HUTH - HALSA - GREMLIN Contacts

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HUTH - Probable histidine ammonia-lyase

UniProt:	Q9HQD5	Sequences: MTTEGVVIDGESLTPAAVDAVARHDAPVSIAAGAREAVRESRARIADVLGGDEAVYGVNTGFGSMSDTRIDAADREALQANLVRSHAAGAGSELDTAAVRALLVTRLNALAKGYSGIRERVLDVLVGLLNEGVHPVVPSRGSLGASGDLAPLAHMSRVLIGEGQADVAGERMPAAEALAAADLEPVTLQAKEGLALINGTQLTTGVAALALVDAERVLRSADTAGALTTEVTMSTTASCAPAIHEVRPHDGQAVSARHIRNLTAGSEVLDHHRDCDRVQDAYSIRCLPQVHGAVRDALDHLRAAVATELNSATDNPLVFAGDRVGPRASGTDRAAVVSGGNFHGEVLALRLGYAASALAELAAISERRTDRLLNPETQEPHLEPFLAPDSGLHSGLMIPQYTAASLVNDLRSLGQPTLDNASVSGAQEDHVSMSAGAAYNFREAVEKAATVVGVELLCGAQGREFLDPDLALGAGTAAAYDLVREVSEPVAGDRALADDMAAVGDLVRAGLVEDAVARALDAPLA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	525 (490)
Sequences:	2676 (1563)
Seq/√Len:	70.6

BACSU - HUTH
HALSA - HUTH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_R	123_D	3.760	1.00
494_R	499_D	3.332	1.00
172_M	180_A	3.315	1.00
158_V	174_A	3.312	1.00
39_R	119_E	3.198	1.00
225_G	287_L	3.138	1.00
21_V	104_V	3.096	1.00
124_V	183_L	3.038	1.00
164_Q	171_R	2.991	1.00
38_V	122_L	2.970	1.00
241_P	260_R	2.823	1.00
362_A	451_V	2.800	1.00
102_L	202_L	2.781	1.00
290_V	364_I	2.779	1.00
165_A	174_A	2.765	1.00
107_L	126_V	2.746	1.00
123_D	127_G	2.715	1.00
96_T	166_D	2.688	1.00
23_R	213_D	2.678	1.00
84_R	162_E	2.662	1.00
143_L	423_V	2.656	1.00
172_M	177_A	2.581	1.00
483_V	503_V	2.507	1.00
42_R	46_A	2.483	1.00
158_V	165_A	2.470	1.00
166_D	171_R	2.446	1.00
215_E	302_R	2.421	1.00
170_E	180_A	2.416	1.00
80_A	84_R	2.385	1.00
177_A	181_A	2.372	1.00
133_V	165_A	2.362	1.00
92_S	139_S	2.360	1.00
203_T	434_S	2.353	1.00
39_R	43_A	2.349	1.00
9_D	12_S	2.338	1.00
93_E	136_V	2.324	1.00
241_P	245_E	2.298	1.00
95_D	98_A	2.291	1.00
38_V	119_E	2.266	1.00
472_L	476_T	2.254	1.00
14_T	17_A	2.254	1.00
464_E	484_R	2.244	1.00
207_A	351_L	2.230	1.00
449_A	508_R	2.230	1.00
251_G	296_D	2.217	1.00
101_A	205_G	2.215	1.00
35_R	119_E	2.209	1.00
173_P	176_E	2.174	1.00
102_L	137_V	2.098	1.00
96_T	132_G	2.092	1.00
243_I	339_G	2.070	1.00
100_R	129_L	1.998	1.00
128_L	158_V	1.952	1.00
460_A	483_V	1.950	1.00
248_P	311_S	1.900	1.00
127_G	131_E	1.890	1.00
410_L	447_K	1.883	1.00
254_V	299_D	1.881	1.00
83_V	197_I	1.878	1.00
76_E	187_T	1.865	1.00
464_E	489_P	1.861	1.00
223_T	479_A	1.861	1.00
