GREMLIN Database
PGK - Phosphoglycerate kinase
UniProt: Q9HQD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (381)
Sequences: 3698 (1863)
Seq/√Len: 95.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_T319_S3.8031.00
390_D395_A3.7721.00
239_D297_G3.5941.00
35_D39_R3.4721.00
17_G58_L3.2721.00
27_T31_G2.9791.00
242_R298_D2.8921.00
307_D310_D2.8851.00
78_R81_A2.7591.00
275_V311_A2.7361.00
178_E182_D2.6561.00
18_V48_L2.5671.00
48_L53_A2.5581.00
9_L172_Y2.4881.00
35_D78_R2.4591.00
334_D366_R2.4081.00
46_A50_A2.2681.00
136_L140_L2.2641.00
47_E175_R2.2641.00
163_V167_E2.2311.00
22_I41_H2.1741.00
281_R287_E2.1711.00
347_A353_S2.1471.00
225_T328_A2.1401.00
234_A247_F2.1281.00
17_G165_F2.1171.00
54_R107_P2.1101.00
230_N301_V2.1051.00
283_G333_D2.1011.00
106_A109_E2.0751.00
105_L111_V2.0551.00
272_H315_V2.0281.00
105_L109_E2.0211.00
78_R82_L1.9871.00
261_A271_L1.9641.00
99_R142_P1.9511.00
341_R367_F1.9491.00
262_D266_A1.9431.00
93_T119_Y1.9111.00
341_R345_D1.9011.00
309_V313_A1.8981.00
211_A263_L1.8961.00
47_E51_A1.8551.00
88_S109_E1.8301.00
138_D168_V1.8261.00
58_L144_L1.8251.00
15_A56_A1.8221.00
275_V307_D1.8181.00
211_A259_R1.8151.00
280_E286_C1.7981.00
345_D349_E1.7891.00
291_D307_D1.7861.00
73_E77_D1.7841.00
67_D70_A1.7801.00
219_A222_V1.7671.00
338_D341_R1.7531.00
310_D314_D1.7391.00
234_A254_G1.7391.00
7_D175_R1.7361.00
80_D86_P1.7231.00
289_S299_E1.7231.00
309_V342_G1.7201.00
316_L350_V1.7131.00
236_T261_A1.6981.00
340_T363_A1.6871.00
100_D104_D1.6751.00
187_V354_I1.6701.00
134_T167_E1.6631.00
154_A162_L1.6481.00
270_A315_V1.6421.00
262_D265_A1.6421.00
254_G258_A1.6131.00
7_D178_E1.6071.00
215_S267_H1.5881.00
173_A397_L1.5801.00
11_A48_L1.5651.00
285_R335_L1.5641.00
195_T221_N1.5521.00
221_N272_H1.5511.00
277_V292_A1.5501.00
198_V210_A1.5471.00
90_C101_A1.5411.00
223_L312_Y1.5411.00
101_A111_V1.5331.00
83_L110_A1.5291.00
13_N107_P1.5271.00
296_A299_E1.5261.00
56_A144_L1.5231.00
281_R299_E1.5141.00
207_V253_Y1.5051.00
215_S263_L1.5001.00
71_R89_Y1.4881.00
281_R298_D1.4661.00
46_A85_A1.4631.00
42_V82_L1.4601.00
148_V172_Y1.4461.00
195_T316_L1.4411.00
181_L394_V1.4261.00
102_V111_V1.4190.99
295_P301_V1.4150.99
49_L54_R1.4120.99
96_T99_R1.3950.99
204_P246_D1.3950.99
58_L116_T1.3880.99
323_V386_L1.3860.99
15_A54_R1.3850.99
166_P396_A1.3830.99
177_M394_V1.3790.99
230_N277_V1.3770.99
26_L61_Q1.3750.99
7_D47_E1.3750.99
