GREMLIN Database
HUTI - Imidazolonepropionase
UniProt: Q9HQD6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (363)
Sequences: 33203 (26408)
Seq/√Len: 1386.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
405_L410_V5.0371.00
372_T377_T4.5511.00
67_K402_E4.1671.00
15_V64_A3.9471.00
403_A410_V3.9121.00
36_V41_A3.8931.00
64_A383_V3.3621.00
70_L384_V3.3521.00
347_A350_D3.1781.00
370_T378_D3.1121.00
374_R377_T3.0951.00
18_P64_A3.0531.00
16_V61_A2.8421.00
378_D407_D2.7681.00
72_G141_T2.7231.00
42_A375_E2.7101.00
365_R370_T2.5631.00
369_G378_D2.4361.00
38_G378_D2.4201.00
70_L382_L2.4141.00
353_L357_A2.3701.00
304_Q308_A2.3041.00
317_P361_S2.1961.00
39_A378_D2.1741.00
14_L34_A2.0941.00
350_D353_L2.0791.00
39_A369_G2.0611.00
381_V405_L2.0331.00
67_K385_D2.0251.00
385_D402_E2.0021.00
44_G47_A2.0011.00
33_V69_V1.9761.00
32_A47_A1.9651.00
13_E405_L1.9481.00
373_L381_V1.9301.00
35_V381_V1.9211.00
38_G407_D1.9131.00
69_V381_V1.8861.00
69_V383_V1.8661.00
277_A314_T1.8491.00
404_V412_V1.7941.00
319_A362_A1.7761.00
67_K383_V1.7641.00
200_D204_A1.7511.00
34_A59_T1.7381.00
16_V32_A1.7281.00
302_D305_Q1.7211.00
18_P69_V1.7181.00
20_A31_G1.7061.00
353_L358_W1.7031.00
382_L401_V1.6961.00
361_S366_G1.6961.00
265_A268_L1.6771.00
233_A236_E1.6731.00
17_G63_D1.6721.00
34_A42_A1.6681.00
56_E59_T1.6681.00
70_L73_F1.6641.00
357_A372_T1.6611.00
357_A361_S1.6431.00
358_W361_S1.6391.00
256_L260_L1.5951.00
224_V228_R1.5931.00
277_A281_D1.5891.00
32_A49_V1.5751.00
190_A193_Y1.5741.00
120_S123_A1.5681.00
201_Q205_A1.5641.00
40_V373_L1.5171.00
24_T374_R1.4941.00
232_D236_E1.4921.00
255_Q259_D1.4911.00
195_D199_D1.4821.00
33_V373_L1.4761.00
252_G256_L1.4381.00
365_R369_G1.4371.00
43_V375_E1.4331.00
352_V356_T1.4301.00
32_A46_T1.4151.00
383_V405_L1.3961.00
15_V35_V1.3951.00
13_E35_V1.3881.00
31_G45_D1.3881.00
33_V381_V1.3761.00
361_S372_T1.3691.00
223_T226_Q1.3681.00
136_L411_A1.3661.00
214_D217_C1.3581.00
193_Y196_A1.3471.00
14_L32_A1.3391.00
196_A200_D1.3341.00
228_R232_D1.3271.00
199_D203_P1.3261.00
76_P319_A1.3041.00
135_M143_A1.2921.00
341_C351_A1.2811.00
70_L352_V1.2801.00
137_A412_V1.2791.00
235_R263_T1.2731.00
272_T275_D1.2671.00
406_T411_A1.2651.00
253_G257_A1.2591.00
334_G338_S1.2541.00
76_P363_L1.2541.00
366_G369_G1.2531.00
19_A28_H1.2501.00
35_V405_L1.2501.00
17_G66_G1.2421.00
233_A237_H1.2301.00
74_V359_A1.2281.00
215_V218_E1.2251.00
211_R214_D1.2241.00
68_T386_A1.2241.00
339_L343_G1.2201.00
76_P359_A1.2161.00
209_P213_C1.2131.00
209_P212_F1.2051.00
305_Q308_A1.2041.00
19_A30_D1.2031.00
319_A358_W1.2011.00
383_V403_A1.2001.00
161_D165_A1.1981.00
34_A41_A1.1971.00
28_H31_G1.1881.00
225_E228_R1.1861.00
197_V200_D1.1831.00
276_A314_T1.1791.00
200_D203_P1.1701.00
240_A364_D1.1681.00
192_A195_D1.1661.00
319_A359_A1.1661.00
278_A282_A1.1611.00
366_G377_T1.1591.00
15_V381_V1.1521.00
216_F219_A1.1501.00
17_G30_D1.1471.00