467_D	477_A	1.859	1.00
13_L	108_N	1.849	1.00
222_D	295_R	1.819	1.00
355_A	444_A	1.777	1.00
464_E	480_Y	1.770	1.00
94_L	202_L	1.766	1.00
74_D	77_A	1.745	1.00
28_V	129_L	1.742	1.00
213_D	449_A	1.740	1.00
407_V	451_V	1.725	1.00
43_A	47_D	1.725	1.00
165_A	177_A	1.724	1.00
94_L	206_V	1.721	1.00
294_V	361_L	1.718	1.00
375_P	384_P	1.704	1.00
294_V	345_E	1.693	1.00
47_D	51_G	1.680	1.00
47_D	334_A	1.677	1.00
242_A	335_A	1.658	0.99
30_I	111_A	1.647	0.99
219_R	258_H	1.645	0.99
233_M	466_L	1.642	0.99
248_P	307_T	1.641	0.99
32_A	36_E	1.631	0.99
355_A	440_N	1.621	0.99
136_V	171_R	1.613	0.99
6_V	26_A	1.612	0.99
104_V	129_L	1.605	0.99
10_G	108_N	1.567	0.99
45_I	58_V	1.552	0.99
453_G	500_M	1.552	0.99
214_A	358_L	1.550	0.99
235_T	238_S	1.543	0.99
118_R	121_V	1.539	0.99
207_A	305_V	1.533	0.99
370_D	374_N	1.526	0.99
265_G	474_A	1.518	0.99
227_L	463_R	1.509	0.99
255_S	295_R	1.508	0.99
124_V	127_G	1.493	0.99
80_A	187_T	1.491	0.99
99_V	134_H	1.482	0.99
174_A	178_L	1.481	0.99
408_N	411_R	1.473	0.99
28_V	130_N	1.465	0.99
172_M	176_E	1.465	0.99
22_A	209_L	1.458	0.99
99_V	137_V	1.454	0.99
368_R	455_E	1.454	0.99
175_A	179_A	1.439	0.99
244_H	256_A	1.418	0.98
477_A	481_D	1.416	0.98
117_I	121_V	1.410	0.98
286_C	340_G	1.405	0.98
449_A	507_V	1.399	0.98
482_L	485_E	1.395	0.98
369_T	458_C	1.392	0.98
22_A	101_A	1.391	0.98
203_T	344_G	1.391	0.98
450_T	501_A	1.380	0.98
250_D	254_V	1.377	0.98
176_E	179_A	1.377	0.98
302_R	306_A	1.377	0.98
202_L	435_A	1.376	0.98
236_T	269_L	1.369	0.98
124_V	128_L	1.364	0.98
222_D	258_H	1.363	0.98
224_A	452_V	1.361	0.98
300_H	353_Y	1.353	0.98
257_R	261_N	1.349	0.98
176_E	180_A	1.332	0.98
231_V	463_R	1.328	0.98
227_L	472_L	1.326	0.98
344_G	434_S	1.325	0.98
218_L	294_V	1.323	0.97
18_V	104_V	1.317	0.97
101_A	209_L	1.316	0.97
20_A	26_A	1.308	0.97
224_A	483_V	1.302	0.97
472_L	477_A	1.299	0.97
450_T	504_G	1.297	0.97
267_E	471_A	1.296	0.97
222_D	291_H	1.294	0.97
501_A	505_D	1.293	0.97
224_A	365_S	1.291	0.97
118_R	192_E	1.289	0.97
36_E	39_R	1.288	0.97
164_Q	498_D	1.288	0.97
164_Q	173_P	1.287	0.97
119_E	123_D	1.283	0.97
13_L	104_V	1.273	0.97
270_D	273_R	1.272	0.97
77_A	492_G	1.262	0.97
362_A	410_L	1.262	0.97
243_I	317_L	1.256	0.97
133_V	181_A	1.251	0.96
456_L	483_V	1.250	0.96
224_A	456_L	1.245	0.96
100_R	132_G	1.244	0.96
