GREMLIN Database
URK - Uridine kinase
UniProt: Q9HQC9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (187)
Sequences: 4535 (2653)
Seq/√Len: 194.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_A80_Q5.1601.00
88_D95_K5.0851.00
41_Y72_H4.4011.00
68_L72_H3.2691.00
71_T75_A3.2371.00
69_L109_L2.9801.00
9_G124_L2.7441.00
138_I161_L2.7401.00
121_N178_H2.5791.00
47_D51_E2.5531.00
77_L125_D2.3741.00
165_K169_E2.2081.00
81_S100_V2.1641.00
83_E98_R2.1361.00
152_E155_G2.0551.00
38_L114_A2.0261.00
158_D162_S1.9291.00
164_V167_M1.8961.00
109_L124_L1.8961.00
72_H75_A1.8931.00
83_E100_V1.8891.00
65_E94_R1.8461.00
136_V139_L1.8361.00
11_A115_L1.7791.00
86_Q97_D1.7631.00
131_E176_K1.7621.00
88_D91_R1.7511.00
26_T108_V1.7331.00
120_V124_L1.7261.00
74_D78_S1.7161.00
44_D47_D1.7011.00
46_S93_V1.6901.00
74_D123_M1.6581.00
138_I142_I1.6451.00
45_L58_Y1.6151.00
81_S102_E1.6081.00
8_I106_V1.6061.00
26_T35_L1.5811.00
24_E27_D1.5281.00
54_A62_S1.5261.00
165_K168_H1.4811.00
134_A169_E1.4711.00
45_L56_A1.4701.00
87_Y92_H1.4441.00
40_N84_M1.4421.00
74_D119_T1.4201.00
44_D93_V1.4181.00
13_G137_R1.4141.00
126_L181_I1.4041.00
118_E122_D1.3901.00
49_P55_N1.3861.00
60_H171_F1.3671.00
166_P170_Q1.3651.00
133_D136_V1.3641.00
115_L127_H1.3511.00
22_A35_L1.3271.00
50_F56_A1.3241.00
22_A108_V1.3161.00
127_H180_D1.2961.00
84_M99_V1.2901.00
91_R95_K1.2791.00
6_F106_V1.2461.00
70_R74_D1.2441.00
156_V159_Q1.2351.00
70_R119_T1.2311.00
50_F54_A1.2281.00
37_P40_N1.2271.00
151_R159_Q1.2241.00
164_V168_H1.2001.00
67_E119_T1.1871.00
153_L157_M1.1801.00
76_L107_I1.1771.00
139_L143_E1.1671.00
65_E68_L1.1371.00
7_A124_L1.1361.00
34_T104_T1.1301.00
6_F126_L1.1281.00
21_V130_V1.1251.00
155_G158_D1.1051.00
47_D52_E1.0921.00
173_E176_K1.0901.00
7_A77_L1.0831.00
155_G159_Q1.0661.00
138_I157_M1.0631.00
43_E47_D1.0421.00
45_L93_V1.0421.00
143_E147_V1.0211.00
38_L64_F1.0091.00
86_Q95_K1.0001.00
157_M161_L0.9880.99
151_R155_G0.9870.99
38_L66_W0.9840.99
89_F92_H0.9700.99
81_S98_R0.9640.99
10_I22_A0.9560.99
81_S103_P0.9510.99
42_Y64_F0.9480.99
68_L85_P0.9400.99
86_Q94_R0.9360.99
50_F55_N0.9340.99
21_V25_I0.9270.99
45_L54_A0.9260.99
146_V156_V0.9250.99
43_E65_E0.9200.99
67_E71_T0.9150.99
137_R168_H0.9140.99
154_E157_M0.9090.99
134_A137_R0.9030.99
141_R164_V0.9010.99
145_D149_R0.8810.99
4_P77_L0.8780.99
73_I124_L0.8780.99
51_E55_N0.8780.99
22_A26_T0.8760.99
61_P116_S0.8750.99
169_E173_E0.8750.99
70_R120_V0.8680.99
86_Q99_V0.8600.99
115_L179_A0.8540.99
72_H82_I0.8530.99
10_I21_V0.8440.98
26_T33_A0.8390.98
34_T107_I0.8390.98
21_V183_I0.8360.98
75_A78_S0.8250.98
45_L92_H0.8250.98
42_Y59_D0.8220.98
14_T164_V0.8200.98
41_Y82_I0.8130.98
8_I108_V0.8110.98
154_E158_D0.8000.98
134_A173_E0.7950.98
73_I120_V0.7950.98
40_N86_Q0.7940.98
101_V104_T0.7910.98
48_R63_A0.7880.97
40_N97_D0.7870.97
88_D93_V0.7870.97
45_L55_N0.7790.97
85_P94_R0.7780.97
113_L116_S0.7700.97
7_A107_I0.7680.97
126_L190_V0.7630.97
24_E189_S0.7610.97
151_R156_V0.7600.97
30_G105_D0.7540.97
16_A137_R0.7510.97
