DHE - HALSA - GREMLIN Contacts

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DHE - Glutamate dehydrogenase A2

UniProt:	Q9HQE1	Sequences: MTESGPLENMLAQMEQAREYVDIDDGIYERLKSPERTLSVSLPVRMDDGSVEVFDAYRCQFDSARGPYKGGIRYHPTVSEEEVSALAGWMTWKTALVDLPFGGAKGGIVCNPKELSDNEIEQLTRRYTEGIRRMIGPETDIPAPDMNTDPRTMAWVMDTYSVYQGYAVPEVVTGKPPEIGGTDGRVEATGRGVSIITEETFEYFDTDIQDADVAIQGFGNVGSVTADLLSERGANIVAVSDVTGAIHDPTGLDIADVQAYADANGGRLEGYDAEPISNDDLLTLDVDALIPAAIEDVITVDVAERLAADVIVEAANGPTTFDAAQVLSDRGVPVVPDILANAGGVIVSYLEWVQNSQQYSWDVEEVNRDLRQRLTGAFDEMLVAYEDRNIPTLRTAAYTIALERSADAHEFRGLFP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	416 (368)
Sequences:	5234 (2581)
Seq/√Len:	134.5

ECOLI - DHE4
BACSU - DHE2 GUDB DHLE
HALSA - DHEB DHE DHE4
SULSO - Q97X22 DHE2 Q97Y81 Q97WS2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
229_L	234_A	4.386	1.00
283_T	305_R	3.719	1.00
215_I	226_A	3.714	1.00
214_A	286_V	3.421	1.00
129_E	159_T	3.296	1.00
286_V	308_A	3.235	1.00
197_T	312_V	2.981	1.00
285_D	307_A	2.959	1.00
253_D	256_D	2.867	1.00
79_S	82_E	2.836	1.00
325_Q	329_D	2.827	1.00
94_T	345_V	2.523	1.00
111_N	114_E	2.518	1.00
118_N	122_Q	2.511	1.00
212_D	235_N	2.497	1.00
199_E	202_E	2.431	1.00
199_E	375_T	2.401	1.00
328_S	392_T	2.389	1.00
101_F	349_Y	2.370	1.00
206_T	211_A	2.369	1.00
146_M	294_I	2.354	1.00
226_A	239_V	2.349	1.00
46_M	52_E	2.307	1.00
384_A	388_R	2.275	1.00
196_I	340_A	2.243	1.00
203_Y	386_E	2.165	1.00
213_V	229_L	2.139	1.00
378_F	382_L	2.136	1.00
193_V	314_A	2.121	1.00
61_F	87_A	2.114	1.00
384_A	403_E	2.105	1.00
259_A	264_N	2.048	1.00
43_P	126_R	2.024	1.00
227_D	231_E	2.023	1.00
149_D	152_T	2.022	1.00
319_T	327_L	2.020	1.00
312_V	340_A	2.009	1.00
335_V	340_A	2.000	1.00
403_E	407_D	1.979	1.00
392_T	395_T	1.975	1.00
199_E	379_D	1.974	1.00
238_A	281_L	1.969	1.00
260_Y	264_N	1.938	1.00
213_V	234_A	1.930	1.00
203_Y	382_L	1.918	1.00
300_V	322_D	1.914	1.00
365_E	369_D	1.902	1.00
259_A	263_A	1.900	1.00
383_V	387_D	1.891	1.00
110_C	115_L	1.868	1.00
282_L	289_L	1.867	1.00
194_S	232_R	1.863	1.00
299_T	302_V	1.835	1.00
59_C	87_A	1.814	1.00
68_Y	104_A	1.800	1.00
303_A	326_V	1.766	1.00
72_I	156_V	1.764	1.00
249_P	274_E	1.763	1.00
125_R	159_T	1.760	1.00
200_T	310_V	1.752	1.00
277_S	280_D	1.735	1.00
65_R	98_D	1.732	1.00
184_G	363_V	1.717	1.00
338_I	398_Y	1.713	1.00
198_E	232_R	1.713	1.00
96_L	339_L	1.710	1.00
