Q9HQE9 - HALSA - GREMLIN Contacts

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Q9HQE9 - Uncharacterized protein

UniProt:	Q9HQE9	Sequences: MSHTQPTTTSDVLHRFWRRYESFIWWTMDAVGVASSVRAKILLAVTIQFAVSLAQVVVPVYFSGPARITAVGVLVVGATLALVNTVLVVERDIVDPVTGLQAAATHIAEGDLAAGDLPRADGQQDEIGALVDDFAAMHSHLRVVAAQAEALADHDFDAAVLETSLPGRFGASLRRMTASLDRYIDRITADRERSTLLNYLVSHDVPNVVNVLSGRLQLARRQTDAQAVRDHLDVADRQVSKIEEVCDVVGKLTRDDGAAAIDVVTLLDSEVARVTESYPDAQVSADLPSPPCRVRGNELLNSVFRNLITNAVEHNDAPTPRVAVSVAVEAESVTVRVADNGPGLDVSDSESFFQHRPVGTGLNIVHTAVRTFGGTVTVADSDLGGTAFEVALPRDAESPSRTVRRPVDPPTVSD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	414 (322)
Sequences:	17715 (14880)
Seq/√Len:	829.3

ECOLI - TORS BARA RCSD GLRK RCSC BAES CREC ATOS NARX CUSS ARCB ENVZ PHOQ CPXA RSTB NARQ YEDV QSEC BASS ZRAS EVGS DPIB PHOR DCUS KDPD YPDA
BACSU - YYCG YVRG RESE PHOR YCLK YKOH CSSS KINE KINB YVCQ YRKQ YCBM KINA DCTS LIAS KINC YESM CITS MALK YXDK BCES KIND LYTS GLNK YWPD YBDK DEGS COMP
HALSA - Q9HQE9 Q9HQ15 Q9HQ16 Q9HQG5 Q9HRE4 Q9HR10 O51970 Q9HRG1 Q9HNM2 Q9HQB9 Q9HNA6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_I	296_G	3.533	1.00
338_A	387_A	3.436	1.00
216_L	235_A	3.381	1.00
377_T	389_E	3.275	1.00
173_L	177_T	2.862	1.00
349_S	378_V	2.858	1.00
332_S	391_A	2.764	1.00
381_S	384_G	2.687	1.00
366_H	370_R	2.631	1.00
339_D	343_G	2.606	1.00
345_D	348_D	2.605	1.00
336_R	387_A	2.584	1.00
260_A	295_R	2.541	1.00
334_T	391_A	2.537	1.00
286_D	323_A	2.513	1.00
296_G	372_F	2.508	1.00
325_S	336_R	2.376	1.00
286_D	321_R	2.370	1.00
288_P	325_S	2.343	1.00
334_T	389_E	2.339	1.00
259_A	298_E	2.317	1.00
323_A	338_A	2.309	1.00
220_R	236_D	2.290	1.00
315_N	340_N	2.248	1.00
220_R	233_D	2.231	1.00
365_V	376_V	2.166	1.00
336_R	389_E	2.151	1.00
344_L	348_D	2.149	1.00
269_S	301_N	2.124	1.00
213_S	239_V	2.115	1.00
378_V	388_F	2.097	1.00
369_V	390_V	2.063	1.00
303_V	369_V	2.062	1.00
325_S	338_A	2.042	1.00
284_S	321_R	2.032	1.00
173_L	176_M	2.021	1.00
159_A	162_E	2.020	1.00
262_D	265_T	2.019	1.00
159_A	163_T	2.013	1.00
379_A	387_A	1.974	1.00
380_D	386_T	1.946	1.00
303_V	365_V	1.910	1.00
327_A	334_T	1.905	1.00
288_P	323_A	1.905	1.00
369_V	374_G	1.875	1.00
274_V	305_R	1.849	1.00
349_S	380_D	1.834	1.00
320_P	340_N	1.825	1.00
321_R	340_N	1.800	1.00
353_F	376_V	1.787	1.00
328_V	394_R	1.771	1.00
184_I	188_T	1.761	1.00
375_T	391_A	1.755	1.00
260_A	293_R	1.741	1.00
152_A	156_F	1.739	1.00
192_E	196_L	1.734	1.00
327_A	336_R	1.708	1.00
213_S	240_S	1.699	1.00
174_R	177_T	1.670	1.00
346_V	349_S	1.661	1.00
335_V	390_V	1.658	1.00
303_V	368_A	1.643	1.00
275_T	279_P	1.614	1.00