240_A	337_V	1.243	0.96
230_E	473_G	1.243	0.96
301_L	354_A	1.241	0.96
414_G	444_A	1.238	0.96
38_V	111_A	1.237	0.96
7_V	29_S	1.236	0.96
467_D	470_L	1.234	0.96
76_E	189_Q	1.234	0.96
505_D	509_A	1.229	0.96
18_V	101_A	1.228	0.96
369_T	403_A	1.226	0.96
19_D	212_V	1.224	0.96
250_D	307_T	1.223	0.96
174_A	177_A	1.222	0.96
453_G	507_V	1.212	0.96
94_L	102_L	1.207	0.96
18_V	208_A	1.203	0.96
318_V	336_V	1.201	0.96
120_R	124_V	1.196	0.95
128_L	159_L	1.194	0.95
36_E	40_E	1.191	0.95
137_V	155_M	1.188	0.95
121_V	186_V	1.184	0.95
15_P	212_V	1.180	0.95
112_K	312_A	1.180	0.95
230_E	476_T	1.179	0.95
93_E	171_R	1.176	0.95
399_P	454_V	1.172	0.95
460_A	464_E	1.172	0.95
17_A	20_A	1.172	0.95
20_A	24_H	1.172	0.95
18_V	309_L	1.172	0.95
90_A	500_M	1.164	0.95
204_T	309_L	1.163	0.95
48_V	336_V	1.163	0.95
268_V	470_L	1.159	0.95
71_D	74_D	1.155	0.94
226_A	262_L	1.155	0.94
80_A	162_E	1.153	0.94
117_I	186_V	1.151	0.94
271_H	275_C	1.141	0.94
246_V	312_A	1.141	0.94
223_T	262_L	1.133	0.94
86_H	197_I	1.133	0.94
210_A	441_F	1.131	0.94
359_A	414_G	1.127	0.94
463_R	472_L	1.127	0.94
96_T	171_R	1.119	0.94
222_D	255_S	1.118	0.93
107_L	129_L	1.118	0.93
411_R	419_D	1.113	0.93
6_V	21_V	1.113	0.93
362_A	448_A	1.109	0.93
105_T	205_G	1.101	0.93
18_V	22_A	1.101	0.93
503_V	506_L	1.101	0.93
453_G	503_V	1.099	0.93
92_S	446_E	1.099	0.93
178_L	185_P	1.098	0.93
486_V	502_A	1.097	0.93
177_A	180_A	1.095	0.93
305_V	347_L	1.092	0.93
118_R	189_Q	1.092	0.93
40_E	43_A	1.089	0.93
40_E	332_D	1.086	0.92
232_T	284_I	1.081	0.92
402_T	454_V	1.080	0.92
30_I	126_V	1.077	0.92
134_H	166_D	1.076	0.92
96_T	134_H	1.070	0.92
82_L	197_I	1.067	0.92
59_N	75_R	1.067	0.92
191_K	314_D	1.064	0.92
304_A	307_T	1.064	0.92
225_G	259_I	1.063	0.92
258_H	261_N	1.060	0.92
90_A	450_T	1.059	0.91
48_V	55_V	1.055	0.91
300_H	304_A	1.055	0.91
105_T	309_L	1.054	0.91
410_L	444_A	1.052	0.91
229_T	239_C	1.052	0.91
231_V	462_G	1.050	0.91
210_A	445_V	1.047	0.91
74_D	389_D	1.045	0.91
347_L	351_L	1.044	0.91
23_R	97_A	1.043	0.91
19_D	23_R	1.039	0.91
98_A	206_V	1.037	0.91
7_V	31_A	1.035	0.91
138_P	154_H	1.032	0.90
47_D	50_G	1.032	0.90
172_M	181_A	1.032	0.90
281_A	371_R	1.026	0.90
160_I	188_L	1.025	0.90
363_A	421_A	1.018	0.90
124_V	159_L	1.016	0.90
136_V	164_Q	1.014	0.90
224_A	503_V	1.013	0.90
57_G	194_L	1.007	0.89