208_I	234_A	1.709	1.00
178_E	407_D	1.655	1.00
128_T	156_V	1.643	1.00
203_Y	378_F	1.611	1.00
154_A	176_P	1.608	1.00
327_L	332_V	1.599	1.00
270_G	273_A	1.594	1.00
214_A	238_A	1.593	1.00
256_D	270_G	1.589	1.00
326_V	330_R	1.579	1.00
390_I	399_T	1.559	1.00
198_E	371_R	1.559	1.00
256_D	259_A	1.552	1.00
254_I	258_Q	1.539	1.00
298_I	306_L	1.538	1.00
72_I	127_Y	1.521	1.00
321_F	324_A	1.515	1.00
390_I	396_A	1.513	1.00
363_V	367_N	1.500	1.00
132_R	164_Q	1.500	1.00
166_Y	169_P	1.470	1.00
195_I	371_R	1.457	1.00
56_A	127_Y	1.445	1.00
238_A	284_L	1.438	1.00
200_T	335_V	1.435	1.00
298_I	319_T	1.407	1.00
45_R	118_N	1.406	1.00
245_A	276_I	1.402	1.00
258_Q	262_D	1.398	1.00
207_D	210_D	1.398	1.00
201_F	288_A	1.393	1.00
315_A	318_P	1.391	1.00
213_V	290_I	1.389	1.00
129_E	162_V	1.381	1.00
265_G	268_L	1.377	1.00
266_G	269_E	1.377	1.00
106_G	127_Y	1.372	1.00
63_S	68_Y	1.353	1.00
300_V	326_V	1.327	1.00
61_F	91_T	1.326	1.00
193_V	312_V	1.324	1.00
312_V	335_V	1.312	1.00
390_I	395_T	1.307	1.00
159_T	162_V	1.299	1.00
252_L	257_V	1.286	1.00
339_L	381_M	1.281	1.00
221_V	314_A	1.279	1.00
195_I	198_E	1.274	1.00
225_T	290_I	1.274	1.00
75_H	294_I	1.273	1.00
379_D	383_V	1.272	1.00
355_N	360_S	1.272	1.00
304_E	326_V	1.265	1.00
195_I	367_N	1.258	1.00
91_T	405_S	1.257	1.00
225_T	292_A	1.255	1.00
203_Y	379_D	1.246	1.00
213_V	236_I	1.238	1.00
178_E	411_F	1.237	1.00
325_Q	328_S	1.234	1.00
378_F	393_L	1.215	1.00
204_F	309_D	1.213	1.00
150_P	186_V	1.209	1.00
198_E	202_E	1.207	1.00
132_R	163_Y	1.201	1.00
257_V	261_A	1.201	1.00
372_Q	376_G	1.200	1.00
201_F	208_I	1.193	0.99
42_L	126_R	1.188	0.99
229_L	236_I	1.184	0.99
212_D	287_D	1.180	0.99
126_R	129_E	1.178	0.99
197_T	288_A	1.169	0.99
121_E	125_R	1.167	0.99
326_V	329_D	1.166	0.99
92_W	338_I	1.165	0.99
125_R	158_D	1.163	0.99
213_V	288_A	1.162	0.99
289_L	306_L	1.160	0.99
242_V	261_A	1.160	0.99
204_F	333_P	1.144	0.99
117_D	151_R	1.142	0.99
92_W	405_S	1.142	0.99
371_R	375_T	1.130	0.99
227_D	258_Q	1.124	0.99
367_N	371_R	1.124	0.99
264_N	267_R	1.122	0.99
388_R	399_T	1.120	0.99
387_D	403_E	1.117	0.99
197_T	290_I	1.117	0.99
384_A	400_I	1.115	0.99
212_D	285_D	1.113	0.99
191_R	228_L	1.113	0.99
55_D	109_V	1.111	0.99
245_A	278_N	1.109	0.99
239_V	257_V	1.101	0.99
310_V	333_P	1.096	0.99
230_S	255_A	1.096	0.99
212_D	249_P	1.095	0.99
407_D	410_E	1.094	0.99
139_T	165_G	1.094	0.99
