GREMLIN Database
Q9HQC4 - Uncharacterized protein
UniProt: Q9HQC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (173)
Sequences: 3079 (2184)
Seq/√Len: 166.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y58_V4.5041.00
41_D130_E3.8991.00
43_V124_I3.0291.00
44_F133_V2.7451.00
79_N91_A2.5051.00
117_E121_N2.4881.00
48_S99_S2.3301.00
164_T173_V2.3041.00
122_A125_R2.2501.00
107_E138_R2.1541.00
15_D31_V2.1171.00
43_V127_I2.1161.00
51_A55_A2.0791.00
21_C116_C2.0001.00
75_S194_L1.9881.00
72_I193_F1.9781.00
28_R101_C1.9491.00
103_H112_E1.8671.00
137_Q141_T1.8311.00
35_Y80_H1.7901.00
19_R25_C1.7881.00
7_T10_N1.7491.00
166_R171_E1.7201.00
25_C28_R1.7111.00
72_I189_W1.7051.00
15_D33_H1.6831.00
164_T171_E1.6191.00
44_F69_F1.6111.00
8_R38_V1.6091.00
186_T190_I1.6051.00
70_Q80_H1.6031.00
134_P174_P1.6031.00
180_E184_A1.5931.00
128_N170_F1.5611.00
18_C21_C1.5611.00
18_C116_C1.5581.00
43_V96_T1.5271.00
11_P126_M1.5081.00
22_A111_D1.5051.00
18_C101_C1.4981.00
158_T176_I1.4901.00
107_E141_T1.4811.00
12_Y16_E1.4681.00
94_Y123_D1.4541.00
52_A56_A1.4461.00
134_P172_L1.4451.00
73_L93_A1.4191.00
166_R169_G1.4011.00
52_A55_A1.3881.00
107_E137_Q1.3791.00
124_I132_L1.3641.00
132_L170_F1.3601.00
131_V173_V1.3511.00
22_A26_D1.3401.00
41_D92_N1.3351.00
14_M122_A1.3341.00
190_I194_L1.3321.00
113_R142_E1.3261.00
106_R112_E1.3241.00
101_C116_C1.3021.00
29_E55_A1.2881.00
156_A159_E1.2831.00
75_S190_I1.2781.00
140_L174_P1.2631.00
100_R123_D1.2361.00
79_N92_N1.2331.00
44_F73_L1.2241.00
28_R31_V1.1951.00
48_S103_H1.1461.00
98_L142_E1.1451.00
193_F196_F1.1441.00
20_N118_P1.1361.00
52_A63_D1.1231.00
133_V196_F1.1191.00
134_P140_L1.1171.00
76_V197_K1.0991.00
96_T123_D1.0971.00
44_F135_V1.0650.99
135_V175_M1.0650.99
53_S61_V1.0620.99
140_L155_L1.0480.99
110_A114_T1.0410.99
32_V59_P1.0400.99
146_E155_L1.0340.99
16_E31_V1.0320.99
37_D92_N1.0110.99
160_L163_D1.0100.99
42_F133_V0.9990.99
134_P143_L0.9960.99
113_R138_R0.9940.99
72_I76_V0.9880.99
10_N13_G0.9810.99
50_S53_S0.9730.99
71_H75_S0.9640.99
144_G172_L0.9600.99
37_D40_A0.9600.99
195_S198_D0.9580.99
131_V171_E0.9580.99
46_A60_L0.9520.99
12_Y33_H0.9470.99
96_T120_L0.9440.99
8_R126_M0.9420.99
13_G17_D0.9400.99
134_P139_A0.9380.99
173_V196_F0.9330.99
13_G16_E0.9290.99
133_V175_M0.9270.99
181_Q189_W0.9240.99
21_C101_C0.9130.98
121_N125_R0.9110.98
140_L160_L0.9110.98
45_V134_P0.9020.98
51_A102_R0.9000.98
19_R26_D0.8910.98
10_N14_M0.8780.98
42_F78_L0.8650.98
20_N119_Y0.8590.98
117_E142_E0.8580.98
155_L160_L0.8550.98
34_G94_Y0.8470.97
22_A25_C0.8470.97
22_A109_T0.8460.97
194_L198_D0.8440.97
45_V143_L0.8420.97
118_P122_A0.8380.97
18_C100_R0.8260.97
180_E183_D0.8180.97
67_E70_Q0.8110.97
21_C24_L0.8040.96
25_C31_V0.8030.96
122_A126_M0.8000.96
9_R13_G0.7990.96
43_V132_L0.7980.96
67_E71_H0.7970.96
186_T189_W0.7940.96
45_V120_L0.7930.96
24_L28_R0.7840.96
138_R141_T0.7810.96
