GREMLIN Database
Q9HQD9 - Uncharacterized protein
UniProt: Q9HQD9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (197)
Sequences: 1864 (1481)
Seq/√Len: 105.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_Y200_E4.3211.00
176_T181_L4.0881.00
163_A167_A3.8271.00
160_V185_F3.4611.00
167_A181_L3.2941.00
188_A191_T3.1331.00
87_L92_C3.0711.00
167_A184_R2.9851.00
191_T195_H2.9741.00
171_E175_E2.9021.00
156_R195_H2.8721.00
176_T180_A2.8371.00
92_C111_A2.8201.00
177_T180_A2.7641.00
165_V205_R2.7141.00
19_T103_G2.5091.00
163_A181_L2.4571.00
178_T192_L2.2491.00
156_R160_V2.2021.00
158_A162_R2.0861.00
172_R193_E2.0371.00
156_R159_A1.9611.00
187_I192_L1.9551.00
63_E68_V1.9011.00
195_H198_R1.8921.00
32_D35_D1.8701.00
161_L204_A1.8281.00
7_R104_Q1.8201.00
57_I60_R1.7671.00
63_E69_A1.7411.00
95_V110_L1.7111.00
160_V195_H1.6921.00
6_L109_V1.6631.00
178_T193_E1.6511.00
189_R193_E1.6191.00
181_L192_L1.5651.00
174_R197_R1.5281.00
195_H202_K1.4671.00
204_A207_A1.4051.00
44_V47_V1.4001.00
63_E71_T1.3851.00
113_S116_A1.3531.00
119_D122_H1.3500.99
203_L207_A1.3370.99
160_V187_I1.3350.99
124_L128_Y1.3280.99
28_L31_N1.3190.99
172_R194_E1.2820.99
169_Y174_R1.2700.99
63_E70_V1.2700.99
4_A10_G1.2610.99
180_A183_D1.2580.99
7_R131_T1.2580.99
70_V73_A1.2450.99
178_T195_H1.2380.99
176_T184_R1.2300.99
44_V48_L1.2250.99
165_V208_V1.2250.99
85_D89_A1.2250.99
15_Y18_A1.2210.99
161_L170_Y1.2200.99
182_A192_L1.2160.99
190_S194_E1.2080.99
17_A22_T1.2040.99
169_Y178_T1.1970.99
191_T196_L1.1940.99
121_Y130_I1.1840.99
168_G175_E1.1740.99
201_G205_R1.1310.98
196_L200_E1.1250.98
160_V199_A1.1240.98
15_Y19_T1.1230.98
48_L70_V1.1220.98
162_R166_D1.1150.98
51_V60_R1.1130.98
170_Y196_L1.1100.98
160_V181_L1.1060.98
165_V170_Y1.1060.98
65_D68_V1.1010.98
38_E69_A1.0940.98
194_E198_R1.0820.98
153_L199_A1.0780.98
183_D186_D1.0750.97
191_T194_E1.0680.97
7_R133_A1.0670.97
159_A162_R1.0620.97
172_R197_R1.0570.97
26_M198_R1.0500.97
172_R190_S1.0430.97
170_Y199_A1.0430.97
150_A207_A1.0360.97
37_L94_L1.0300.97
17_A54_R1.0270.97
116_A119_D1.0230.97
160_V192_L1.0180.96
97_P170_Y1.0130.96
62_T69_A0.9890.96
111_A131_T0.9870.96
203_L206_A0.9860.96
110_L170_Y0.9790.96
94_L109_V0.9590.95
179_A189_R0.9500.95
6_L121_Y0.9490.95
106_H133_A0.9470.95
82_G85_D0.9460.95
61_V176_T0.9400.95
68_V71_T0.9390.94
4_A117_L0.9370.94
91_G113_S0.9350.94
161_L208_V0.9330.94
167_A176_T0.9320.94
62_T67_T0.9290.94
152_D206_A0.9280.94
43_G46_R0.9240.94
62_T70_V0.9220.94
189_R198_R0.9200.94
44_V68_V0.9140.94
132_V135_K0.9100.94
135_K169_Y0.9070.93
188_A197_R0.9030.93
178_T189_R0.8830.92
33_H98_L0.8720.92
165_V204_A0.8720.92
32_D183_D0.8710.92
181_L185_F0.8630.92
28_L37_L0.8610.91
29_W38_E0.8590.91
191_T199_A0.8580.91
143_S151_A0.8540.91
63_E73_A0.8480.91
170_Y178_T0.8430.91
178_T191_T0.8410.91
156_R194_E0.8350.90
49_A85_D0.8340.90
17_A21_N0.8320.90
172_R201_G0.8270.90
90_H123_A0.8270.90
91_G123_A0.8240.90
163_A184_R0.8180.89
120_V194_E0.8130.89
58_R61_V0.8100.89
46_R49_A0.8100.89
111_A170_Y0.8050.89
162_R208_V0.8020.88
46_R66_T0.7950.88
167_A192_L0.7950.88
121_Y191_T0.7950.88
172_R179_A0.7940.88
185_F192_L0.7870.87
88_A181_L0.7830.87
40_S46_R0.7830.87
99_T106_H0.7700.86
28_L114_P0.7700.86
118_T121_Y0.7690.86
81_D170_Y0.7680.86
