GREMLIN Database
DHE - Glutamate dehydrogenase A2
UniProt: Q9HQE1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (368)
Sequences: 5234 (2581)
Seq/√Len: 134.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_L234_A4.3861.00
283_T305_R3.7191.00
215_I226_A3.7141.00
214_A286_V3.4211.00
129_E159_T3.2961.00
286_V308_A3.2351.00
197_T312_V2.9811.00
285_D307_A2.9591.00
253_D256_D2.8671.00
79_S82_E2.8361.00
325_Q329_D2.8271.00
94_T345_V2.5231.00
111_N114_E2.5181.00
118_N122_Q2.5111.00
212_D235_N2.4971.00
199_E202_E2.4311.00
199_E375_T2.4011.00
328_S392_T2.3891.00
101_F349_Y2.3701.00
206_T211_A2.3691.00
146_M294_I2.3541.00
226_A239_V2.3491.00
46_M52_E2.3071.00
384_A388_R2.2751.00
196_I340_A2.2431.00
203_Y386_E2.1651.00
213_V229_L2.1391.00
378_F382_L2.1361.00
193_V314_A2.1211.00
61_F87_A2.1141.00
384_A403_E2.1051.00
259_A264_N2.0481.00
43_P126_R2.0241.00
227_D231_E2.0231.00
149_D152_T2.0221.00
319_T327_L2.0201.00
312_V340_A2.0091.00
335_V340_A2.0001.00
403_E407_D1.9791.00
392_T395_T1.9751.00
199_E379_D1.9741.00
238_A281_L1.9691.00
260_Y264_N1.9381.00
213_V234_A1.9301.00
203_Y382_L1.9181.00
300_V322_D1.9141.00
365_E369_D1.9021.00
259_A263_A1.9001.00
383_V387_D1.8911.00
110_C115_L1.8681.00
282_L289_L1.8671.00
194_S232_R1.8631.00
299_T302_V1.8351.00
59_C87_A1.8141.00
68_Y104_A1.8001.00
303_A326_V1.7661.00
72_I156_V1.7641.00
249_P274_E1.7631.00
125_R159_T1.7601.00
200_T310_V1.7521.00
277_S280_D1.7351.00
65_R98_D1.7321.00
184_G363_V1.7171.00
338_I398_Y1.7131.00
198_E232_R1.7131.00
96_L339_L1.7101.00
208_I234_A1.7091.00
178_E407_D1.6551.00
128_T156_V1.6431.00
203_Y378_F1.6111.00
154_A176_P1.6081.00
327_L332_V1.5991.00
270_G273_A1.5941.00
214_A238_A1.5931.00
256_D270_G1.5891.00
326_V330_R1.5791.00
390_I399_T1.5591.00
198_E371_R1.5591.00
256_D259_A1.5521.00
254_I258_Q1.5391.00
298_I306_L1.5381.00
72_I127_Y1.5211.00
321_F324_A1.5151.00
390_I396_A1.5131.00
363_V367_N1.5001.00
132_R164_Q1.5001.00
166_Y169_P1.4701.00
195_I371_R1.4571.00
56_A127_Y1.4451.00
238_A284_L1.4381.00
200_T335_V1.4351.00
298_I319_T1.4071.00
45_R118_N1.4061.00
245_A276_I1.4021.00
258_Q262_D1.3981.00
207_D210_D1.3981.00
201_F288_A1.3931.00
315_A318_P1.3911.00
213_V290_I1.3891.00
129_E162_V1.3811.00
265_G268_L1.3771.00
266_G269_E1.3771.00
106_G127_Y1.3721.00
63_S68_Y1.3531.00
300_V326_V1.3271.00
61_F91_T1.3261.00
193_V312_V1.3241.00
312_V335_V1.3121.00
390_I395_T1.3071.00
159_T162_V1.2991.00
252_L257_V1.2861.00
339_L381_M1.2811.00
221_V314_A1.2791.00
195_I198_E1.2741.00
225_T290_I1.2741.00
75_H294_I1.2731.00
379_D383_V1.2721.00
355_N360_S1.2721.00
304_E326_V1.2651.00
195_I367_N1.2581.00
91_T405_S1.2571.00
225_T292_A1.2551.00
203_Y379_D1.2461.00
213_V236_I1.2381.00
178_E411_F1.2371.00
325_Q328_S1.2341.00
378_F393_L1.2151.00
204_F309_D1.2131.00
150_P186_V1.2091.00
198_E202_E1.2071.00
132_R163_Y1.2011.00
257_V261_A1.2011.00
372_Q376_G1.2001.00
201_F208_I1.1930.99
42_L126_R1.1880.99
229_L236_I1.1840.99