258_A	295_R	1.594	1.00
125_D	128_G	1.591	1.00
304_F	335_V	1.564	1.00
380_D	384_G	1.547	1.00
379_A	389_E	1.539	1.00
220_R	229_R	1.531	1.00
370_R	375_T	1.525	1.00
296_G	300_L	1.516	1.00
344_L	352_F	1.509	1.00
329_E	334_T	1.501	1.00
152_A	155_D	1.501	1.00
217_Q	236_D	1.498	1.00
219_A	232_L	1.497	1.00
345_D	382_D	1.495	1.00
315_N	320_P	1.479	1.00
177_T	180_L	1.461	1.00
368_A	372_F	1.460	1.00
212_L	239_V	1.450	1.00
215_R	231_H	1.447	1.00
225_A	228_V	1.442	1.00
184_I	187_I	1.436	1.00
155_D	159_A	1.429	1.00
348_D	351_S	1.396	1.00
180_L	184_I	1.393	1.00
106_H	111_D	1.389	1.00
243_E	247_D	1.379	1.00
216_L	236_D	1.378	1.00
176_M	180_L	1.377	1.00
181_D	184_I	1.373	1.00
236_D	240_S	1.353	1.00
158_A	161_L	1.345	1.00
351_S	354_Q	1.337	1.00
299_L	302_S	1.327	1.00
278_Y	312_V	1.319	1.00
264_V	326_V	1.314	1.00
377_T	391_A	1.309	1.00
219_A	228_V	1.309	1.00
148_A	152_A	1.306	1.00
315_N	322_V	1.305	1.00
86_V	90_E	1.304	1.00
180_L	183_Y	1.295	1.00
289_S	326_V	1.290	1.00
224_D	228_V	1.275	1.00
222_Q	228_V	1.270	1.00
380_D	383_L	1.266	1.00
155_D	158_A	1.262	1.00
145_A	149_E	1.259	1.00
344_L	386_T	1.255	1.00
144_V	148_A	1.249	1.00
256_D	297_N	1.247	1.00
262_D	293_R	1.245	1.00
188_T	191_R	1.234	1.00
264_V	268_D	1.228	1.00
158_A	162_E	1.227	1.00
233_D	237_R	1.225	1.00
309_T	313_E	1.210	1.00
299_L	368_A	1.209	1.00
123_Q	128_G	1.208	1.00
212_L	235_A	1.207	1.00
177_T	181_D	1.204	1.00
215_R	234_V	1.182	1.00
213_S	243_E	1.171	1.00
186_R	189_A	1.169	1.00
333_V	394_R	1.169	1.00
183_Y	187_I	1.168	1.00
148_A	151_L	1.164	1.00
205_V	242_I	1.162	1.00
194_S	198_N	1.157	1.00
176_M	179_S	1.155	1.00
216_L	239_V	1.151	1.00
274_V	308_I	1.150	1.00
277_S	280_D	1.150	1.00
216_L	220_R	1.146	1.00
181_D	185_D	1.144	1.00
271_V	287_L	1.139	1.00
269_S	298_E	1.133	1.00
211_V	238_Q	1.132	1.00
124_Q	128_G	1.117	1.00
332_S	393_P	1.106	1.00
158_A	163_T	1.101	1.00
332_S	375_T	1.099	1.00
306_N	365_V	1.091	1.00
299_L	371_T	1.087	1.00
273_R	305_R	1.084	1.00
183_Y	186_R	1.079	1.00
230_D	234_V	1.079	1.00
93_I	96_P	1.064	1.00
179_S	183_Y	1.054	1.00
258_A	372_F	1.043	1.00
211_V	215_R	1.042	1.00
262_D	292_C	1.039	1.00
268_D	287_L	1.039	1.00
174_R	178_A	1.038	1.00
111_D	114_A	1.029	1.00
101_Q	129_A	1.021	1.00
256_D	299_L	1.019	1.00
303_V	390_V	1.016	1.00
156_F	159_A	1.015	1.00
258_A	296_G	1.001	1.00
178_A	181_D	1.000	1.00
300_L	372_F	0.997	1.00
90_E	94_V	0.992	1.00
101_Q	105_T	0.989	1.00
141_L	144_V	0.984	1.00
295_R	395_D	0.980	1.00
298_E	301_N	0.974	1.00
353_F	378_V	0.972	1.00
355_H	367_T	0.963	1.00
311_A	322_V	0.962	1.00
197_L	201_V	0.962	1.00