224_V	227_D	1.088	0.99
43_P	53_V	1.088	0.99
115_L	123_L	1.086	0.99
214_A	284_L	1.086	0.99
97_V	342_A	1.084	0.99
364_E	368_R	1.079	0.99
78_V	82_E	1.079	0.99
206_T	309_D	1.076	0.99
300_V	324_A	1.071	0.99
248_D	256_D	1.064	0.99
97_V	346_I	1.063	0.99
57_Y	109_V	1.063	0.99
194_S	229_L	1.061	0.99
298_I	327_L	1.059	0.99
148_T	153_M	1.059	0.99
155_W	158_D	1.056	0.99
218_F	239_V	1.055	0.99
289_L	297_V	1.043	0.99
237_V	247_H	1.039	0.99
376_G	380_E	1.034	0.99
191_R	367_N	1.032	0.99
402_L	405_S	1.030	0.99
76_P	111_N	1.030	0.99
300_V	304_E	1.029	0.99
193_V	290_I	1.026	0.98
62_D	409_H	1.023	0.98
212_D	233_G	1.023	0.98
193_V	292_A	1.015	0.98
362_D	365_E	1.015	0.98
324_A	394_R	1.009	0.98
176_P	179_I	1.006	0.98
280_D	283_T	0.996	0.98
214_A	237_V	0.996	0.98
74_Y	148_T	0.990	0.98
74_Y	124_T	0.981	0.98
264_N	269_E	0.974	0.98
237_V	286_V	0.970	0.98
311_I	327_L	0.970	0.98
191_R	371_R	0.969	0.98
226_A	236_I	0.967	0.98
110_C	123_L	0.964	0.98
65_R	95_A	0.964	0.98
200_T	312_V	0.958	0.98
46_M	54_F	0.958	0.98
384_A	399_T	0.952	0.98
59_C	80_E	0.950	0.97
193_V	197_T	0.942	0.97
225_T	229_L	0.937	0.97
64_A	405_S	0.933	0.97
126_R	130_G	0.933	0.97
362_D	372_Q	0.932	0.97
306_L	311_I	0.931	0.97
279_D	283_T	0.927	0.97
197_T	310_V	0.920	0.97
131_I	134_M	0.916	0.97
203_Y	383_V	0.913	0.97
290_I	312_V	0.910	0.97
186_V	224_V	0.907	0.97
77_T	82_E	0.906	0.97
291_P	315_A	0.901	0.97
204_F	310_V	0.895	0.96
75_H	146_M	0.894	0.96
345_V	348_S	0.890	0.96
126_R	162_V	0.887	0.96
179_I	411_F	0.884	0.96
81_E	84_S	0.882	0.96
45_R	52_E	0.875	0.96
278_N	281_L	0.874	0.96
260_Y	266_G	0.872	0.96
72_I	142_P	0.872	0.96
124_T	156_V	0.872	0.96
368_R	371_R	0.869	0.96
386_E	389_N	0.866	0.96
257_V	267_R	0.865	0.96
76_P	79_S	0.861	0.96
257_V	260_Y	0.860	0.95
259_A	262_D	0.857	0.95
133_R	165_G	0.851	0.95
98_D	373_R	0.850	0.95
301_D	304_E	0.849	0.95
198_E	208_I	0.845	0.95
105_K	316_N	0.843	0.95
69_K	345_V	0.842	0.95
230_S	236_I	0.837	0.95
138_E	356_S	0.836	0.95
261_A	264_N	0.835	0.95
385_Y	390_I	0.832	0.95
298_I	303_A	0.832	0.95
193_V	225_T	0.831	0.95
153_M	156_V	0.828	0.94
243_T	266_G	0.824	0.94
261_A	275_P	0.822	0.94
368_R	372_Q	0.821	0.94
253_D	261_A	0.821	0.94
130_G	133_R	0.817	0.94
382_L	386_E	0.816	0.94
260_Y	270_G	0.813	0.94
300_V	323_A	0.812	0.94
128_T	172_V	0.806	0.94
257_V	270_G	0.805	0.94
230_S	253_D	0.804	0.94
224_V	228_L	0.803	0.94
