GREMLIN Database
HUTG - Probable formimidoylglutamase
UniProt: Q9HQD7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 306 (263)
Sequences: 5249 (3364)
Seq/√Len: 207.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_I119_V3.7571.00
233_V258_L3.7011.00
103_R131_A3.2601.00
60_S87_D3.1921.00
130_V169_L3.1611.00
238_L293_A2.9651.00
107_A136_A2.6141.00
235_I245_A2.4091.00
275_F301_F2.3371.00
100_A104_E2.1471.00
193_G197_D2.1061.00
238_L258_L2.0531.00
142_G227_D2.0361.00
41_V109_V2.0161.00
235_I280_T1.9661.00
42_G63_R1.9651.00
110_H132_P1.9511.00
146_V261_L1.9251.00
106_A129_N1.9161.00
60_S64_E1.9151.00
33_A112_T1.9141.00
201_R218_A1.9101.00
146_V237_V1.8851.00
255_P293_A1.8821.00
39_V114_A1.8701.00
201_R222_A1.8681.00
140_A227_D1.8451.00
43_E102_V1.8451.00
179_V182_A1.8311.00
231_V272_I1.8281.00
43_E118_F1.8221.00
103_R132_P1.8201.00
167_R171_D1.8071.00
212_R216_L1.7921.00
209_A256_R1.7901.00
103_R136_A1.7571.00
106_A118_F1.7571.00
97_D101_A1.7541.00
62_I294_A1.7391.00
119_V298_I1.6661.00
237_V253_I1.6651.00
63_R84_D1.6611.00
127_Y172_A1.6501.00
127_Y131_A1.6471.00
277_L298_I1.6441.00
107_A111_E1.6341.00
178_A201_R1.6161.00
46_D56_R1.6041.00
118_F129_N1.5931.00
280_T294_A1.5631.00
63_R87_D1.5611.00
110_H133_L1.5551.00
94_D97_D1.5461.00
194_F198_Q1.5281.00
242_Y255_P1.5131.00
42_G86_G1.5061.00
39_V85_L1.4991.00
230_Y274_G1.4981.00
235_I277_L1.4981.00
84_D87_D1.4951.00
214_G217_D1.4871.00
217_D221_E1.4721.00
42_G87_D1.4621.00
117_V275_F1.4591.00
139_G228_H1.4581.00
37_D81_G1.4541.00
43_E98_T1.4541.00
39_V109_V1.4351.00
63_R86_G1.4231.00
38_A302_L1.4231.00
254_Q257_E1.4141.00
263_E300_H1.4091.00
125_L278_V1.3921.00
211_D215_S1.3901.00
209_A257_E1.3841.00
133_L141_V1.3831.00
182_A202_I1.3831.00
62_I280_T1.3771.00
99_Q124_S1.3771.00
228_H271_R1.3731.00
140_A176_A1.3651.00
214_G218_A1.3611.00
117_V298_I1.3481.00
231_V275_F1.3451.00
210_A260_A1.3421.00
280_T290_T1.3251.00
41_V118_F1.3241.00
220_R264_A1.3221.00
244_G290_T1.3221.00
144_V265_L1.3151.00
176_A227_D1.3091.00
142_G226_V1.3061.00
103_R107_A1.2931.00
61_A291_V1.2861.00
167_R194_F1.2851.00
237_V258_L1.2821.00
145_S179_V1.2761.00
235_I294_A1.2591.00
109_V116_P1.2231.00
168_Q171_D1.2191.00
105_A108_E1.2191.00
217_D264_A1.2091.00
162_S246_S1.2061.00
57_D283_T1.2001.00
123_N232_S1.1961.00
162_S247_A1.1951.00
52_R284_L1.1821.00
102_V118_F1.1811.00
143_V166_Y1.1721.00
178_A222_A1.1701.00
41_V106_A1.1661.00
264_A267_A1.1631.00
259_F300_H1.1471.00
61_A64_E1.1421.00
204_T207_A1.1391.00
154_A168_Q1.1351.00
42_G84_D1.1291.00
41_V105_A1.1191.00
99_Q128_A1.1161.00
106_A116_P1.1071.00
107_A132_P1.1021.00
216_L264_A1.0941.00
150_L185_F1.0841.00
213_D217_D1.0811.00
129_N276_E1.0811.00
244_G285_D1.0771.00
98_T102_V1.0721.00
131_A172_A1.0691.00
223_L226_V1.0681.00
38_A115_L1.0621.00
115_L275_F1.0571.00
32_D35_D1.0561.00
