GREMLIN Database
Q9HQF0 - Acyl-CoA dehydrogenase
UniProt: Q9HQF0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 340 (329)
Sequences: 32284 (17578)
Seq/√Len: 969.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_E178_R4.2151.00
251_K290_E3.3941.00
109_D176_A3.3401.00
101_K181_E3.2091.00
71_P76_D2.9071.00
71_P77_A2.8641.00
154_T175_D2.7321.00
24_S27_E2.6801.00
244_K294_E2.6581.00
62_D66_R2.6311.00
111_N173_V2.5661.00
102_D178_R2.4911.00
215_R256_R2.2741.00
223_A227_E2.2281.00
142_S184_L2.1741.00
102_D107_I2.1371.00
111_N171_E2.0911.00
190_G193_L2.0361.00
124_F148_S1.9951.00
306_N311_E1.9351.00
15_P57_T1.9171.00
218_T252_T1.9021.00
187_T190_G1.9001.00
234_P237_D1.8981.00
240_A243_H1.8971.00
154_T173_V1.8741.00
156_E173_V1.8361.00
128_C144_I1.8361.00
311_E315_R1.8281.00
62_D65_K1.8031.00
265_S276_L1.7991.00
229_E234_P1.7971.00
107_I178_R1.7931.00
220_R309_D1.7931.00
33_E256_R1.7811.00
37_A219_E1.7691.00
118_G170_A1.7621.00
261_K265_S1.7611.00
107_I176_A1.7581.00
255_A284_A1.7401.00
102_D105_E1.7361.00
233_Q237_D1.7331.00
150_R177_V1.7321.00
80_G124_F1.7221.00
16_M22_G1.7111.00
290_E294_E1.7061.00
225_A298_I1.7001.00
286_R327_T1.6881.00
61_T64_Q1.6691.00
289_V321_Q1.6611.00
100_E109_D1.6171.00
34_E37_A1.6161.00
67_R71_P1.6101.00
106_W144_I1.6051.00
26_V264_W1.6011.00
67_R182_E1.5761.00
215_R219_E1.5711.00
156_E171_E1.5671.00
119_S170_A1.5581.00
147_E183_N1.5521.00
66_R70_E1.5501.00
254_A283_F1.5501.00
217_A292_A1.5441.00
222_L226_Q1.5411.00
101_K188_R1.5371.00
248_M291_V1.5321.00
216_G220_R1.5181.00
160_G306_N1.5051.00
39_D42_I1.4991.00
302_A308_F1.4831.00
221_A295_A1.4751.00
225_A241_I1.4691.00
220_R223_A1.4671.00
70_E74_A1.4661.00
59_F197_Q1.4621.00
249_Q253_E1.4581.00
184_L188_R1.4571.00
131_D134_A1.4561.00
264_W268_H1.4481.00
214_A252_T1.4171.00
37_A215_R1.4161.00
180_P183_N1.4081.00
109_D175_D1.4061.00
63_D67_R1.4041.00
241_I298_I1.3971.00
101_K105_E1.3931.00
71_P74_A1.3901.00
181_E184_L1.3831.00
289_V293_D1.3741.00
214_A291_V1.3701.00
248_M294_E1.3611.00
77_A122_D1.3611.00
87_D96_S1.3601.00
33_E215_R1.3601.00
251_K287_I1.3541.00
253_E261_K1.3361.00
233_Q238_F1.3301.00
18_Y65_K1.3271.00
63_D182_E1.3241.00
293_D318_K1.3211.00
230_Q238_F1.3201.00
261_K264_W1.3171.00
29_A263_A1.3171.00
104_D181_E1.3121.00
106_W181_E1.3101.00
101_K106_W1.3101.00
147_E150_R1.2941.00
23_Y27_E1.2861.00
25_P267_D1.2831.00
200_D274_T1.2721.00
251_K294_E1.2711.00
288_A317_A1.2701.00
148_S155_A1.2601.00
58_A197_Q1.2581.00
127_L143_Q1.2551.00
265_S270_D1.2411.00
33_E260_R1.2371.00
150_R183_N1.2351.00
257_T261_K1.2321.00
100_E107_I1.2311.00
82_A115_I1.2311.00
