D	314_Y	0.916	1.00
244_K	247_E	0.906	1.00
290_E	293_D	0.903	1.00
108_I	128_C	0.900	1.00
202_T	324_E	0.899	1.00
15_P	18_Y	0.897	1.00
314_Y	318_K	0.894	1.00
150_R	153_F	0.892	1.00
213_I	313_F	0.892	1.00
165_R	306_N	0.889	1.00
218_T	249_Q	0.887	1.00
273_L	276_L	0.887	1.00
225_A	245_L	0.885	1.00
122_D	149_D	0.880	1.00
142_S	188_R	0.874	1.00
152_G	177_V	0.871	1.00
151_D	178_R	0.871	1.00
100_E	131_D	0.870	1.00
124_F	172_L	0.866	1.00
155_A	172_L	0.863	1.00
164_I	319_I	0.862	1.00
244_K	297_Q	0.858	1.00
144_I	179_V	0.858	1.00
123_Y	145_V	0.855	1.00
17_A	62_D	0.854	1.00
217_A	313_F	0.852	1.00
286_R	331_K	0.852	1.00
250_T	279_M	0.852	1.00
247_E	290_E	0.850	1.00
217_A	295_A	0.847	1.00
319_I	323_Y	0.845	1.00
119_S	168_D	0.843	1.00
220_R	313_F	0.841	1.00
162_L	311_E	0.839	1.00
242_Q	332_N	0.838	1.00
178_R	181_E	0.835	1.00
320_T	323_Y	0.834	1.00
207_A	280_A	0.831	1.00
174_L	177_V	0.828	1.00
285_S	327_T	0.828	1.00
289_V	318_K	0.826	1.00
41_G	166_A	0.822	1.00
108_I	126_V	0.821	1.00
225_A	235_V	0.819	1.00
258_L	280_A	0.819	1.00
292_A	313_F	0.818	1.00
99_A	106_W	0.818	1.00
221_A	299_H	0.817	1.00
243_H	332_N	0.813	1.00
52_G	125_V	0.812	1.00
153_F	172_L	0.810	1.00
223_A	226_Q	0.808	1.00
53_A	72_V	0.807	1.00
253_E	256_R	0.805	1.00
221_A	298_I	0.804	1.00
12_P	23_Y	0.802	1.00
250_T	282_S	0.799	1.00
98_T	131_D	0.799	1.00
64_Q	145_V	0.797	1.00
327_T	331_K	0.792	1.00
95_V	127_L	0.788	1.00
219_E	223_A	0.788	1.00
122_D	148_S	0.788	1.00
286_R	321_Q	0.787	1.00
216_G	219_E	0.787	1.00
250_T	283_F	0.778	1.00
214_A	287_I	0.777	1.00
253_E	257_T	0.777	1.00
214_A	255_A	0.773	1.00
261_K	276_L	0.771	1.00
18_Y	62_D	0.767	1.00
118_G	155_A	0.766	1.00
224_Y	302_A	0.761	1.00
106_W	184_L	0.758	1.00
244_K	298_I	0.757	1.00
251_K	254_A	0.755	1.00
215_R	249_Q	0.755	1.00
99_A	130_T	0.748	1.00
98_T	132_P	0.748	1.00
4_A	9_L	0.744	1.00
83_I	199_F	0.742	1.00
206_V	324_E	0.742	1.00
239_Q	243_H	0.738	1.00
80_G	121_G	0.737	1.00
61_T	65_K	0.732	1.00
14_I	18_Y	0.731	1.00
256_R	260_R	0.731	1.00
242_Q	335_A	0.726	1.00
190_G	194_Q	0.723	1.00
332_N	336_R	0.723	1.00
215_R	252_T	0.720	1.00
37_A	216_G	0.718	1.00
11_G	21_A	0.718	1.00
67_R	70_E	0.718	1.00
120_V	168_D	0.715	1.00
207_A	259_T	0.714	1.00
68_F	183_N	0.713	1.00
254_A	258_L	0.708	1.00
114_W	305_V	0.707	1.00
115_I	172_L	0.706	1.00