473_G	476_T	1.007	0.89
249_H	304_A	1.004	0.89
482_L	486_V	1.003	0.89
128_L	178_L	1.002	0.89
448_A	451_V	1.001	0.89
227_L	459_G	0.999	0.89
167_V	181_A	0.997	0.89
131_E	181_A	0.989	0.88
298_L	354_A	0.986	0.88
99_V	103_L	0.976	0.88
124_V	131_E	0.974	0.88
268_V	472_L	0.974	0.88
303_A	307_T	0.972	0.88
16_A	302_R	0.969	0.87
388_P	491_A	0.968	0.87
490_V	496_L	0.965	0.87
229_T	234_S	0.963	0.87
140_R	443_E	0.962	0.87
220_S	507_V	0.959	0.87
258_H	295_R	0.957	0.87
98_A	442_R	0.952	0.86
33_G	36_E	0.950	0.86
65_M	390_S	0.948	0.86
241_P	253_A	0.943	0.86
365_S	452_V	0.937	0.86
94_L	139_S	0.936	0.86
98_A	209_L	0.936	0.86
362_A	447_K	0.935	0.85
93_E	166_D	0.935	0.85
297_A	353_Y	0.933	0.85
137_V	202_L	0.926	0.85
242_A	319_F	0.923	0.85
35_R	39_R	0.922	0.85
240_A	335_A	0.920	0.85
124_V	181_A	0.912	0.84
21_V	28_V	0.906	0.84
345_E	360_E	0.905	0.84
449_A	504_G	0.904	0.83
461_Q	465_F	0.900	0.83
41_S	114_Y	0.899	0.83
486_V	506_L	0.898	0.83
208_A	305_V	0.898	0.83
436_G	439_Y	0.897	0.83
377_T	426_A	0.893	0.83
62_F	78_L	0.893	0.83
247_R	313_T	0.888	0.82
504_G	508_R	0.887	0.82
230_E	472_L	0.885	0.82
412_S	415_Q	0.885	0.82
412_S	436_G	0.884	0.82
398_I	424_S	0.881	0.82
230_E	269_L	0.880	0.82
124_V	186_V	0.879	0.82
497_A	501_A	0.877	0.82
77_A	80_A	0.876	0.81
397_M	401_Y	0.876	0.81
170_E	176_E	0.875	0.81
25_D	96_T	0.871	0.81
243_I	337_V	0.869	0.81
117_I	122_L	0.869	0.81
128_L	131_E	0.868	0.81
28_V	126_V	0.863	0.81
107_L	122_L	0.861	0.80
9_D	108_N	0.859	0.80
8_I	111_A	0.858	0.80
126_V	130_N	0.855	0.80
244_H	252_Q	0.853	0.80
99_V	166_D	0.853	0.80
396_L	496_L	0.852	0.80
417_T	420_N	0.851	0.80
44_R	320_A	0.850	0.80
95_D	99_V	0.844	0.79
460_A	484_R	0.842	0.79
136_V	166_D	0.841	0.79
80_A	160_I	0.840	0.79
127_G	183_L	0.840	0.79
242_A	337_V	0.837	0.78
118_R	186_V	0.837	0.78
120_R	184_E	0.833	0.78
471_A	477_A	0.833	0.78
36_E	43_A	0.833	0.78
211_L	298_L	0.831	0.78
296_D	496_L	0.831	0.78
454_V	500_M	0.827	0.78
218_L	298_L	0.827	0.78
282_Y	342_F	0.825	0.77
227_L	460_A	0.825	0.77
86_H	394_S	0.824	0.77
481_D	485_E	0.824	0.77
229_T	263_T	0.820	0.77
8_I	104_V	0.820	0.77
250_D	303_A	0.819	0.77
249_H	307_T	0.819	0.77
45_I	116_G	0.818	0.77
361_L	364_I	0.813	0.76
75_R	190_A	0.813	0.76
19_D	209_L	0.813	0.76
228_T	368_R	0.812	0.76
254_V	257_R	0.812	0.76
