Q9HQE0 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HQE0 - Uncharacterized protein

UniProt:	Q9HQE0	Sequences: MTLLTADTVVQDADRVLQDGAVVVVDDRITAVGDRAALADAHPDHERIDVDVLAPGLVGAHVHSVQSLGRGIADDQELLDWLFDHVLPMEAGLDAAEMRAAADLAYLEFVESGTTGVVDHLSVDHAGEAFGAAADSGVRARLGKVLMDKDSPDGLQEDTDAALAETEALIREWDGACDGRIQYAITPRFAVSCTEACLRGCRALADEYGVRIHTHASENQGEIETVETETGKRNIHWLDDVGLTGEDVVLAHCVWTDDSERALLAETGTHVTHCPSSNMKLASGVAPVADYRERGINVALGTDGPPCNNTLDGFAEMRQASLLGKVDALDPTALPARSVFEMATHNGAKAAGFENVGRIAEGWTADLVGLSTDAARSTPIHDPYSHLVYAAHGDDVTLTMVAGDVLYRDGAHVRMDAPAIRERAREFAAEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	431 (345)
Sequences:	29043 (22410)
Seq/√Len:	1206.5

ECOLI - SSNA GUAD CODA YAHJ PHNM IADA ALLB PHYDA
BACSU - HUTI YTCJ ALLB NAGA PYRC
HALSA - Q9HQE0 MTAD HUTI Q9HHS1 Q9HNZ2 PYRC
SULSO - Q7LXN1 Q97V65 Q97XD4 Q97WS6 Q97VT3 Q97W09 Q980B7 PYRC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
400_M	405_V	4.952	1.00
358_R	363_W	4.229	1.00
51_D	397_T	4.098	1.00
25_V	30_T	3.916	1.00
398_L	405_V	3.913	1.00
4_L	50_V	3.391	1.00
5_T	47_R	3.064	1.00
54_A	370_L	3.007	1.00
335_P	338_S	2.969	1.00
360_A	363_W	2.936	1.00
56_G	115_T	2.892	1.00
50_V	369_G	2.845	1.00
7_D	50_V	2.809	1.00
364_T	402_A	2.772	1.00
31_A	361_E	2.695	1.00
356_V	364_T	2.642	1.00
289_A	293_E	2.626	1.00
341_E	345_H	2.531	1.00
355_N	364_T	2.415	1.00
353_F	356_V	2.406	1.00
297_N	349_K	2.290	1.00
262_A	294_R	2.288	1.00
204_L	207_E	2.269	1.00
239_D	267_T	2.243	1.00
54_A	368_V	2.234	1.00
28_R	364_T	2.217	1.00
27_D	364_T	2.214	1.00
405_V	408_R	2.177	1.00
338_S	341_E	2.056	1.00
110_V	406_L	2.011	1.00
53_L	369_G	1.954	1.00
22_V	53_L	1.937	1.00
51_D	371_S	1.936	1.00
21_A	36_A	1.926	1.00
341_E	346_N	1.924	1.00
27_D	402_A	1.918	1.00
33_G	36_A	1.886	1.00
28_R	355_N	1.883	1.00
165_E	168_A	1.860	1.00
24_V	367_L	1.857	1.00
371_S	397_T	1.850	1.00
23_V	45_H	1.845	1.00
46_E	408_R	1.842	1.00
346_N	349_K	1.811	1.00
367_L	400_M	1.802	1.00
398_L	408_R	1.779	1.00
23_V	31_A	1.773	1.00
359_I	367_L	1.768	1.00
287_P	290_D	1.761	1.00
53_L	367_L	1.744	1.00
349_K	354_E	1.731	1.00
299_A	350_A	1.711	1.00
111_E	407_Y	1.702	1.00
9_V	20_G	1.701	1.00
7_D	53_L	1.680	1.00
51_D	369_G	1.680	1.00
195_E	199_R	1.677	1.00
22_V	359_I	1.674	1.00
5_T	21_A	1.674	1.00
399_T	407_Y	1.662	1.00
345_H	358_R	1.646	1.00
32_V	361_E	1.639	1.00
292_R	338_S	1.628	1.00
236_H	240_D	1.572	1.00
258_D	290_D	1.556	1.00
345_H	349_K	1.554	1.00
54_A	57_L	1.540	1.00
13_A	360_A	1.539	1.00
368_V	396_V	1.532	1.00
6_A	49_D	1.515	1.00
139_R	142_L	1.511	1.00
262_A	266_E	1.496	1.00
17_L	20_G	1.495	1.00
21_A	38_L	1.469	1.00
199_R	203_A	1.447	1.00
20_G	34_D	1.440	1.00
60_A	299_A	1.407	1.00