267_L	326_V	0.956	1.00
367_T	370_R	0.954	1.00
142_R	146_A	0.953	1.00
179_S	182_R	0.948	1.00
344_L	378_V	0.942	1.00
216_L	232_L	0.941	1.00
274_V	312_V	0.930	1.00
209_V	246_C	0.929	1.00
270_E	308_I	0.927	1.00
261_I	266_L	0.925	1.00
145_A	148_A	0.925	1.00
264_V	289_S	0.924	1.00
352_F	378_V	0.923	1.00
201_V	249_V	0.920	1.00
302_S	368_A	0.917	1.00
271_V	275_T	0.916	1.00
229_R	233_D	0.915	1.00
301_N	305_R	0.910	1.00
323_A	340_N	0.906	1.00
339_D	385_G	0.903	1.00
128_G	131_V	0.900	1.00
234_V	238_Q	0.898	1.00
178_A	182_R	0.894	1.00
329_E	391_A	0.884	1.00
151_L	155_D	0.883	1.00
369_V	376_V	0.876	1.00
141_L	145_A	0.875	1.00
104_A	133_D	0.872	1.00
270_E	301_N	0.871	1.00
266_L	296_G	0.870	1.00
307_L	390_V	0.867	1.00
182_R	186_R	0.867	1.00
149_E	152_A	0.862	1.00
176_M	184_I	0.859	1.00
176_M	183_Y	0.859	1.00
237_R	269_S	0.857	1.00
374_G	392_L	0.855	1.00
292_C	333_V	0.848	1.00
266_L	270_E	0.847	1.00
154_H	158_A	0.847	1.00
185_D	188_T	0.842	1.00
365_V	369_V	0.840	1.00
175_R	179_S	0.838	1.00
270_E	305_R	0.836	1.00
369_V	392_L	0.834	1.00
215_R	235_A	0.831	1.00
344_L	349_S	0.827	1.00
268_D	272_A	0.827	1.00
191_R	194_S	0.826	1.00
304_F	308_I	0.819	1.00
214_G	218_L	0.817	1.00
151_L	154_H	0.817	1.00
346_V	381_S	0.815	1.00
238_Q	241_K	0.812	1.00
254_R	358_V	0.810	1.00
247_D	251_K	0.809	1.00
207_N	211_V	0.807	1.00
204_D	302_S	0.803	1.00
104_A	108_A	0.803	1.00
131_V	135_A	0.803	1.00
200_L	355_H	0.799	1.00
135_A	138_H	0.798	1.00
98_T	101_Q	0.796	1.00
241_K	301_N	0.796	1.00
256_D	371_T	0.787	1.00
140_H	144_V	0.784	1.00
96_P	100_L	0.780	1.00
105_T	109_E	0.780	1.00
138_H	141_L	0.779	1.00
186_R	190_D	0.776	1.00
107_I	138_H	0.774	1.00
231_H	235_A	0.771	1.00
103_A	118_P	0.769	1.00
203_H	306_N	0.768	1.00
203_H	207_N	0.765	1.00
307_L	388_F	0.762	1.00
104_A	107_I	0.761	1.00
207_N	214_G	0.761	1.00
111_D	115_G	0.759	1.00
100_L	104_A	0.757	1.00
307_L	376_V	0.756	1.00
91_R	95_D	0.754	1.00
256_D	372_F	0.754	1.00
314_H	342_P	0.754	1.00
272_A	275_T	0.753	1.00
154_H	159_A	0.753	1.00
263_V	335_V	0.751	1.00
155_D	162_E	0.750	1.00
374_G	393_P	0.749	1.00
360_T	364_I	0.748	1.00
271_V	285_A	0.745	1.00
192_E	195_T	0.742	1.00
226_Q	229_R	0.738	1.00
264_V	291_P	0.737	1.00
311_A	337_V	0.736	1.00
265_T	269_S	0.735	1.00
278_Y	285_A	0.734	1.00
270_E	274_V	0.734	1.00
147_Q	150_A	0.734	1.00
315_N	318_P	0.732	1.00
235_A	239_V	0.731	1.00
206_P	243_E	0.731	1.00
224_D	227_A	0.727	1.00
196_L	355_H	0.725	1.00
258_A	395_D	0.723	1.00
206_P	250_G	0.723	1.00
143_V	147_Q	0.722	1.00
140_H	143_V	0.720	1.00
150_A	154_H	0.719	1.00
115_G	139_S	0.719	1.00