178_L	183_L	0.811	0.76
216_R	449_A	0.811	0.76
495_A	498_D	0.807	0.76
128_L	132_G	0.807	0.76
19_D	216_R	0.806	0.76
220_S	452_V	0.806	0.76
19_D	22_A	0.805	0.76
226_A	259_I	0.804	0.76
231_V	372_L	0.803	0.76
424_S	428_E	0.803	0.76
221_A	452_V	0.801	0.75
378_Q	381_H	0.801	0.75
312_A	317_L	0.800	0.75
85_S	394_S	0.799	0.75
167_V	172_M	0.798	0.75
394_S	398_I	0.795	0.75
30_I	35_R	0.794	0.75
482_L	506_L	0.791	0.74
133_V	174_A	0.791	0.74
412_S	440_N	0.790	0.74
297_A	349_L	0.786	0.74
407_V	421_A	0.786	0.74
50_G	72_A	0.785	0.74
228_T	455_E	0.784	0.74
409_D	439_Y	0.780	0.73
235_T	275_C	0.780	0.73
157_R	162_E	0.777	0.73
234_S	280_D	0.777	0.73
227_L	476_T	0.777	0.73
167_V	170_E	0.774	0.73
403_A	451_V	0.771	0.73
131_E	183_L	0.769	0.72
474_A	478_A	0.767	0.72
38_V	255_S	0.766	0.72
122_L	126_V	0.766	0.72
55_V	58_V	0.765	0.72
507_V	510_G	0.764	0.72
83_V	160_I	0.764	0.72
97_A	213_D	0.762	0.72
54_A	69_R	0.760	0.71
487_S	503_V	0.759	0.71
107_L	111_A	0.759	0.71
389_D	492_G	0.758	0.71
216_R	220_S	0.758	0.71
31_A	36_E	0.757	0.71
90_A	406_L	0.756	0.71
12_S	108_N	0.754	0.71
365_S	368_R	0.752	0.71
422_S	426_A	0.746	0.70
394_S	397_M	0.746	0.70
484_R	487_S	0.746	0.70
18_V	21_V	0.744	0.70
142_S	435_A	0.744	0.70
293_A	346_V	0.744	0.70
168_A	180_A	0.740	0.69
174_A	181_A	0.740	0.69
396_L	458_C	0.739	0.69
51_G	55_V	0.739	0.69
372_L	378_Q	0.738	0.69
83_V	156_S	0.736	0.69
387_A	393_H	0.736	0.69
398_I	401_Y	0.735	0.69
385_F	397_M	0.734	0.69
398_I	428_E	0.734	0.69
90_A	504_G	0.734	0.69
424_S	427_Q	0.734	0.69
86_H	398_I	0.733	0.69
397_M	424_S	0.733	0.69
299_D	303_A	0.732	0.69
8_I	12_S	0.727	0.68
34_A	37_A	0.727	0.68
133_V	158_V	0.726	0.68
251_G	292_G	0.726	0.68
229_T	284_I	0.725	0.68
6_V	17_A	0.725	0.68
365_S	369_T	0.724	0.68
301_L	350_R	0.723	0.68
366_E	403_A	0.723	0.68
103_L	129_L	0.722	0.68
409_D	436_G	0.721	0.67
343_H	430_H	0.721	0.67
490_V	494_R	0.719	0.67
211_L	301_L	0.719	0.67
457_L	503_V	0.718	0.67
396_L	490_V	0.717	0.67
124_V	178_L	0.717	0.67
198_N	282_Y	0.716	0.67
348_A	417_T	0.714	0.67
206_V	435_A	0.714	0.67
382_L	462_G	0.712	0.66
211_L	305_V	0.712	0.66
483_V	506_L	0.711	0.66
262_L	475_G	0.709	0.66
358_L	448_A	0.708	0.66
28_V	107_L	0.707	0.66
245_E	253_A	0.707	0.66
103_L	125_L	0.706	0.66
355_A	441_F	0.705	0.66
218_L	361_L	0.704	0.66