270_H	297_N	1.407	1.00
22_V	367_L	1.391	1.00
21_A	35_R	1.374	1.00
52_V	372_T	1.366	1.00
23_V	30_T	1.365	1.00
167_E	204_L	1.360	1.00
401_V	406_L	1.358	1.00
109_F	117_V	1.356	1.00
29_I	359_I	1.353	1.00
277_S	280_K	1.351	1.00
315_A	318_R	1.346	1.00
290_D	294_R	1.343	1.00
54_A	340_F	1.336	1.00
8_T	17_L	1.335	1.00
369_G	400_M	1.317	1.00
203_A	207_E	1.315	1.00
349_K	358_R	1.311	1.00
184_A	187_P	1.302	1.00
200_G	203_A	1.295	1.00
58_V	347_G	1.287	1.00
204_L	208_Y	1.286	1.00
291_Y	296_I	1.282	1.00
31_A	38_L	1.281	1.00
60_A	347_G	1.276	1.00
168_A	172_E	1.267	1.00
145_V	149_K	1.251	1.00
270_H	350_A	1.250	1.00
131_G	135_D	1.248	1.00
160_D	164_A	1.240	1.00
263_L	267_T	1.235	1.00
369_G	398_L	1.234	1.00
9_V	22_V	1.232	1.00
376_R	395_D	1.222	1.00
24_V	400_M	1.215	1.00
168_A	171_R	1.205	1.00
4_L	24_V	1.203	1.00
261_R	294_R	1.202	1.00
116_G	356_V	1.202	1.00
194_T	197_C	1.189	1.00
167_E	171_R	1.174	1.00
8_T	19_D	1.170	1.00
158_D	161_A	1.168	1.00
6_A	19_D	1.167	1.00
290_D	293_E	1.160	1.00
118_V	351_A	1.155	1.00
11_Q	14_D	1.148	1.00
33_G	37_A	1.137	1.00
253_C	256_T	1.133	1.00
147_M	151_S	1.128	1.00
20_G	33_G	1.126	1.00
313_G	316_E	1.122	1.00
273_H	276_S	1.122	1.00
167_E	207_E	1.116	1.00
299_A	347_G	1.105	1.00
211_R	352_G	1.102	1.00
60_A	351_A	1.101	1.00
8_T	18_Q	1.100	1.00
340_F	344_T	1.096	1.00
213_H	251_A	1.096	1.00
258_D	262_A	1.089	1.00
103_D	107_L	1.089	1.00
196_A	199_R	1.087	1.00
263_L	266_E	1.087	1.00
48_I	400_M	1.081	1.00
272_T	276_S	1.078	1.00
20_G	32_V	1.078	1.00
21_A	37_A	1.072	1.00
318_R	322_L	1.070	1.00
259_S	262_A	1.070	1.00
342_M	346_N	1.067	1.00
46_E	405_V	1.065	1.00
250_L	253_C	1.063	1.00
299_A	346_N	1.059	1.00
60_A	272_T	1.056	1.00
129_A	132_A	1.055	1.00
130_F	134_A	1.051	1.00
146_L	149_K	1.050	1.00
199_R	240_D	1.049	1.00
21_A	33_G	1.049	1.00
316_E	319_Q	1.049	1.00
58_V	116_G	1.043	1.00
164_A	167_E	1.039	1.00
132_A	135_D	1.038	1.00
312_D	315_A	1.036	1.00
50_V	53_L	1.035	1.00
252_H	256_T	1.034	1.00
162_A	165_E	1.032	1.00
370_L	396_V	1.028	1.00
354_E	363_W	1.028	1.00
171_R	208_Y	1.027	1.00
4_L	400_M	1.024	1.00
205_A	212_I	1.021	1.00
31_A	37_A	1.007	1.00
128_E	132_A	1.001	1.00
253_C	271_V	1.001	1.00
23_V	44_D	1.000	1.00
205_A	210_V	0.997	1.00
99_R	131_G	0.997	1.00
265_A	296_I	0.996	1.00
12_D	345_H	0.996	1.00
144_K	148_D	0.990	1.00
136_S	139_R	0.987	1.00
321_S	339_V	0.986	1.00
161_A	165_E	0.982	1.00
334_L	342_M	0.974	1.00
147_M	150_D	0.966	1.00
355_N	363_W	0.963	1.00
8_T	52_V	0.951	1.00
264_L	271_V	0.948	1.00
29_I	367_L	0.942	1.00
269_T	272_T	0.942	1.00
257_D	260_E	0.939	1.00
128_E	131_G	0.939	1.00
313_G	318_R	0.939	1.00
16_V	337_R	0.935	1.00
144_K	150_D	0.935	1.00
