GREMLIN Database
Q9HQE0 - Uncharacterized protein
UniProt: Q9HQE0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 431 (345)
Sequences: 29043 (22410)
Seq/√Len: 1206.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
400_M405_V4.9521.00
358_R363_W4.2291.00
51_D397_T4.0981.00
25_V30_T3.9161.00
398_L405_V3.9131.00
4_L50_V3.3911.00
5_T47_R3.0641.00
54_A370_L3.0071.00
335_P338_S2.9691.00
360_A363_W2.9361.00
56_G115_T2.8921.00
50_V369_G2.8451.00
7_D50_V2.8091.00
364_T402_A2.7721.00
31_A361_E2.6951.00
356_V364_T2.6421.00
289_A293_E2.6261.00
341_E345_H2.5311.00
355_N364_T2.4151.00
353_F356_V2.4061.00
297_N349_K2.2901.00
262_A294_R2.2881.00
204_L207_E2.2691.00
239_D267_T2.2431.00
54_A368_V2.2341.00
28_R364_T2.2171.00
27_D364_T2.2141.00
405_V408_R2.1771.00
338_S341_E2.0561.00
110_V406_L2.0111.00
53_L369_G1.9541.00
22_V53_L1.9371.00
51_D371_S1.9361.00
21_A36_A1.9261.00
341_E346_N1.9241.00
27_D402_A1.9181.00
33_G36_A1.8861.00
28_R355_N1.8831.00
165_E168_A1.8601.00
24_V367_L1.8571.00
371_S397_T1.8501.00
23_V45_H1.8451.00
46_E408_R1.8421.00
346_N349_K1.8111.00
367_L400_M1.8021.00
398_L408_R1.7791.00
23_V31_A1.7731.00
359_I367_L1.7681.00
287_P290_D1.7611.00
53_L367_L1.7441.00
349_K354_E1.7311.00
299_A350_A1.7111.00
111_E407_Y1.7021.00
9_V20_G1.7011.00
7_D53_L1.6801.00
51_D369_G1.6801.00
195_E199_R1.6771.00
22_V359_I1.6741.00
5_T21_A1.6741.00
399_T407_Y1.6621.00
345_H358_R1.6461.00
32_V361_E1.6391.00
292_R338_S1.6281.00
236_H240_D1.5721.00
258_D290_D1.5561.00
345_H349_K1.5541.00
54_A57_L1.5401.00
13_A360_A1.5391.00
368_V396_V1.5321.00
6_A49_D1.5151.00
139_R142_L1.5111.00
262_A266_E1.4961.00
17_L20_G1.4951.00
21_A38_L1.4691.00
199_R203_A1.4471.00
20_G34_D1.4401.00
60_A299_A1.4071.00
270_H297_N1.4071.00
22_V367_L1.3911.00
21_A35_R1.3741.00
52_V372_T1.3661.00
23_V30_T1.3651.00
167_E204_L1.3601.00
401_V406_L1.3581.00
109_F117_V1.3561.00
29_I359_I1.3531.00
277_S280_K1.3511.00
315_A318_R1.3461.00
290_D294_R1.3431.00
54_A340_F1.3361.00
8_T17_L1.3351.00
369_G400_M1.3171.00
203_A207_E1.3151.00
349_K358_R1.3111.00
184_A187_P1.3021.00
200_G203_A1.2951.00
58_V347_G1.2871.00
204_L208_Y1.2861.00
291_Y296_I1.2821.00
31_A38_L1.2811.00
60_A347_G1.2761.00
168_A172_E1.2671.00
145_V149_K1.2511.00
270_H350_A1.2501.00
131_G135_D1.2481.00
160_D164_A1.2401.00
263_L267_T1.2351.00
369_G398_L1.2341.00
9_V22_V1.2321.00
376_R395_D1.2221.00
24_V400_M1.2151.00
168_A171_R1.2051.00
4_L24_V1.2031.00
261_R294_R1.2021.00
116_G356_V1.2021.00
194_T197_C1.1891.00
167_E171_R1.1741.00
8_T19_D1.1701.00
158_D161_A1.1681.00
6_A19_D1.1671.00
290_D293_E1.1601.00
118_V351_A1.1551.00
11_Q14_D1.1481.00
33_G37_A1.1371.00
253_C256_T1.1331.00
147_M151_S1.1281.00
20_G33_G1.1261.00
313_G316_E1.1221.00
273_H276_S1.1221.00