229_R232_D1.1471.00
19_A29_A1.1461.00
285_T317_P1.1271.00
44_G48_D1.1231.00
244_H323_D1.1231.00
151_L154_E1.1141.00
335_F338_S1.1091.00
17_G65_T1.1071.00
285_T362_A1.1051.00
20_A33_V1.1001.00
268_L286_P1.0991.00
32_A48_D1.0951.00
354_A358_W1.0871.00
264_S268_L1.0861.00
384_V401_V1.0811.00
191_D195_D1.0741.00
179_L182_H1.0661.00
182_H185_P1.0641.00
32_A44_G1.0631.00
31_G44_G1.0621.00
212_F216_F1.0591.00
60_T410_V1.0581.00
332_S335_F1.0551.00
64_A69_V1.0481.00
74_V370_T1.0461.00
42_A49_V1.0451.00
15_V405_L1.0441.00
190_A194_V1.0441.00
192_A196_A1.0411.00
62_I405_L1.0291.00
197_V201_Q1.0231.00
201_Q204_A1.0211.00
31_G43_V1.0201.00
273_P305_Q1.0181.00
331_H334_G1.0181.00
158_R161_D1.0171.00
13_E60_T1.0121.00
18_P383_V1.0121.00
208_G212_F1.0021.00
203_P207_N0.9991.00
40_V381_V0.9991.00
134_V137_A0.9961.00
202_L205_A0.9941.00
214_D218_E0.9891.00
198_I201_Q0.9861.00
334_G337_V0.9811.00
41_A375_E0.9801.00
76_P287_V0.9801.00
23_D357_A0.9751.00
215_V219_A0.9751.00
208_G214_D0.9741.00
74_V142_T0.9741.00
208_G213_C0.9731.00
211_R215_V0.9711.00
346_M354_A0.9691.00
234_G241_P0.9671.00
256_L259_D0.9661.00
157_C161_D0.9651.00
62_I403_A0.9621.00
337_V351_A0.9601.00
235_R260_L0.9581.00
255_Q258_A0.9571.00
77_H244_H0.9551.00
180_G183_A0.9541.00
142_T370_T0.9531.00
164_A167_A0.9511.00
114_D117_R0.9501.00
177_T180_G0.9451.00
300_Y304_Q0.9451.00
42_A48_D0.9411.00
130_A133_D0.9411.00
133_D137_A0.9401.00
274_E277_A0.9391.00
181_A184_V0.9371.00
209_P214_D0.9361.00
214_D219_A0.9311.00
306_F316_A0.9301.00
213_C216_F0.9301.00
217_C220_D0.9281.00
252_G255_Q0.9271.00
203_P206_A0.9261.00
79_H244_H0.9251.00
145_V148_G0.9251.00
132_L136_L0.9251.00
336_V339_L0.9241.00
130_A134_V0.9231.00
194_V197_V0.9221.00
382_L404_V0.9191.00
385_D400_N0.9191.00
181_A186_D0.9181.00
307_L350_D0.9121.00
253_G256_L0.9121.00
333_M355_A0.9041.00
58_A61_A0.8991.00
176_T180_G0.8971.00
129_T133_D0.8971.00
163_I168_A0.8951.00
185_P188_T0.8941.00
279_L286_P0.8931.00
74_V360_A0.8891.00
203_P237_H0.8831.00
16_V63_D0.8811.00
15_V62_I0.8781.00
297_D301_A0.8731.00
22_G25_L0.8731.00
19_A68_T0.8731.00
242_K266_D0.8731.00
228_R260_L0.8721.00
278_A281_D0.8711.00
266_D269_L0.8701.00
335_F339_L0.8691.00
165_A168_A0.8681.00
301_A305_Q0.8661.00
287_V319_A0.8541.00
331_H338_S0.8521.00
297_D300_Y0.8501.00
293_A296_L0.8441.00
178_F182_H0.8411.00
34_A58_A0.8401.00
156_E159_M0.8391.00
355_A359_A0.8391.00
280_A316_A0.8361.00
204_A207_N0.8351.00
152_D155_T0.8351.00
370_T380_D0.8341.00
182_H188_T0.8331.00
183_A186_D0.8311.00
380_D407_D0.8291.00
332_S338_S0.8291.00
182_H186_D0.8291.00
125_V165_A0.8271.00
74_V363_L0.8271.00
184_V187_D0.8221.00
177_T181_A0.8191.00
212_F215_V0.8171.00
267_H270_H0.8161.00
251_L255_Q0.8161.00
213_C218_E0.8141.00
196_A199_D0.8141.00
95_R99_Y0.8131.00
21_G352_V0.8091.00
155_T158_R0.8071.00
357_A377_T0.8071.00
180_G184_V0.8071.00
338_S342_N0.8051.00
