GREMLIN Database
CDC68 - ORC1-type DNA replication protein 8
UniProt: Q9HQC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (333)
Sequences: 2547 (1852)
Seq/√Len: 101.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_R278_D3.9661.00
244_L247_R3.0271.00
343_Q347_H2.6461.00
330_A334_A2.6341.00
269_D278_D2.5461.00
275_T278_D2.4371.00
342_S346_V2.4371.00
343_Q346_V2.4151.00
344_R347_H2.2761.00
239_P243_A2.2031.00
299_T302_G2.1421.00
237_V241_C2.0761.00
231_G235_G2.0571.00
163_Q166_R2.0141.00
230_S233_L2.0121.00
340_P344_R1.9731.00
326_Y330_A1.9731.00
162_Y166_R1.9731.00
17_V21_H1.9551.00
163_Q167_A1.9411.00
275_T279_V1.8981.00
94_C148_L1.8831.00
276_E279_V1.8631.00
331_D335_E1.8281.00
232_V236_G1.8221.00
341_L346_V1.8161.00
347_H350_L1.7991.00
315_A319_P1.7971.00
325_L329_Y1.7961.00
160_L163_Q1.7951.00
233_L237_V1.7881.00
160_L166_R1.7851.00
350_L354_S1.7811.00
230_S235_G1.7721.00
308_A312_T1.7621.00
346_V350_L1.7611.00
316_D319_P1.7421.00
327_E331_D1.7391.00
37_Y53_V1.7291.00
29_E218_T1.7291.00
345_S349_H1.7271.00
290_R294_S1.7191.00
164_L167_A1.7091.00
236_G239_P1.7071.00
345_S348_D1.7051.00
76_Y79_D1.7011.00
328_V331_D1.6781.00
271_R275_T1.6581.00
71_M147_V1.6431.00
33_E209_P1.6431.00
192_D197_V1.6311.00
237_V240_Q1.6171.00
322_A326_Y1.6131.00
235_G239_P1.6131.00
351_N355_M1.6091.00
350_L356_L1.6061.00
220_L255_A1.6051.00
240_Q243_A1.6041.00
278_D282_A1.6031.00
329_Y333_A1.6001.00
303_Q306_L1.5951.00
191_N196_K1.5921.00
160_L165_P1.5901.00
217_V221_D1.5781.00
236_G243_A1.5751.00
301_H329_Y1.5711.00
212_D215_E1.5711.00
342_S347_H1.5641.00
193_L198_Q1.5621.00
27_I65_A1.5371.00
299_T303_Q1.5311.00
342_S350_L1.5301.00
333_A337_A1.5241.00
54_F151_I1.5021.00
231_G237_V1.4991.00
319_P323_K1.4941.00
135_D139_A1.4931.00
231_G234_T1.4891.00
232_V235_G1.4821.00
330_A333_A1.4811.00
164_L168_K1.4801.00
159_M162_Y1.4791.00
305_V309_V1.4711.00
315_A326_Y1.4661.00
236_G240_Q1.4441.00
160_L164_L1.4411.00
344_R348_D1.4271.00
323_K327_E1.4181.00
274_V279_V1.4131.00
233_L239_P1.4111.00
291_I294_S1.4101.00
319_P333_A1.4061.00
233_L236_G1.4061.00
193_L197_V1.4051.00
350_L353_L1.3931.00
319_P322_A1.3891.00
162_Y165_P1.3690.99
151_I182_G1.3580.99
191_N197_V1.3570.99
233_L240_Q1.3520.99
326_Y329_Y1.3500.99
231_G240_Q1.3450.99
298_L302_G1.3450.99
217_V239_P1.3410.99
302_G306_L1.3310.99
318_T329_Y1.3260.99
283_V286_V1.3090.99
272_E275_T1.2970.99
298_L305_V1.2960.99
150_E185_N1.2860.99
231_G236_G1.2800.99
250_G254_Q1.2720.99
230_S236_G1.2710.99
307_L311_Q1.2650.99
165_P168_K1.2550.99
321_R324_E1.2520.99
272_E278_D1.2390.99
307_L310_T1.2340.99
270_E274_V1.2290.99
323_K334_A1.2280.99
273_T279_V1.2200.99
320_V325_L1.2110.99
343_Q349_H1.2090.99
