GREMLIN Database
Q9HQD0 - Uncharacterized protein
UniProt: Q9HQD0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (197)
Sequences: 2706 (1495)
Seq/√Len: 106.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_D146_E4.6031.00
29_Y191_P4.1991.00
210_Q214_E3.6831.00
166_R174_G3.5241.00
176_P199_P3.2351.00
117_L140_V3.2091.00
53_V76_V2.9471.00
104_V108_D2.9351.00
190_D194_S2.8601.00
35_R38_N2.7311.00
28_Y31_G2.6911.00
60_P64_T2.4141.00
189_G219_L2.4031.00
57_A61_D2.3771.00
179_T189_G2.3421.00
118_S143_A2.3361.00
185_G215_R2.3221.00
214_E217_G2.2531.00
54_S57_A2.2431.00
60_P103_S2.2171.00
189_G200_T2.2151.00
81_D146_E2.1701.00
64_T68_E2.1171.00
190_D223_L2.1041.00
55_A83_A2.0991.00
190_D222_A2.0941.00
122_T125_D2.0221.00
119_V148_I1.9941.00
62_A86_F1.8961.00
218_G222_A1.8701.00
53_V57_A1.8531.00
204_A212_V1.8181.00
125_D128_D1.8061.00
128_D132_R1.7771.00
105_T108_D1.7721.00
25_H211_G1.7021.00
86_F109_V1.6851.00
217_G221_A1.6401.00
117_L121_A1.6291.00
61_D64_T1.5671.00
31_G34_Y1.5621.00
31_G35_R1.5441.00
56_S107_A1.5401.00
141_V145_A1.5291.00
78_R81_D1.4731.00
121_A125_D1.4641.00
58_A61_D1.4491.00
76_V106_V1.4291.00
62_A66_L1.4261.00
123_V127_I1.4191.00
115_V133_T1.3941.00
184_S187_A1.3911.00
53_V62_A1.3761.00
187_A190_D1.3160.99
213_C217_G1.2990.99
145_A148_I1.2890.99
131_A134_G1.2870.99
51_V71_A1.2790.99
215_R218_G1.2710.99
63_A67_R1.2670.99
193_E197_G1.2600.99
214_E218_G1.2580.99
186_G218_G1.2540.99
53_V106_V1.2530.99
157_A161_A1.2490.99
54_S79_A1.2360.99
126_A138_V1.2360.99
66_L74_A1.2260.99
189_G223_L1.2240.99
56_S105_T1.2130.99
55_A107_A1.2100.99
101_L104_V1.2000.99
95_V100_G1.1670.99
202_A219_L1.1610.99
202_A216_C1.1520.98
34_Y38_N1.1500.98
210_Q213_C1.1290.98
222_A225_R1.1250.98
63_A102_D1.1240.98
54_S78_R1.1090.98
46_L140_V1.1030.98
118_S121_A1.0970.98
186_G222_A1.0940.98
95_V104_V1.0830.98
46_L52_T1.0800.98
221_A224_G1.0790.98
63_A91_V1.0770.98
179_T200_T1.0600.97
70_D88_A1.0510.97
51_V74_A1.0380.97
130_M138_V1.0260.97
80_G146_E1.0200.97
34_Y37_M1.0200.97
71_A74_A0.9920.96
59_V109_V0.9890.96
78_R83_A0.9880.96
118_S144_D0.9880.96
66_L91_V0.9790.96
119_V143_A0.9740.96
218_G221_A0.9640.95
174_G199_P0.9490.95
55_A78_R0.9250.94
65_T74_A0.9150.94
104_V109_V0.9130.94
169_S174_G0.9080.94
34_Y68_E0.8980.93
30_R187_A0.8900.93
107_A112_D0.8890.93
118_S125_D0.8860.93
99_H102_D0.8850.93
60_P102_D0.8780.92
168_G173_L0.8780.92
179_T185_G0.8770.92
123_V156_I0.8640.92
187_A191_P0.8640.92
57_A74_A0.8610.92
66_L71_A0.8520.91
127_I156_I0.8510.91
36_R177_D0.8510.91
211_G214_E0.8460.91
179_T202_A0.8450.91
48_A170_R0.8450.91
37_M148_I0.8440.91
54_S107_A0.8430.91
82_L137_C0.8280.90
24_V27_F0.8270.90
59_V104_V0.8250.90
168_G171_P0.8230.90
51_V76_V0.8220.90
55_A86_F0.8170.89
55_A77_Q0.8160.89
183_A187_A0.8060.89
191_P194_S0.7970.88
177_D197_G0.7960.88
56_S79_A0.7930.88
100_G128_D0.7840.87
221_A225_R0.7810.87
56_S78_R0.7790.87
62_A106_V0.7760.87
78_R146_E0.7750.87
180_P184_S0.7650.86
182_G185_G0.7640.86
128_D131_A0.7640.86
210_Q217_G0.7640.86
81_D144_D0.7620.86
181_V185_G0.7600.86
79_A146_E0.7600.86
156_I160_A0.7600.86
95_V101_L0.7580.86
202_A212_V0.7510.85
181_V215_R0.7480.85
114_P139_L0.7480.85
62_A127_I0.7480.85
134_G220_A0.7470.85
99_H104_V0.7440.85
89_D114_P0.7330.84