257_A260_L0.8051.00
254_A258_A0.8051.00
45_D48_D0.8041.00
173_D176_T0.8021.00
15_V69_V0.8021.00
268_L271_A0.8001.00
401_V404_V0.7991.00
162_A165_A0.7991.00
67_K403_A0.7981.00
198_I205_A0.7961.00
79_H267_H0.7921.00
369_G377_T0.7921.00
298_E301_A0.7901.00
34_A44_G0.7901.00
27_T349_A0.7891.00
64_A67_K0.7881.00
134_V138_H0.7871.00
304_Q307_L0.7861.00
146_K242_K0.7851.00
273_P277_A0.7841.00
144_E363_L0.7831.00
360_A371_G0.7821.00
317_P358_W0.7821.00
215_V220_D0.7751.00
166_A169_E0.7721.00
79_H323_D0.7721.00
199_D236_E0.7721.00
305_Q314_T0.7711.00
198_I202_L0.7681.00
201_Q206_A0.7671.00
46_T49_V0.7651.00
125_V129_T0.7641.00
178_F181_A0.7631.00
73_F355_A0.7631.00
191_D194_V0.7621.00
200_D205_A0.7581.00
333_M337_V0.7491.00
197_V205_A0.7481.00
195_D198_I0.7461.00
164_A168_A0.7461.00
193_Y197_V0.7461.00
24_T27_T0.7461.00
195_D229_R0.7411.00
208_G211_R0.7391.00
209_P218_E0.7381.00
183_A188_T0.7381.00
33_V43_V0.7371.00
163_I167_A0.7331.00
165_A169_E0.7311.00
96_G99_Y0.7301.00
349_A353_L0.7291.00
180_G185_P0.7251.00
331_H335_F0.7231.00
32_A42_A0.7231.00
342_N345_R0.7221.00
180_G186_D0.7211.00
175_V179_L0.7201.00
197_V202_L0.7201.00
214_D220_D0.7171.00
163_I166_A0.7141.00
216_F220_D0.7131.00
337_V355_A0.7121.00
136_L412_V0.7121.00
17_G64_A0.7061.00
332_S339_L0.7051.00
75_D78_T0.7041.00
73_F333_M0.7031.00
301_A306_F0.7021.00
181_A185_P0.7001.00
75_D322_T0.6991.00
13_E62_I0.6981.00
213_C217_C0.6971.00
30_D65_T0.6971.00
184_V188_T0.6961.00
21_G68_T0.6941.00
320_L354_A0.6921.00
23_D352_V0.6921.00
298_E302_D0.6901.00
183_A187_D0.6861.00
332_S336_V0.6851.00
264_S362_A0.6851.00
387_P390_V0.6841.00
150_G154_E0.6841.00
159_M162_A0.6801.00
254_A257_A0.6801.00
279_L282_A0.6771.00
199_D202_L0.6771.00
372_T375_E0.6751.00
18_P381_V0.6741.00
232_D235_R0.6731.00
195_D200_D0.6711.00
163_I169_E0.6681.00
259_D278_A0.6671.00
285_T319_A0.6611.00
299_A302_D0.6581.00
211_R217_C0.6561.00
24_T372_T0.6551.00
209_P216_F0.6551.00
176_T179_L0.6541.00
77_H323_D0.6531.00
332_S337_V0.6501.00
211_R218_E0.6501.00
177_T182_H0.6481.00
179_L184_V0.6481.00
248_F298_E0.6471.00
194_V199_D0.6461.00
44_G49_V0.6461.00
253_G260_L0.6451.00
49_V56_E0.6431.00
199_D237_H0.6421.00
210_A214_D0.6411.00
194_V198_I0.6411.00
34_A47_A0.6411.00
370_T377_T0.6361.00
173_D177_T0.6351.00
21_G28_H0.6331.00
95_R98_P0.6331.00
289_L321_G0.6331.00
194_V205_A0.6321.00
16_V46_T0.6311.00
212_F217_C0.6281.00
209_P217_C0.6271.00
31_G46_T0.6261.00
78_T135_M0.6251.00
194_V201_Q0.6251.00
209_P215_V0.6241.00
190_A195_D0.6241.00
175_V180_G0.6231.00
208_G215_V0.6231.00
162_A167_A0.6231.00
266_D270_H0.6221.00
261_G264_S0.6201.00
199_D206_A0.6191.00
210_A215_V0.6181.00
268_L279_L0.6171.00
213_C219_A0.6161.00
160_L163_I0.6151.00
255_Q278_A0.6131.00
176_T181_A0.6121.00
121_D125_V0.6091.00
242_K264_S0.6091.00
18_P66_G0.6071.00
280_A314_T0.6071.00
202_L206_A0.6061.00