304_E	330_R	0.801	0.93
196_I	381_M	0.801	0.93
124_T	128_T	0.800	0.93
182_T	361_W	0.794	0.93
247_H	274_E	0.791	0.93
256_D	265_G	0.789	0.93
223_S	258_Q	0.788	0.93
285_D	308_A	0.788	0.93
276_I	284_L	0.786	0.93
74_Y	108_I	0.783	0.93
113_K	242_V	0.783	0.93
230_S	254_I	0.780	0.93
261_A	265_G	0.774	0.92
257_V	275_P	0.763	0.92
75_H	78_V	0.760	0.92
257_V	269_E	0.758	0.91
265_G	269_E	0.758	0.91
278_N	282_L	0.758	0.91
212_D	237_V	0.755	0.91
235_N	250_T	0.755	0.91
246_I	257_V	0.755	0.91
229_L	290_I	0.754	0.91
348_S	351_E	0.754	0.91
157_M	161_S	0.751	0.91
105_K	189_T	0.750	0.91
324_A	328_S	0.749	0.91
108_I	127_Y	0.747	0.91
247_H	284_L	0.744	0.91
254_I	257_V	0.743	0.91
256_D	260_Y	0.742	0.91
93_K	316_N	0.742	0.91
311_I	319_T	0.737	0.90
346_I	374_L	0.736	0.90
154_A	158_D	0.735	0.90
375_T	379_D	0.733	0.90
157_M	168_V	0.733	0.90
188_A	370_L	0.729	0.90
46_M	50_S	0.729	0.90
333_P	393_L	0.724	0.89
69_K	101_F	0.723	0.89
401_A	405_S	0.720	0.89
44_V	54_F	0.716	0.89
241_D	244_G	0.714	0.89
190_G	225_T	0.713	0.89
116_S	119_E	0.712	0.89
208_I	213_V	0.711	0.89
135_I	156_V	0.709	0.88
215_I	239_V	0.709	0.88
385_Y	388_R	0.708	0.88
308_A	332_V	0.708	0.88
256_D	261_A	0.708	0.88
370_L	374_L	0.707	0.88
385_Y	393_L	0.706	0.88
255_A	258_Q	0.706	0.88
353_V	359_Y	0.706	0.88
126_R	159_T	0.705	0.88
151_R	154_A	0.703	0.88
306_L	327_L	0.702	0.88
287_D	309_D	0.700	0.88
384_A	396_A	0.700	0.88
189_T	344_G	0.700	0.88
243_T	267_R	0.698	0.88
87_A	91_T	0.696	0.88
111_N	116_S	0.695	0.87
159_T	163_Y	0.695	0.87
259_A	266_G	0.694	0.87
196_I	312_V	0.693	0.87
129_E	163_Y	0.692	0.87
373_R	376_G	0.689	0.87
248_D	272_D	0.688	0.87
254_I	260_Y	0.687	0.87
256_D	264_N	0.687	0.87
277_S	281_L	0.685	0.87
261_A	267_R	0.685	0.87
298_I	311_I	0.685	0.87
275_P	278_N	0.684	0.87
255_A	259_A	0.684	0.87
263_A	266_G	0.680	0.86
280_D	302_V	0.680	0.86
237_V	284_L	0.680	0.86
223_S	260_Y	0.679	0.86
245_A	283_T	0.678	0.86
223_S	263_A	0.678	0.86
334_V	337_D	0.677	0.86
298_I	337_D	0.675	0.86
160_Y	163_Y	0.672	0.86
383_V	386_E	0.672	0.86
238_A	245_A	0.670	0.85
52_E	114_E	0.670	0.85
114_E	117_D	0.669	0.85
243_T	275_P	0.669	0.85
245_A	284_L	0.666	0.85
385_Y	389_N	0.665	0.85
42_L	123_L	0.661	0.85
185_R	220_N	0.661	0.85
257_V	268_L	0.656	0.84
144_P	185_R	0.655	0.84
400_I	404_R	0.655	0.84
147_N	221_V	0.652	0.84
221_V	242_V	0.651	0.84
78_V	107_G	0.649	0.84
132_R	161_S	0.649	0.84