42_F196_F0.7760.96
137_Q156_A0.7740.96
118_P121_N0.7730.96
157_V174_P0.7730.96
187_D190_I0.7710.95
187_D191_D0.7670.95
188_A191_D0.7640.95
61_V97_L0.7630.95
114_T145_K0.7610.95
124_I143_L0.7410.94
44_F93_A0.7410.94
7_T126_M0.7400.94
102_R105_D0.7320.94
50_S65_A0.7300.94
46_A177_H0.7300.94
191_D195_S0.7260.94
68_R190_I0.7210.94
111_D114_T0.7210.94
110_A141_T0.7170.93
37_D94_Y0.7160.93
25_C101_C0.7160.93
50_S97_L0.7130.93
42_F93_A0.7010.93
56_A61_V0.7000.93
189_W193_F0.6940.92
146_E160_L0.6930.92
60_L104_P0.6920.92
96_T100_R0.6900.92
78_L93_A0.6830.92
186_T192_F0.6830.92
98_L113_R0.6810.91
193_F197_K0.6790.91
12_Y38_V0.6750.91
50_S59_P0.6750.91
70_Q95_V0.6740.91
186_T193_F0.6690.91
124_I170_F0.6690.91
74_G79_N0.6660.91
132_L143_L0.6650.90
98_L117_E0.6590.90
20_N115_R0.6530.90
179_R183_D0.6520.90
167_G172_L0.6510.90
12_Y31_V0.6500.89
176_I188_A0.6500.89
9_R12_Y0.6500.89
9_R38_V0.6480.89
15_D119_Y0.6460.89
18_C28_R0.6450.89
24_L54_E0.6440.89
102_R106_R0.6430.89
68_R181_Q0.6400.89
181_Q186_T0.6390.89
97_L177_H0.6390.89
129_P132_L0.6370.89
145_K154_S0.6360.88
161_H175_M0.6310.88
30_R54_E0.6300.88
181_Q184_A0.6270.88
144_G165_V0.6260.88
176_I180_E0.6260.88
34_G123_D0.6240.88
8_R12_Y0.6220.87
33_H94_Y0.6210.87
59_P97_L0.6210.87
72_I181_Q0.6170.87
71_H194_L0.6160.87
27_Q30_R0.6160.87
8_R11_P0.6140.87
42_F131_V0.6120.87
191_D194_L0.6030.86
155_L174_P0.6000.85
164_T195_S0.5980.85
71_H74_G0.5980.85
40_A96_T0.5970.85
73_L76_V0.5960.85
63_D185_Q0.5940.85
29_E54_E0.5930.85
31_V101_C0.5880.84
165_V174_P0.5830.84
51_A63_D0.5810.84
134_P165_V0.5810.84
167_G171_E0.5800.83
72_I190_I0.5750.83
160_L174_P0.5700.82
111_D115_R0.5650.82
175_M189_W0.5630.82
188_A192_F0.5620.82
125_R168_R0.5570.81
189_W192_F0.5560.81
68_R183_D0.5550.81
48_S63_D0.5530.80
59_P65_A0.5500.80
28_R54_E0.5470.80
97_L105_D0.5460.80
68_R182_S0.5440.79
14_M119_Y0.5420.79
12_Y94_Y0.5420.79
59_P68_R0.5420.79
11_P15_D0.5400.79
24_L116_C0.5380.79
131_V196_F0.5370.79
160_L165_V0.5340.78
47_E97_L0.5330.78
53_S70_Q0.5300.78
70_Q73_L0.5300.78
167_G170_F0.5290.78
76_V194_L0.5250.77
98_L141_T0.5240.77
120_L124_I0.5190.76
30_R57_G0.5180.76
69_F73_L0.5170.76
94_Y127_I0.5170.76
40_A127_I0.5160.76
46_A97_L0.5160.76
32_V53_S0.5130.75
99_S135_V0.5100.75
47_E61_V0.5080.75
71_H190_I0.5060.74
76_V193_F0.5030.74
36_G40_A0.5020.74
180_E193_F0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vk2A 1 0.8714 100 0.255 Contact Map
1ui0A 1 0.8714 100 0.269 Contact Map
2d3yA 1 0.9381 100 0.302 Contact Map
3ikbA 1 0.8524 100 0.357 Contact Map
1wywA 1 0.8476 100 0.48 Contact Map
1mugA 1 0.7476 100 0.542 Contact Map
1oe4A 2 0.8429 100 0.558 Contact Map
2c2qA 1 0.8286 99.9 0.607 Contact Map
2l3fA 1 0.7333 98.6 0.836 Contact Map
1vddA 7 0.619 35.5 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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