272_Q	276_L	0.706	1.00
129_R	132_P	0.706	1.00
296_V	310_V	0.703	1.00
184_L	187_T	0.703	1.00
248_M	295_A	0.703	1.00
258_L	279_M	0.702	1.00
17_A	65_K	0.702	1.00
54_E	58_A	0.696	1.00
207_A	284_A	0.696	1.00
82_A	126_V	0.695	1.00
129_R	134_A	0.694	1.00
312_R	316_D	0.691	1.00
213_I	317_A	0.691	1.00
238_F	242_Q	0.691	1.00
221_A	225_A	0.690	1.00
292_A	314_Y	0.689	1.00
299_H	310_V	0.688	1.00
111_N	156_E	0.688	1.00
255_A	283_F	0.685	1.00
17_A	20_G	0.683	1.00
251_K	286_R	0.682	1.00
127_L	195_L	0.681	1.00
131_D	189_G	0.679	1.00
114_W	302_A	0.677	1.00
309_D	313_F	0.677	1.00
54_E	57_T	0.673	1.00
68_F	145_V	0.672	1.00
11_G	73_T	0.671	1.00
259_T	284_A	0.670	1.00
82_A	172_L	0.669	1.00
193_L	197_Q	0.669	1.00
258_L	283_F	0.668	1.00
309_D	312_R	0.668	1.00
101_K	104_D	0.668	1.00
30_I	33_E	0.667	1.00
263_A	267_D	0.667	1.00
17_A	22_G	0.667	1.00
326_T	329_I	0.666	1.00
34_E	38_A	0.666	1.00
146_V	174_L	0.665	1.00
55_A	198_F	0.664	1.00
235_V	238_F	0.664	1.00
296_V	303_G	0.660	1.00
25_P	266_V	0.660	1.00
55_A	59_F	0.659	1.00
57_T	65_K	0.659	1.00
287_I	291_V	0.657	1.00
129_R	140_G	0.656	1.00
97_A	110_G	0.656	1.00
28_V	50_G	0.653	1.00
221_A	248_M	0.653	1.00
210_G	285_S	0.651	1.00
28_V	205_T	0.650	1.00
95_V	141_F	0.650	1.00
235_V	241_I	0.650	1.00
142_S	189_G	0.649	1.00
86_P	111_N	0.647	1.00
164_I	323_Y	0.646	1.00
211_V	215_R	0.646	1.00
85_E	97_A	0.645	1.00
292_A	310_V	0.643	1.00
95_V	129_R	0.639	1.00
97_A	112_K	0.637	1.00
130_T	188_R	0.635	1.00
60_G	65_K	0.633	1.00
289_V	317_A	0.633	1.00
90_S	329_I	0.633	1.00
201_E	266_V	0.628	1.00
158_I	171_E	0.627	1.00
97_A	126_V	0.627	1.00
253_E	258_L	0.624	1.00
44_L	164_I	0.623	1.00
80_G	148_S	0.620	1.00
105_E	182_E	0.619	1.00
216_G	309_D	0.618	1.00
330_Q	333_V	0.614	1.00
302_A	305_V	0.612	1.00
64_Q	67_R	0.611	1.00
133_D	140_G	0.610	1.00
155_A	170_A	0.610	1.00
247_E	286_R	0.608	1.00
149_D	152_G	0.608	1.00
146_V	177_V	0.607	1.00
250_T	254_A	0.606	1.00
81_S	195_L	0.605	1.00
240_A	244_K	0.604	1.00
218_T	248_M	0.602	1.00
230_Q	235_V	0.601	1.00
266_V	273_L	0.601	1.00
204_T	266_V	0.598	1.00
214_A	288_A	0.597	1.00
131_D	140_G	0.596	1.00
72_V	123_Y	0.595	1.00
200_D	277_A	0.595	1.00
149_D	153_F	0.594	1.00
83_I	127_L	0.587	1.00
118_G	172_L	0.586	1.00
125_V	185_I	0.583	1.00
258_L	262_S	0.583	1.00
68_F	77_A	0.581	1.00
78_I	120_V	0.579	1.00
