GREMLIN Database
Q9HQE5 - Uncharacterized protein
UniProt: Q9HQE5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 458 (345)
Sequences: 13404 (10407)
Seq/√Len: 560.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_V129_E4.2181.00
34_K133_T3.7741.00
369_N373_H3.7231.00
14_A349_A3.6421.00
7_A160_T3.3271.00
5_D28_D3.2791.00
5_D161_E3.0411.00
32_Y158_V2.9291.00
18_A164_V2.8801.00
72_D119_D2.6271.00
136_T176_R2.6201.00
4_V30_V2.5021.00
7_A32_Y2.4501.00
21_A357_G2.4371.00
165_L173_I2.2851.00
120_R123_A2.2631.00
14_A331_T2.2361.00
17_T350_H2.1911.00
132_T154_G2.1661.00
129_E132_T2.1071.00
115_D119_D2.0951.00
359_L371_A2.0181.00
137_V163_L2.0031.00
20_Y120_R1.9891.00
25_A361_A1.9871.00
120_R124_A1.9841.00
190_T193_S1.9811.00
324_V366_E1.9751.00
5_D30_V1.9551.00
166_A331_T1.8991.00
276_S280_H1.8891.00
191_V194_P1.8891.00
63_G70_P1.8721.00
6_V27_A1.8681.00
19_A31_V1.8551.00
71_D75_E1.8421.00
324_V329_A1.8161.00
190_T194_P1.8021.00
132_T156_E1.7881.00
140_H159_T1.7811.00
140_H143_G1.7761.00
61_V354_L1.7701.00
275_G278_Y1.7581.00
162_Y365_L1.7451.00
353_G357_G1.7361.00
373_H377_G1.7231.00
28_D127_R1.6791.00
283_L287_Y1.6561.00
72_D75_E1.6341.00
283_L286_V1.6281.00
121_A126_A1.5771.00
355_L359_L1.5641.00
18_A353_G1.5491.00
165_L330_V1.5431.00
355_L371_A1.5431.00
148_H152_L1.5391.00
277_E281_R1.5381.00
72_D123_A1.5331.00
23_A126_A1.5231.00
135_K153_G1.5211.00
72_D120_R1.5191.00
278_Y281_R1.5061.00
7_A158_V1.5041.00
219_K222_W1.5041.00
132_T152_L1.4881.00
278_Y282_F1.4851.00
30_V158_V1.4781.00
316_S384_V1.4781.00
177_V182_L1.4771.00
8_V18_A1.4771.00
275_G279_I1.4671.00
281_R284_T1.4541.00
150_L155_G1.4521.00
322_S325_E1.4481.00
160_T163_L1.4461.00
133_T153_G1.4221.00
358_R371_A1.4111.00
164_V329_A1.4081.00
323_P376_I1.4001.00
172_Q176_R1.3961.00
58_W350_H1.3941.00
359_L367_E1.3891.00
189_S193_S1.3841.00
359_L364_S1.3831.00
192_L195_P1.3671.00
149_T157_T1.3591.00
276_S283_L1.3531.00
167_D171_R1.3481.00
90_V93_D1.3451.00
7_A150_L1.3441.00
118_R130_A1.3411.00
58_W347_H1.3341.00
6_V22_A1.3281.00
203_Q206_R1.3121.00
201_A204_E1.3081.00
85_G89_R1.3041.00
71_D74_I1.3031.00
352_T372_W1.3011.00
398_W401_T1.2991.00
275_G286_V1.2991.00
139_S325_E1.2961.00
20_Y121_A1.2951.00
274_S278_Y1.2941.00
143_G159_T1.2861.00
134_V150_L1.2821.00
134_V137_V1.2811.00
322_S369_N1.2731.00
164_V331_T1.2711.00
152_L158_V1.2671.00
136_T151_H1.2661.00
149_T159_T1.2621.00
172_Q175_M1.2621.00
336_G352_T1.2541.00
21_A65_D1.2531.00
150_L154_G1.2491.00
138_D149_T1.2491.00
276_S279_I1.2481.00
276_S286_V1.2391.00
278_Y283_L1.2371.00
13_P346_D1.2371.00
191_V195_P1.2351.00
70_P74_I1.2281.00
151_H157_T1.2221.00
138_D151_H1.2201.00
149_T152_L1.2151.00
275_G282_F1.2111.00
280_H284_T1.2051.00
282_F285_E1.2051.00