247_R	346_V	0.701	0.65
455_E	459_G	0.701	0.65
387_A	461_Q	0.701	0.65
296_D	303_A	0.700	0.65
147_G	282_Y	0.700	0.65
133_V	167_V	0.698	0.65
128_L	177_A	0.698	0.65
173_P	177_A	0.698	0.65
374_N	425_G	0.697	0.65
365_S	455_E	0.696	0.65
204_T	347_L	0.695	0.65
158_V	164_Q	0.692	0.64
351_L	441_F	0.690	0.64
168_A	181_A	0.686	0.64
294_V	297_A	0.686	0.64
100_R	134_H	0.684	0.63
457_L	487_S	0.683	0.63
228_T	459_G	0.682	0.63
108_N	112_K	0.681	0.63
417_T	422_S	0.680	0.63
25_D	132_G	0.680	0.63
35_R	38_V	0.678	0.63
32_A	35_R	0.675	0.62
247_R	307_T	0.675	0.62
396_L	399_P	0.673	0.62
221_A	291_H	0.672	0.62
202_L	206_V	0.671	0.62
123_D	126_V	0.670	0.62
360_E	430_H	0.669	0.62
502_A	505_D	0.669	0.62
139_S	442_R	0.665	0.61
237_A	337_V	0.665	0.61
220_S	510_G	0.665	0.61
362_A	407_V	0.663	0.61
349_L	353_Y	0.663	0.61
165_A	181_A	0.663	0.61
301_L	441_F	0.662	0.61
496_L	499_D	0.662	0.61
74_D	392_L	0.660	0.61
88_A	398_I	0.660	0.61
338_S	428_E	0.659	0.60
44_R	334_A	0.659	0.60
93_E	138_P	0.658	0.60
238_S	281_A	0.658	0.60
433_M	436_G	0.657	0.60
291_H	364_I	0.656	0.60
48_V	318_V	0.652	0.60
420_N	431_V	0.652	0.60
165_A	172_M	0.651	0.60
73_A	485_E	0.650	0.59
227_L	479_A	0.650	0.59
479_A	482_L	0.648	0.59
233_M	271_H	0.646	0.59
15_P	306_A	0.646	0.59
218_L	295_R	0.645	0.59
8_I	21_V	0.644	0.59
52_D	69_R	0.644	0.59
398_I	427_Q	0.643	0.59
179_A	184_E	0.642	0.58
101_A	106_R	0.641	0.58
486_V	505_D	0.640	0.58
300_H	303_A	0.640	0.58
22_A	100_R	0.639	0.58
43_A	46_A	0.639	0.58
152_L	342_F	0.639	0.58
234_S	239_C	0.639	0.58
218_L	255_S	0.639	0.58
215_E	299_D	0.638	0.58
42_R	190_A	0.636	0.58
14_T	306_A	0.635	0.58
359_A	407_V	0.633	0.57
86_H	150_A	0.631	0.57
356_S	444_A	0.631	0.57
62_F	282_Y	0.631	0.57
440_N	444_A	0.630	0.57
482_L	509_A	0.629	0.57
263_T	269_L	0.628	0.57
77_A	81_N	0.628	0.57
410_L	451_V	0.628	0.57
501_A	504_G	0.626	0.57
195_A	318_V	0.626	0.57
228_T	284_I	0.626	0.57
244_H	253_A	0.624	0.56
85_S	398_I	0.624	0.56
62_F	70_I	0.624	0.56
67_D	277_R	0.620	0.56
145_A	431_V	0.620	0.56
291_H	361_L	0.619	0.56
39_R	120_R	0.619	0.56
78_L	200_T	0.618	0.56
125_L	155_M	0.617	0.55
87_A	157_R	0.616	0.55
230_E	475_G	0.615	0.55
387_A	492_G	0.612	0.55
461_Q	464_E	0.612	0.55
401_Y	424_S	0.612	0.55
259_I	287_L	0.611	0.55
249_H	311_S	0.610	0.55
45_I	55_V	0.610	0.55
487_S	499_D	0.608	0.54