258_A318_V0.6031.00
142_T380_D0.6021.00
275_D278_A0.6021.00
192_A197_V0.6021.00
212_F219_A0.6011.00
23_D372_T0.6011.00
35_V41_A0.6001.00
34_A56_E0.6001.00
31_G373_L0.6001.00
303_P307_L0.6001.00
273_P314_T0.5991.00
246_E269_L0.5991.00
189_D193_Y0.5981.00
19_A387_P0.5981.00
30_D46_T0.5981.00
191_D198_I0.5961.00
231_L235_R0.5961.00
189_D192_A0.5951.00
159_M163_I0.5921.00
200_D206_A0.5911.00
136_L406_T0.5891.00
210_A213_C0.5881.00
211_R219_A0.5861.00
245_A265_A0.5861.00
80_A131_Q0.5851.00
299_A303_P0.5851.00
23_D349_A0.5841.00
300_Y306_F0.5821.00
190_A201_Q0.5821.00
159_M164_A0.5791.00
190_A197_V0.5781.00
174_V178_F0.5751.00
300_Y303_P0.5751.00
253_G258_A0.5741.00
194_V202_L0.5731.00
331_H336_V0.5731.00
301_A304_Q0.5721.00
179_L183_A0.5711.00
14_L58_A0.5711.00
154_E157_C0.5701.00
195_D205_A0.5701.00
340_A343_G0.5691.00
271_A275_D0.5691.00
293_A297_D0.5681.00
403_A412_V0.5681.00
224_V227_S0.5651.00
342_N398_V0.5641.00
273_P302_D0.5581.00
222_F226_Q0.5581.00
193_Y201_Q0.5571.00
158_R162_A0.5561.00
251_L256_L0.5561.00
157_C164_A0.5551.00
210_A217_C0.5541.00
156_E164_A0.5541.00
191_D197_V0.5531.00
151_L156_E0.5531.00
226_Q229_R0.5521.00
197_V203_P0.5521.00
286_P289_L0.5521.00
161_D164_A0.5501.00
21_G349_A0.5501.00
346_M350_D0.5491.00
229_R233_A0.5471.00
180_G188_T0.5461.00
190_A205_A0.5451.00
159_M169_E0.5421.00
73_F352_V0.5421.00
350_D354_A0.5421.00
40_V377_T0.5411.00
279_L284_V0.5391.00
126_A129_T0.5381.00
360_A377_T0.5361.00
195_D206_A0.5361.00
156_E163_I0.5351.00
210_A216_F0.5351.00
252_G257_A0.5351.00
208_G216_F0.5351.00
318_V354_A0.5341.00
190_A202_L0.5331.00
76_P362_A0.5331.00
357_A366_G0.5331.00
160_L165_A0.5311.00
190_A196_A0.5311.00
302_D306_F0.5311.00
24_T28_H0.5301.00
33_V40_V0.5281.00
19_A386_A0.5271.00
265_A279_L0.5271.00
153_T156_E0.5261.00
20_A29_A0.5241.00
42_A47_A0.5221.00
226_Q230_I0.5221.00
199_D207_N0.5211.00
162_A166_A0.5201.00
397_G400_N0.5201.00
213_C220_D0.5191.00
121_D124_L0.5161.00
175_V178_F0.5141.00
73_F401_V0.5131.00
159_M166_A0.5131.00
141_T380_D0.5121.00
211_R216_F0.5121.00
225_E229_R0.5111.00
251_L254_A0.5111.00
202_L207_N0.5111.00
279_L316_A0.5081.00
121_D161_D0.5081.00
30_D45_D0.5081.00
197_V204_A0.5071.00
240_A263_T0.5071.00
230_I233_A0.5061.00
123_A126_A0.5061.00
193_Y205_A0.5051.00
231_L241_P0.5051.00
155_T159_M0.5051.00
68_T384_V0.5021.00
140_T333_M0.5011.00
257_A262_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bb0A 2 0.9496 100 0.287 Contact Map
2q09A 2 0.94 100 0.295 Contact Map
3lnpA 2 0.8993 100 0.316 Contact Map
2pajA 2 0.8393 100 0.319 Contact Map
4dzhA 2 0.9041 100 0.319 Contact Map
4v1xA 5 0.9257 100 0.324 Contact Map
3hpaA 2 0.8801 100 0.328 Contact Map
3ls9A 2 0.9209 100 0.331 Contact Map
4gbdA 2 0.9017 100 0.331 Contact Map
2i9uA 2 0.8873 100 0.335 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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