5_T	49_D	0.934	1.00
48_I	398_L	0.933	1.00
7_D	369_G	0.925	1.00
58_V	356_V	0.924	1.00
237_W	241_V	0.924	1.00
259_S	263_L	0.921	1.00
316_E	321_S	0.921	1.00
143_G	147_M	0.919	1.00
258_D	287_P	0.919	1.00
58_V	348_A	0.917	1.00
161_A	164_A	0.913	1.00
145_V	148_D	0.913	1.00
371_S	395_D	0.911	1.00
138_V	141_R	0.911	1.00
133_A	136_S	0.909	1.00
4_L	367_L	0.908	1.00
316_E	320_A	0.903	1.00
272_T	275_P	0.903	1.00
163_L	167_E	0.902	1.00
319_Q	322_L	0.898	1.00
164_A	168_A	0.895	1.00
143_G	146_L	0.895	1.00
30_T	361_E	0.894	1.00
290_D	332_T	0.893	1.00
180_R	184_A	0.891	1.00
297_N	346_N	0.881	1.00
10_V	52_V	0.881	1.00
107_L	111_E	0.880	1.00
106_Y	110_V	0.879	1.00
144_K	149_K	0.876	1.00
317_M	343_A	0.874	1.00
166_T	169_L	0.873	1.00
318_R	321_S	0.872	1.00
130_F	133_A	0.871	1.00
343_A	347_G	0.871	1.00
110_V	401_V	0.870	1.00
337_R	341_E	0.869	1.00
300_L	342_M	0.868	1.00
63_H	252_H	0.868	1.00
36_A	39_A	0.865	1.00
183_Y	187_P	0.864	1.00
310_T	315_A	0.858	1.00
4_L	48_I	0.851	1.00
368_V	399_T	0.850	1.00
252_H	257_D	0.850	1.00
138_V	142_L	0.850	1.00
233_R	236_H	0.850	1.00
314_F	317_M	0.847	1.00
251_A	254_V	0.846	1.00
23_V	33_G	0.845	1.00
310_T	313_G	0.845	1.00
44_D	47_R	0.843	1.00
108_E	111_E	0.841	1.00
141_R	145_V	0.840	1.00
315_A	319_Q	0.840	1.00
314_F	318_R	0.838	1.00
252_H	255_W	0.836	1.00
134_A	137_G	0.832	1.00
182_Q	187_P	0.832	1.00
272_T	299_A	0.830	1.00
130_F	137_G	0.830	1.00
310_T	314_F	0.829	1.00
4_L	53_L	0.829	1.00
178_D	182_Q	0.827	1.00
129_A	136_S	0.826	1.00
58_V	351_A	0.822	1.00
265_A	294_R	0.820	1.00
158_D	162_A	0.820	1.00
63_H	215_H	0.814	1.00
146_L	150_D	0.812	1.00
215_H	303_D	0.812	1.00
312_D	316_E	0.810	1.00
148_D	151_S	0.809	1.00
197_C	200_G	0.808	1.00
33_G	38_L	0.806	1.00
120_H	213_H	0.801	1.00
145_V	150_D	0.799	1.00
321_S	325_K	0.798	1.00
313_G	319_Q	0.793	1.00
64_S	117_V	0.790	1.00
234_N	238_L	0.787	1.00
144_K	147_M	0.786	1.00
51_D	398_L	0.783	1.00
252_H	303_D	0.782	1.00
64_S	105_A	0.782	1.00
22_V	32_V	0.781	1.00
35_R	38_L	0.776	1.00
198_L	214_T	0.775	1.00
145_V	151_S	0.774	1.00
13_A	358_R	0.773	1.00
21_A	31_A	0.773	1.00
256_T	291_Y	0.773	1.00
206_D	244_T	0.764	1.00
57_L	114_T	0.761	1.00
345_H	363_W	0.759	1.00
99_R	135_D	0.758	1.00
6_A	50_V	0.758	1.00
239_D	263_L	0.756	1.00
13_A	16_V	0.755	1.00
313_G	320_A	0.754	1.00
260_E	263_L	0.753	1.00
63_H	303_D	0.751	1.00
236_H	239_D	0.749	1.00
289_A	292_R	0.747	1.00
99_R	103_D	0.747	1.00
110_V	407_Y	0.747	1.00
237_W	240_D	0.746	1.00
316_E	322_L	0.743	1.00
170_I	210_V	0.743	1.00
180_R	183_Y	0.740	1.00
182_Q	186_T	0.739	1.00
7_D	367_L	0.739	1.00
356_V	366_D	0.735	1.00
264_L	269_T	0.733	1.00
160_D	163_L	0.729	1.00