308_T312_Y1.3730.99
138_D142_P1.3650.99
352_H373_D1.3290.99
313_A346_A1.3220.99
221_N315_V1.3200.99
17_G144_L1.3190.99
39_R82_L1.3190.99
317_A349_E1.3160.99
96_T100_D1.3100.99
18_V57_V1.3040.99
158_S163_V1.2950.99
242_R300_A1.2890.99
91_D97_G1.2880.99
280_E302_C1.2780.99
18_V45_L1.2740.99
221_N270_A1.2710.99
88_S101_A1.2690.99
45_L57_V1.2650.99
85_A109_E1.2600.99
365_R370_T1.2560.99
253_Y256_E1.2470.99
90_C98_A1.2450.99
137_V164_G1.2410.99
290_T306_S1.2380.99
221_N319_S1.2230.98
121_E136_L1.2220.98
314_D317_A1.2190.98
48_L55_V1.2160.98
313_A317_A1.2030.98
342_G345_D1.2000.98
20_V57_V1.1990.98
187_V323_V1.1970.98
311_A315_V1.1930.98
132_A164_G1.1860.98
285_R334_D1.1800.98
255_T258_A1.1760.98
18_V44_T1.1750.98
119_Y136_L1.1740.98
76_A80_D1.1670.98
116_T136_L1.1640.98
155_A177_M1.1630.98
151_A154_A1.1570.98
97_G101_A1.1480.98
291_D294_P1.1410.98
77_D80_D1.1300.97
185_S385_L1.1230.97
9_L146_A1.1210.97
240_L245_T1.1180.97
236_T265_A1.1170.97
59_A72_L1.1080.97
119_Y139_G1.1070.97
12_A107_P1.1050.97
246_D252_D1.1020.97
350_V353_S1.1010.97
183_A352_H1.1000.97
233_L238_V1.1000.97
328_A343_V1.0970.97
134_T168_V1.0910.97
102_V105_L1.0910.97
134_T138_D1.0890.97
223_L308_T1.0860.97
338_D342_G1.0820.97
185_S189_D1.0810.97
316_L346_A1.0800.97
49_L85_A1.0720.96
12_A52_D1.0710.96
58_L165_F1.0630.96
94_F119_Y1.0590.96
20_V41_H1.0540.96
221_N318_D1.0540.96
304_I328_A1.0530.96
227_V244_S1.0500.96
184_L385_L1.0430.96
277_V301_V1.0420.96
94_F139_G1.0360.96
234_A239_D1.0330.96
27_T30_G1.0270.96
238_V293_L1.0250.95
72_L89_Y1.0200.95
92_A95_S1.0100.95
278_A290_T1.0090.95
73_E89_Y1.0090.95
137_V160_P1.0040.95
281_R286_C1.0030.95
132_A163_V1.0020.95
34_D365_R1.0000.95
90_C111_V0.9990.95
192_T220_D0.9950.95
155_A162_L0.9950.95
233_L273_L0.9920.95
207_V256_E0.9910.95
36_A365_R0.9910.95
322_V351_E0.9880.94
73_E91_D0.9860.94
6_L48_L0.9810.94
369_I372_F0.9800.94
234_A245_T0.9790.94
135_A139_G0.9780.94
5_T178_E0.9770.94
314_D318_D0.9740.94
276_D305_G0.9710.94
94_F136_L0.9710.94
309_V338_D0.9700.94
182_D186_G0.9700.94
77_D81_A0.9680.94
144_L169_L0.9660.94
272_H312_Y0.9630.94
279_V299_E0.9580.94
137_V168_V0.9560.93
322_V347_A0.9520.93
223_L315_V0.9510.93
315_V318_D0.9500.93
334_D337_A0.9500.93
245_T254_G0.9440.93
86_P109_E0.9440.93
278_A309_V0.9440.93
263_L266_A0.9330.93
337_A367_F0.9320.93
196_Y219_A0.9250.92
355_V364_I0.9250.92
42_V83_L0.9210.92
27_T33_A0.9170.92