73_A170_Y0.7670.86
19_T102_D0.7670.86
171_E201_G0.7600.85
54_R57_I0.7580.85
26_M39_V0.7540.85
19_T22_T0.7520.85
140_A171_E0.7490.85
94_L119_D0.7450.84
179_A197_R0.7250.83
134_D181_L0.7200.82
122_H126_A0.7190.82
159_A163_A0.7140.82
37_L72_E0.7110.81
39_V47_V0.7040.81
117_L159_A0.7010.81
46_R50_A0.6960.80
186_D194_E0.6920.80
57_I74_C0.6880.79
69_A73_A0.6880.79
56_G95_V0.6830.79
10_G13_S0.6800.79
156_R200_E0.6780.78
135_K190_S0.6760.78
47_V68_V0.6760.78
97_P200_E0.6750.78
72_E94_L0.6710.78
198_R201_G0.6700.78
45_A48_L0.6690.77
63_E76_R0.6680.77
112_L125_R0.6670.77
12_G77_A0.6670.77
27_Q30_C0.6660.77
174_R203_L0.6660.77
20_A82_G0.6580.76
199_A204_A0.6570.76
47_V175_E0.6550.76
131_T139_S0.6550.76
46_R67_T0.6550.76
103_G126_A0.6550.76
48_L60_R0.6540.76
198_R203_L0.6520.76
143_S155_A0.6520.76
30_C74_C0.6510.75
172_R195_H0.6490.75
92_C141_P0.6460.75
87_L107_L0.6460.75
152_D205_R0.6460.75
161_L199_A0.6430.75
6_L9_A0.6390.74
98_L107_L0.6340.74
100_Y105_K0.6340.74
69_A190_S0.6340.74
163_A185_F0.6340.74
73_A76_R0.6330.73
94_L150_A0.6270.73
118_T191_T0.6260.73
92_C97_P0.6190.72
86_T127_D0.6180.72
150_A160_V0.6140.71
88_A140_A0.6140.71
191_T198_R0.6130.71
45_A49_A0.6100.71
23_D77_A0.6090.71
90_H154_T0.6080.70
132_V187_I0.6070.70
28_L110_L0.6040.70
38_E41_G0.6040.70
168_G171_E0.6030.70
204_A208_V0.6010.70
187_I195_H0.6010.70
168_G193_E0.5990.69
64_G199_A0.5990.69
77_A131_T0.5970.69
17_A20_A0.5960.69
20_A166_D0.5950.69
176_T192_L0.5940.69
16_A19_T0.5940.69
113_S158_A0.5920.68
155_A165_V0.5890.68
45_A58_R0.5880.68
112_L155_A0.5860.68
24_A41_G0.5860.68
49_A143_S0.5840.67
51_V198_R0.5830.67
117_L135_K0.5780.67
154_T202_K0.5770.66
84_E192_L0.5770.66
114_P135_K0.5760.66
137_E152_D0.5760.66
38_E190_S0.5720.66
187_I190_S0.5710.66
97_P166_D0.5700.66
117_L181_L0.5670.65
10_G107_L0.5640.65
177_T192_L0.5550.63
125_R187_I0.5520.63
62_T71_T0.5510.63
42_G115_A0.5500.63
74_C84_E0.5480.63
16_A22_T0.5440.62
92_C98_L0.5420.62
27_Q49_A0.5410.62
10_G14_A0.5390.61
11_S167_A0.5380.61
178_T199_A0.5370.61
40_S133_A0.5370.61
26_M154_T0.5370.61
52_D60_R0.5360.61
9_A13_S0.5340.61
29_W93_L0.5330.60
163_A176_T0.5330.60
159_A187_I0.5320.60
111_A120_V0.5320.60
47_V55_V0.5320.60
12_G129_E0.5320.60
25_R150_A0.5290.60
85_D91_G0.5280.60
84_E94_L0.5280.60
31_N125_R0.5260.59
45_A60_R0.5260.59
109_V113_S0.5250.59
24_A39_V0.5240.59
191_T207_A0.5190.58
87_L130_I0.5190.58
27_Q205_R0.5190.58
156_R191_T0.5180.58
38_E42_G0.5140.58
43_G51_V0.5140.58
58_R75_L0.5130.58
169_Y196_L0.5120.57
95_V177_T0.5090.57
36_L98_L0.5050.56
150_A158_A0.5040.56
51_V54_R0.5030.56
23_D29_W0.5030.56
80_A87_L0.5020.56
62_T66_T0.5010.56
109_V120_V0.5010.56
130_I193_E0.5000.56
125_R175_E0.5000.56
161_L200_E0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wszA 2 0.2619 97.6 0.833 Contact Map
1s7oA 3 0.3286 97.5 0.838 Contact Map
1ku3A 1 0.2905 97.5 0.838 Contact Map
1je8A 2 0.2667 97.3 0.844 Contact Map
1xsvA 2 0.3238 97.3 0.844 Contact Map
1x3uA 1 0.3143 97.2 0.846 Contact Map
3c57A 2 0.2429 97.2 0.846 Contact Map
2o8xA 7 0.2905 97.1 0.847 Contact Map
1fseA 2 0.2714 97.1 0.849 Contact Map
3hugA 3 0.3619 97.1 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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