167_E207_E1.1161.00
299_A347_G1.1051.00
211_R352_G1.1021.00
60_A351_A1.1011.00
8_T18_Q1.1001.00
340_F344_T1.0961.00
213_H251_A1.0961.00
258_D262_A1.0891.00
103_D107_L1.0891.00
196_A199_R1.0871.00
263_L266_E1.0871.00
48_I400_M1.0811.00
272_T276_S1.0781.00
20_G32_V1.0781.00
21_A37_A1.0721.00
318_R322_L1.0701.00
259_S262_A1.0701.00
342_M346_N1.0671.00
46_E405_V1.0651.00
250_L253_C1.0631.00
299_A346_N1.0591.00
60_A272_T1.0561.00
129_A132_A1.0551.00
130_F134_A1.0511.00
146_L149_K1.0501.00
199_R240_D1.0491.00
21_A33_G1.0491.00
316_E319_Q1.0491.00
58_V116_G1.0431.00
164_A167_E1.0391.00
132_A135_D1.0381.00
312_D315_A1.0361.00
50_V53_L1.0351.00
252_H256_T1.0341.00
162_A165_E1.0321.00
370_L396_V1.0281.00
354_E363_W1.0281.00
171_R208_Y1.0271.00
4_L400_M1.0241.00
205_A212_I1.0211.00
31_A37_A1.0071.00
128_E132_A1.0011.00
253_C271_V1.0011.00
23_V44_D1.0001.00
205_A210_V0.9971.00
99_R131_G0.9971.00
265_A296_I0.9961.00
12_D345_H0.9961.00
144_K148_D0.9901.00
136_S139_R0.9871.00
321_S339_V0.9861.00
161_A165_E0.9821.00
334_L342_M0.9741.00
147_M150_D0.9661.00
355_N363_W0.9631.00
8_T52_V0.9511.00
264_L271_V0.9481.00
29_I367_L0.9421.00
269_T272_T0.9421.00
257_D260_E0.9391.00
128_E131_G0.9391.00
313_G318_R0.9391.00
16_V337_R0.9351.00
144_K150_D0.9351.00
5_T49_D0.9341.00
48_I398_L0.9331.00
7_D369_G0.9251.00
58_V356_V0.9241.00
237_W241_V0.9241.00
259_S263_L0.9211.00
316_E321_S0.9211.00
143_G147_M0.9191.00
258_D287_P0.9191.00
58_V348_A0.9171.00
161_A164_A0.9131.00
145_V148_D0.9131.00
371_S395_D0.9111.00
138_V141_R0.9111.00
133_A136_S0.9091.00
4_L367_L0.9081.00
316_E320_A0.9031.00
272_T275_P0.9031.00
163_L167_E0.9021.00
319_Q322_L0.8981.00
164_A168_A0.8951.00
143_G146_L0.8951.00
30_T361_E0.8941.00
290_D332_T0.8931.00
180_R184_A0.8911.00
297_N346_N0.8811.00
10_V52_V0.8811.00
107_L111_E0.8801.00
106_Y110_V0.8791.00
144_K149_K0.8761.00
317_M343_A0.8741.00
166_T169_L0.8731.00
318_R321_S0.8721.00
130_F133_A0.8711.00
343_A347_G0.8711.00
110_V401_V0.8701.00
337_R341_E0.8691.00
300_L342_M0.8681.00
63_H252_H0.8681.00
36_A39_A0.8651.00
183_Y187_P0.8641.00
310_T315_A0.8581.00
4_L48_I0.8511.00
368_V399_T0.8501.00
252_H257_D0.8501.00
138_V142_L0.8501.00
233_R236_H0.8501.00
314_F317_M0.8471.00
251_A254_V0.8461.00
23_V33_G0.8451.00
310_T313_G0.8451.00
44_D47_R0.8431.00
108_E111_E0.8411.00
141_R145_V0.8401.00
315_A319_Q0.8401.00
314_F318_R0.8381.00
252_H255_W0.8361.00
134_A137_G0.8321.00
182_Q187_P0.8321.00
272_T299_A0.8301.00
130_F137_G0.8301.00
310_T314_F0.8291.00
4_L53_L0.8291.00
178_D182_Q0.8271.00
129_A136_S0.8261.00
58_V351_A0.8221.00
265_A294_R0.8201.00
158_D162_A0.8201.00
63_H215_H0.8141.00
146_L150_D0.8121.00
215_H303_D0.8121.00
312_D316_E0.8101.00
148_D151_S0.8091.00
197_C200_G0.8081.00
33_G38_L0.8061.00