67_D123_Y0.9150.92
255_T259_R0.9110.92
205_D208_E0.9110.92
355_V360_T0.9050.91
227_V240_L0.9040.91
54_R102_V0.9030.91
135_A138_D0.9010.91
316_L343_V0.9000.91
80_D112_V0.8970.91
337_A341_R0.8950.91
99_R139_G0.8940.91
45_L110_A0.8910.91
49_L110_A0.8900.91
93_T140_L0.8890.91
311_A314_D0.8860.91
10_A51_A0.8860.91
240_L301_V0.8850.90
102_V143_A0.8840.90
47_E50_A0.8830.90
309_V343_V0.8820.90
264_L269_D0.8810.90
39_R78_R0.8760.90
91_D101_A0.8760.90
57_V112_V0.8650.89
68_E71_R0.8630.89
265_A270_A0.8620.89
288_L335_L0.8610.89
71_R114_E0.8610.89
313_A342_G0.8600.89
361_A365_R0.8590.89
310_D313_A0.8570.89
153_A378_G0.8540.89
121_E139_G0.8520.89
88_S104_D0.8480.89
68_E118_F0.8470.88
98_A113_L0.8470.88
116_T140_L0.8460.88
54_R105_L0.8450.88
259_R262_D0.8440.88
186_G352_H0.8410.88
282_D300_A0.8400.88
35_D82_L0.8370.88
281_R289_S0.8310.88
36_A40_A0.8270.87
32_L78_R0.8220.87
284_A333_D0.8210.87
99_R103_A0.8200.87
283_G302_C0.8170.87
32_L79_L0.8170.87
197_V347_A0.8150.86
149_N155_A0.8140.86
75_H112_V0.8100.86
166_P171_S0.8090.86
46_A84_D0.8090.86
259_R263_L0.8090.86
234_A240_L0.8080.86
183_A373_D0.8060.86
281_R296_A0.8050.86
36_A361_A0.8040.86
116_T161_S0.8030.86
256_E259_R0.8030.86
304_I308_T0.8020.86
162_L166_P0.8020.86
233_L277_V0.8000.85
101_A104_D0.8000.85
18_V55_V0.8000.85
45_L55_V0.7980.85
97_G100_D0.7960.85
26_L33_A0.7950.85
49_L55_V0.7940.85
49_L109_E0.7910.85
258_A262_D0.7890.85
364_I372_F0.7880.85
26_L30_G0.7870.85
230_N292_A0.7870.85
100_D103_A0.7860.84
304_I339_G0.7840.84
246_D253_Y0.7810.84
154_A159_Q0.7790.84
59_A154_A0.7780.84
302_C330_V0.7780.84
247_F254_G0.7770.84
288_L333_D0.7750.84
302_C333_D0.7740.84
146_A172_Y0.7710.83
227_V245_T0.7700.83
114_E118_F0.7690.83
346_A350_V0.7650.83
238_V291_D0.7640.83
275_V308_T0.7630.83
208_E211_A0.7620.83
149_N154_A0.7600.82
215_S219_A0.7560.82
66_G70_A0.7530.82
344_F364_I0.7530.82
272_H311_A0.7500.82
131_A134_T0.7480.81
287_E299_E0.7480.81
11_A16_I0.7460.81
355_V372_F0.7420.81
347_A372_F0.7400.81
278_A338_D0.7380.81
7_D51_A0.7370.80
10_A14_R0.7360.80
88_S105_L0.7350.80
95_S98_A0.7340.80
235_A257_I0.7330.80
139_G142_P0.7280.80
38_L78_R0.7250.79
330_V333_D0.7250.79
374_H382_A0.7250.79
149_N159_Q0.7240.79
285_R333_D0.7180.79
191_P321_T0.7170.79
244_S300_A0.7160.78
163_V396_A0.7150.78
102_V109_E0.7140.78
384_N389_A0.7140.78
283_G286_C0.7130.78
184_L188_A0.7130.78
264_L267_H0.7100.78
173_A177_M0.7100.78
