GREMLIN Database
AROC - Chorismate synthase
UniProt: Q9HQC2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (351)
Sequences: 3224 (1560)
Seq/√Len: 83.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_S86_E4.7811.00
231_V300_T3.5721.00
247_S254_R3.1881.00
216_A356_L3.1711.00
44_E142_K3.1681.00
40_M143_A3.1591.00
85_I132_V3.0951.00
325_D330_E2.9981.00
206_D262_K2.9541.00
252_L291_D2.9531.00
219_V305_I2.8731.00
144_V361_L2.6671.00
234_R363_F2.5461.00
204_R260_A2.3291.00
254_R310_S2.3141.00
185_C194_M2.2871.00
72_Q120_W2.2741.00
235_L356_L2.2621.00
102_P112_S2.2541.00
30_C81_I2.2471.00
217_R304_P2.2361.00
320_T333_A2.1981.00
239_L307_G2.1901.00
247_S310_S2.1531.00
12_V25_V2.1441.00
27_V140_V2.1431.00
160_Q258_S2.1031.00
216_A360_I2.0651.00
249_E308_E2.0321.00
65_V83_M2.0041.00
200_D204_R1.9961.00
37_D40_M1.9911.00
239_L356_L1.9831.00
15_Y82_G1.9681.00
157_H186_A1.9621.00
35_A75_Y1.9611.00
154_V357_Y1.9521.00
62_P88_K1.9101.00
229_D237_Q1.8961.00
181_N191_A1.8511.00
267_D322_A1.8491.00
163_E197_L1.8431.00
270_V331_E1.8331.00
107_G297_G1.8281.00
288_A322_A1.8131.00
307_G356_L1.8071.00
190_T193_R1.7971.00
322_A333_A1.7881.00
25_V83_M1.7771.00
160_Q163_E1.7681.00
269_T288_A1.7661.00
130_E134_W1.7621.00
271_A282_E1.7591.00
197_L201_Y1.7581.00
160_Q165_E1.7481.00
234_R237_Q1.7111.00
213_Y308_E1.7051.00
22_G84_T1.7031.00
242_I352_V1.6991.00
201_Y208_I1.6401.00
256_A264_R1.6291.00
150_H364_M1.6271.00
320_T335_T1.6041.00
36_L140_V1.5951.00
42_Q46_D1.5861.00
22_G68_Q1.5851.00
215_E304_P1.5801.00
182_E195_R1.5661.00
234_R366_L1.5631.00
5_R13_T1.5531.00
15_Y24_G1.5261.00
192_E195_R1.4930.99
177_H180_D1.4570.99
210_G345_P1.4450.99
159_N213_Y1.4450.99
83_M136_A1.4420.99
311_W352_V1.4410.99
239_L309_A1.4340.99
259_V264_R1.4320.99
295_L305_I1.4320.99
211_S308_E1.4290.99
30_C140_V1.4290.99
309_A352_V1.4260.99
41_I139_A1.4200.99
255_D258_S1.4130.99
265_N321_Q1.4120.99
21_P66_S1.4110.99
10_F30_C1.4100.99
146_A153_R1.4010.99
101_A332_K1.3940.99
179_E184_R1.3900.99
109_Y268_W1.3820.99
214_F352_V1.3720.99
269_T286_I1.3630.99
295_L300_T1.3630.99
71_L81_I1.3570.99
183_V198_I1.3440.99
97_P337_T1.3430.99
238_A359_T1.3420.99
161_I343_S1.3400.99
25_V137_A1.3360.99
142_K353_E1.3290.99
268_W287_P1.3230.99
35_A147_Q1.3150.99
36_L76_T1.3120.98
102_P326_W1.3100.98
239_L248_V1.3080.98
236_G240_F1.3060.98
325_D332_K1.3020.98
286_I303_E1.2960.98
153_R217_R1.2950.98
248_V307_G1.2950.98
54_M199_D1.2940.98
100_T327_E1.2890.98
199_D202_Q1.2880.98
34_V144_V1.2770.98
155_K178_S1.2680.98
8_R11_E1.2610.98
226_P299_I1.2560.98
44_E139_A1.2530.98
245_T311_W1.2520.98
47_R353_E1.2420.98
75_Y117_T1.2310.98
156_A349_V1.2280.98
244_A344_L1.2180.98
25_V133_N1.2110.97
112_S326_W1.2040.97
206_D260_A1.1990.97
160_Q211_S1.1970.97
21_P86_E1.1960.97