120_H213_H0.8011.00
145_V150_D0.7991.00
321_S325_K0.7981.00
313_G319_Q0.7931.00
64_S117_V0.7901.00
234_N238_L0.7871.00
144_K147_M0.7861.00
51_D398_L0.7831.00
252_H303_D0.7821.00
64_S105_A0.7821.00
22_V32_V0.7811.00
35_R38_L0.7761.00
198_L214_T0.7751.00
145_V151_S0.7741.00
13_A358_R0.7731.00
21_A31_A0.7731.00
256_T291_Y0.7731.00
206_D244_T0.7641.00
57_L114_T0.7611.00
345_H363_W0.7591.00
99_R135_D0.7581.00
6_A50_V0.7581.00
239_D263_L0.7561.00
13_A16_V0.7551.00
313_G320_A0.7541.00
260_E263_L0.7531.00
63_H303_D0.7511.00
236_H239_D0.7491.00
289_A292_R0.7471.00
99_R103_D0.7471.00
110_V407_Y0.7471.00
237_W240_D0.7461.00
316_E322_L0.7431.00
170_I210_V0.7431.00
180_R183_Y0.7401.00
182_Q186_T0.7391.00
7_D367_L0.7391.00
356_V366_D0.7351.00
264_L269_T0.7331.00
160_D163_L0.7291.00
169_L172_E0.7281.00
34_D37_A0.7281.00
216_A250_L0.7261.00
104_L108_E0.7261.00
374_A395_D0.7241.00
61_H303_D0.7181.00
358_R361_E0.7161.00
135_D138_V0.7161.00
250_L264_L0.7121.00
57_L343_A0.7121.00
304_G307_C0.7111.00
258_D294_R0.7101.00
276_S280_K0.7091.00
20_G35_R0.7091.00
61_H215_H0.7081.00
371_S374_A0.7081.00
196_A200_G0.7081.00
338_S342_M0.7071.00
131_G134_A0.7061.00
313_G317_M0.7031.00
171_R175_G0.7031.00
104_L107_L0.7011.00
264_L267_T0.6991.00
235_I239_D0.6991.00
159_T162_A0.6991.00
110_V399_T0.6971.00
318_R323_L0.6961.00
170_I174_D0.6951.00
396_V399_T0.6941.00
311_L316_E0.6921.00
313_G322_L0.6911.00
235_I238_L0.6911.00
23_V36_A0.6901.00
271_V274_C0.6861.00
180_R185_I0.6851.00
314_F319_Q0.6851.00
261_R291_Y0.6841.00
314_F321_S0.6831.00
178_D181_I0.6821.00
116_G366_D0.6821.00
132_A136_S0.6811.00
143_G148_D0.6751.00
202_R206_D0.6731.00
316_E323_L0.6731.00
236_H259_S0.6721.00
143_G149_K0.6701.00
24_V30_T0.6701.00
319_Q323_L0.6691.00
310_T316_E0.6661.00
99_R132_A0.6661.00
274_C301_G0.6641.00
19_D35_R0.6631.00
202_R212_I0.6611.00
31_A39_A0.6601.00
10_V340_F0.6581.00
277_S281_L0.6571.00
142_L149_K0.6571.00
323_L326_V0.6561.00
144_K151_S0.6561.00
348_A357_G0.6561.00
286_A290_D0.6551.00
374_A397_T0.6541.00
129_A134_A0.6521.00
5_T35_R0.6501.00
64_S106_Y0.6491.00
234_N237_W0.6471.00
262_A265_A0.6421.00
199_R241_V0.6421.00
276_S319_Q0.6401.00
311_L318_R0.6381.00
162_A166_T0.6381.00
59_G302_T0.6341.00
251_A256_T0.6331.00
115_T399_T0.6291.00
108_E112_S0.6231.00
133_A140_A0.6191.00
62_V109_F0.6191.00
59_G62_V0.6191.00
321_S324_G0.6181.00
20_G359_I0.6181.00
345_H354_E0.6171.00
35_R39_A0.6171.00
133_A138_V0.6171.00
180_R187_P0.6171.00
233_R260_E0.6151.00
283_S286_A0.6141.00
312_D319_Q0.6141.00
274_C277_S0.6111.00
17_L337_R0.6111.00
356_V363_W0.6101.00
8_T373_D0.6101.00
314_F320_A0.6081.00
373_D376_R0.6081.00
116_G351_A0.6081.00
195_E240_D0.6061.00
139_R143_G0.6051.00
312_D318_R0.6011.00
129_A133_A0.6011.00