212_D287_D1.1800.99
126_R129_E1.1780.99
197_T288_A1.1690.99
121_E125_R1.1670.99
326_V329_D1.1660.99
92_W338_I1.1650.99
125_R158_D1.1630.99
213_V288_A1.1620.99
289_L306_L1.1600.99
242_V261_A1.1600.99
204_F333_P1.1440.99
117_D151_R1.1420.99
92_W405_S1.1420.99
371_R375_T1.1300.99
227_D258_Q1.1240.99
367_N371_R1.1240.99
264_N267_R1.1220.99
388_R399_T1.1200.99
387_D403_E1.1170.99
197_T290_I1.1170.99
384_A400_I1.1150.99
212_D285_D1.1130.99
191_R228_L1.1130.99
55_D109_V1.1110.99
245_A278_N1.1090.99
239_V257_V1.1010.99
310_V333_P1.0960.99
230_S255_A1.0960.99
212_D249_P1.0950.99
407_D410_E1.0940.99
139_T165_G1.0940.99
224_V227_D1.0880.99
43_P53_V1.0880.99
115_L123_L1.0860.99
214_A284_L1.0860.99
97_V342_A1.0840.99
364_E368_R1.0790.99
78_V82_E1.0790.99
206_T309_D1.0760.99
300_V324_A1.0710.99
248_D256_D1.0640.99
97_V346_I1.0630.99
57_Y109_V1.0630.99
194_S229_L1.0610.99
298_I327_L1.0590.99
148_T153_M1.0590.99
155_W158_D1.0560.99
218_F239_V1.0550.99
289_L297_V1.0430.99
237_V247_H1.0390.99
376_G380_E1.0340.99
191_R367_N1.0320.99
402_L405_S1.0300.99
76_P111_N1.0300.99
300_V304_E1.0290.99
193_V290_I1.0260.98
62_D409_H1.0230.98
212_D233_G1.0230.98
193_V292_A1.0150.98
362_D365_E1.0150.98
324_A394_R1.0090.98
176_P179_I1.0060.98
280_D283_T0.9960.98
214_A237_V0.9960.98
74_Y148_T0.9900.98
74_Y124_T0.9810.98
264_N269_E0.9740.98
237_V286_V0.9700.98
311_I327_L0.9700.98
191_R371_R0.9690.98
226_A236_I0.9670.98
110_C123_L0.9640.98
65_R95_A0.9640.98
200_T312_V0.9580.98
46_M54_F0.9580.98
384_A399_T0.9520.98
59_C80_E0.9500.97
193_V197_T0.9420.97
225_T229_L0.9370.97
64_A405_S0.9330.97
126_R130_G0.9330.97
362_D372_Q0.9320.97
306_L311_I0.9310.97
279_D283_T0.9270.97
197_T310_V0.9200.97
131_I134_M0.9160.97
203_Y383_V0.9130.97
290_I312_V0.9100.97
186_V224_V0.9070.97
77_T82_E0.9060.97
291_P315_A0.9010.97
204_F310_V0.8950.96
75_H146_M0.8940.96
345_V348_S0.8900.96
126_R162_V0.8870.96
179_I411_F0.8840.96
81_E84_S0.8820.96
45_R52_E0.8750.96
278_N281_L0.8740.96
260_Y266_G0.8720.96
72_I142_P0.8720.96
124_T156_V0.8720.96
368_R371_R0.8690.96
386_E389_N0.8660.96
257_V267_R0.8650.96
76_P79_S0.8610.96
257_V260_Y0.8600.95
259_A262_D0.8570.95
133_R165_G0.8510.95
98_D373_R0.8500.95
301_D304_E0.8490.95
198_E208_I0.8450.95
105_K316_N0.8430.95
69_K345_V0.8420.95
230_S236_I0.8370.95
138_E356_S0.8360.95
261_A264_N0.8350.95
385_Y390_I0.8320.95
298_I303_A0.8320.95
193_V225_T0.8310.95
153_M156_V0.8280.94
243_T266_G0.8240.94
261_A275_P0.8220.94
368_R372_Q0.8210.94
253_D261_A0.8210.94
130_G133_R0.8170.94
382_L386_E0.8160.94
260_Y270_G0.8130.94
300_V323_A0.8120.94
128_T172_V0.8060.94
257_V270_G0.8050.94
230_S253_D0.8040.94
224_V228_L0.8030.94
304_E330_R0.8010.93
196_I381_M0.8010.93
124_T128_T0.8000.93
182_T361_W0.7940.93
247_H274_E0.7910.93
256_D265_G0.7890.93
223_S258_Q0.7880.93
285_D308_A0.7880.93
276_I284_L0.7860.93
74_Y108_I0.7830.93
113_K242_V0.7830.93
230_S254_I0.7800.93
261_A265_G0.7740.92
257_V275_P0.7630.92
75_H78_V0.7600.92