126_A150_V0.7310.84
32_L36_R0.7310.84
181_V211_G0.7310.84
42_L162_T0.7300.83
183_A186_G0.7190.83
186_G215_R0.7190.83
186_G189_G0.7160.82
54_S83_A0.7150.82
153_A157_A0.7140.82
66_L138_V0.6940.80
127_I159_L0.6890.80
30_R191_P0.6870.80
117_L139_L0.6770.79
91_V123_V0.6750.78
27_F31_G0.6700.78
204_A211_G0.6670.78
50_R207_Y0.6650.77
220_A224_G0.6630.77
54_S77_Q0.6580.77
201_T205_N0.6570.76
58_A105_T0.6550.76
184_S215_R0.6530.76
166_R170_R0.6460.75
75_V147_A0.6460.75
190_D193_E0.6450.75
49_S147_A0.6430.75
46_L51_V0.6410.75
66_L156_I0.6390.75
181_V184_S0.6370.74
211_G215_R0.6350.74
185_G204_A0.6330.74
177_D192_P0.6310.74
33_L191_P0.6310.74
25_H180_P0.6300.73
180_P188_P0.6290.73
197_G200_T0.6270.73
181_V216_C0.6260.73
209_E213_C0.6240.73
82_L139_L0.6240.73
177_D180_P0.6220.73
216_C220_A0.6210.72
63_A160_A0.6190.72
127_I134_G0.6190.72
203_G207_Y0.6190.72
37_M68_E0.6170.72
185_G202_A0.6160.72
75_V82_L0.6120.71
176_P201_T0.6120.71
218_G223_L0.6080.71
118_S122_T0.6060.71
113_T145_A0.6030.70
123_V159_L0.6020.70
43_E167_R0.5990.70
95_V99_H0.5970.69
219_L224_G0.5960.69
41_R131_A0.5950.69
108_D112_D0.5940.69
92_V140_V0.5920.69
53_V65_T0.5920.69
73_A150_V0.5910.69
121_A140_V0.5870.68
29_Y33_L0.5870.68
189_G193_E0.5840.68
119_V142_D0.5830.68
84_G110_M0.5830.68
85_V111_A0.5810.67
68_E217_G0.5800.67
182_G215_R0.5800.67
72_T216_C0.5780.67
73_A137_C0.5780.67
44_E47_S0.5770.67
120_D140_V0.5770.67
56_S64_T0.5760.67
82_L130_M0.5750.67
192_P198_D0.5700.66
41_R88_A0.5700.66
193_E223_L0.5670.66
136_G154_Q0.5660.65
72_T153_A0.5610.65
126_A130_M0.5600.65
117_L120_D0.5580.64
58_A63_A0.5580.64
57_A106_V0.5580.64
181_V204_A0.5550.64
126_A134_G0.5550.64
86_F153_A0.5530.64
60_P146_E0.5510.63
126_A151_A0.5510.63
30_R190_D0.5490.63
77_Q80_G0.5490.63
178_R207_Y0.5480.63
44_E50_R0.5480.63
53_V91_V0.5460.63
73_A136_G0.5450.62
74_A106_V0.5430.62
95_V102_D0.5420.62
89_D137_C0.5420.62
178_R198_D0.5410.62
34_Y60_P0.5400.62
44_E131_A0.5380.61
139_L147_A0.5370.61
109_V159_L0.5370.61
35_R153_A0.5360.61
44_E196_D0.5350.61
92_V204_A0.5330.61
69_H74_A0.5330.61
168_G172_P0.5310.60
144_D221_A0.5310.60
124_A161_A0.5290.60
123_V129_A0.5290.60
25_H223_L0.5280.60
42_L69_H0.5270.60
42_L140_V0.5270.60
186_G190_D0.5260.60
216_C219_L0.5260.60
112_D145_A0.5260.60
65_T106_V0.5240.59
183_A218_G0.5240.59
120_D125_D0.5230.59
61_D106_V0.5220.59
34_Y63_A0.5220.59
78_R107_A0.5220.59
218_G224_G0.5160.58
24_V28_Y0.5140.58
26_G75_V0.5140.58
190_D218_G0.5130.58
180_P189_G0.5130.58
195_R198_D0.5130.58
53_V123_V0.5130.58
118_S140_V0.5120.58
26_G178_R0.5120.58
128_D144_D0.5110.58
64_T67_R0.5090.57
124_A127_I0.5090.57
65_T69_H0.5080.57
157_A174_G0.5060.57
136_G206_T0.5040.57
41_R53_V0.5010.56
47_S129_A0.5000.56
60_P101_L0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3usbA 4 0.9622 99.9 0.565 Contact Map
1jcnA 6 0.7983 99.9 0.566 Contact Map
1vrdA 3 0.5042 99.9 0.574 Contact Map
4af0A 3 0.4916 99.9 0.576 Contact Map
3l2bA 2 0.4958 99.9 0.578 Contact Map
1zfjA 4 0.9664 99.9 0.596 Contact Map
2cu0A 4 0.4832 99.9 0.596 Contact Map
4cooA 2 0.6807 99.9 0.596 Contact Map
5ahnA 3 0.4958 99.9 0.601 Contact Map
3fhmA 2 0.5504 99.9 0.604 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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