228_H273_R1.0561.00
149_H236_D1.0551.00
166_Y179_V1.0521.00
53_R57_D1.0491.00
111_E137_D1.0371.00
49_V55_A1.0321.00
253_I261_L1.0291.00
152_C195_L1.0241.00
126_S130_V1.0191.00
129_N230_Y1.0131.00
281_A284_L1.0111.00
43_E125_L1.0101.00
161_T164_T1.0001.00
46_D54_G0.9961.00
205_S209_A0.9921.00
97_D100_A0.9911.00
258_L297_T0.9851.00
108_E111_E0.9821.00
147_D151_D0.9761.00
145_S232_S0.9761.00
104_E108_E0.9741.00
231_V262_V0.9711.00
211_D214_G0.9641.00
90_L98_T0.9631.00
286_T289_R0.9560.99
40_L119_V0.9560.99
290_T294_A0.9520.99
183_R240_A0.9400.99
219_A222_A0.9370.99
55_A281_A0.9370.99
209_A260_A0.9300.99
61_A65_S0.9270.99
206_D263_E0.9200.99
133_L274_G0.9160.99
53_R56_R0.9150.99
194_F197_D0.9110.99
154_A167_R0.9110.99
150_L179_V0.9050.99
162_S279_E0.9040.99
150_L202_I0.9000.99
88_V101_A0.8910.99
203_V208_V0.8880.99
85_L109_V0.8810.99
126_S276_E0.8740.99
146_V253_I0.8740.99
162_S245_A0.8730.99
106_A132_P0.8690.99
163_G247_A0.8680.99
153_R191_Y0.8620.99
141_V273_R0.8590.99
150_L182_A0.8550.99
166_Y177_L0.8530.99
130_V143_V0.8530.99
142_G176_A0.8460.99
46_D52_R0.8380.99
245_A248_P0.8370.99
183_R239_D0.8370.99
126_S165_P0.8330.99
142_G178_A0.8330.99
143_V169_L0.8320.99
233_V297_T0.8310.99
206_D260_A0.8270.99
41_V116_P0.8240.99
46_D55_A0.8230.98
178_A219_A0.8220.98
238_L255_P0.8210.98
152_C170_F0.8180.98
144_V223_L0.8170.98
129_N274_G0.8170.98
288_G291_V0.8130.98
109_V114_A0.8110.98
261_L264_A0.8060.98
85_L105_A0.8060.98
123_N162_S0.8040.98
218_A222_A0.8020.98
133_L273_R0.8010.98
177_L200_G0.7990.98
130_V141_V0.7990.98
146_V231_V0.7990.98
229_V271_R0.7980.98
282_P285_D0.7950.98
213_D264_A0.7930.98
46_D53_R0.7930.98
100_A103_R0.7880.98
298_I301_F0.7850.98
45_Y95_V0.7840.98
210_A213_D0.7790.98
231_V301_F0.7790.98
58_G282_P0.7740.98
238_L242_Y0.7680.98
215_S219_A0.7660.98
196_R202_I0.7650.98
289_R293_A0.7640.98
37_D114_A0.7640.98
184_H249_T0.7600.97
255_P259_F0.7590.97
123_N276_E0.7580.97
148_A183_R0.7550.97
104_E107_A0.7510.97
48_A122_D0.7460.97
144_V180_V0.7440.97
123_N279_E0.7410.97
152_C194_F0.7400.97
110_H137_D0.7380.97
203_V218_A0.7350.97
253_I258_L0.7350.97
208_V257_E0.7310.97
44_P87_D0.7260.97
203_V222_A0.7240.97
195_L200_G0.7240.97
108_E112_T0.7140.96
38_A80_S0.7140.96
170_F175_D0.7120.96
218_A221_E0.7090.96
205_S253_I0.7080.96
47_G98_T0.7040.96
33_A36_Y0.7030.96
142_G223_L0.7020.96
138_N228_H0.7010.96
208_V261_L0.6960.96
58_G61_A0.6950.96
244_G280_T0.6950.96
285_D288_G0.6930.96
65_S291_V0.6930.96
183_R249_T0.6870.95
154_A159_G0.6850.95
259_F297_T0.6830.95
243_P290_T0.6760.95
116_P133_L0.6760.95
58_G281_A0.6740.95
118_F125_L0.6700.95
151_D279_E0.6700.95
101_A104_E0.6690.95
48_A95_V0.6690.95
50_I247_A0.6640.95
124_S160_P0.6640.95
141_V228_H0.6630.94
219_A223_L0.6630.94
64_E288_G0.6620.94
126_S166_Y0.6600.94
144_V178_A0.6600.94
180_V253_I0.6590.94