169_L	172_E	0.728	1.00
34_D	37_A	0.728	1.00
216_A	250_L	0.726	1.00
104_L	108_E	0.726	1.00
374_A	395_D	0.724	1.00
61_H	303_D	0.718	1.00
358_R	361_E	0.716	1.00
135_D	138_V	0.716	1.00
250_L	264_L	0.712	1.00
57_L	343_A	0.712	1.00
304_G	307_C	0.711	1.00
258_D	294_R	0.710	1.00
276_S	280_K	0.709	1.00
20_G	35_R	0.709	1.00
61_H	215_H	0.708	1.00
371_S	374_A	0.708	1.00
196_A	200_G	0.708	1.00
338_S	342_M	0.707	1.00
131_G	134_A	0.706	1.00
313_G	317_M	0.703	1.00
171_R	175_G	0.703	1.00
104_L	107_L	0.701	1.00
264_L	267_T	0.699	1.00
235_I	239_D	0.699	1.00
159_T	162_A	0.699	1.00
110_V	399_T	0.697	1.00
318_R	323_L	0.696	1.00
170_I	174_D	0.695	1.00
396_V	399_T	0.694	1.00
311_L	316_E	0.692	1.00
313_G	322_L	0.691	1.00
235_I	238_L	0.691	1.00
23_V	36_A	0.690	1.00
271_V	274_C	0.686	1.00
180_R	185_I	0.685	1.00
314_F	319_Q	0.685	1.00
261_R	291_Y	0.684	1.00
314_F	321_S	0.683	1.00
178_D	181_I	0.682	1.00
116_G	366_D	0.682	1.00
132_A	136_S	0.681	1.00
143_G	148_D	0.675	1.00
202_R	206_D	0.673	1.00
316_E	323_L	0.673	1.00
236_H	259_S	0.672	1.00
143_G	149_K	0.670	1.00
24_V	30_T	0.670	1.00
319_Q	323_L	0.669	1.00
310_T	316_E	0.666	1.00
99_R	132_A	0.666	1.00
274_C	301_G	0.664	1.00
19_D	35_R	0.663	1.00
202_R	212_I	0.661	1.00
31_A	39_A	0.660	1.00
10_V	340_F	0.658	1.00
277_S	281_L	0.657	1.00
142_L	149_K	0.657	1.00
323_L	326_V	0.656	1.00
144_K	151_S	0.656	1.00
348_A	357_G	0.656	1.00
286_A	290_D	0.655	1.00
374_A	397_T	0.654	1.00
129_A	134_A	0.652	1.00
5_T	35_R	0.650	1.00
64_S	106_Y	0.649	1.00
234_N	237_W	0.647	1.00
262_A	265_A	0.642	1.00
199_R	241_V	0.642	1.00
276_S	319_Q	0.640	1.00
311_L	318_R	0.638	1.00
162_A	166_T	0.638	1.00
59_G	302_T	0.634	1.00
251_A	256_T	0.633	1.00
115_T	399_T	0.629	1.00
108_E	112_S	0.623	1.00
133_A	140_A	0.619	1.00
62_V	109_F	0.619	1.00
59_G	62_V	0.619	1.00
321_S	324_G	0.618	1.00
20_G	359_I	0.618	1.00
345_H	354_E	0.617	1.00
35_R	39_A	0.617	1.00
133_A	138_V	0.617	1.00
180_R	187_P	0.617	1.00
233_R	260_E	0.615	1.00
283_S	286_A	0.614	1.00
312_D	319_Q	0.614	1.00
274_C	277_S	0.611	1.00
17_L	337_R	0.611	1.00
356_V	363_W	0.610	1.00
8_T	373_D	0.610	1.00
314_F	320_A	0.608	1.00
373_D	376_R	0.608	1.00
116_G	351_A	0.608	1.00
195_E	240_D	0.606	1.00
139_R	143_G	0.605	1.00
312_D	318_R	0.601	1.00
129_A	133_A	0.601	1.00
200_G	204_L	0.600	1.00
261_R	264_L	0.600	1.00
217_S	254_V	0.599	1.00
398_L	407_Y	0.597	1.00
320_A	323_L	0.597	1.00
32_V	359_I	0.597	1.00
366_D	402_A	0.596	1.00
238_L	242_G	0.591	1.00
135_D	139_R	0.590	1.00
178_D	184_A	0.590	1.00
10_V	17_L	0.590	1.00
152_P	156_Q	0.589	1.00
258_D	261_R	0.588	1.00
270_H	299_A	0.587	1.00
242_G	245_G	0.587	1.00
10_V	16_V	0.586	1.00
163_L	200_G	0.584	1.00