363_F366_L1.1950.97
196_A200_D1.1870.97
257_R310_S1.1850.97
37_D143_A1.1810.97
240_F250_F1.1790.97
10_F27_V1.1790.97
216_A305_I1.1730.97
164_I190_T1.1700.97
142_K357_Y1.1700.97
233_A237_Q1.1640.97
322_A331_E1.1630.97
128_A344_L1.1600.97
197_L260_A1.1590.97
252_L256_A1.1570.97
270_V329_G1.1520.97
36_L40_M1.1460.96
205_G318_P1.1430.96
10_F358_C1.1430.96
27_V83_M1.1420.96
216_A219_V1.1410.96
152_V364_M1.1350.96
105_S296_Q1.1310.96
223_L364_M1.1160.96
311_W348_A1.1070.96
91_E94_K1.1070.96
267_D288_A1.1060.96
225_A363_F1.1060.96
323_T332_K1.1050.96
167_P190_T1.1020.96
204_R319_K1.0900.95
197_L200_D1.0870.95
187_D190_T1.0810.95
262_K317_I1.0780.95
40_M43_D1.0750.95
141_A358_C1.0730.95
58_S89_D1.0720.95
100_T325_D1.0670.95
49_K62_P1.0660.95
269_T331_E1.0650.95
311_W344_L1.0620.95
252_L259_V1.0590.94
296_Q301_T1.0560.94
245_T309_A1.0510.94
207_S314_P1.0480.94
211_S254_R1.0460.94
323_T334_V1.0400.94
195_R199_D1.0400.94
219_V223_L1.0390.94
10_F141_A1.0380.94
271_A286_I1.0320.94
287_P303_E1.0260.93
40_M146_A1.0190.93
113_A221_R1.0100.93
165_E258_S1.0090.93
356_L360_I1.0080.93
212_I352_V1.0000.93
160_Q257_R0.9930.92
33_G75_Y0.9910.92
134_W355_M0.9880.92
238_A355_M0.9820.92
110_T268_W0.9800.92
242_I355_M0.9780.92
17_E77_T0.9760.92
11_E28_S0.9670.91
109_Y113_A0.9630.91
42_Q45_L0.9590.91
164_I193_R0.9580.91
193_R196_A0.9570.91
49_K60_G0.9550.91
58_S202_Q0.9520.91
191_A195_R0.9500.90
213_Y306_Y0.9480.90
192_E196_A0.9350.90
110_T299_I0.9330.90
185_C191_A0.9330.90
30_C34_V0.9310.90
235_L307_G0.9220.89
252_L255_D0.9170.89
237_Q241_A0.9160.89
212_I311_W0.9070.88
105_S292_H0.9030.88
23_M133_N0.9020.88
181_N188_P0.8950.88
32_A370_I0.8950.88
267_D289_G0.8950.88
164_I197_L0.8950.88
96_E120_W0.8930.88
155_K217_R0.8910.87
214_F307_G0.8900.87
98_F120_W0.8880.87
158_V345_P0.8870.87
259_V263_Q0.8800.87
190_T194_M0.8790.87
177_H188_P0.8780.87
9_L366_L0.8780.87
53_S56_T0.8770.87
143_A146_A0.8760.87
183_V191_A0.8740.86
167_P187_D0.8730.86
23_M132_V0.8720.86
201_Y260_A0.8690.86
157_H213_Y0.8670.86
271_A284_D0.8660.86
189_E193_R0.8640.86
25_V82_G0.8630.86
52_Q56_T0.8630.86
67_I71_L0.8580.85
156_A214_F0.8560.85
66_S84_T0.8540.85
197_L208_I0.8530.85
211_S247_S0.8520.85
316_S336_V0.8520.85
214_F309_A0.8520.85
158_V161_I0.8500.85
230_S243_P0.8470.85
162_G208_I0.8440.84
110_T296_Q0.8430.84
314_P342_P0.8390.84
96_E99_V0.8380.84
164_I194_M0.8370.84
285_P324_V0.8320.84
155_K215_E0.8290.83
162_G197_L0.8280.83
252_L264_R0.8240.83
216_A307_G0.8240.83
231_V363_F0.8240.83
68_Q84_T0.8230.83
41_I67_I0.8230.83
176_E180_D0.8220.83
206_D319_K0.8210.83
191_A194_M0.8190.83
130_E227_R0.8160.82
270_V285_P0.8160.82
151_D218_G0.8150.82
134_W241_A0.8130.82
327_E330_E0.8070.82
185_C190_T0.8070.82
72_Q121_G0.8020.81
101_A323_T0.8010.81