301_H304_Y1.2050.99
279_V282_A1.2040.99
319_P334_A1.1950.99
193_L196_K1.1930.99
224_A259_L1.1930.99
332_I337_A1.1850.98
237_V243_A1.1850.98
341_L350_L1.1830.98
277_D281_T1.1810.98
162_Y167_A1.1790.98
293_D297_D1.1790.98
269_D281_T1.1720.98
344_R350_L1.1720.98
303_Q307_L1.1710.98
234_T240_Q1.1670.98
24_P27_I1.1630.98
265_V268_E1.1590.98
231_G243_A1.1510.98
160_L167_A1.1490.98
348_D352_D1.1460.98
274_V277_D1.1420.98
154_L162_Y1.1310.98
260_R264_N1.1290.98
343_Q348_D1.1270.98
309_V359_L1.1220.98
230_S234_T1.1210.98
128_D132_A1.1200.98
341_L347_H1.1170.98
279_V286_V1.1140.98
343_Q350_L1.1120.98
341_L344_R1.1090.98
326_Y334_A1.1060.98
318_T321_R1.1000.98
152_D185_N1.0980.97
271_R279_V1.0870.97
346_V353_L1.0870.97
295_I301_H1.0870.97
274_V278_D1.0870.97
301_H340_P1.0860.97
341_L349_H1.0790.97
341_L354_S1.0760.97
342_S353_L1.0750.97
251_S254_Q1.0640.97
194_S198_Q1.0640.97
323_K332_I1.0630.97
302_G305_V1.0620.97
346_V349_H1.0610.97
160_L168_K1.0590.97
161_L166_R1.0590.97
292_K296_K1.0560.97
40_A53_V1.0530.97
249_R254_Q1.0530.97
196_K199_D1.0510.97
30_R33_E1.0480.97
329_Y332_I1.0310.96
342_S345_S1.0300.96
231_G239_P1.0290.96
234_T243_A1.0280.96
94_C154_L1.0230.96
345_S350_L1.0230.96
316_D320_V1.0190.96
163_Q168_K1.0170.96
230_S239_P1.0160.96
273_T278_D1.0130.96
235_G243_A1.0120.96
352_D356_L1.0090.96
301_H305_V1.0080.96
320_V324_E1.0060.96
230_S240_Q1.0010.96
316_D337_A0.9970.96
361_Q364_R0.9940.95
244_L249_R0.9910.95
235_G240_Q0.9900.95
317_D321_R0.9900.95
355_M359_L0.9890.95
265_V278_D0.9890.95
232_V239_P0.9870.95
199_D202_C0.9860.95
281_T284_R0.9790.95
272_E276_E0.9740.95
323_K337_A0.9730.95
343_Q351_N0.9650.95
340_P343_Q0.9650.95
194_S197_V0.9610.95
245_A248_D0.9570.94
329_Y336_Y0.9560.94
346_V352_D0.9540.94
343_Q353_L0.9520.94
297_D301_H0.9490.94
232_V237_V0.9470.94
308_A311_Q0.9470.94
306_L310_T0.9400.94
41_L45_V0.9390.94
191_N198_Q0.9350.94
234_T273_T0.9340.94
333_A336_Y0.9330.94
162_Y196_K0.9310.94
66_V208_F0.9220.93
351_N354_S0.9210.93
288_R294_S0.9210.93
98_P164_L0.9210.93
346_V355_M0.9180.93
344_R353_L0.9170.93
341_L345_S0.9160.93
347_H356_L0.9140.93
159_M163_Q0.9140.93
347_H351_N0.9130.93
304_Y308_A0.9130.93
240_Q244_L0.9090.93
315_A320_V0.9090.93
39_N268_E0.9070.93
255_A260_R0.9050.93
295_I306_L0.9000.92
340_P346_V0.8990.92
309_V313_A0.8980.92
350_L359_L0.8910.92
323_K326_Y0.8910.92
346_V351_N0.8890.92
279_V284_R0.8890.92
277_D280_E0.8880.92
316_D332_I0.8830.92
232_V240_Q0.8800.92
323_K336_Y0.8740.91
342_S351_N0.8730.91
166_R200_T0.8630.91
223_R229_S0.8620.91
334_A337_A0.8590.91
41_L70_M0.8590.91
282_A286_V0.8570.90
300_T303_Q0.8550.90
221_D235_G0.8540.90
342_S348_D0.8530.90
316_D333_A0.8520.90
301_H308_A0.8520.90
