GREMLIN Database
AROA - 3-phosphoshikimate 1-carboxyvinyltransferase
UniProt: Q9HQC1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 439 (396)
Sequences: 7915 (4856)
Seq/√Len: 244.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R270_E4.1401.00
366_S377_R3.8841.00
49_R240_E3.5411.00
266_A301_V3.3201.00
190_G229_R3.2401.00
425_D428_E3.1001.00
266_A303_T3.0611.00
49_R242_A3.0181.00
218_G229_R2.8911.00
24_R270_E2.8301.00
389_D414_A2.7911.00
45_E81_T2.7291.00
258_A291_A2.7021.00
423_F429_V2.6991.00
43_D233_A2.6731.00
212_L217_V2.6631.00
47_V240_E2.6421.00
120_T126_R2.6391.00
268_V301_V2.6031.00
336_T377_R2.5891.00
165_S192_E2.4861.00
359_S362_K2.4811.00
259_L402_V2.4711.00
387_S414_A2.4691.00
308_E334_D2.4691.00
160_P188_E2.4291.00
53_V58_R2.4141.00
62_R65_E2.3701.00
255_A329_L2.3401.00
267_V433_L2.2911.00
296_D299_S2.2861.00
387_S412_T2.2551.00
72_A79_V2.2361.00
47_V79_V2.2081.00
45_E79_V2.1741.00
136_A180_L2.1711.00
49_R77_D2.1691.00
370_R373_E2.1441.00
173_S176_F2.1111.00
404_G411_T2.0731.00
190_G227_R2.0341.00
53_V73_R2.0301.00
47_V77_D2.0301.00
20_R266_A2.0281.00
332_A406_V2.0251.00
313_E340_T2.0181.00
181_L209_L1.9961.00
338_R375_V1.9721.00
359_S400_L1.9601.00
382_E408_D1.8971.00
39_A46_T1.8651.00
70_A81_T1.8651.00
131_G135_D1.8441.00
32_T51_P1.8371.00
143_T158_D1.8301.00
63_A94_I1.8161.00
360_L365_A1.8051.00
37_L60_T1.7581.00
328_V399_A1.7191.00
192_E227_R1.7161.00
368_E375_V1.7021.00
163_G187_T1.7011.00
368_E377_R1.6801.00
61_A78_W1.6711.00
108_A179_A1.6601.00
310_S334_D1.6561.00
268_V296_D1.6501.00
35_A211_V1.6451.00
135_D139_G1.6351.00
251_S322_L1.6201.00
363_L411_T1.6181.00
365_A383_L1.6091.00
336_T375_V1.6021.00
363_L386_A1.5991.00
89_I116_T1.5951.00
114_D156_V1.5551.00
192_E225_G1.5431.00
145_R156_V1.5401.00
36_L64_V1.5381.00
162_S188_E1.5341.00
313_E338_R1.5281.00
220_S229_R1.5161.00
213_D222_T1.5001.00
357_A367_V1.4981.00
254_L283_V1.4901.00
327_A356_M1.4901.00
268_V299_S1.4881.00
22_R268_V1.4881.00
430_L435_A1.4871.00
401_A426_F1.4861.00
292_D305_Q1.4771.00
61_A71_A1.4771.00
103_M153_A1.4591.00
44_G238_G1.4421.00
388_V400_L1.4401.00
284_D287_E1.4101.00
357_A369_E1.3951.00
292_D303_T1.3871.00
222_T226_Y1.3871.00
256_A405_L1.3691.00
331_A365_A1.3631.00
73_R78_W1.3631.00
244_P275_S1.3621.00
116_T154_P1.3571.00
124_S127_A1.3561.00
65_E71_A1.3461.00
165_S197_T1.3341.00
335_G378_G1.3321.00
254_L269_V1.3301.00
69_G80_V1.3281.00
330_G337_T1.3241.00
215_F239_A1.3241.00
429_V432_G1.3151.00
363_L403_A1.3061.00
327_A339_I1.3051.00
23_A433_L1.3021.00
48_V243_V1.3001.00
254_L302_I1.2981.00
99_S102_T1.2981.00
134_L146_S1.2931.00
142_G161_V1.2921.00
250_A272_M1.2911.00
36_L61_A1.2851.00
311_G336_T1.2841.00
289_M312_V1.2811.00
58_R73_R1.2801.00
357_A374_L1.2791.00
72_A81_T1.2751.00
255_A282_I1.2741.00