79_M123_Y1.2301.00
220_R299_H1.2291.00
12_P31_I1.2231.00
179_V183_N1.2191.00
255_A287_I1.2191.00
99_A144_I1.2191.00
105_E181_E1.2191.00
67_R183_N1.2091.00
130_T142_S1.2041.00
218_T222_L1.2021.00
295_A310_V1.1921.00
29_A208_A1.1851.00
216_G313_F1.1841.00
247_E331_K1.1791.00
282_S327_T1.1691.00
208_A259_T1.1631.00
68_F123_Y1.1611.00
72_V79_M1.1601.00
148_S153_F1.1561.00
287_I290_E1.1531.00
226_Q236_A1.1461.00
84_S114_W1.1351.00
82_A124_F1.1331.00
108_I144_I1.1281.00
293_D321_Q1.1251.00
104_D178_R1.1241.00
14_I73_T1.1241.00
247_E251_K1.1181.00
85_E112_K1.1181.00
5_A10_L1.1171.00
252_T291_V1.1101.00
126_V146_V1.1031.00
65_K69_L1.1021.00
225_A236_A1.1011.00
244_K328_E1.0951.00
126_V174_L1.0871.00
99_A128_C1.0831.00
282_S331_K1.0831.00
59_F194_Q1.0821.00
318_K321_Q1.0741.00
286_R290_E1.0731.00
127_L141_F1.0641.00
113_M171_E1.0631.00
153_F177_V1.0581.00
222_L245_L1.0581.00
82_A174_L1.0571.00
123_Y147_E1.0571.00
30_I34_E1.0551.00
13_G28_V1.0551.00
289_V314_Y1.0531.00
64_Q68_F1.0511.00
278_S330_Q1.0441.00
24_S267_D1.0421.00
124_F153_F1.0421.00
247_E294_E1.0391.00
91_D94_S1.0381.00
98_T109_D1.0331.00
296_V314_Y1.0331.00
292_A317_A1.0321.00
17_A66_R1.0311.00
30_I260_R1.0241.00
26_V267_D1.0241.00
52_G79_M1.0201.00
210_G320_T1.0191.00
100_E176_A1.0191.00
60_G64_Q1.0091.00
192_F196_M1.0081.00
213_I288_A1.0081.00
211_V252_T0.9991.00
211_V259_T0.9981.00
77_A123_Y0.9941.00
63_D66_R0.9921.00
105_E180_P0.9891.00
249_Q279_M0.9891.00
262_S280_A0.9861.00
26_V260_R0.9811.00
97_A108_I0.9751.00
36_F43_G0.9661.00
251_K283_F0.9591.00
243_H247_E0.9561.00
162_L314_Y0.9531.00
26_V30_I0.9461.00
108_I179_V0.9461.00
64_Q183_N0.9461.00
67_R147_E0.9451.00
211_V255_A0.9431.00
321_Q327_T0.9401.00
106_W130_T0.9371.00
125_V143_Q0.9321.00
144_I184_L0.9301.00
283_F287_I0.9181.00
14_I53_A0.9171.00
106_W188_R0.9161.00
129_R141_F0.9161.00
293_D314_Y0.9161.00
244_K247_E0.9061.00
290_E293_D0.9031.00
108_I128_C0.9001.00
202_T324_E0.8991.00
15_P18_Y0.8971.00
314_Y318_K0.8941.00
150_R153_F0.8921.00
213_I313_F0.8921.00
165_R306_N0.8891.00
218_T249_Q0.8871.00
273_L276_L0.8871.00
225_A245_L0.8851.00
122_D149_D0.8801.00
142_S188_R0.8741.00
152_G177_V0.8711.00
151_D178_R0.8711.00
100_E131_D0.8701.00
124_F172_L0.8661.00
155_A172_L0.8631.00
164_I319_I0.8621.00
244_K297_Q0.8581.00
144_I179_V0.8581.00
123_Y145_V0.8551.00
17_A62_D0.8541.00
217_A313_F0.8521.00
286_R331_K0.8521.00
250_T279_M0.8521.00
247_E290_E0.8501.00
217_A295_A0.8471.00
319_I323_Y0.8451.00
119_S168_D0.8431.00
220_R313_F0.8411.00
162_L311_E0.8391.00
242_Q332_N0.8381.00
178_R181_E0.8351.00
320_T323_Y0.8341.00
207_A280_A0.8311.00
174_L177_V0.8281.00