191_R	195_T	0.718	1.00
115_G	135_A	0.716	1.00
304_F	337_V	0.715	1.00
283_V	312_V	0.711	1.00
352_F	363_N	0.711	1.00
127_I	131_V	0.710	1.00
251_K	299_L	0.708	1.00
185_D	189_A	0.708	1.00
343_G	386_T	0.708	1.00
378_V	386_T	0.708	1.00
151_L	158_A	0.707	1.00
248_V	299_L	0.706	1.00
252_L	363_N	0.702	1.00
250_G	253_T	0.699	1.00
182_R	185_D	0.697	1.00
344_L	350_E	0.696	1.00
234_V	237_R	0.696	1.00
213_S	217_Q	0.695	1.00
134_F	137_M	0.692	1.00
90_E	93_I	0.690	1.00
138_H	142_R	0.690	1.00
147_Q	151_L	0.690	1.00
209_V	242_I	0.690	1.00
149_E	153_D	0.687	1.00
83_V	87_L	0.686	1.00
100_L	103_A	0.686	1.00
196_L	200_L	0.684	1.00
125_D	131_V	0.684	1.00
349_S	379_A	0.682	1.00
339_D	386_T	0.681	1.00
189_A	193_R	0.679	1.00
206_P	242_I	0.678	1.00
277_S	309_T	0.677	1.00
352_F	388_F	0.676	1.00
310_N	361_G	0.674	1.00
204_D	207_N	0.673	1.00
344_L	380_D	0.673	1.00
265_T	298_E	0.666	1.00
146_A	149_E	0.666	1.00
331_E	394_R	0.665	1.00
377_T	390_V	0.665	1.00
82_L	86_V	0.664	1.00
69_T	73_V	0.664	1.00
176_M	181_D	0.662	1.00
218_L	231_H	0.658	1.00
84_N	88_V	0.657	1.00
213_S	236_D	0.657	1.00
374_G	390_V	0.656	1.00
261_I	298_E	0.654	1.00
199_Y	204_D	0.654	1.00
104_A	134_F	0.652	1.00
274_V	309_T	0.652	1.00
154_H	157_D	0.652	1.00
138_H	145_A	0.648	1.00
307_L	365_V	0.647	1.00
273_R	301_N	0.646	1.00
211_V	214_G	0.645	1.00
308_I	324_V	0.645	1.00
152_A	158_A	0.644	1.00
258_A	373_G	0.643	1.00
146_A	150_A	0.641	1.00
367_T	371_T	0.641	1.00
156_F	160_V	0.640	1.00
267_L	304_F	0.638	1.00
239_V	243_E	0.638	1.00
204_D	208_V	0.632	1.00
154_H	163_T	0.631	1.00
210_N	214_G	0.631	1.00
187_I	190_D	0.630	1.00
195_T	199_Y	0.628	1.00
329_E	332_S	0.628	1.00
244_E	248_V	0.627	1.00
223_T	228_V	0.627	1.00
267_L	324_V	0.617	1.00
189_A	192_E	0.613	1.00
131_V	134_F	0.611	1.00
76_V	80_L	0.610	1.00
308_I	322_V	0.609	1.00
321_R	338_A	0.609	1.00
268_D	289_S	0.609	1.00
206_P	247_D	0.609	1.00
282_Q	318_P	0.608	1.00
98_T	102_A	0.608	1.00
349_S	388_F	0.607	1.00
105_T	129_A	0.607	1.00
152_A	159_A	0.604	1.00
252_L	367_T	0.599	1.00
342_P	386_T	0.597	1.00
119_R	122_G	0.595	1.00
106_H	109_E	0.595	1.00
366_H	375_T	0.594	1.00
299_L	372_F	0.592	1.00
113_A	142_R	0.591	1.00
334_T	377_T	0.591	1.00
175_R	178_A	0.590	1.00
202_S	207_N	0.588	1.00
130_L	135_A	0.588	1.00
267_L	287_L	0.587	1.00
233_D	236_D	0.586	1.00
88_V	92_D	0.584	1.00
307_L	337_V	0.584	1.00
230_D	233_D	0.583	1.00
324_V	337_V	0.583	1.00
105_T	108_A	0.582	1.00
349_S	353_F	0.581	1.00
177_T	184_I	0.581	1.00
173_L	178_A	0.579	1.00
326_V	335_V	0.579	1.00
316_D	342_P	0.578	1.00
145_A	152_A	0.575	1.00
250_G	254_R	0.575	1.00