311_G337_T1.2711.00
35_A243_V1.2681.00
213_D218_G1.2681.00
207_I241_Y1.2671.00
144_A155_L1.2651.00
25_A269_V1.2631.00
93_V118_V1.2571.00
370_R375_V1.2531.00
286_L291_A1.2491.00
62_R66_L1.2431.00
181_L228_V1.2421.00
389_D415_G1.2401.00
209_L219_A1.2361.00
254_L286_L1.2341.00
51_P57_T1.2161.00
214_A239_A1.2131.00
42_A46_T1.2121.00
32_T57_T1.2091.00
138_S143_T1.2091.00
220_S227_R1.2011.00
193_T199_L1.1981.00
116_T156_V1.1921.00
116_T158_D1.1841.00
206_D210_D1.1771.00
24_R271_G1.1651.00
140_L164_G1.1501.00
365_A379_G1.1471.00
397_V419_V1.1461.00
425_D429_V1.1441.00
266_A305_Q1.1441.00
316_V341_D1.1411.00
315_G341_D1.1411.00
253_L423_F1.1341.00
46_T211_V1.1271.00
404_G413_I1.1201.00
33_H60_T1.1081.00
48_V80_V1.1061.00
328_V403_A1.1061.00
135_D138_S1.1001.00
294_D301_V1.0971.00
286_L329_L1.0961.00
69_G82_G1.0931.00
397_V418_H1.0901.00
256_A402_V1.0851.00
285_V326_I1.0751.00
59_A97_A1.0701.00
55_A420_D1.0691.00
184_G191_I1.0681.00
201_S224_A1.0661.00
65_E70_A1.0621.00
332_A379_G1.0611.00
259_L406_V1.0561.00
161_V187_T1.0521.00
367_V374_L1.0511.00
188_E232_Q1.0511.00
202_A205_V1.0491.00
260_A265_A1.0471.00
388_V411_T1.0441.00
103_M178_T1.0431.00
74_E77_D1.0401.00
252_Y398_M1.0341.00
59_A62_R1.0321.00
134_L138_S1.0301.00
428_E431_A1.0291.00
65_E73_R1.0261.00
336_T378_G1.0251.00
39_A80_V1.0231.00
258_A307_S1.0211.00
251_S325_T1.0151.00
44_G237_S1.0141.00
285_V314_V1.0111.00
145_R158_D1.0111.00
289_M333_A1.0101.00
143_T156_V1.0051.00
287_E295_W1.0011.00
64_V69_G0.9991.00
178_T208_T0.9981.00
46_T239_A0.9981.00
19_V256_A0.9871.00
96_C125_L0.9861.00
255_A322_L0.9811.00
146_S151_G0.9791.00
343_E371_P0.9711.00
209_L222_T0.9671.00
361_S366_S0.9671.00
249_S429_V0.9661.00
285_V288_R0.9641.00
255_A286_L0.9631.00
217_V234_Y0.9611.00
168_L180_L0.9601.00
407_A411_T0.9601.00
330_G339_I0.9451.00
42_A238_G0.9441.00
405_L435_A0.9431.00
189_T230_G0.9341.00
386_A411_T0.9341.00
362_K386_A0.9331.00
93_V120_T0.9311.00
247_F282_I0.9281.00
132_P170_G0.9261.00
35_A48_V0.9161.00
322_L325_T0.9161.00
213_D221_E0.9151.00
66_L91_D0.9131.00
114_D154_P0.9131.00
264_G306_R0.9091.00
51_P78_W0.9071.00
61_A65_E0.9061.00
339_I374_L0.9031.00
50_D242_A0.9021.00
415_G418_H0.9021.00
133_L179_A0.9021.00
37_L109_A0.9001.00
257_G260_A0.8991.00
145_R149_G0.8961.00
287_E292_D0.8961.00
294_D303_T0.8961.00
392_G415_G0.8951.00
34_R37_L0.8921.00
241_Y244_P0.8901.00
260_A264_G0.8851.00
289_M309_L0.8821.00
356_M396_L0.8800.99
254_L257_G0.8750.99
163_G188_E0.8740.99
204_Y247_F0.8740.99
166_V169_P0.8710.99
105_L137_L0.8710.99
311_G333_A0.8690.99
390_G397_V0.8670.99
242_A271_G0.8600.99
118_V156_V0.8600.99
331_A360_L0.8590.99
311_G335_G0.8560.99
342_A373_E0.8530.99
379_G382_E0.8510.99
213_D219_A0.8510.99
327_A374_L0.8490.99
331_A379_G0.8480.99
123_E394_H0.8470.99