285_S327_T0.8281.00
289_V318_K0.8261.00
41_G166_A0.8221.00
108_I126_V0.8211.00
225_A235_V0.8191.00
258_L280_A0.8191.00
292_A313_F0.8181.00
99_A106_W0.8181.00
221_A299_H0.8171.00
243_H332_N0.8131.00
52_G125_V0.8121.00
153_F172_L0.8101.00
223_A226_Q0.8081.00
53_A72_V0.8071.00
253_E256_R0.8051.00
221_A298_I0.8041.00
12_P23_Y0.8021.00
250_T282_S0.7991.00
98_T131_D0.7991.00
64_Q145_V0.7971.00
327_T331_K0.7921.00
95_V127_L0.7881.00
219_E223_A0.7881.00
122_D148_S0.7881.00
286_R321_Q0.7871.00
216_G219_E0.7871.00
250_T283_F0.7781.00
214_A287_I0.7771.00
253_E257_T0.7771.00
214_A255_A0.7731.00
261_K276_L0.7711.00
18_Y62_D0.7671.00
118_G155_A0.7661.00
224_Y302_A0.7611.00
106_W184_L0.7581.00
244_K298_I0.7571.00
251_K254_A0.7551.00
215_R249_Q0.7551.00
99_A130_T0.7481.00
98_T132_P0.7481.00
4_A9_L0.7441.00
83_I199_F0.7421.00
206_V324_E0.7421.00
239_Q243_H0.7381.00
80_G121_G0.7371.00
61_T65_K0.7321.00
14_I18_Y0.7311.00
256_R260_R0.7311.00
242_Q335_A0.7261.00
190_G194_Q0.7231.00
332_N336_R0.7231.00
215_R252_T0.7201.00
37_A216_G0.7181.00
11_G21_A0.7181.00
67_R70_E0.7181.00
120_V168_D0.7151.00
207_A259_T0.7141.00
68_F183_N0.7131.00
254_A258_L0.7081.00
114_W305_V0.7071.00
115_I172_L0.7061.00
272_Q276_L0.7061.00
129_R132_P0.7061.00
296_V310_V0.7031.00
184_L187_T0.7031.00
248_M295_A0.7031.00
258_L279_M0.7021.00
17_A65_K0.7021.00
54_E58_A0.6961.00
207_A284_A0.6961.00
82_A126_V0.6951.00
129_R134_A0.6941.00
312_R316_D0.6911.00
213_I317_A0.6911.00
238_F242_Q0.6911.00
221_A225_A0.6901.00
292_A314_Y0.6891.00
299_H310_V0.6881.00
111_N156_E0.6881.00
255_A283_F0.6851.00
17_A20_G0.6831.00
251_K286_R0.6821.00
127_L195_L0.6811.00
131_D189_G0.6791.00
114_W302_A0.6771.00
309_D313_F0.6771.00
54_E57_T0.6731.00
68_F145_V0.6721.00
11_G73_T0.6711.00
259_T284_A0.6701.00
82_A172_L0.6691.00
193_L197_Q0.6691.00
258_L283_F0.6681.00
309_D312_R0.6681.00
101_K104_D0.6681.00
30_I33_E0.6671.00
263_A267_D0.6671.00
17_A22_G0.6671.00
326_T329_I0.6661.00
34_E38_A0.6661.00
146_V174_L0.6651.00
55_A198_F0.6641.00
235_V238_F0.6641.00
296_V303_G0.6601.00
25_P266_V0.6601.00
55_A59_F0.6591.00
57_T65_K0.6591.00
287_I291_V0.6571.00
129_R140_G0.6561.00
97_A110_G0.6561.00
28_V50_G0.6531.00
221_A248_M0.6531.00
210_G285_S0.6511.00
28_V205_T0.6501.00
95_V141_F0.6501.00
235_V241_I0.6501.00
142_S189_G0.6491.00
86_P111_N0.6471.00
164_I323_Y0.6461.00
211_V215_R0.6461.00
85_E97_A0.6451.00
292_A310_V0.6431.00
95_V129_R0.6391.00
97_A112_K0.6371.00
130_T188_R0.6351.00
60_G65_K0.6331.00
289_V317_A0.6331.00
90_S329_I0.6331.00
201_E266_V0.6281.00
158_I171_E0.6271.00
97_A126_V0.6271.00
253_E258_L0.6241.00
44_L164_I0.6231.00