202_Y205_Y1.2011.00
9_V173_I1.1971.00
91_T94_R1.1971.00
4_V7_A1.1961.00
64_L358_R1.1951.00
129_E156_E1.1951.00
147_E152_L1.1911.00
85_G88_E1.1901.00
24_D124_A1.1881.00
276_S285_E1.1871.00
147_E150_L1.1831.00
323_P369_N1.1781.00
32_Y129_E1.1691.00
275_G280_H1.1461.00
245_G248_M1.1441.00
118_R128_Y1.1431.00
329_A368_Y1.1361.00
11_G33_E1.1351.00
277_E280_H1.1301.00
18_A22_A1.1281.00
331_T368_Y1.1261.00
23_A124_A1.1241.00
152_L155_G1.1231.00
338_T348_V1.1221.00
7_A30_V1.1211.00
275_G285_E1.1201.00
18_A331_T1.1181.00
279_I282_F1.1131.00
276_S282_F1.1101.00
49_T52_A1.1091.00
273_P276_S1.1051.00
9_V163_L1.1021.00
9_V134_V1.0941.00
324_V369_N1.0931.00
8_V19_A1.0901.00
330_V334_A1.0881.00
138_D157_T1.0861.00
32_Y152_L1.0821.00
134_V173_I1.0811.00
275_G284_T1.0801.00
13_P350_H1.0701.00
279_I283_L1.0701.00
119_D122_E1.0631.00
189_S192_L1.0621.00
182_L185_D1.0581.00
8_V29_A1.0461.00
129_E158_V1.0451.00
274_S283_L1.0431.00
243_R247_T1.0381.00
139_S327_G1.0381.00
274_S277_E1.0371.00
9_V167_D1.0351.00
17_T21_A1.0231.00
351_R375_A1.0201.00
30_V127_R1.0171.00
395_P399_D1.0151.00
118_R122_E1.0101.00
282_F286_V1.0071.00
150_L153_G1.0071.00
32_Y160_T1.0031.00
27_A361_A1.0001.00
20_Y24_D1.0001.00
11_G16_S0.9871.00
275_G287_Y0.9861.00
63_G74_I0.9851.00
17_T65_D0.9851.00
205_Y208_F0.9821.00
245_G249_P0.9801.00
177_V328_I0.9771.00
173_I328_I0.9731.00
137_V173_I0.9711.00
216_A222_W0.9691.00
275_G283_L0.9641.00
137_V176_R0.9561.00
137_V177_V0.9531.00
357_G361_A0.9501.00
139_S326_A0.9501.00
273_P277_E0.9491.00
329_A356_A0.9451.00
342_H383_N0.9431.00
24_D120_R0.9391.00
76_H79_A0.9391.00
397_D401_T0.9361.00
64_L354_L0.9321.00
185_D321_E0.9301.00
181_L184_A0.9281.00
367_E370_D0.9281.00
72_D116_W0.9281.00
20_Y124_A0.9281.00
31_V128_Y0.9271.00
23_A125_G0.9271.00
359_L362_T0.9261.00
362_T367_E0.9251.00
323_P335_M0.9241.00
5_D27_A0.9171.00
202_Y206_R0.9161.00
137_V328_I0.9141.00
152_L156_E0.9071.00
169_P337_A0.9071.00
86_P89_R0.9051.00
60_D63_G0.9041.00
314_I339_S0.9011.00
181_L185_D0.8991.00
112_R115_D0.8951.00
116_W119_D0.8901.00
218_L222_W0.8901.00
220_F223_G0.8861.00
57_Y351_R0.8851.00
330_V335_M0.8851.00
204_E207_Q0.8821.00
134_V176_R0.8811.00
29_A126_A0.8801.00
245_G250_I0.8801.00
281_R285_E0.8771.00
188_A193_S0.8751.00
57_Y375_A0.8731.00
221_W224_W0.8711.00
148_H151_H0.8701.00
148_H155_G0.8701.00
189_S194_P0.8671.00
32_Y132_T0.8661.00
33_E130_A0.8631.00
19_A29_A0.8621.00
52_A346_D0.8611.00
70_P73_V0.8591.00
182_L320_I0.8531.00
59_L106_F0.8521.00
171_R174_T0.8481.00
42_D45_G0.8451.00
384_V388_N0.8451.00
394_G397_D0.8441.00
163_L328_I0.8411.00
207_Q211_D0.8411.00
216_A219_K0.8371.00
278_Y285_E0.8371.00
218_L223_G0.8361.00
84_I89_R0.8331.00
218_L221_W0.8331.00
338_T380_V0.8301.00