384_S408_D0.8470.99
157_V160_P0.8470.99
190_G230_G0.8460.99
107_T157_V0.8450.99
210_D214_A0.8450.99
187_T191_I0.8430.99
211_V215_F0.8410.99
296_D301_V0.8400.99
25_A253_L0.8400.99
41_Y109_A0.8340.99
309_L333_A0.8330.99
185_A217_V0.8320.99
125_L344_H0.8310.99
417_E420_D0.8310.99
333_A337_T0.8230.99
259_L332_A0.8230.99
19_V265_A0.8180.99
169_P285_V0.8180.99
25_A250_A0.8160.99
135_D169_P0.8150.99
44_G82_G0.8150.99
332_A381_T0.8140.99
404_G430_L0.8090.99
146_S150_N0.8020.99
163_G191_I0.7970.99
327_A376_V0.7960.99
63_A96_C0.7860.99
256_A435_A0.7850.99
211_V239_A0.7850.99
132_P169_P0.7840.99
45_E82_G0.7810.99
134_L144_A0.7800.99
295_W300_G0.7780.99
390_G413_I0.7770.99
76_G424_P0.7740.99
295_W299_S0.7730.99
69_G83_F0.7730.99
214_A241_Y0.7710.99
192_E197_T0.7710.99
213_D220_S0.7700.99
102_T130_H0.7680.99
64_V106_V0.7650.99
289_M330_G0.7630.99
31_Y211_V0.7620.99
32_T243_V0.7610.99
210_D213_D0.7590.99
325_T402_V0.7580.98
24_R50_D0.7580.98
40_G64_V0.7580.98
35_A241_Y0.7570.98
110_A117_T0.7540.98
291_A309_L0.7510.98
110_A119_L0.7500.98
28_S32_T0.7490.98
123_E127_A0.7490.98
257_G267_V0.7480.98
23_A269_V0.7470.98
385_G407_A0.7440.98
50_D271_G0.7430.98
416_S419_V0.7410.98
184_G193_T0.7400.98
268_V303_T0.7380.98
55_A59_A0.7380.98
140_L166_V0.7360.98
61_A73_R0.7340.98
401_A419_V0.7330.98
289_M329_L0.7330.98
258_A286_L0.7320.98
163_G189_T0.7310.98
26_P249_S0.7290.98
259_L328_V0.7280.98
36_L80_V0.7270.98
283_V287_E0.7270.98
282_I322_L0.7250.98
161_V189_T0.7240.98
420_D427_F0.7240.98
26_P429_V0.7240.98
369_E373_E0.7210.98
254_L258_A0.7180.98
337_T376_V0.7180.98
21_G433_L0.7180.98
31_Y207_I0.7170.98
38_A211_V0.7160.98
340_T370_R0.7150.98
324_P396_L0.7150.98
65_E72_A0.7100.98
253_L429_V0.7090.98
340_T373_E0.7090.98
181_L226_Y0.7090.98
363_L407_A0.7080.98
132_P172_V0.7080.98
73_R76_G0.7060.98
36_L78_W0.7050.98
45_E238_G0.7050.98
316_V323_L0.7040.98
180_L193_T0.7040.98
385_G411_T0.7030.98
222_T225_G0.7030.98
293_I302_I0.7030.98
264_G307_S0.7020.98
183_A187_T0.7010.98
206_D221_E0.7000.97
93_V126_R0.6980.97
363_L388_V0.6940.97
229_R232_Q0.6940.97
168_L193_T0.6920.97
250_A269_V0.6910.97
53_V76_G0.6880.97
27_P243_V0.6870.97
283_V295_W0.6870.97
252_Y325_T0.6840.97
61_A80_V0.6840.97
207_I210_D0.6790.97
305_Q309_L0.6780.97
315_G340_T0.6770.97
39_A82_G0.6760.97
175_Q205_V0.6760.97
260_A405_L0.6730.97
230_G234_Y0.6720.97
88_A114_D0.6710.97
82_G111_A0.6680.97
32_T52_L0.6670.97
312_V337_T0.6660.97
212_L234_Y0.6660.97
218_G231_G0.6650.97
74_E79_V0.6640.97
257_G269_V0.6620.96
92_A126_R0.6620.96
168_L172_V0.6610.96
427_F431_A0.6580.96
256_A430_L0.6530.96
103_M107_T0.6510.96
96_C119_L0.6510.96
18_R265_A0.6490.96
90_P95_D0.6490.96
107_T119_L0.6460.96
23_A429_V0.6460.96
200_K204_Y0.6460.96
405_L430_L0.6450.96
162_S189_T0.6430.96
125_L153_A0.6430.96