273_T277_D0.8500.90
302_G309_V0.8470.90
316_D325_L0.8440.90
108_V133_L0.8420.90
286_V294_S0.8360.89
340_P345_S0.8330.89
306_L309_V0.8320.89
284_R288_R0.8300.89
353_L357_G0.8280.89
340_P350_L0.8280.89
297_D303_Q0.8280.89
347_H355_M0.8270.89
315_A333_A0.8230.89
315_A336_Y0.8220.89
230_S237_V0.8210.88
342_S352_D0.8190.88
218_T221_D0.8110.88
322_A350_L0.8100.88
234_T239_P0.8090.88
272_E279_V0.8080.88
302_G311_Q0.8050.88
326_Y333_A0.8040.87
291_I295_I0.8020.87
349_H353_L0.8010.87
348_D351_N0.8000.87
265_V269_D0.7980.87
195_P198_Q0.7980.87
281_T286_V0.7950.87
197_V200_T0.7920.87
353_L356_L0.7880.86
316_D323_K0.7840.86
342_S356_L0.7800.86
244_L250_G0.7800.86
345_S355_M0.7780.86
278_D281_T0.7780.86
273_T281_T0.7780.86
354_S359_L0.7720.85
211_Y219_I0.7710.85
316_D330_A0.7710.85
162_Y168_K0.7680.85
320_V330_A0.7660.85
236_G241_C0.7620.84
233_L274_V0.7620.84
344_R351_N0.7600.84
349_H352_D0.7590.84
338_S344_R0.7550.84
188_T192_D0.7540.84
34_I66_V0.7460.83
351_N356_L0.7460.83
339_D343_Q0.7450.83
343_Q355_M0.7410.83
299_T309_V0.7410.83
319_P326_Y0.7410.83
304_Y307_L0.7400.83
320_V332_I0.7370.82
220_L238_I0.7340.82
196_K200_T0.7300.82
270_E277_D0.7280.82
39_N265_V0.7270.82
299_T304_Y0.7260.82
276_E280_E0.7260.82
68_R91_E0.7260.82
193_L199_D0.7240.81
321_R326_Y0.7220.81
365_N368_R0.7210.81
289_G293_D0.7210.81
351_N358_F0.7210.81
352_D355_M0.7200.81
314_I325_L0.7190.81
259_L279_V0.7170.81
303_Q310_T0.7170.81
246_A250_G0.7170.81
332_I336_Y0.7160.81
327_E333_A0.7160.81
317_D323_K0.7160.81
347_H353_L0.7130.80
162_Y199_D0.7130.80
159_M164_L0.7120.80
261_E264_N0.7110.80
282_A288_R0.7110.80
361_Q365_N0.7100.80
341_L351_N0.7100.80
217_V238_I0.7090.80
340_P347_H0.7090.80
347_H354_S0.7090.80
322_A325_L0.7070.80
93_N96_H0.7040.80
325_L333_A0.7040.80
338_S358_F0.7030.79
271_R274_V0.7020.79
290_R297_D0.7010.79
41_L181_V0.6960.79
233_L243_A0.6960.79
270_E281_T0.6940.79
289_G311_Q0.6930.78
296_K301_H0.6920.78
255_A263_V0.6920.78
302_G310_T0.6900.78
230_S243_A0.6900.78
288_R291_I0.6880.78
191_N199_D0.6870.78
282_A285_R0.6800.77
112_R115_T0.6790.77
147_V183_I0.6780.77
331_D336_Y0.6780.77
162_Y200_T0.6760.77
273_T282_A0.6760.77
36_Q39_N0.6730.76
28_R222_D0.6720.76
316_D326_Y0.6720.76
359_L363_D0.6710.76
57_G62_G0.6690.76
234_T237_V0.6680.76
309_V312_T0.6680.76
93_N162_Y0.6670.76
315_A323_K0.6670.76
208_F211_Y0.6650.76
154_L179_A0.6640.75
95_H164_L0.6630.75
94_C97_H0.6600.75
307_L312_T0.6580.75
299_T306_L0.6580.75
75_E79_D0.6570.75
272_E282_A0.6560.75
245_A249_R0.6550.74
245_A250_G0.6540.74
108_V112_R0.6530.74
134_F137_I0.6520.74
130_L134_F0.6520.74
217_V242_A0.6500.74
86_S143_T0.6480.74
57_G60_G0.6480.74
310_T313_A0.6480.74
350_L358_F0.6450.73
