GREMLIN Database
Q9HQE2 - Uncharacterized protein
UniProt: Q9HQE2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (206)
Sequences: 29512 (23213)
Seq/√Len: 1617.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_E179_D4.0841.00
139_A144_A2.7851.00
168_V172_R2.7791.00
158_R162_A2.7301.00
184_G190_D2.6241.00
194_A201_S2.5641.00
131_T135_L2.5031.00
5_A175_V2.4181.00
114_D146_R2.3401.00
110_R114_D2.3101.00
3_H200_T2.2521.00
168_V171_A2.2261.00
122_D148_D2.2111.00
124_A149_C2.1951.00
131_T155_E2.1571.00
126_V165_M2.1511.00
127_T134_Q2.1151.00
158_R164_V2.0971.00
170_L180_A2.0671.00
8_V123_V2.0531.00
222_E226_D2.0121.00
191_V201_S2.0071.00
195_N218_D1.9841.00
149_C172_R1.9841.00
176_A179_D1.9021.00
115_R119_A1.8701.00
192_V196_G1.8561.00
200_T218_D1.7741.00
6_V121_L1.7671.00
117_R146_R1.7471.00
170_L199_L1.7001.00
7_F182_M1.6841.00
117_R148_D1.6551.00
182_M194_A1.6451.00
181_V202_V1.6051.00
109_V224_F1.5801.00
170_L177_P1.5511.00
123_V147_V1.5491.00
7_F169_P1.5191.00
40_S43_A1.5181.00
5_A173_L1.5051.00
7_F126_V1.4981.00
205_N222_E1.4971.00
92_A96_W1.4721.00
106_F206_N1.4271.00
175_V180_A1.4231.00
124_A173_L1.4041.00
6_V116_L1.3841.00
6_V183_V1.3811.00
135_L144_A1.3811.00
112_T224_F1.3681.00
202_V221_I1.3541.00
205_N220_R1.3331.00
27_A31_T1.2831.00
10_L15_Y1.2791.00
223_S226_D1.2781.00
202_V219_H1.2741.00
187_V192_V1.2681.00
10_L125_V1.2671.00
13_T183_V1.2631.00
115_R118_D1.2591.00
90_A94_A1.2501.00
14_L109_V1.2491.00
94_A98_A1.2441.00
91_L95_Y1.2411.00
31_T94_A1.2371.00
163_S167_T1.2291.00
3_H181_V1.2271.00
135_L139_A1.2101.00
70_L73_K1.2061.00
108_G111_E1.1841.00
87_D91_L1.1751.00
151_L172_R1.1691.00
10_L134_Q1.1561.00
7_F180_A1.1471.00
89_L93_D1.1411.00
166_F193_G1.1401.00
84_N87_D1.1371.00
30_E38_D1.1311.00
151_L169_P1.1301.00
28_A32_A1.1291.00
31_T90_A1.1251.00
134_Q152_T1.1221.00
166_F182_M1.1171.00
105_L143_L1.1161.00
5_A180_A1.1031.00
27_A94_A1.0961.00
94_A97_D1.0931.00
111_E225_R1.0911.00
47_L50_R1.0831.00
11_D17_Y1.0801.00
27_A30_E1.0701.00
180_A199_L1.0601.00
87_D90_A1.0571.00
166_F199_L1.0381.00
23_A27_A1.0321.00
125_V147_V1.0321.00
70_L74_R1.0261.00
117_R123_V1.0231.00
86_A90_A1.0231.00
5_A122_D1.0221.00
114_D118_D1.0201.00
92_A95_Y1.0161.00
167_T171_A1.0141.00
95_Y99_Y1.0101.00
27_A98_A1.0081.00
142_G145_D1.0051.00
113_L147_V1.0051.00
126_V169_P1.0031.00
10_L129_L0.9981.00
77_E80_A0.9961.00
49_S52_R0.9811.00
195_N201_S0.9761.00
167_T197_V0.9701.00
164_V168_V0.9691.00
164_V167_T0.9661.00
149_C173_L0.9641.00
110_R146_R0.9631.00
136_R140_A0.9621.00
182_M199_L0.9561.00
169_P173_L0.9501.00
131_T152_T0.9461.00
88_A92_A0.9351.00
26_Q41_R0.9331.00
23_A26_Q0.9331.00
32_A90_A0.9281.00
131_T154_Q0.9271.00
156_V168_V0.9251.00
136_R139_A0.9211.00
114_D145_D0.9181.00
26_Q30_E0.9181.00
45_E48_Y0.9161.00
191_V217_P0.9151.00
166_F184_G0.9141.00
88_A91_L0.9131.00
80_A83_P0.9081.00
5_A124_A0.9071.00
76_I79_Q0.9041.00
74_R77_E0.9031.00
167_T177_P0.8981.00
189_S192_V0.8881.00
90_A93_D0.8861.00
73_K77_E0.8851.00
111_E114_D0.8821.00
69_G73_K0.8791.00
105_L110_R0.8781.00
195_N216_S0.8781.00
23_A102_A0.8731.00
11_D129_L0.8691.00
200_T219_H0.8681.00
7_F199_L0.8661.00
11_D127_T0.8631.00
42_A46_S0.8611.00
127_T152_T0.8601.00
7_F173_L0.8591.00
183_V202_V0.8581.00
193_G197_V0.8571.00
108_G223_S0.8501.00
177_P199_L0.8471.00
134_Q137_K0.8451.00
93_D97_D0.8351.00
151_L168_V0.8321.00