248_D	273_A	0.648	0.84
74_Y	110_C	0.648	0.84
263_A	268_L	0.647	0.83
228_L	367_N	0.646	0.83
226_A	254_I	0.645	0.83
153_M	158_D	0.643	0.83
52_E	115_L	0.642	0.83
378_F	381_M	0.641	0.83
279_D	301_D	0.641	0.83
89_W	317_G	0.641	0.83
299_T	319_T	0.641	0.83
60_Q	68_Y	0.640	0.83
258_Q	261_A	0.640	0.83
290_I	314_A	0.637	0.83
202_E	375_T	0.634	0.82
304_E	329_D	0.632	0.82
95_A	401_A	0.630	0.82
354_Q	361_W	0.629	0.82
196_I	335_V	0.629	0.82
407_D	411_F	0.629	0.82
244_G	267_R	0.629	0.82
201_F	211_A	0.628	0.82
229_L	288_A	0.628	0.82
288_A	310_V	0.627	0.82
289_L	311_I	0.625	0.81
319_T	323_A	0.623	0.81
110_C	116_S	0.622	0.81
263_A	269_E	0.622	0.81
214_A	245_A	0.621	0.81
214_A	281_L	0.620	0.81
253_D	257_V	0.620	0.81
156_V	172_V	0.619	0.81
84_S	87_A	0.618	0.81
374_L	377_A	0.617	0.80
228_L	232_R	0.616	0.80
185_R	347_V	0.614	0.80
187_E	224_V	0.614	0.80
382_L	385_Y	0.611	0.80
263_A	267_R	0.610	0.80
151_R	155_W	0.609	0.80
216_Q	297_V	0.608	0.80
193_V	340_A	0.608	0.80
388_R	403_E	0.608	0.80
83_V	87_A	0.608	0.80
194_S	225_T	0.607	0.79
264_N	268_L	0.607	0.79
128_T	159_T	0.606	0.79
257_V	264_N	0.606	0.79
200_T	333_P	0.604	0.79
93_K	105_K	0.603	0.79
346_I	373_R	0.603	0.79
75_H	79_S	0.601	0.79
394_R	398_Y	0.601	0.79
402_L	406_A	0.599	0.79
347_V	366_V	0.599	0.79
92_W	402_L	0.595	0.78
194_S	198_E	0.594	0.78
335_V	393_L	0.594	0.78
319_T	334_V	0.593	0.78
88_G	92_W	0.592	0.78
193_V	221_V	0.592	0.78
349_Y	353_V	0.592	0.78
113_K	261_A	0.589	0.77
165_G	168_V	0.589	0.77
100_P	353_V	0.589	0.77
320_T	324_A	0.587	0.77
260_Y	269_E	0.585	0.77
376_G	379_D	0.585	0.77
308_A	311_I	0.583	0.77
182_T	347_V	0.583	0.77
384_A	387_D	0.583	0.77
105_K	143_A	0.583	0.77
350_L	365_E	0.582	0.77
156_V	159_T	0.582	0.77
259_A	268_L	0.582	0.77
369_D	372_Q	0.581	0.76
256_D	272_D	0.581	0.76
295_E	317_G	0.578	0.76
194_S	228_L	0.578	0.76
311_I	332_V	0.577	0.76
380_E	383_V	0.577	0.76
283_T	302_V	0.576	0.76
153_M	179_I	0.576	0.76
124_T	152_T	0.576	0.76
64_A	409_H	0.575	0.76
240_S	282_L	0.575	0.76
198_E	375_T	0.575	0.76
311_I	323_A	0.575	0.76
161_S	412_R	0.574	0.76
98_D	376_G	0.573	0.75
324_A	334_V	0.573	0.75
381_M	385_Y	0.572	0.75
69_K	94_T	0.571	0.75
298_I	304_E	0.570	0.75
254_I	261_A	0.570	0.75
260_Y	271_Y	0.569	0.75
188_A	220_N	0.569	0.75
298_I	334_V	0.568	0.75
347_V	361_W	0.567	0.75
148_T	188_A	0.566	0.75
334_V	394_R	0.566	0.75