108_N	111_A	0.607	0.54
94_L	99_V	0.606	0.54
44_R	318_V	0.605	0.54
387_A	490_V	0.605	0.54
225_G	368_R	0.604	0.54
209_L	213_D	0.603	0.54
479_A	506_L	0.603	0.54
494_R	497_A	0.603	0.54
124_V	177_A	0.601	0.54
128_L	133_V	0.601	0.54
120_R	183_L	0.600	0.53
105_T	408_N	0.598	0.53
216_R	510_G	0.598	0.53
342_F	432_S	0.598	0.53
208_A	309_L	0.597	0.53
268_V	275_C	0.596	0.53
423_V	431_V	0.595	0.53
358_L	444_A	0.594	0.53
52_D	72_A	0.593	0.53
38_V	126_V	0.593	0.53
231_V	459_G	0.592	0.52
396_L	484_R	0.592	0.52
213_D	442_R	0.591	0.52
145_A	342_F	0.591	0.52
415_Q	418_L	0.590	0.52
21_V	25_D	0.587	0.52
62_F	82_L	0.584	0.51
358_L	445_V	0.583	0.51
15_P	208_A	0.583	0.51
351_L	438_A	0.583	0.51
145_A	282_Y	0.582	0.51
94_L	98_A	0.581	0.51
297_A	300_H	0.579	0.51
230_E	266_S	0.577	0.51
15_P	302_R	0.576	0.51
254_V	295_R	0.576	0.51
10_G	13_L	0.575	0.50
88_A	402_T	0.575	0.50
286_C	374_N	0.575	0.50
210_A	358_L	0.574	0.50
499_D	502_A	0.574	0.50
223_T	258_H	0.573	0.50
62_F	66_S	0.573	0.50
319_F	337_V	0.572	0.50
287_L	291_H	0.572	0.50
118_R	190_A	0.572	0.50
353_Y	356_S	0.572	0.50
366_E	400_Q	0.571	0.50
27_P	130_N	0.571	0.50
49_L	55_V	0.569	0.50
107_L	117_I	0.567	0.49
103_L	128_L	0.567	0.49
282_Y	431_V	0.565	0.49
46_A	50_G	0.565	0.49
33_G	37_A	0.565	0.49
120_R	123_D	0.564	0.49
313_T	344_G	0.563	0.49
156_S	160_I	0.563	0.49
396_L	457_L	0.562	0.49
268_V	271_H	0.562	0.49
320_A	332_D	0.562	0.49
233_M	275_C	0.562	0.49
475_G	478_A	0.560	0.49
506_L	509_A	0.559	0.48
86_H	401_Y	0.558	0.48
117_I	195_A	0.557	0.48
15_P	18_V	0.556	0.48
128_L	185_P	0.556	0.48
413_L	416_P	0.555	0.48
269_L	274_D	0.554	0.48
396_L	503_V	0.554	0.48
114_Y	246_V	0.554	0.48
241_P	257_R	0.554	0.48
210_A	442_R	0.553	0.48
404_A	424_S	0.552	0.48
374_N	377_T	0.551	0.47
84_R	495_A	0.551	0.47
21_V	129_L	0.550	0.47
401_Y	427_Q	0.550	0.47
267_E	477_A	0.549	0.47
384_P	425_G	0.548	0.47
232_T	425_G	0.548	0.47
215_E	218_L	0.547	0.47
166_D	172_M	0.547	0.47
368_R	428_E	0.547	0.47
170_E	173_P	0.546	0.47
110_L	117_I	0.546	0.47
279_Q	285_R	0.545	0.47
406_L	447_K	0.544	0.47
396_L	461_Q	0.543	0.46
175_A	485_E	0.543	0.46
450_T	453_G	0.541	0.46
147_G	198_N	0.541	0.46
214_A	448_A	0.540	0.46
72_A	453_G	0.540	0.46
303_A	306_A	0.539	0.46
132_G	168_A	0.538	0.46
40_E	505_D	0.538	0.46
112_K	248_P	0.537	0.46