18_Q	34_D	0.581	1.00
251_A	255_W	0.580	1.00
251_A	272_T	0.578	1.00
100_A	103_D	0.577	1.00
167_E	208_Y	0.576	1.00
336_A	375_A	0.575	1.00
261_R	290_D	0.574	1.00
174_D	210_V	0.574	1.00
271_V	296_I	0.574	1.00
64_S	119_D	0.573	1.00
195_E	237_W	0.572	1.00
206_D	248_V	0.571	1.00
270_H	274_C	0.570	1.00
285_V	289_A	0.570	1.00
116_G	353_F	0.569	1.00
141_R	146_L	0.569	1.00
313_G	321_S	0.566	1.00
165_E	169_L	0.566	1.00
19_D	34_D	0.565	1.00
181_I	185_I	0.564	1.00
62_V	117_V	0.563	1.00
330_D	333_A	0.563	1.00
298_V	342_M	0.562	1.00
189_F	192_S	0.560	1.00
179_G	183_Y	0.560	1.00
269_T	273_H	0.559	1.00
57_L	368_V	0.557	1.00
215_H	252_H	0.556	1.00
233_R	237_W	0.556	1.00
146_L	151_S	0.556	1.00
29_I	363_W	0.554	1.00
315_A	320_A	0.550	1.00
203_A	206_D	0.549	1.00
179_G	182_Q	0.547	1.00
178_D	183_Y	0.544	1.00
282_A	285_V	0.543	1.00
97_E	100_A	0.540	1.00
13_A	17_L	0.539	1.00
188_R	192_S	0.538	1.00
289_A	338_S	0.538	1.00
236_H	263_L	0.537	1.00
12_D	341_E	0.536	1.00
366_D	401_V	0.536	1.00
12_D	337_R	0.535	1.00
239_D	242_G	0.535	1.00
169_L	173_W	0.534	1.00
268_G	297_N	0.534	1.00
319_Q	325_K	0.532	1.00
50_V	398_L	0.532	1.00
256_T	287_P	0.532	1.00
348_A	363_W	0.531	1.00
141_R	144_K	0.530	1.00
158_D	163_L	0.530	1.00
378_T	381_H	0.530	1.00
140_A	143_G	0.530	1.00
317_M	320_A	0.529	1.00
319_Q	324_G	0.529	1.00
12_D	340_F	0.528	1.00
100_A	105_A	0.527	1.00
253_C	264_L	0.527	1.00
22_V	29_I	0.525	1.00
5_T	39_A	0.525	1.00
249_V	272_T	0.524	1.00
183_Y	186_T	0.523	1.00
31_A	36_A	0.523	1.00
143_G	150_D	0.522	1.00
13_A	345_H	0.520	1.00
277_S	282_A	0.520	1.00
322_L	325_K	0.520	1.00
109_F	114_T	0.519	1.00
178_D	185_I	0.518	1.00
188_R	191_V	0.516	1.00
312_D	323_L	0.515	1.00
57_L	340_F	0.515	1.00
310_T	321_S	0.514	1.00
114_T	313_G	0.513	1.00
178_D	186_T	0.513	1.00
137_G	141_R	0.513	1.00
16_V	19_D	0.512	1.00
273_H	288_V	0.512	1.00
61_H	252_H	0.512	1.00
238_L	241_V	0.511	1.00
346_N	350_A	0.510	1.00
372_T	381_H	0.510	1.00
293_E	338_S	0.507	1.00
10_V	337_R	0.507	1.00
115_T	366_D	0.506	1.00
271_V	276_S	0.505	1.00
310_T	319_Q	0.505	1.00
48_I	405_V	0.505	1.00
347_G	350_A	0.504	1.00
120_H	251_A	0.503	1.00
254_V	257_D	0.503	1.00
292_R	334_L	0.501	1.00
312_D	320_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4dzhA	2	0.9861	100	0.283	Contact Map
3ls9A	2	0.9861	100	0.288	Contact Map
2pajA	2	0.9026	100	0.289	Contact Map
3lnpA	2	0.9861	100	0.291	Contact Map
4gbdA	2	0.9814	100	0.306	Contact Map
4v1xA	5	0.9884	100	0.311	Contact Map
4f0rA	2	0.9838	100	0.312	Contact Map
3hpaA	2	0.949	100	0.317	Contact Map
1p1mA	2	0.9304	100	0.322	Contact Map
2i9uA	2	0.9304	100	0.333	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.