232_P246_T0.8000.81
81_I140_V0.7970.81
314_P344_L0.7950.81
17_E20_G0.7920.80
292_H296_Q0.7910.80
367_G370_I0.7890.80
30_C141_A0.7890.80
85_I133_N0.7870.80
345_P348_A0.7840.80
8_R366_L0.7820.80
315_T351_V0.7810.80
235_L359_T0.7790.79
93_G96_E0.7790.79
14_T130_E0.7780.79
55_I198_I0.7780.79
71_L143_A0.7780.79
232_P236_G0.7770.79
161_I198_I0.7730.79
14_T134_W0.7720.79
67_I136_A0.7710.79
5_R11_E0.7680.78
208_I260_A0.7670.78
223_L360_I0.7650.78
6_F358_C0.7650.78
170_S173_D0.7630.78
225_A229_D0.7560.77
64_E88_K0.7500.77
47_R350_P0.7500.77
232_P250_F0.7490.77
239_L352_V0.7490.77
287_P301_T0.7480.77
199_D203_E0.7450.76
205_G319_K0.7440.76
158_V346_P0.7420.76
166_A190_T0.7420.76
34_V361_L0.7410.76
42_Q64_E0.7390.76
55_I195_R0.7380.76
110_T301_T0.7370.76
359_T362_D0.7350.75
163_E258_S0.7340.75
45_L132_V0.7330.75
200_D203_E0.7310.75
23_M85_I0.7290.75
130_E133_N0.7270.75
229_D234_R0.7250.74
348_A352_V0.7250.74
198_I343_S0.7240.74
97_P101_A0.7180.74
38_E42_Q0.7180.74
211_S257_R0.7170.74
262_K319_K0.7170.74
240_F307_G0.7170.74
211_S310_S0.7160.73
255_D259_V0.7140.73
38_E66_S0.7140.73
234_R359_T0.7140.73
256_A292_H0.7130.73
229_D366_L0.7130.73
128_A243_P0.7110.73
46_D49_K0.7100.73
83_M140_V0.7070.72
300_T305_I0.7070.72
311_W351_V0.7050.72
154_V360_I0.7020.72
24_G68_Q0.7000.72
42_Q49_K0.7000.72
15_Y26_V0.6980.72
10_F361_L0.6960.71
194_M198_I0.6930.71
55_I183_V0.6930.71
26_V82_G0.6930.71
219_V299_I0.6930.71
76_T143_A0.6920.71
225_A366_L0.6910.71
32_A367_G0.6890.71
219_V364_M0.6880.70
318_P336_V0.6870.70
6_F355_M0.6860.70
13_T26_V0.6850.70
67_I83_M0.6850.70
270_V283_G0.6850.70
33_G117_T0.6790.69
268_W296_Q0.6780.69
196_A199_D0.6760.69
268_W285_P0.6750.69
212_I348_A0.6740.69
142_K154_V0.6720.69
240_F248_V0.6700.68
260_A263_Q0.6690.68
193_R197_L0.6670.68
12_V358_C0.6670.68
12_V137_A0.6670.68
105_S315_T0.6660.68
98_F334_V0.6650.68
90_A94_K0.6650.68
269_T322_A0.6630.68
20_G121_G0.6610.67
111_Y126_S0.6600.67
27_V141_A0.6560.67
6_F238_A0.6550.67
232_P248_V0.6540.67
167_P170_S0.6520.66
256_A259_V0.6510.66
99_V120_W0.6490.66
201_Y204_R0.6480.66
295_L301_T0.6460.66
214_F356_L0.6440.65
125_R130_E0.6440.65
68_Q82_G0.6430.65
42_Q65_V0.6430.65
292_H305_I0.6390.65
128_A351_V0.6380.65
159_N165_E0.6370.65
153_R218_G0.6370.65
168_D187_D0.6340.64
89_D93_G0.6300.64
166_A186_A0.6280.63
230_S233_A0.6280.63
270_V324_V0.6280.63
12_V355_M0.6260.63
92_S121_G0.6250.63
14_T230_S0.6250.63
14_T125_R0.6240.63
305_I360_I0.6230.63
36_L143_A0.6230.63
112_S120_W0.6220.63
159_N211_S0.6210.63
14_T133_N0.6210.63
143_A147_Q0.6190.62
365_L368_G0.6190.62
344_L351_V0.6160.62
44_E47_R0.6150.62
39_R43_D0.6140.62
72_Q119_N0.6110.61
244_A348_A0.6110.61
198_I201_Y0.6080.61
68_Q86_E0.6040.60
41_I83_M0.6030.60
24_G82_G0.6020.60
269_T285_P0.6010.60