200_G204_L0.6001.00
261_R264_L0.6001.00
217_S254_V0.5991.00
398_L407_Y0.5971.00
320_A323_L0.5971.00
32_V359_I0.5971.00
366_D402_A0.5961.00
238_L242_G0.5911.00
135_D139_R0.5901.00
178_D184_A0.5901.00
10_V17_L0.5901.00
152_P156_Q0.5891.00
258_D261_R0.5881.00
270_H299_A0.5871.00
242_G245_G0.5871.00
10_V16_V0.5861.00
163_L200_G0.5841.00
18_Q34_D0.5811.00
251_A255_W0.5801.00
251_A272_T0.5781.00
100_A103_D0.5771.00
167_E208_Y0.5761.00
336_A375_A0.5751.00
261_R290_D0.5741.00
174_D210_V0.5741.00
271_V296_I0.5741.00
64_S119_D0.5731.00
195_E237_W0.5721.00
206_D248_V0.5711.00
270_H274_C0.5701.00
285_V289_A0.5701.00
116_G353_F0.5691.00
141_R146_L0.5691.00
313_G321_S0.5661.00
165_E169_L0.5661.00
19_D34_D0.5651.00
181_I185_I0.5641.00
62_V117_V0.5631.00
330_D333_A0.5631.00
298_V342_M0.5621.00
189_F192_S0.5601.00
179_G183_Y0.5601.00
269_T273_H0.5591.00
57_L368_V0.5571.00
215_H252_H0.5561.00
233_R237_W0.5561.00
146_L151_S0.5561.00
29_I363_W0.5541.00
315_A320_A0.5501.00
203_A206_D0.5491.00
179_G182_Q0.5471.00
178_D183_Y0.5441.00
282_A285_V0.5431.00
97_E100_A0.5401.00
13_A17_L0.5391.00
188_R192_S0.5381.00
289_A338_S0.5381.00
236_H263_L0.5371.00
12_D341_E0.5361.00
366_D401_V0.5361.00
12_D337_R0.5351.00
239_D242_G0.5351.00
169_L173_W0.5341.00
268_G297_N0.5341.00
319_Q325_K0.5321.00
50_V398_L0.5321.00
256_T287_P0.5321.00
348_A363_W0.5311.00
141_R144_K0.5301.00
158_D163_L0.5301.00
378_T381_H0.5301.00
140_A143_G0.5301.00
317_M320_A0.5291.00
319_Q324_G0.5291.00
12_D340_F0.5281.00
100_A105_A0.5271.00
253_C264_L0.5271.00
22_V29_I0.5251.00
5_T39_A0.5251.00
249_V272_T0.5241.00
183_Y186_T0.5231.00
31_A36_A0.5231.00
143_G150_D0.5221.00
13_A345_H0.5201.00
277_S282_A0.5201.00
322_L325_K0.5201.00
109_F114_T0.5191.00
178_D185_I0.5181.00
188_R191_V0.5161.00
312_D323_L0.5151.00
57_L340_F0.5151.00
310_T321_S0.5141.00
114_T313_G0.5131.00
178_D186_T0.5131.00
137_G141_R0.5131.00
16_V19_D0.5121.00
273_H288_V0.5121.00
61_H252_H0.5121.00
238_L241_V0.5111.00
346_N350_A0.5101.00
372_T381_H0.5101.00
293_E338_S0.5071.00
10_V337_R0.5071.00
115_T366_D0.5061.00
271_V276_S0.5051.00
310_T319_Q0.5051.00
48_I405_V0.5051.00
347_G350_A0.5041.00
120_H251_A0.5031.00
254_V257_D0.5031.00
292_R334_L0.5011.00
312_D320_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dzhA 2 0.9861 100 0.283 Contact Map
3ls9A 2 0.9861 100 0.288 Contact Map
2pajA 2 0.9026 100 0.289 Contact Map
3lnpA 2 0.9861 100 0.291 Contact Map
4gbdA 2 0.9814 100 0.306 Contact Map
4v1xA 5 0.9884 100 0.311 Contact Map
4f0rA 2 0.9838 100 0.312 Contact Map
3hpaA 2 0.949 100 0.317 Contact Map
1p1mA 2 0.9304 100 0.322 Contact Map
2i9uA 2 0.9304 100 0.333 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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