107_I	137_M	0.573	1.00
102_A	106_H	0.573	1.00
71_V	74_L	0.572	1.00
70_A	73_V	0.572	1.00
99_G	102_A	0.572	1.00
190_D	194_S	0.571	1.00
306_N	309_T	0.571	1.00
336_R	379_A	0.569	1.00
103_A	114_A	0.567	1.00
339_D	342_P	0.567	1.00
278_Y	283_V	0.567	1.00
101_Q	104_A	0.566	1.00
187_I	191_R	0.566	1.00
104_A	137_M	0.565	1.00
219_A	235_A	0.564	1.00
118_P	135_A	0.564	1.00
204_D	364_I	0.563	1.00
257_G	297_N	0.563	1.00
110_G	114_A	0.562	1.00
230_D	272_A	0.560	1.00
353_F	388_F	0.557	1.00
266_L	300_L	0.556	1.00
276_E	279_P	0.556	1.00
300_L	392_L	0.556	1.00
120_A	123_Q	0.555	1.00
115_G	118_P	0.555	1.00
205_V	208_V	0.553	1.00
288_P	327_A	0.549	1.00
157_D	161_L	0.549	1.00
239_V	242_I	0.549	1.00
151_L	159_A	0.549	1.00
263_V	333_V	0.548	1.00
292_C	394_R	0.548	1.00
126_E	131_V	0.546	1.00
205_V	245_V	0.545	1.00
227_A	231_H	0.545	1.00
130_L	134_F	0.541	1.00
134_F	138_H	0.541	1.00
222_Q	231_H	0.541	1.00
217_Q	221_R	0.539	1.00
179_S	184_I	0.539	1.00
176_M	185_D	0.538	1.00
332_S	394_R	0.537	1.00
220_R	232_L	0.536	1.00
104_A	130_L	0.536	1.00
190_D	193_R	0.536	1.00
66_A	70_A	0.534	1.00
225_A	229_R	0.532	1.00
346_V	350_E	0.532	1.00
264_V	292_C	0.530	1.00
204_D	306_N	0.529	1.00
272_A	276_E	0.526	1.00
128_G	132_D	0.526	1.00
198_N	201_V	0.523	1.00
97_V	101_Q	0.523	1.00
278_Y	322_V	0.521	1.00
215_R	238_Q	0.520	1.00
115_G	142_R	0.520	1.00
144_V	147_Q	0.520	1.00
281_A	312_V	0.520	1.00
143_V	146_A	0.519	1.00
153_D	157_D	0.518	1.00
219_A	231_H	0.517	1.00
344_L	362_L	0.516	1.00
138_H	144_V	0.516	1.00
210_N	213_S	0.516	1.00
206_P	214_G	0.516	1.00
302_S	305_R	0.515	1.00
154_H	162_E	0.514	1.00
100_L	134_F	0.513	1.00
157_D	160_V	0.513	1.00
237_R	272_A	0.511	1.00
210_N	215_R	0.510	1.00
156_F	162_E	0.510	1.00
102_A	105_T	0.508	1.00
338_A	381_S	0.508	1.00
173_L	180_L	0.508	1.00
271_V	308_I	0.507	1.00
303_V	372_F	0.507	1.00
343_G	385_G	0.504	1.00
208_V	242_I	0.504	1.00
198_N	210_N	0.504	1.00
108_A	112_L	0.504	1.00
283_V	340_N	0.503	1.00
215_R	219_A	0.503	1.00
278_Y	282_Q	0.503	1.00
313_E	356_R	0.502	1.00
213_S	216_L	0.501	1.00
278_Y	281_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.7295	100	0.379	Contact Map
4bixA	2	0.5242	100	0.463	Contact Map
4ctiA	2	0.5435	100	0.486	Contact Map
4r39A	1	0.5072	100	0.511	Contact Map
4q20A	2	0.5217	100	0.511	Contact Map
3d36A	2	0.5072	100	0.511	Contact Map
3jz3A	2	0.3671	100	0.513	Contact Map
4mpcA	2	0.7367	100	0.517	Contact Map
4gczA	2	0.8188	100	0.519	Contact Map
3a0rA	2	0.7585	100	0.521	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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