11_A51_A0.7090.78
123_Y159_Q0.7070.78
73_E76_A0.7070.78
361_A364_I0.7070.78
215_S218_L0.7050.77
31_G77_D0.7010.77
283_G300_A0.7010.77
208_E389_A0.7000.77
88_S111_V0.6990.77
59_A116_T0.6980.77
195_T315_V0.6970.77
89_Y101_A0.6950.76
313_A349_E0.6930.76
42_V46_A0.6930.76
12_A51_A0.6910.76
92_A98_A0.6910.76
210_A214_L0.6900.76
133_D137_V0.6890.76
309_V346_A0.6880.76
92_A119_Y0.6870.76
89_Y116_T0.6860.75
48_L148_V0.6840.75
26_L74_R0.6800.75
334_D338_D0.6790.75
270_A311_A0.6770.75
134_T164_G0.6760.74
50_A85_A0.6750.74
175_R178_E0.6740.74
214_L269_D0.6730.74
179_A183_A0.6720.74
44_T175_R0.6710.74
93_T136_L0.6700.74
281_R284_A0.6690.74
337_A366_R0.6660.73
279_V289_S0.6660.73
229_A277_V0.6650.73
99_R143_A0.6630.73
93_T121_E0.6620.73
80_D85_A0.6610.73
198_V361_A0.6610.73
22_I57_V0.6600.73
300_A333_D0.6570.72
133_D164_G0.6560.72
327_P331_F0.6560.72
77_D86_P0.6550.72
355_V361_A0.6550.72
93_T116_T0.6540.72
56_A111_V0.6530.72
66_G123_Y0.6520.72
149_N396_A0.6520.72
322_V350_V0.6520.72
211_A256_E0.6510.72
201_A205_D0.6440.71
230_N300_A0.6420.71
212_H215_S0.6410.70
360_T382_A0.6410.70
324_V344_F0.6410.70
181_L185_S0.6410.70
341_R366_R0.6410.70
70_A116_T0.6400.70
247_F255_T0.6390.70
335_L338_D0.6360.70
196_Y223_L0.6350.70
15_A103_A0.6340.70
288_L299_E0.6330.70
93_T98_A0.6310.69
281_R288_L0.6310.69
204_P252_D0.6300.69
98_A101_A0.6300.69
140_L161_S0.6290.69
58_L113_L0.6270.69
238_V277_V0.6240.68
263_L267_H0.6210.68
349_E371_G0.6210.68
48_L169_L0.6190.68
242_R282_D0.6140.67
14_R145_D0.6140.67
193_P321_T0.6140.67
20_V58_L0.6130.67
260_A271_L0.6120.67
307_D311_A0.6100.67
372_F375_V0.6090.67
4_R9_L0.6070.66
20_V59_A0.6060.66
362_A366_R0.6060.66
30_G74_R0.6060.66
33_A362_A0.6040.66
253_Y374_H0.6040.66
153_A176_V0.6020.66
56_A143_A0.6020.66
194_R323_V0.5990.65
113_L140_L0.5990.65
11_A53_A0.5990.65
256_E260_A0.5980.65
56_A102_V0.5980.65
57_V110_A0.5970.65
316_L319_S0.5970.65
212_H388_D0.5970.65
205_D210_A0.5950.65
41_H153_A0.5950.65
204_P228_V0.5910.64
223_L272_H0.5900.64
235_A254_G0.5890.64
171_S397_L0.5880.64
116_T162_L0.5880.64
211_A260_A0.5880.64
137_V165_F0.5870.64
284_A335_L0.5870.64
193_P220_D0.5850.63
304_I309_V0.5840.63
238_V292_A0.5830.63
227_V330_V0.5830.63
195_T318_D0.5820.63
147_Y166_P0.5820.63
179_A374_H0.5810.63
45_L79_L0.5800.63
283_G330_V0.5800.63
5_T182_D0.5770.62
149_N166_P0.5770.62
61_Q70_A0.5760.62
151_A159_Q0.5760.62