134_A	140_G	0.579	1.00
48_S	52_G	0.578	1.00
188_R	191_G	0.576	1.00
108_I	146_V	0.576	1.00
88_T	96_S	0.576	1.00
241_I	244_K	0.574	1.00
204_T	263_A	0.573	1.00
204_T	259_T	0.571	1.00
162_L	315_R	0.570	1.00
29_A	260_R	0.569	1.00
238_F	241_I	0.568	1.00
254_A	257_T	0.568	1.00
157_K	170_A	0.568	1.00
4_A	42_I	0.567	1.00
208_A	212_G	0.566	1.00
16_M	21_A	0.566	1.00
279_M	334_I	0.566	1.00
14_I	57_T	0.566	1.00
214_A	217_A	0.566	1.00
83_I	92_V	0.565	1.00
123_Y	183_N	0.564	1.00
160_G	165_R	0.561	1.00
101_K	107_I	0.559	1.00
103_G	178_R	0.558	1.00
288_A	292_A	0.557	1.00
253_E	279_M	0.556	1.00
153_F	174_L	0.554	1.00
58_A	201_E	0.552	1.00
163_G	316_D	0.552	1.00
130_T	140_G	0.550	1.00
129_R	138_Y	0.548	1.00
41_G	45_C	0.547	1.00
282_S	330_Q	0.547	1.00
53_A	69_L	0.544	1.00
199_F	203_R	0.544	1.00
228_R	231_F	0.543	1.00
282_S	286_R	0.542	1.00
241_I	245_L	0.542	1.00
217_A	221_A	0.539	1.00
115_I	118_G	0.537	1.00
247_E	250_T	0.537	1.00
119_S	155_A	0.536	1.00
32_V	36_F	0.531	1.00
97_A	128_C	0.531	1.00
220_R	310_V	0.528	1.00
181_E	188_R	0.528	1.00
29_A	259_T	0.528	1.00
97_A	174_L	0.527	1.00
251_K	291_V	0.526	1.00
265_S	272_Q	0.525	1.00
18_Y	66_R	0.523	1.00
249_Q	275_A	0.521	1.00
68_F	71_P	0.520	1.00
251_K	255_A	0.519	1.00
297_Q	318_K	0.518	1.00
134_A	139_E	0.518	1.00
231_F	238_F	0.517	1.00
142_S	186_G	0.516	1.00
103_G	107_I	0.514	1.00
218_T	245_L	0.512	1.00
56_I	60_G	0.512	1.00
224_Y	308_F	0.511	1.00
57_T	69_L	0.511	1.00
275_A	279_M	0.510	1.00
26_V	263_A	0.507	1.00
222_L	249_Q	0.506	1.00
301_G	304_Y	0.506	1.00
40_P	213_I	0.506	1.00
318_K	322_L	0.504	1.00
51_F	202_T	0.503	1.00
163_G	304_Y	0.503	1.00
278_S	333_V	0.503	1.00
293_D	297_Q	0.503	1.00
43_G	46_V	0.503	1.00
255_A	291_V	0.503	1.00
39_D	166_A	0.501	1.00
28_V	32_V	0.500	1.00
150_R	179_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2uxwA	2	1	100	0.095	Contact Map
3pfdA	4	0.9882	100	0.095	Contact Map
2d29A	4	0.9971	100	0.096	Contact Map
2jifA	4	0.9882	100	0.098	Contact Map
1rx0A	4	0.9912	100	0.099	Contact Map
1ivhA	4	0.9971	100	0.101	Contact Map
1ukwA	4	0.9912	100	0.102	Contact Map
4l1fA	4	0.9912	100	0.103	Contact Map
2z1qA	2	0.9794	100	0.103	Contact Map
3owaA	3	0.9794	100	0.104	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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