242_Y254_Q0.6580.94
33_A114_A0.6570.94
190_T194_F0.6570.94
155_V168_Q0.6550.94
38_A117_V0.6540.94
36_Y114_A0.6530.94
40_L117_V0.6510.94
266_A272_I0.6510.94
180_V219_A0.6510.94
61_A288_G0.6470.94
280_T291_V0.6470.94
146_V180_V0.6460.94
52_R248_P0.6460.94
151_D236_D0.6430.94
45_Y98_T0.6380.93
129_N133_L0.6320.93
102_V106_A0.6290.93
285_D290_T0.6260.93
170_F200_G0.6260.93
256_R260_A0.6240.93
193_G196_R0.6240.93
102_V128_A0.6240.93
144_V229_V0.6210.92
134_V141_V0.6200.92
95_V99_Q0.6170.92
43_E129_N0.6140.92
213_D260_A0.6140.92
137_D140_A0.6130.92
170_F177_L0.6130.92
277_L297_T0.6120.92
128_A132_P0.6110.92
123_N230_Y0.6080.92
145_S166_Y0.6080.92
65_S288_G0.6060.91
139_G227_D0.6060.91
260_A264_A0.6060.91
58_G246_S0.6050.91
50_I162_S0.6040.91
242_Y293_A0.5940.91
145_S247_A0.5910.90
123_N149_H0.5910.90
181_G237_V0.5910.90
241_A255_P0.5900.90
107_A137_D0.5890.90
235_I290_T0.5890.90
131_A169_L0.5890.90
232_S278_V0.5890.90
178_A203_V0.5850.90
155_V159_G0.5840.90
152_C198_Q0.5840.90
164_T168_Q0.5830.90
212_R261_L0.5810.90
134_V172_A0.5790.89
41_V85_L0.5780.89
245_A281_A0.5780.89
180_V208_V0.5770.89
277_L294_A0.5760.89
203_V207_A0.5760.89
153_R247_A0.5710.89
37_D83_A0.5680.89
230_Y276_E0.5680.89
98_T101_A0.5670.88
211_D257_E0.5660.88
127_Y168_Q0.5650.88
227_D271_R0.5640.88
147_D236_D0.5640.88
73_H300_H0.5640.88
212_R260_A0.5630.88
102_V125_L0.5630.88
251_G259_F0.5620.88
134_V173_G0.5610.88
203_V215_S0.5600.88
264_A269_D0.5580.88
120_G125_L0.5570.88
88_V105_A0.5570.88
143_V177_L0.5550.87
150_L153_R0.5550.87
163_G236_D0.5540.87
36_Y83_A0.5540.87
226_V229_V0.5540.87
66_L69_V0.5510.87
187_T193_G0.5500.87
150_L195_L0.5490.87
61_A280_T0.5450.86
49_V53_R0.5450.86
215_S218_A0.5440.86
288_G292_D0.5440.86
91_P101_A0.5430.86
126_S278_V0.5420.86
229_V272_I0.5380.86
47_G95_V0.5380.86
272_I301_F0.5380.86
244_G282_P0.5350.85
295_A298_I0.5340.85
229_V270_D0.5340.85
134_V176_A0.5330.85
101_A105_A0.5330.85
62_I295_A0.5290.85
54_G246_S0.5280.85
105_A109_V0.5280.85
54_G281_A0.5280.85
216_L220_R0.5280.85
178_A223_L0.5270.85
61_A282_P0.5250.84
60_S288_G0.5240.84
170_F173_G0.5180.84
239_D242_Y0.5180.84
232_S276_E0.5180.84
40_L82_V0.5180.84
111_E136_A0.5130.83
185_F299_A0.5120.83
275_F298_I0.5110.83
158_R164_T0.5090.83
265_L270_D0.5080.82
94_D158_R0.5070.82
170_F194_F0.5040.82
186_E191_Y0.5030.82
292_D295_A0.5020.82
150_L192_A0.5000.81
95_V161_T0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xfkA 1 0.9575 100 0.172 Contact Map
3m1rA 5 0.9771 100 0.199 Contact Map
1gq6A 5 0.9412 100 0.202 Contact Map
3niqA 5 0.9608 100 0.205 Contact Map
3nioA 5 0.9444 100 0.208 Contact Map
1wohA 5 0.9477 100 0.215 Contact Map
4mykA 3 0.8922 100 0.219 Contact Map
4q40A 5 0.8693 100 0.233 Contact Map
4dz4A 5 0.9444 100 0.235 Contact Map
2cevA 5 0.8562 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.