GREMLIN Database
Q9HQE3 - Fuculose-1-phosphate aldolase
UniProt: Q9HQE3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (193)
Sequences: 6322 (3817)
Seq/√Len: 274.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_T60_D4.9071.00
160_D164_D3.2161.00
177_K181_R3.0731.00
94_W181_R3.0351.00
34_R54_V2.8971.00
5_E29_V2.6861.00
103_D183_R2.6401.00
8_D163_A2.5391.00
35_F76_T2.4631.00
36_A52_V2.3911.00
130_D134_E2.2121.00
84_A158_V2.2011.00
94_W177_K2.1211.00
77_G134_E2.1181.00
31_D34_R2.0431.00
97_T181_R2.0401.00
193_D197_A2.0241.00
192_T195_Q2.0201.00
120_P145_S2.0111.00
93_P177_K2.0031.00
34_R62_V1.9401.00
94_W180_L1.9121.00
36_A54_V1.9001.00
48_D51_D1.8841.00
10_V49_A1.8811.00
147_A172_V1.8741.00
77_G80_Q1.8551.00
7_V11_D1.8241.00
29_V162_L1.7801.00
181_R184_R1.7711.00
88_V165_A1.7481.00
123_E151_A1.7461.00
141_A144_D1.6741.00
55_V72_V1.6321.00
86_A162_L1.6081.00
85_G161_D1.5941.00
161_D164_D1.5811.00
159_G164_D1.5661.00
9_V27_L1.5661.00
12_Y166_V1.5161.00
110_Y116_G1.5071.00
58_D80_Q1.5061.00
124_Y127_Y1.4961.00
17_S170_I1.4721.00
102_G151_A1.4631.00
125_A135_L1.4401.00
155_L172_V1.4231.00
104_E118_R1.4051.00
90_T169_T1.3831.00
29_V86_A1.3501.00
10_V14_P1.3471.00
91_H153_H1.3451.00
106_P179_Y1.3421.00
9_V52_V1.3161.00
7_V49_A1.3131.00
61_V64_G1.3071.00
93_P97_T1.3041.00
157_V169_T1.2901.00
10_V52_V1.2881.00
35_F57_L1.2601.00
28_S87_I1.2411.00
98_L183_R1.2291.00
89_H153_H1.2151.00
30_R85_G1.2131.00
76_T80_Q1.2071.00
96_S99_A1.1991.00
146_D168_N1.1941.00
134_E138_T1.1881.00
180_L185_H1.1861.00
93_P174_E1.1631.00
135_L138_T1.1541.00
28_S79_Y1.1501.00
95_A155_L1.1431.00
105_L176_C1.1381.00
16_L27_L1.1381.00
123_E138_T1.1331.00
42_V51_D1.1251.00
79_Y87_I1.1221.00
195_Q198_A1.1201.00
54_V63_A1.1161.00
150_L156_V1.1091.00
101_L185_H1.1061.00
90_T155_L1.1051.00
37_A69_T1.1031.00
179_Y183_R1.0981.00
94_W173_E1.0981.00
173_E177_K1.0891.00
140_M158_V1.0851.00
12_Y162_L1.0631.00
39_P42_V1.0601.00
110_Y113_T1.0461.00
111_M114_A1.0391.00
180_L184_R1.0391.00
104_E121_V1.0321.00
147_A157_V1.0311.00
102_G189_D1.0241.00
42_V66_M1.0151.00
95_A172_V1.0021.00
174_E177_K1.0011.00
35_F72_V0.9901.00
109_H112_I0.9891.00
111_M116_G0.9881.00
81_R84_A0.9741.00
117_R197_A0.9741.00
140_M148_C0.9671.00
51_D66_M0.9651.00
159_G168_N0.9541.00
105_L149_I0.9471.00
57_L80_Q0.9471.00
16_L88_V0.9461.00
195_Q199_V0.9441.00
131_D134_E0.9431.00
92_S95_A0.9391.00
13_A27_L0.9351.00
39_P52_V0.9341.00
108_I179_Y0.9311.00
78_I140_M0.9241.00
155_L169_T0.9211.00
136_V150_L0.9191.00
74_M136_V0.9131.00
17_S166_V0.9101.00
119_V172_V0.9091.00
194_D198_A0.9061.00
189_D192_T0.9051.00
123_E135_L0.9041.00
56_T62_V0.9031.00
47_F51_D0.9011.00
12_Y27_L0.8891.00
53_P67_T0.8881.00
93_P181_R0.8871.00
122_A135_L0.8831.00
97_T180_L0.8821.00
15_A166_V0.8781.00
92_S169_T0.8771.00
74_M156_V0.8771.00
10_V47_F0.8751.00
88_V169_T0.8731.00
8_D11_D0.8651.00
37_A71_E0.8621.00
6_R36_A0.8611.00
51_D65_E0.8541.00
8_D29_V0.8541.00
81_R158_V0.8461.00
78_I84_A0.8411.00
151_A189_D0.8401.00
77_G137_V0.8220.99
30_R33_D0.8200.99
16_L166_V0.8140.99
92_S173_E0.7860.99
164_D168_N0.7820.99
122_A139_E0.7780.99
35_F55_V0.7770.99