257_V269_E0.7580.91
265_G269_E0.7580.91
278_N282_L0.7580.91
212_D237_V0.7550.91
235_N250_T0.7550.91
246_I257_V0.7550.91
229_L290_I0.7540.91
348_S351_E0.7540.91
157_M161_S0.7510.91
105_K189_T0.7500.91
324_A328_S0.7490.91
108_I127_Y0.7470.91
247_H284_L0.7440.91
254_I257_V0.7430.91
256_D260_Y0.7420.91
93_K316_N0.7420.91
311_I319_T0.7370.90
346_I374_L0.7360.90
154_A158_D0.7350.90
375_T379_D0.7330.90
157_M168_V0.7330.90
188_A370_L0.7290.90
46_M50_S0.7290.90
333_P393_L0.7240.89
69_K101_F0.7230.89
401_A405_S0.7200.89
44_V54_F0.7160.89
241_D244_G0.7140.89
190_G225_T0.7130.89
116_S119_E0.7120.89
208_I213_V0.7110.89
135_I156_V0.7090.88
215_I239_V0.7090.88
385_Y388_R0.7080.88
308_A332_V0.7080.88
256_D261_A0.7080.88
370_L374_L0.7070.88
385_Y393_L0.7060.88
255_A258_Q0.7060.88
353_V359_Y0.7060.88
126_R159_T0.7050.88
151_R154_A0.7030.88
306_L327_L0.7020.88
287_D309_D0.7000.88
384_A396_A0.7000.88
189_T344_G0.7000.88
243_T267_R0.6980.88
87_A91_T0.6960.88
111_N116_S0.6950.87
159_T163_Y0.6950.87
259_A266_G0.6940.87
196_I312_V0.6930.87
129_E163_Y0.6920.87
373_R376_G0.6890.87
248_D272_D0.6880.87
254_I260_Y0.6870.87
256_D264_N0.6870.87
277_S281_L0.6850.87
261_A267_R0.6850.87
298_I311_I0.6850.87
275_P278_N0.6840.87
255_A259_A0.6840.87
263_A266_G0.6800.86
280_D302_V0.6800.86
237_V284_L0.6800.86
223_S260_Y0.6790.86
245_A283_T0.6780.86
223_S263_A0.6780.86
334_V337_D0.6770.86
298_I337_D0.6750.86
160_Y163_Y0.6720.86
383_V386_E0.6720.86
238_A245_A0.6700.85
52_E114_E0.6700.85
114_E117_D0.6690.85
243_T275_P0.6690.85
245_A284_L0.6660.85
385_Y389_N0.6650.85
42_L123_L0.6610.85
185_R220_N0.6610.85
257_V268_L0.6560.84
144_P185_R0.6550.84
400_I404_R0.6550.84
147_N221_V0.6520.84
221_V242_V0.6510.84
78_V107_G0.6490.84
132_R161_S0.6490.84
248_D273_A0.6480.84
74_Y110_C0.6480.84
263_A268_L0.6470.83
228_L367_N0.6460.83
226_A254_I0.6450.83
153_M158_D0.6430.83
52_E115_L0.6420.83
378_F381_M0.6410.83
279_D301_D0.6410.83
89_W317_G0.6410.83
299_T319_T0.6410.83
60_Q68_Y0.6400.83
258_Q261_A0.6400.83
290_I314_A0.6370.83
202_E375_T0.6340.82
304_E329_D0.6320.82
95_A401_A0.6300.82
354_Q361_W0.6290.82
196_I335_V0.6290.82
407_D411_F0.6290.82
244_G267_R0.6290.82
201_F211_A0.6280.82
229_L288_A0.6280.82
288_A310_V0.6270.82
289_L311_I0.6250.81
319_T323_A0.6230.81
110_C116_S0.6220.81
263_A269_E0.6220.81
214_A245_A0.6210.81
214_A281_L0.6200.81
253_D257_V0.6200.81
156_V172_V0.6190.81
84_S87_A0.6180.81
374_L377_A0.6170.80
228_L232_R0.6160.80
185_R347_V0.6140.80
187_E224_V0.6140.80
382_L385_Y0.6110.80
263_A267_R0.6100.80
151_R155_W0.6090.80
216_Q297_V0.6080.80
193_V340_A0.6080.80
388_R403_E0.6080.80
83_V87_A0.6080.80
194_S225_T0.6070.79
264_N268_L0.6070.79
128_T159_T0.6060.79
257_V264_N0.6060.79
200_T333_P0.6040.79
93_K105_K0.6030.79
346_I373_R0.6030.79
75_H79_S0.6010.79
394_R398_Y0.6010.79
402_L406_A0.5990.79
347_V366_V0.5990.79
92_W402_L0.5950.78
194_S198_E0.5940.78
335_V393_L0.5940.78
319_T334_V0.5930.78