221_A	361_L	0.536	0.46
250_D	253_A	0.535	0.46
85_S	401_Y	0.535	0.46
211_L	302_R	0.533	0.45
92_S	443_E	0.532	0.45
232_T	371_R	0.532	0.45
21_V	24_H	0.531	0.45
294_V	359_A	0.530	0.45
139_S	439_Y	0.529	0.45
62_F	193_G	0.529	0.45
103_L	155_M	0.528	0.45
242_A	333_R	0.528	0.45
27_P	478_A	0.528	0.45
89_G	154_H	0.528	0.45
214_A	444_A	0.527	0.45
37_A	40_E	0.527	0.45
27_P	184_E	0.527	0.45
27_P	306_A	0.526	0.44
224_A	262_L	0.525	0.44
252_Q	256_A	0.523	0.44
418_L	451_V	0.522	0.44
59_N	72_A	0.522	0.44
448_A	452_V	0.522	0.44
147_G	342_F	0.522	0.44
145_A	151_P	0.522	0.44
79_Q	193_G	0.521	0.44
184_E	264_A	0.521	0.44
32_A	175_A	0.521	0.44
120_R	186_V	0.521	0.44
464_E	487_S	0.520	0.44
317_L	340_G	0.520	0.44
56_Y	63_G	0.520	0.44
213_D	445_V	0.519	0.44
475_G	483_V	0.519	0.44
283_S	364_I	0.519	0.44
152_L	282_Y	0.517	0.43
59_N	190_A	0.517	0.43
105_T	201_Q	0.517	0.43
343_H	410_L	0.516	0.43
24_H	27_P	0.516	0.43
246_V	317_L	0.516	0.43
48_V	53_E	0.515	0.43
128_L	181_A	0.515	0.43
472_L	480_Y	0.514	0.43
238_S	437_A	0.514	0.43
6_V	25_D	0.514	0.43
102_L	435_A	0.514	0.43
151_P	282_Y	0.513	0.43
394_S	401_Y	0.513	0.43
461_Q	484_R	0.513	0.43
486_V	503_V	0.513	0.43
255_S	287_L	0.512	0.43
405_S	423_V	0.511	0.43
214_A	298_L	0.511	0.43
103_L	139_S	0.510	0.43
28_V	128_L	0.509	0.42
349_L	357_A	0.509	0.42
478_A	481_D	0.509	0.42
138_P	423_V	0.508	0.42
414_G	418_L	0.508	0.42
482_L	488_E	0.508	0.42
219_R	223_T	0.507	0.42
257_R	299_D	0.505	0.42
16_A	215_E	0.505	0.42
475_G	479_A	0.505	0.42
338_S	368_R	0.504	0.42
445_V	449_A	0.504	0.42
19_D	213_D	0.503	0.42
106_R	281_A	0.503	0.42
45_I	318_V	0.502	0.42
106_R	342_F	0.502	0.42
25_D	505_D	0.502	0.42
450_T	507_V	0.501	0.41
290_V	430_H	0.501	0.41
297_A	354_A	0.500	0.41
366_E	421_A	0.500	0.41
29_S	32_A	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1gkmA	4	0.96	100	0.038	Contact Map
2qveA	3	0.9619	100	0.048	Contact Map
3unvA	2	0.9429	100	0.049	Contact Map
2o6yA	4	0.941	100	0.055	Contact Map
2nynA	4	0.9086	100	0.055	Contact Map
1y2mA	4	0.939	100	0.1	Contact Map
1w27A	4	0.9676	100	0.104	Contact Map
4c5sA	4	0.9581	100	0.12	Contact Map
4f0lA	2	0.301	17.1	0.983	Contact Map
4jf3A	3	0.1714	16.1	0.983	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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