147_E153_G0.8291.00
247_T250_I0.8221.00
324_V365_L0.8181.00
81_A85_G0.8161.00
366_E370_D0.8151.00
274_S280_H0.8151.00
69_I120_R0.8141.00
73_V106_F0.8111.00
16_S121_A0.8101.00
279_I285_E0.8101.00
336_G372_W0.8091.00
371_A374_A0.7901.00
346_D350_H0.7871.00
84_I88_E0.7871.00
312_Y315_S0.7871.00
243_R246_L0.7851.00
121_A125_G0.7841.00
138_D141_I0.7821.00
135_K151_H0.7811.00
69_I116_W0.7801.00
377_G381_K0.7791.00
203_Q207_Q0.7791.00
162_Y329_A0.7791.00
367_E371_A0.7741.00
140_H149_T0.7721.00
274_S286_V0.7711.00
246_L250_I0.7711.00
216_A221_W0.7691.00
148_H153_G0.7691.00
280_H286_V0.7691.00
55_L58_W0.7681.00
208_F212_V0.7661.00
277_E283_L0.7651.00
220_F225_M0.7641.00
57_Y60_D0.7601.00
222_W225_M0.7561.00
209_P212_V0.7551.00
338_T383_N0.7551.00
5_D160_T0.7541.00
53_G107_T0.7521.00
183_P321_E0.7511.00
20_Y65_D0.7511.00
23_A29_A0.7501.00
81_A84_I0.7491.00
62_A69_I0.7451.00
4_V28_D0.7421.00
30_V160_T0.7411.00
206_R209_P0.7411.00
363_G367_E0.7401.00
23_A122_E0.7391.00
203_Q208_F0.7381.00
252_L255_A0.7371.00
149_T155_G0.7361.00
374_A378_D0.7321.00
220_F224_W0.7301.00
190_T195_P0.7301.00
59_L70_P0.7291.00
53_G105_G0.7271.00
244_V248_M0.7241.00
112_R238_Q0.7221.00
164_V360_A0.7221.00
165_L177_V0.7191.00
206_R211_D0.7181.00
306_A309_T0.7151.00
218_L224_W0.7151.00
58_W61_V0.7091.00
205_Y209_P0.7081.00
280_H287_Y0.7071.00
73_V113_F0.7071.00
201_A205_Y0.7061.00
150_L163_L0.7061.00
4_V127_R0.7041.00
122_E127_R0.7031.00
394_G401_T0.7021.00
348_V376_I0.7011.00
122_E125_G0.6991.00
253_D256_D0.6971.00
355_L358_R0.6971.00
280_H285_E0.6961.00
341_F387_A0.6941.00
23_A121_A0.6931.00
244_V247_T0.6931.00
396_D400_D0.6921.00
63_G103_A0.6901.00
274_S282_F0.6881.00
223_G226_P0.6851.00
26_G29_A0.6801.00
57_Y344_G0.6791.00
204_E209_P0.6781.00
32_Y150_L0.6751.00
164_V356_A0.6751.00
309_T312_Y0.6741.00
69_I73_V0.6741.00
219_K223_G0.6741.00
188_A192_L0.6721.00
22_A360_A0.6671.00
65_D69_I0.6651.00
246_L249_P0.6641.00
81_A86_P0.6641.00
279_I287_Y0.6611.00
277_E286_V0.6611.00
23_A127_R0.6581.00
233_W245_G0.6581.00
320_I323_P0.6571.00
279_I286_V0.6561.00
274_S284_T0.6561.00
273_P283_L0.6541.00
188_A191_V0.6541.00
208_F211_D0.6531.00
69_I72_D0.6511.00
148_H154_G0.6501.00
18_A360_A0.6491.00
109_H112_R0.6471.00
134_V172_Q0.6451.00
274_S285_E0.6451.00
207_Q210_D0.6451.00
16_S118_R0.6421.00
173_I176_R0.6421.00
134_V152_L0.6411.00
320_I330_V0.6411.00
217_S220_F0.6391.00
394_G400_D0.6391.00
232_P236_P0.6391.00
50_D110_R0.6371.00
82_E91_T0.6361.00
310_E315_S0.6361.00
55_L347_H0.6361.00
396_D399_D0.6341.00
285_E288_G0.6341.00
147_E151_H0.6311.00
207_Q241_V0.6301.00
45_G130_A0.6301.00
275_G288_G0.6281.00
344_G347_H0.6261.00
121_A128_Y0.6241.00
114_D130_A0.6241.00
114_D118_R0.6231.00
148_H327_G0.6231.00