320_V323_K0.6440.73
130_L163_Q0.6440.73
338_S347_H0.6410.73
235_G241_C0.6410.73
338_S350_L0.6390.73
306_L311_Q0.6370.72
297_D307_L0.6360.72
326_Y336_Y0.6360.72
314_I336_Y0.6340.72
340_P348_D0.6310.72
308_A332_I0.6300.72
53_V206_I0.6300.72
312_T316_D0.6290.71
376_Y379_D0.6290.71
345_S352_D0.6230.71
346_V354_S0.6180.70
256_I260_R0.6180.70
315_A334_A0.6130.70
379_D384_M0.6100.69
373_F376_Y0.6100.69
324_E327_E0.6090.69
275_T286_V0.6080.69
255_A259_L0.6080.69
273_T276_E0.6060.69
37_Y87_V0.6050.69
185_N250_G0.6040.68
315_A329_Y0.6040.68
320_V334_A0.6030.68
349_H355_M0.6030.68
356_L359_L0.6030.68
303_Q311_Q0.6020.68
229_S238_I0.6010.68
161_L165_P0.6000.68
362_H366_Y0.5970.68
270_E276_E0.5960.67
314_I318_T0.5930.67
346_V356_L0.5930.67
191_N195_P0.5920.67
53_V181_V0.5910.67
291_I302_G0.5910.67
256_I264_N0.5900.67
325_L336_Y0.5860.66
325_L337_A0.5860.66
318_T334_A0.5830.66
349_H356_L0.5810.65
315_A318_T0.5770.65
248_D254_Q0.5760.65
155_D158_D0.5740.65
323_K333_A0.5730.64
113_G133_L0.5730.64
341_L353_L0.5730.64
312_T315_A0.5710.64
308_A313_A0.5710.64
230_S241_C0.5690.64
281_T288_R0.5690.64
107_L133_L0.5670.64
107_L110_E0.5670.64
34_I69_Y0.5660.63
314_I332_I0.5660.63
298_L301_H0.5630.63
296_K300_T0.5620.63
231_G241_C0.5620.63
322_A329_Y0.5590.62
233_L241_C0.5560.62
43_D47_G0.5560.62
271_R284_R0.5540.62
234_T238_I0.5520.62
130_L137_I0.5500.61
232_V238_I0.5500.61
108_V114_D0.5500.61
266_A274_V0.5470.61
338_S345_S0.5450.61
18_L24_P0.5450.61
278_D284_R0.5450.61
315_A330_A0.5450.61
315_A325_L0.5440.60
327_E332_I0.5440.60
317_D320_V0.5420.60
52_N203_E0.5420.60
278_D286_V0.5400.60
326_Y337_A0.5390.60
325_L332_I0.5390.60
206_I269_D0.5390.60
90_V151_I0.5380.60
87_V94_C0.5380.60
316_D329_Y0.5350.59
338_S343_Q0.5260.58
234_T241_C0.5240.58
320_V329_Y0.5230.57
194_S199_D0.5230.57
210_P282_A0.5230.57
298_L306_L0.5220.57
30_R211_Y0.5200.57
298_L307_L0.5170.57
318_T326_Y0.5160.56
339_D342_S0.5150.56
67_T190_R0.5140.56
57_G63_K0.5140.56
213_A243_A0.5130.56
272_E277_D0.5130.56
149_D219_I0.5120.56
192_D196_K0.5100.56
301_H307_L0.5090.55
46_D131_N0.5080.55
296_K302_G0.5040.55
216_L220_L0.5040.55
328_V333_A0.5030.55
356_L361_Q0.5010.54
318_T322_A0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbyA 1 0.9144 100 0.363 Contact Map
2v1uA 1 0.9496 100 0.377 Contact Map
4xgcA 1 0.7733 100 0.38 Contact Map
1w5sA 1 0.937 100 0.423 Contact Map
2qbyB 1 0.9093 100 0.425 Contact Map
1fnnA 1 0.9194 100 0.456 Contact Map
4xgcD 1 0.932 100 0.461 Contact Map
3te6A 1 0.6751 100 0.586 Contact Map
4xgcE 1 0.8287 100 0.635 Contact Map
4ko8A 3 0.6398 100 0.673 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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