214_L222_V0.5750.62
348_S371_G0.5740.62
280_E336_F0.5740.62
286_C333_D0.5730.62
147_Y159_Q0.5720.62
158_S164_G0.5710.62
49_L107_P0.5700.61
4_R172_Y0.5700.61
353_S373_D0.5690.61
55_V110_A0.5680.61
121_E140_L0.5670.61
42_V76_A0.5660.61
198_V205_D0.5660.61
54_R106_A0.5650.61
202_K358_G0.5630.61
18_V148_V0.5620.60
183_A187_V0.5620.60
20_V32_L0.5580.60
3_I181_L0.5580.60
289_S296_A0.5580.60
61_Q75_H0.5570.60
315_V319_S0.5520.59
144_L165_F0.5520.59
328_A367_F0.5520.59
116_T119_Y0.5520.59
222_V271_L0.5520.59
258_A265_A0.5510.59
205_D361_A0.5510.59
331_F363_A0.5500.59
183_A354_I0.5500.59
16_I172_Y0.5500.59
208_E387_T0.5500.59
214_L264_L0.5490.59
344_F369_I0.5490.59
93_T139_G0.5490.59
132_A135_A0.5460.58
70_A118_F0.5440.58
317_A346_A0.5430.58
22_I59_A0.5410.58
358_G380_G0.5400.57
94_F140_L0.5390.57
205_D253_Y0.5380.57
346_A349_E0.5370.57
304_I343_V0.5370.57
59_A151_A0.5350.57
277_V293_L0.5340.57
370_T375_V0.5340.57
90_C93_T0.5340.57
103_A107_P0.5310.56
204_P321_T0.5300.56
220_D267_H0.5300.56
208_E253_Y0.5290.56
3_I374_H0.5280.56
194_R205_D0.5260.55
68_E73_E0.5250.55
98_A102_V0.5250.55
89_Y98_A0.5240.55
361_A375_V0.5230.55
224_V228_V0.5220.55
41_H45_L0.5220.55
162_L393_A0.5210.55
342_G346_A0.5210.55
230_N295_P0.5200.55
93_T113_L0.5200.55
39_R365_R0.5190.54
6_L178_E0.5180.54
147_Y151_A0.5170.54
46_A49_L0.5170.54
259_R266_A0.5170.54
98_A119_Y0.5170.54
102_V107_P0.5160.54
235_A258_A0.5160.54
165_F169_L0.5150.54
42_V57_V0.5150.54
95_S99_R0.5140.54
70_A123_Y0.5140.54
3_I8_D0.5140.54
304_I312_Y0.5140.54
276_D308_T0.5130.54
62_G207_V0.5120.53
6_L148_V0.5120.53
15_A145_D0.5120.53
65_G123_Y0.5100.53
95_S101_A0.5090.53
94_F143_A0.5090.53
230_N244_S0.5090.53
239_D299_E0.5080.53
163_V166_P0.5070.53
56_A105_L0.5050.52
233_L292_A0.5050.52
308_T311_A0.5040.52
264_L268_N0.5020.52
51_A175_R0.5010.52
113_L119_Y0.5010.52
147_Y396_A0.5010.52
238_V294_P0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1phpA 1 0.9648 100 -0.004 Contact Map
1vpeA 1 0.9623 100 0.004 Contact Map
2cunA 2 0.9799 100 0.006 Contact Map
3q3vA 1 0.9623 100 0.006 Contact Map
1v6sA 1 0.9573 100 0.009 Contact Map
1qpgA 1 0.9799 100 0.01 Contact Map
3zlbA 1 0.9573 100 0.013 Contact Map
3oz7A 2 0.9799 100 0.013 Contact Map
16pkA 1 0.9673 100 0.015 Contact Map
2wzbA 1 0.9724 100 0.016 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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