23_R27_D0.7480.97
51_E54_A0.7480.97
13_G168_H0.7430.96
49_P52_E0.7410.96
176_K182_I0.7410.96
22_A37_P0.7310.96
89_F95_K0.7260.96
26_T30_G0.7260.96
9_G115_L0.7240.96
54_A92_H0.7170.96
14_T168_H0.7120.95
34_T99_V0.7080.95
153_L156_V0.7060.95
38_L69_L0.7060.95
146_V153_L0.7040.95
58_Y89_F0.7010.95
69_L73_I0.6980.95
138_I165_K0.6900.95
13_G129_Y0.6890.95
48_R56_A0.6860.94
59_D167_M0.6860.94
73_I109_L0.6860.94
57_N60_H0.6850.94
133_D184_P0.6810.94
169_E177_R0.6770.94
42_Y141_R0.6760.94
7_A123_M0.6720.94
11_A127_H0.6720.94
134_A165_K0.6700.94
72_H84_M0.6680.94
79_G101_V0.6660.94
131_E184_P0.6640.93
122_D127_H0.6620.93
25_I108_V0.6600.93
24_E28_N0.6590.93
142_I157_M0.6540.93
15_G185_E0.6490.93
43_E48_R0.6480.93
83_E95_K0.6470.93
116_S175_T0.6410.92
57_N167_M0.6400.92
66_W70_R0.6370.92
23_R26_T0.6360.92
161_L166_P0.6320.92
44_D94_R0.6300.92
39_D144_R0.6300.92
68_L94_R0.6290.92
9_G120_V0.6270.91
4_P78_S0.6230.91
135_D139_L0.6190.91
9_G114_A0.6190.91
139_L190_V0.6180.91
29_V106_V0.6170.91
52_E55_N0.6120.90
59_D141_R0.6090.90
21_V24_E0.6080.90
87_Y93_V0.6020.90
146_V150_G0.6010.90
109_L172_I0.6010.90
83_E86_Q0.6000.90
142_I153_L0.5990.89
49_P54_A0.5980.89
156_V160_Y0.5960.89
129_Y175_T0.5960.89
68_L71_T0.5950.89
26_T34_T0.5920.89
161_L165_K0.5900.89
44_D96_A0.5880.89
70_R124_L0.5880.89
121_N160_Y0.5840.88
68_L96_A0.5840.88
54_A58_Y0.5800.88
117_D122_D0.5800.88
135_D180_D0.5800.88
58_Y164_V0.5790.88
12_G17_G0.5780.88
163_T168_H0.5760.88
57_N164_V0.5720.87
163_T167_M0.5710.87
77_L123_M0.5680.87
14_T89_F0.5680.87
129_Y132_T0.5660.87
36_I84_M0.5620.86
127_H178_H0.5610.86
102_E105_D0.5590.86
23_R35_L0.5550.86
19_T164_V0.5540.85
57_N170_Q0.5530.85
119_T122_D0.5530.85
42_Y48_R0.5530.85
15_G38_L0.5500.85
34_T101_V0.5480.85
90_E155_G0.5470.85
151_R154_E0.5460.85
70_R123_M0.5450.85
122_D178_H0.5450.85
114_A124_L0.5450.85
8_I128_I0.5430.84
121_N125_D0.5430.84
66_W114_A0.5420.84
66_W117_D0.5410.84
35_L108_V0.5380.84
139_L157_M0.5370.84
104_T107_I0.5350.83
87_Y149_R0.5350.83
30_G33_A0.5350.83
57_N62_S0.5350.83
89_F141_R0.5340.83
12_G18_K0.5330.83
11_A172_I0.5330.83
19_T23_R0.5300.83
121_N124_L0.5290.83
71_T78_S0.5290.83
135_D184_P0.5280.83
162_S166_P0.5240.82
76_L82_I0.5240.82
40_N112_I0.5230.82
14_T39_D0.5230.82
84_M98_R0.5220.82
14_T141_R0.5170.81
159_Q164_V0.5160.81
91_R97_D0.5150.81
60_H63_A0.5140.81
83_E99_V0.5130.81
48_R51_E0.5100.80
130_V185_E0.5100.80
129_Y176_K0.5100.80
39_D87_Y0.5090.80
11_A124_L0.5070.80
42_Y89_F0.5060.80
89_F149_R0.5060.80
32_S103_P0.5040.80
14_T42_Y0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqcA 2 0.88 100 0.462 Contact Map
2jeoA 3 0.8889 100 0.463 Contact Map
2ga8A 1 0.8311 100 0.481 Contact Map
1a7jA 5 0.9644 100 0.507 Contact Map
1uj2A 3 0.8978 100 0.541 Contact Map
1rz3A 1 0.7067 100 0.545 Contact Map
3w34A 2 0.92 99.9 0.547 Contact Map
4bfzA 2 0.8756 99.9 0.561 Contact Map
4ne2A 2 0.8756 99.9 0.57 Contact Map
2qt1A 1 0.8178 99.9 0.579 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.