6_V18_A0.6231.00
230_A237_N0.6221.00
276_S287_Y0.6211.00
338_T342_H0.6211.00
116_W120_R0.6201.00
284_T287_Y0.6201.00
280_H283_L0.6191.00
202_Y207_Q0.6191.00
29_A121_A0.6171.00
219_K224_W0.6141.00
9_V137_V0.6141.00
135_K155_G0.6131.00
6_V162_Y0.6131.00
165_L328_I0.6131.00
376_I380_V0.6121.00
147_E155_G0.6111.00
310_E313_P0.6091.00
82_E85_G0.6081.00
21_A61_V0.6081.00
21_A354_L0.6071.00
139_S328_I0.6071.00
119_D123_A0.6061.00
29_A127_R0.6061.00
397_D400_D0.6041.00
235_F245_G0.6001.00
211_D214_D0.6001.00
21_A24_D0.5971.00
189_S195_P0.5961.00
5_D158_V0.5911.00
151_H154_G0.5901.00
319_P377_G0.5901.00
68_D71_D0.5901.00
363_G366_E0.5881.00
217_S222_W0.5871.00
330_V368_Y0.5861.00
17_T62_A0.5841.00
84_I87_T0.5811.00
73_V116_W0.5791.00
209_P213_F0.5771.00
354_L358_R0.5760.99
17_T117_L0.5760.99
325_E328_I0.5750.99
274_S287_Y0.5750.99
312_Y316_S0.5750.99
16_S128_Y0.5740.99
249_P252_L0.5710.99
188_A194_P0.5690.99
378_D381_K0.5680.99
370_D374_A0.5680.99
392_S395_P0.5680.99
28_D161_E0.5670.99
134_V163_L0.5660.99
45_G118_R0.5650.99
52_A110_R0.5650.99
216_A220_F0.5620.99
243_R250_I0.5610.99
177_V325_E0.5600.99
342_H386_M0.5590.99
110_R114_D0.5590.99
19_A126_A0.5580.99
210_D213_F0.5570.99
339_S342_H0.5570.99
394_G399_D0.5550.99
61_V65_D0.5550.99
19_A121_A0.5540.99
81_A88_E0.5530.99
63_G71_D0.5530.99
351_R372_W0.5520.99
273_P286_V0.5510.99
356_A360_A0.5510.99
310_E314_I0.5470.99
278_Y287_Y0.5460.99
139_S143_G0.5460.99
278_Y286_V0.5430.99
25_A357_G0.5430.99
133_T172_Q0.5400.99
151_H155_G0.5330.99
274_S279_I0.5330.99
16_S114_D0.5320.99
319_P323_P0.5320.99
81_A89_R0.5310.99
386_M389_I0.5310.99
22_A357_G0.5300.99
344_G348_V0.5290.99
20_Y23_A0.5280.99
204_E208_F0.5280.99
62_A113_F0.5250.99
338_T344_G0.5240.99
243_R248_M0.5220.99
346_D349_A0.5200.99
150_L156_E0.5180.99
165_L171_R0.5170.99
221_W225_M0.5170.99
250_I253_D0.5170.99
16_S31_V0.5150.99
252_L256_D0.5140.99
333_G343_E0.5130.99
331_T353_G0.5120.99
79_A216_A0.5120.99
216_A225_M0.5120.99
385_A388_N0.5100.99
44_L130_A0.5100.99
284_T288_G0.5100.99
210_D214_D0.5080.99
309_T313_P0.5080.99
61_V351_R0.5080.99
277_E285_E0.5080.99
43_R46_P0.5060.99
185_D188_A0.5050.99
162_Y360_A0.5050.99
90_V94_R0.5020.99
395_P401_T0.5010.99
278_Y284_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k22A 4 0.7424 100 0.431 Contact Map
4n9xA 5 0.786 100 0.437 Contact Map
4bjzA 2 0.8122 100 0.44 Contact Map
3rp8A 1 0.81 100 0.443 Contact Map
1pn0A 3 0.8646 100 0.443 Contact Map
2qa1A 2 0.8406 100 0.444 Contact Map
2qa2A 2 0.8515 100 0.447 Contact Map
2x3nA 1 0.7555 100 0.45 Contact Map
3c96A 1 0.7882 100 0.452 Contact Map
4k5sA 2 0.8428 100 0.455 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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