80_G148_S0.6201.00
105_E182_E0.6191.00
216_G309_D0.6181.00
330_Q333_V0.6141.00
302_A305_V0.6121.00
64_Q67_R0.6111.00
133_D140_G0.6101.00
155_A170_A0.6101.00
247_E286_R0.6081.00
149_D152_G0.6081.00
146_V177_V0.6071.00
250_T254_A0.6061.00
81_S195_L0.6051.00
240_A244_K0.6041.00
218_T248_M0.6021.00
230_Q235_V0.6011.00
266_V273_L0.6011.00
204_T266_V0.5981.00
214_A288_A0.5971.00
131_D140_G0.5961.00
72_V123_Y0.5951.00
200_D277_A0.5951.00
149_D153_F0.5941.00
83_I127_L0.5871.00
118_G172_L0.5861.00
125_V185_I0.5831.00
258_L262_S0.5831.00
68_F77_A0.5811.00
78_I120_V0.5791.00
134_A140_G0.5791.00
48_S52_G0.5781.00
188_R191_G0.5761.00
108_I146_V0.5761.00
88_T96_S0.5761.00
241_I244_K0.5741.00
204_T263_A0.5731.00
204_T259_T0.5711.00
162_L315_R0.5701.00
29_A260_R0.5691.00
238_F241_I0.5681.00
254_A257_T0.5681.00
157_K170_A0.5681.00
4_A42_I0.5671.00
208_A212_G0.5661.00
16_M21_A0.5661.00
279_M334_I0.5661.00
14_I57_T0.5661.00
214_A217_A0.5661.00
83_I92_V0.5651.00
123_Y183_N0.5641.00
160_G165_R0.5611.00
101_K107_I0.5591.00
103_G178_R0.5581.00
288_A292_A0.5571.00
253_E279_M0.5561.00
153_F174_L0.5541.00
58_A201_E0.5521.00
163_G316_D0.5521.00
130_T140_G0.5501.00
129_R138_Y0.5481.00
41_G45_C0.5471.00
282_S330_Q0.5471.00
53_A69_L0.5441.00
199_F203_R0.5441.00
228_R231_F0.5431.00
282_S286_R0.5421.00
241_I245_L0.5421.00
217_A221_A0.5391.00
115_I118_G0.5371.00
247_E250_T0.5371.00
119_S155_A0.5361.00
32_V36_F0.5311.00
97_A128_C0.5311.00
220_R310_V0.5281.00
181_E188_R0.5281.00
29_A259_T0.5281.00
97_A174_L0.5271.00
251_K291_V0.5261.00
265_S272_Q0.5251.00
18_Y66_R0.5231.00
249_Q275_A0.5211.00
68_F71_P0.5201.00
251_K255_A0.5191.00
297_Q318_K0.5181.00
134_A139_E0.5181.00
231_F238_F0.5171.00
142_S186_G0.5161.00
103_G107_I0.5141.00
218_T245_L0.5121.00
56_I60_G0.5121.00
224_Y308_F0.5111.00
57_T69_L0.5111.00
275_A279_M0.5101.00
26_V263_A0.5071.00
222_L249_Q0.5061.00
301_G304_Y0.5061.00
40_P213_I0.5061.00
318_K322_L0.5041.00
51_F202_T0.5031.00
163_G304_Y0.5031.00
278_S333_V0.5031.00
293_D297_Q0.5031.00
43_G46_V0.5031.00
255_A291_V0.5031.00
39_D166_A0.5011.00
28_V32_V0.5001.00
150_R179_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uxwA 2 1 100 0.095 Contact Map
3pfdA 4 0.9882 100 0.095 Contact Map
2d29A 4 0.9971 100 0.096 Contact Map
2jifA 4 0.9882 100 0.098 Contact Map
1rx0A 4 0.9912 100 0.099 Contact Map
1ivhA 4 0.9971 100 0.101 Contact Map
1ukwA 4 0.9912 100 0.102 Contact Map
4l1fA 4 0.9912 100 0.103 Contact Map
2z1qA 2 0.9794 100 0.103 Contact Map
3owaA 3 0.9794 100 0.104 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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