157_H215_E0.6000.60
28_S227_R0.5970.60
233_A241_A0.5970.60
270_V282_E0.5970.60
38_E64_E0.5970.60
35_A143_A0.5950.59
249_E253_G0.5940.59
355_M359_T0.5940.59
27_V30_C0.5930.59
134_W227_R0.5930.59
76_T140_V0.5920.59
227_R241_A0.5920.59
244_A311_W0.5920.59
156_A353_E0.5910.59
53_S181_N0.5900.59
73_D120_W0.5870.58
235_L248_V0.5860.58
268_W324_V0.5860.58
235_L239_L0.5850.58
242_I351_V0.5840.58
215_E306_Y0.5840.58
165_E255_D0.5800.57
38_E143_A0.5780.57
147_Q150_H0.5770.57
12_V27_V0.5770.57
34_V143_A0.5760.57
249_E254_R0.5760.57
60_G89_D0.5740.57
205_G335_T0.5710.56
227_R230_S0.5680.56
216_A235_L0.5660.56
361_L365_L0.5650.55
250_F307_G0.5650.55
37_D43_D0.5650.55
137_A358_C0.5640.55
166_A185_C0.5600.55
72_Q77_T0.5600.55
202_Q205_G0.5600.55
228_F243_P0.5590.55
173_D180_D0.5570.54
344_L348_A0.5540.54
77_T122_G0.5530.54
47_R179_E0.5510.54
130_E241_A0.5510.54
157_H166_A0.5500.53
44_E135_V0.5500.53
59_R94_K0.5490.53
82_G133_N0.5490.53
193_R200_D0.5480.53
52_Q199_D0.5480.53
65_V71_L0.5470.53
159_N306_Y0.5470.53
36_L43_D0.5470.53
30_C358_C0.5470.53
216_A223_L0.5470.53
79_T111_Y0.5470.53
126_S130_E0.5460.53
159_N308_E0.5460.53
114_K225_A0.5450.53
164_I201_Y0.5450.53
60_G88_K0.5440.53
52_Q57_T0.5430.52
156_A352_V0.5420.52
36_L67_I0.5410.52
229_D363_F0.5410.52
30_C144_V0.5400.52
41_I143_A0.5400.52
315_T335_T0.5400.52
45_L136_A0.5390.52
27_V139_A0.5360.52
220_P364_M0.5360.52
32_A79_T0.5350.51
152_V219_V0.5330.51
8_R229_D0.5330.51
243_P348_A0.5330.51
206_D263_Q0.5320.51
296_Q316_S0.5310.51
166_A187_D0.5310.51
166_A169_V0.5310.51
83_M133_N0.5310.51
364_M368_G0.5290.51
49_K52_Q0.5290.51
340_H347_R0.5290.51
41_I45_L0.5290.51
25_V243_P0.5280.51
316_S351_V0.5270.50
125_R134_W0.5270.50
188_P191_A0.5260.50
264_R292_H0.5250.50
69_S82_G0.5230.50
157_H178_S0.5230.50
198_I202_Q0.5220.50
318_P337_T0.5210.50
350_P368_G0.5200.49
91_E96_E0.5190.49
292_H295_L0.5180.49
14_T227_R0.5170.49
156_A212_I0.5170.49
270_V284_D0.5160.49
43_D46_D0.5140.49
31_P365_L0.5140.49
38_E67_I0.5140.49
180_D188_P0.5130.49
45_L220_P0.5130.49
227_R237_Q0.5120.48
142_K146_A0.5110.48
53_S346_P0.5110.48
12_V83_M0.5110.48
17_E121_G0.5110.48
172_E176_E0.5080.48
10_F365_L0.5080.48
20_G77_T0.5070.48
73_D96_E0.5060.48
88_K91_E0.5020.47
56_T346_P0.5000.47
77_T119_N0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r53A 4 0.703 100 0.074 Contact Map
1sq1A 4 0.731 100 0.078 Contact Map
4ob9A 2 0.7944 100 0.078 Contact Map
1q1lA 4 0.8299 100 0.082 Contact Map
1um0A 4 0.9112 100 0.083 Contact Map
2o11A 4 0.9137 100 0.083 Contact Map
4ecdA 3 0.6802 100 0.085 Contact Map
1qxoA 4 0.934 100 0.086 Contact Map
4wdcA 1 0.4264 34.9 0.979 Contact Map
2ekmA 3 0.1371 28.1 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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