181_V200_T0.8311.00
124_A169_P0.8301.00
106_F204_C0.8301.00
43_A46_S0.8141.00
221_I227_V0.8121.00
203_L220_R0.8071.00
113_L146_R0.8011.00
89_L92_A0.7971.00
116_L121_L0.7971.00
106_F109_V0.7961.00
157_G164_V0.7951.00
201_S218_D0.7951.00
15_Y137_K0.7861.00
129_L134_Q0.7841.00
116_L123_V0.7791.00
186_S189_S0.7791.00
15_Y141_T0.7771.00
10_L137_K0.7751.00
108_G225_R0.7741.00
6_V181_V0.7731.00
4_E121_L0.7651.00
22_E26_Q0.7601.00
123_V146_R0.7601.00
85_A89_L0.7591.00
183_V227_V0.7581.00
48_Y52_R0.7521.00
98_A101_D0.7391.00
191_V203_L0.7371.00
110_R145_D0.7361.00
43_A47_L0.7351.00
110_R142_G0.7351.00
175_V179_D0.7311.00
21_N25_Q0.7291.00
41_R45_E0.7241.00
128_N159_E0.7231.00
105_L141_T0.7231.00
24_G28_A0.7191.00
11_D185_D0.7181.00
202_V227_V0.7181.00
4_E122_D0.7171.00
74_R78_L0.7151.00
68_R71_Y0.7111.00
206_N224_F0.7091.00
111_E115_R0.7081.00
182_M190_D0.7071.00
91_L94_A0.7071.00
47_L51_A0.7061.00
13_T190_D0.7001.00
152_T155_E0.6981.00
134_Q150_V0.6951.00
3_H121_L0.6881.00
165_M169_P0.6881.00
3_H179_D0.6881.00
7_F124_A0.6861.00
138_L144_A0.6841.00
166_F190_D0.6761.00
155_E172_R0.6741.00
31_T91_L0.6731.00
4_E175_V0.6721.00
21_N129_L0.6721.00
122_D175_V0.6711.00
212_T216_S0.6681.00
212_T215_E0.6681.00
163_S196_G0.6681.00
204_C224_F0.6671.00
68_R72_F0.6671.00
221_I224_F0.6661.00
149_C169_P0.6661.00
177_P180_A0.6641.00
192_V195_N0.6641.00
19_P104_S0.6641.00
39_V44_F0.6611.00
12_N18_Q0.6601.00
20_C103_L0.6561.00
123_V148_D0.6551.00
128_N161_P0.6491.00
42_A45_E0.6491.00
16_P104_S0.6481.00
165_M193_G0.6461.00
128_N189_S0.6421.00
33_T37_Y0.6351.00
88_A95_Y0.6311.00
156_V165_M0.6301.00
112_T183_V0.6271.00
108_G112_T0.6251.00
182_M193_G0.6221.00
71_Y75_A0.6211.00
126_V182_M0.6201.00
151_L165_M0.6181.00
15_Y103_L0.6181.00
48_Y51_A0.6141.00
135_L150_V0.6121.00
17_Y129_L0.6091.00
91_L96_W0.6081.00
11_D137_K0.6071.00
147_V150_V0.6061.00
69_G85_A0.6021.00
109_V113_L0.5951.00
100_I136_R0.5911.00
153_S165_M0.5851.00
72_F75_A0.5851.00
44_F47_L0.5851.00
170_L175_V0.5831.00
16_P19_P0.5811.00
170_L197_V0.5761.00
13_T204_C0.5761.00
134_Q138_L0.5731.00
16_P106_F0.5731.00
189_S193_G0.5711.00
210_G213_G0.5711.00
71_Y74_R0.5701.00
86_A89_L0.5691.00
117_R145_D0.5671.00
8_V112_T0.5631.00
114_D117_R0.5631.00
203_L212_T0.5621.00
167_T170_L0.5591.00
108_G206_N0.5561.00
100_I140_A0.5541.00
109_V112_T0.5501.00
7_F166_F0.5421.00
129_L184_G0.5391.00
149_C152_T0.5371.00
39_V43_A0.5361.00
72_F76_I0.5351.00
125_V138_L0.5331.00
107_D225_R0.5301.00
105_L109_V0.5281.00
139_A145_D0.5281.00
45_E52_R0.5271.00
22_E44_F0.5251.00
129_L133_V0.5241.00
112_T115_R0.5221.00
14_L125_V0.5211.00
76_I81_G0.5201.00
203_L217_P0.5201.00
6_V123_V0.5201.00
192_V215_E0.5181.00
19_P23_A0.5171.00
45_E49_S0.5151.00
126_V151_L0.5151.00
132_R136_R0.5131.00
112_T116_L0.5121.00
87_D94_A0.5061.00
46_S50_R0.5051.00
151_L173_L0.5041.00
30_E33_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eekA 2 0.9138 100 0.281 Contact Map
4uw9A 1 0.8578 100 0.288 Contact Map
3l5kA 1 0.9138 100 0.289 Contact Map
3qnmA 1 0.9741 100 0.294 Contact Map
1swvA 2 0.9526 100 0.298 Contact Map
2om6A 2 0.9655 100 0.298 Contact Map
2hdoA 1 0.8836 100 0.3 Contact Map
2zg6A 2 0.8621 100 0.301 Contact Map
3qxgA 3 0.9095 100 0.301 Contact Map
3ed5A 1 0.9655 100 0.302 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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