132_R	162_V	0.564	0.74
85_A	317_G	0.563	0.74
138_E	358_Q	0.561	0.74
106_G	142_P	0.561	0.74
218_F	254_I	0.559	0.74
79_S	109_V	0.558	0.74
382_L	393_L	0.558	0.74
327_L	334_V	0.557	0.73
54_F	110_C	0.556	0.73
144_P	220_N	0.556	0.73
346_I	350_L	0.555	0.73
45_R	51_V	0.554	0.73
342_A	346_I	0.552	0.73
252_L	260_Y	0.552	0.73
214_A	285_D	0.551	0.73
185_R	348_S	0.551	0.73
212_D	247_H	0.549	0.72
246_I	270_G	0.548	0.72
282_L	297_V	0.547	0.72
188_A	347_V	0.546	0.72
210_D	233_G	0.545	0.72
250_T	270_G	0.544	0.72
260_Y	263_A	0.544	0.72
191_R	227_D	0.544	0.72
64_A	408_A	0.544	0.72
244_G	275_P	0.544	0.72
260_Y	265_G	0.542	0.71
218_F	267_R	0.542	0.71
97_V	377_A	0.542	0.71
250_T	272_D	0.539	0.71
259_A	267_R	0.538	0.71
101_F	352_W	0.538	0.71
303_A	327_L	0.537	0.71
314_A	340_A	0.537	0.71
189_T	341_N	0.537	0.71
203_Y	333_P	0.536	0.71
298_I	302_V	0.535	0.70
353_V	357_Q	0.534	0.70
292_A	314_A	0.532	0.70
65_R	404_R	0.528	0.69
196_I	339_L	0.528	0.69
396_A	399_T	0.527	0.69
299_T	320_T	0.527	0.69
243_T	269_E	0.527	0.69
134_M	139_T	0.526	0.69
83_V	107_G	0.525	0.69
60_Q	139_T	0.523	0.69
335_V	378_F	0.523	0.69
319_T	324_A	0.522	0.69
215_I	229_L	0.522	0.69
225_T	314_A	0.519	0.68
59_C	104_A	0.519	0.68
200_T	382_L	0.518	0.68
121_E	159_T	0.518	0.68
297_V	303_A	0.518	0.68
201_F	310_V	0.518	0.68
190_G	314_A	0.517	0.68
230_S	264_N	0.516	0.68
218_F	257_V	0.516	0.68
144_P	347_V	0.513	0.67
50_S	53_V	0.513	0.67
58_R	131_I	0.511	0.67
205_D	211_A	0.510	0.67
139_T	166_Y	0.510	0.67
276_I	281_L	0.510	0.67
143_A	220_N	0.510	0.67
399_T	402_L	0.509	0.67
252_L	264_N	0.509	0.67
144_P	348_S	0.508	0.66
367_N	370_L	0.507	0.66
197_T	314_A	0.507	0.66
253_D	265_G	0.506	0.66
69_K	348_S	0.506	0.66
373_R	377_A	0.505	0.66
113_K	116_S	0.505	0.66
97_V	374_L	0.503	0.66
173_T	185_R	0.501	0.65
182_T	366_V	0.501	0.65
120_I	124_T	0.500	0.65
248_D	270_G	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xgiA	6	0.9832	100	0.057	Contact Map
2yfqA	5	0.9399	100	0.06	Contact Map
2tmgA	5	0.9784	100	0.068	Contact Map
1v9lA	4	0.988	100	0.071	Contact Map
3aogA	8	0.9976	100	0.076	Contact Map
3aoeE	3	0.988	100	0.076	Contact Map
3k92A	5	0.9928	100	0.082	Contact Map
4fccA	5	0.9928	100	0.09	Contact Map
3r3jA	5	0.9952	100	0.092	Contact Map
2bmaA	5	0.9952	100	0.094	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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