120_P148_C0.7750.99
40_T67_T0.7700.99
38_T47_F0.7690.99
46_G163_A0.7680.99
30_R57_L0.7670.99
42_V47_F0.7660.99
38_T79_Y0.7660.99
104_E120_P0.7630.99
118_R145_S0.7590.99
139_E148_C0.7570.99
196_L199_V0.7480.99
11_D46_G0.7470.99
98_L179_Y0.7400.99
122_A150_L0.7390.99
117_R193_D0.7260.99
33_D57_L0.7250.99
85_G160_D0.7220.99
114_A171_H0.7210.99
112_I116_G0.7160.99
25_G44_Y0.7120.98
114_A168_N0.7090.98
28_S37_A0.7080.98
21_P174_E0.7060.98
100_V108_I0.7060.98
72_V76_T0.7050.98
9_V36_A0.7020.98
6_R63_A0.6970.98
191_L195_Q0.6960.98
192_T198_A0.6930.98
26_N69_T0.6910.98
190_T193_D0.6830.98
73_P130_D0.6790.98
131_D135_L0.6780.98
5_E8_D0.6740.98
96_S178_V0.6740.98
188_P191_L0.6660.98
188_P195_Q0.6660.98
110_Y115_V0.6650.98
31_D54_V0.6620.98
164_D167_E0.6580.97
172_V176_C0.6580.97
138_T141_A0.6570.97
182_A186_G0.6560.97
13_A44_Y0.6540.97
46_G51_D0.6540.97
105_L175_L0.6530.97
81_R141_A0.6530.97
101_L182_A0.6520.97
71_E132_L0.6510.97
23_R40_T0.6500.97
152_H189_D0.6490.97
34_R57_L0.6460.97
81_R140_M0.6440.97
193_D196_L0.6440.97
99_A149_I0.6430.97
126_P198_A0.6430.97
21_P24_T0.6390.97
9_V13_A0.6390.97
22_G167_E0.6380.97
157_V168_N0.6360.97
80_Q137_V0.6340.97
43_P46_G0.6300.97
183_R187_D0.6290.97
98_L180_L0.6270.97
30_R35_F0.6220.96
97_T178_V0.6190.96
86_A165_A0.6190.96
59_G76_T0.6180.96
124_Y150_L0.6170.96
98_L176_C0.6160.96
137_V140_M0.6160.96
77_G130_D0.6150.96
101_L180_L0.6130.96
146_D164_D0.6130.96
137_V141_A0.6100.96
57_L76_T0.6090.96
26_N71_E0.6090.96
40_T69_T0.6070.96
94_W97_T0.6050.96
106_P190_T0.6050.96
92_S155_L0.6050.96
194_D197_A0.6040.96
103_D187_D0.6000.96
6_R49_A0.5900.95
135_L139_E0.5890.95
187_D196_L0.5880.95
73_P77_G0.5880.95
54_V62_V0.5880.95
148_C156_V0.5870.95
24_T174_E0.5860.95
95_A176_C0.5850.95
18_D177_K0.5820.95
83_D160_D0.5820.95
188_P192_T0.5790.95
109_H113_T0.5770.95
98_L103_D0.5740.94
78_I156_V0.5700.94
96_S109_H0.5670.94
183_R186_G0.5670.94
95_A169_T0.5660.94
108_I183_R0.5650.94
119_V147_A0.5640.94
96_S154_G0.5640.94
149_I155_L0.5630.94
122_A125_A0.5590.94
13_A38_T0.5580.94
15_A22_G0.5580.94
6_R52_V0.5580.94
121_V151_A0.5550.93
182_A188_P0.5510.93
103_D106_P0.5510.93
9_V29_V0.5480.93
38_T52_V0.5440.93
78_I87_I0.5440.93
5_E36_A0.5410.93
79_Y86_A0.5380.92
20_T27_L0.5380.92
114_A167_E0.5360.92
40_T70_S0.5350.92
167_E174_E0.5300.92
61_V67_T0.5290.92
88_V157_V0.5280.92
26_N38_T0.5270.92
13_A47_F0.5260.92
185_H188_P0.5240.91
146_D160_D0.5230.91
16_L19_L0.5210.91
26_N40_T0.5210.91
47_F52_V0.5190.91
110_Y114_A0.5180.91
29_V52_V0.5150.91
49_A52_V0.5100.90
8_D162_L0.5090.90
146_D158_V0.5090.90
189_D193_D0.5080.90
144_D196_L0.5080.90
188_P196_L0.5040.90
187_D191_L0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c24A 3 0.9573 100 0.14 Contact Map
1e4cP 3 0.9479 100 0.149 Contact Map
1k0wA 3 0.9479 100 0.184 Contact Map
2opiA 3 0.9336 100 0.195 Contact Map
3ocrA 4 0.981 100 0.201 Contact Map
2fk5A 4 0.8815 100 0.215 Contact Map
2z7bA 3 0.9763 100 0.224 Contact Map
4xxfA 3 0.9431 100 0.232 Contact Map
2v9lA 3 0.9763 100 0.243 Contact Map
4m6rA 3 0.9384 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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