88_G92_W0.5920.78
193_V221_V0.5920.78
349_Y353_V0.5920.78
113_K261_A0.5890.77
165_G168_V0.5890.77
100_P353_V0.5890.77
320_T324_A0.5870.77
260_Y269_E0.5850.77
376_G379_D0.5850.77
308_A311_I0.5830.77
182_T347_V0.5830.77
384_A387_D0.5830.77
105_K143_A0.5830.77
350_L365_E0.5820.77
156_V159_T0.5820.77
259_A268_L0.5820.77
369_D372_Q0.5810.76
256_D272_D0.5810.76
295_E317_G0.5780.76
194_S228_L0.5780.76
311_I332_V0.5770.76
380_E383_V0.5770.76
283_T302_V0.5760.76
153_M179_I0.5760.76
124_T152_T0.5760.76
64_A409_H0.5750.76
240_S282_L0.5750.76
198_E375_T0.5750.76
311_I323_A0.5750.76
161_S412_R0.5740.76
98_D376_G0.5730.75
324_A334_V0.5730.75
381_M385_Y0.5720.75
69_K94_T0.5710.75
298_I304_E0.5700.75
254_I261_A0.5700.75
260_Y271_Y0.5690.75
188_A220_N0.5690.75
298_I334_V0.5680.75
347_V361_W0.5670.75
148_T188_A0.5660.75
334_V394_R0.5660.75
132_R162_V0.5640.74
85_A317_G0.5630.74
138_E358_Q0.5610.74
106_G142_P0.5610.74
218_F254_I0.5590.74
79_S109_V0.5580.74
382_L393_L0.5580.74
327_L334_V0.5570.73
54_F110_C0.5560.73
144_P220_N0.5560.73
346_I350_L0.5550.73
45_R51_V0.5540.73
342_A346_I0.5520.73
252_L260_Y0.5520.73
214_A285_D0.5510.73
185_R348_S0.5510.73
212_D247_H0.5490.72
246_I270_G0.5480.72
282_L297_V0.5470.72
188_A347_V0.5460.72
210_D233_G0.5450.72
250_T270_G0.5440.72
260_Y263_A0.5440.72
191_R227_D0.5440.72
64_A408_A0.5440.72
244_G275_P0.5440.72
260_Y265_G0.5420.71
218_F267_R0.5420.71
97_V377_A0.5420.71
250_T272_D0.5390.71
259_A267_R0.5380.71
101_F352_W0.5380.71
303_A327_L0.5370.71
314_A340_A0.5370.71
189_T341_N0.5370.71
203_Y333_P0.5360.71
298_I302_V0.5350.70
353_V357_Q0.5340.70
292_A314_A0.5320.70
65_R404_R0.5280.69
196_I339_L0.5280.69
396_A399_T0.5270.69
299_T320_T0.5270.69
243_T269_E0.5270.69
134_M139_T0.5260.69
83_V107_G0.5250.69
60_Q139_T0.5230.69
335_V378_F0.5230.69
319_T324_A0.5220.69
215_I229_L0.5220.69
225_T314_A0.5190.68
59_C104_A0.5190.68
200_T382_L0.5180.68
121_E159_T0.5180.68
297_V303_A0.5180.68
201_F310_V0.5180.68
190_G314_A0.5170.68
230_S264_N0.5160.68
218_F257_V0.5160.68
144_P347_V0.5130.67
50_S53_V0.5130.67
58_R131_I0.5110.67
205_D211_A0.5100.67
139_T166_Y0.5100.67
276_I281_L0.5100.67
143_A220_N0.5100.67
399_T402_L0.5090.67
252_L264_N0.5090.67
144_P348_S0.5080.66
367_N370_L0.5070.66
197_T314_A0.5070.66
253_D265_G0.5060.66
69_K348_S0.5060.66
373_R377_A0.5050.66
113_K116_S0.5050.66
97_V374_L0.5030.66
173_T185_R0.5010.65
182_T366_V0.5010.65
120_I124_T0.5000.65
248_D270_G0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgiA 6 0.9832 100 0.057 Contact Map
2yfqA 5 0.9399 100 0.06 Contact Map
2tmgA 5 0.9784 100 0.068 Contact Map
1v9lA 4 0.988 100 0.071 Contact Map
3aogA 8 0.9976 100 0.076 Contact Map
3aoeE 3 0.988 100 0.076 Contact Map
3k92A 5 0.9928 100 0.082 Contact Map
4fccA 5 0.9928 100 0.09 Contact Map
3r3jA 5 0.9952 100 0.092 Contact Map
2bmaA 5 0.9952 100 0.094 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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