GREMLIN Database
Q9HQD2 - Sporulation regulator homolog
UniProt: Q9HQD2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 160 (139)
Sequences: 10518 (8303)
Seq/√Len: 704.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_R58_T3.3271.00
20_Q91_A3.1021.00
108_E139_Y3.0981.00
67_V107_A2.6091.00
64_V94_F2.4371.00
55_A106_H2.3111.00
101_S137_R2.2971.00
106_H109_R2.2911.00
101_S136_R2.0791.00
83_G111_L2.0611.00
110_E114_R2.0571.00
56_V63_T2.0451.00
59_Q94_F2.0411.00
13_A16_E1.9911.00
128_A132_R1.9371.00
110_E113_S1.9181.00
57_T99_R1.8931.00
94_F97_D1.8781.00
4_R10_D1.8521.00
104_L137_R1.7581.00
131_R135_E1.7491.00
108_E119_L1.7361.00
135_E141_P1.6661.00
71_T116_A1.6421.00
59_Q64_V1.6251.00
62_R91_A1.6141.00
59_Q97_D1.6071.00
106_H110_E1.5941.00
62_R93_G1.5781.00
58_T63_T1.5631.00
132_R135_E1.5501.00
6_A14_V1.5471.00
121_I134_Y1.5091.00
55_A110_E1.4831.00
69_F107_A1.4681.00
16_E91_A1.4591.00
101_S105_T1.4461.00
105_T137_R1.4101.00
141_P144_V1.4081.00
65_G90_V1.3811.00
13_A63_T1.3791.00
16_E20_Q1.3721.00
58_T61_G1.3331.00
131_R141_P1.2631.00
83_G116_A1.2321.00
109_R113_S1.2321.00
125_A144_V1.2291.00
95_R129_A1.2151.00
111_L116_A1.1871.00
111_L119_L1.1811.00
62_R94_F1.1811.00
123_A127_N1.1761.00
41_A44_L1.1691.00
69_F110_E1.1601.00
98_G101_S1.1551.00
67_V85_I1.1541.00
82_R120_A1.1461.00
15_A19_V1.1351.00
91_A94_F1.1181.00
17_L63_T1.1121.00
130_A134_Y1.1001.00
69_F111_L1.0891.00
57_T65_G1.0731.00
67_V103_L1.0631.00
104_L134_Y1.0611.00
19_V23_A1.0321.00
59_Q62_R1.0251.00
37_N40_Q1.0231.00
85_I104_L1.0231.00
33_L36_E1.0221.00
42_R46_G1.0161.00
64_V99_R0.9931.00
6_A54_V0.9871.00
127_N130_A0.9841.00
17_L21_L0.9711.00
11_I15_A0.9651.00
39_A42_R0.9591.00
33_L37_N0.9591.00
88_L134_Y0.9531.00
71_T114_R0.9481.00
70_H86_D0.9451.00
65_G103_L0.9441.00
108_E112_R0.9361.00
38_H42_R0.9221.00
20_Q93_G0.9181.00
100_G133_L0.9171.00
17_L91_A0.9101.00
20_Q92_P0.9091.00
10_D58_T0.9081.00
133_L137_R0.8971.00
121_I139_Y0.8941.00
102_A105_T0.8861.00
123_A130_A0.8821.00
6_A56_V0.8761.00
8_G42_R0.8741.00
82_R118_A0.8701.00
123_A131_R0.8631.00
12_D16_E0.8611.00
36_E40_Q0.8581.00
40_Q44_L0.8571.00
90_V99_R0.8571.00
53_G110_E0.8511.00
108_E137_R0.8451.00
13_A62_R0.8451.00
5_P110_E0.8341.00
25_Q28_H0.8331.00
105_T109_R0.8311.00
128_A131_R0.8281.00
3_V55_A0.8181.00
37_N41_A0.8141.00
23_A28_H0.8131.00
41_A45_I0.8121.00
109_R112_R0.8121.00
96_G129_A0.7961.00
71_T83_G0.7931.00
21_L89_Y0.7751.00
44_L48_Y0.7591.00
5_P55_A0.7581.00
18_W66_F0.7571.00
99_R102_A0.7491.00
119_L139_Y0.7491.00
14_V66_F0.7481.00
84_V122_E0.7471.00
53_G114_R0.7441.00
121_I130_A0.7441.00
128_A135_E0.7351.00
72_E84_V0.7341.00
57_T103_L0.7301.00
24_E27_A0.7291.00
102_A106_H0.7251.00
129_A132_R0.7241.00
8_G46_G0.7241.00
7_S10_D0.7231.00
24_E92_P0.7161.00
68_M86_D0.7151.00
104_L133_L0.7111.00
54_V68_M0.7011.00
66_F89_Y0.7001.00
104_L139_Y0.6981.00
54_V58_T0.6971.00
13_A17_L0.6931.00
3_V106_H0.6921.00
47_Q51_A0.6881.00
106_H113_S0.6871.00
34_A38_H0.6731.00
84_V120_A0.6681.00
3_V102_A0.6631.00
105_T108_E0.6591.00
118_A142_H0.6501.00
40_Q43_D0.6471.00
84_V87_N0.6431.00
130_A133_L0.6421.00
12_D38_H0.6421.00
26_R29_G0.6331.00
45_I48_Y0.6311.00
77_E80_R0.6281.00
3_V103_L0.6241.00
85_I121_I0.6221.00
87_N124_L0.6171.00
16_E19_V0.6111.00
96_G100_G0.6051.00
123_A134_Y0.6021.00
81_T117_D0.6001.00
22_A26_R0.5901.00
16_E62_R0.5811.00
6_A11_I0.5791.00
18_W22_A0.5761.00
65_G99_R0.5761.00
57_T64_V0.5721.00
32_L37_N0.5701.00
94_F99_R0.5671.00
10_D13_A0.5671.00
88_L121_I0.5661.00
132_R136_R0.5621.00
13_A56_V0.5621.00
85_I119_L0.5611.00
72_E82_R0.5571.00
13_A91_A0.5571.00
49_V52_D0.5541.00
88_L104_L0.5531.00
88_L130_A0.5501.00
32_L35_A0.5471.00
85_I107_A0.5421.00
135_E140_A0.5381.00
71_T81_T0.5311.00
23_A26_R0.5311.00
30_S33_L0.5301.00
96_G132_R0.5241.00
8_G11_I0.5241.00
18_W41_A0.5221.00
127_N133_L0.5221.00
35_A39_A0.5191.00
4_R56_V0.5181.00
37_N45_I0.5171.00
85_I88_L0.5161.00
127_N131_R0.5151.00
101_S132_R0.5151.00
22_A89_Y0.5141.00
133_L136_R0.5131.00
21_L24_E0.5120.99
36_E41_A0.5120.99
68_M87_N0.5110.99
39_A43_D0.5070.99
85_I134_Y0.5040.99
96_G136_R0.5040.99
12_D15_A0.5020.99
53_G69_F0.5010.99
83_G107_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fynA 2 0.8938 99.8 0.327 Contact Map
2oh1A 1 0.9313 99.8 0.343 Contact Map
1ufhA 3 0.9187 99.8 0.344 Contact Map
3dr6A 2 0.975 99.8 0.347 Contact Map
3zj0A 1 0.9375 99.8 0.353 Contact Map
1z4eA 2 0.925 99.8 0.355 Contact Map
3i9sA 4 0.9875 99.8 0.356 Contact Map
1on0A 4 0.9313 99.8 0.356 Contact Map
1s3zA 2 0.8938 99.8 0.357 Contact Map
2j8mA 2 0.9688 99.8 0.357 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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