366_S379_G0.6420.96
324_P356_M0.6410.96
328_V400_L0.6400.96
31_Y34_R0.6390.96
137_L142_G0.6380.96
363_L383_L0.6320.95
201_S205_V0.6300.95
166_V193_T0.6290.95
140_L191_I0.6270.95
19_V435_A0.6260.95
119_L153_A0.6250.95
63_A106_V0.6240.95
258_A309_L0.6240.95
221_E226_Y0.6220.95
131_G151_G0.6210.95
55_A58_R0.6210.95
132_P135_D0.6200.95
253_L430_L0.6200.95
231_G234_Y0.6190.95
251_S282_I0.6180.95
43_D82_G0.6170.95
191_I230_G0.6170.95
287_E293_I0.6160.95
64_V71_A0.6140.95
128_R395_R0.6140.95
181_L193_T0.6140.95
311_G334_D0.6140.95
98_N122_D0.6120.95
96_C103_M0.6090.94
339_I342_A0.6080.94
213_D217_V0.6070.94
253_L426_F0.6070.94
316_V319_T0.6040.94
107_T182_M0.6020.94
107_T110_A0.6010.94
83_F86_R0.6010.94
42_A82_G0.6010.94
257_G265_A0.6010.94
23_A253_L0.6000.94
210_D241_Y0.5990.94
111_A142_G0.5980.94
384_S409_G0.5980.94
356_M399_A0.5970.94
170_G342_A0.5970.94
296_D303_T0.5940.94
255_A325_T0.5930.94
202_A206_D0.5920.94
40_G69_G0.5920.94
419_V427_F0.5920.94
46_T238_G0.5900.93
130_H134_L0.5900.93
102_T421_V0.5890.93
328_V331_A0.5880.93
327_A357_A0.5880.93
361_S367_V0.5870.93
233_A237_S0.5870.93
346_R371_P0.5850.93
362_K389_D0.5840.93
245_G269_V0.5830.93
138_S144_A0.5820.93
401_A427_F0.5820.93
346_R369_E0.5820.93
365_A403_A0.5810.93
390_G418_H0.5810.93
320_P345_V0.5780.93
398_M426_F0.5780.93
383_L407_A0.5770.93
201_S204_Y0.5770.93
211_V241_Y0.5760.93
42_A215_F0.5750.93
305_Q308_E0.5750.93
66_L92_A0.5740.93
356_M400_L0.5740.93
43_D111_A0.5730.92
134_L155_L0.5720.92
63_A104_R0.5710.92
42_A81_T0.5700.92
62_R97_A0.5700.92
397_V427_F0.5690.92
33_H37_L0.5680.92
217_V233_A0.5670.92
67_L110_A0.5650.92
53_V75_N0.5630.92
285_V312_V0.5620.92
53_V78_W0.5620.92
130_H153_A0.5600.92
217_V231_G0.5600.92
254_L293_I0.5590.92
149_G154_P0.5590.92
311_G378_G0.5580.91
259_L329_L0.5580.91
209_L226_Y0.5570.91
327_A367_V0.5570.91
212_L215_F0.5560.91
278_G284_D0.5550.91
288_R318_D0.5540.91
146_S155_L0.5540.91
88_A112_L0.5530.91
257_G264_G0.5530.91
207_I244_P0.5510.91
83_F87_P0.5500.91
210_D222_T0.5490.91
283_V293_I0.5490.91
55_A97_A0.5470.91
161_V183_A0.5460.91
338_R370_R0.5460.91
221_E224_A0.5460.91
345_V422_S0.5440.90
257_G291_A0.5440.90
338_R373_E0.5440.90
179_A183_A0.5430.90
73_R77_D0.5430.90
138_S150_N0.5430.90
416_S427_F0.5430.90
165_S199_L0.5410.90
44_G239_A0.5410.90
383_L386_A0.5410.90
19_V267_V0.5400.90
270_E299_S0.5400.90
29_K128_R0.5370.90
328_V360_L0.5370.90
248_S394_H0.5370.90
331_A406_V0.5370.90
136_A140_L0.5350.90
44_G81_T0.5350.90
392_G418_H0.5340.90
316_V326_I0.5340.90
58_R62_R0.5330.90
26_P424_P0.5330.90
138_S146_S0.5320.89
49_R76_G0.5310.89
362_K400_L0.5310.89
200_K344_H0.5300.89
272_M299_S0.5300.89
292_D307_S0.5290.89
345_V355_A0.5290.89
175_Q178_T0.5270.89
96_C102_T0.5240.89
218_G232_Q0.5240.89
285_V319_T0.5230.89
199_L205_V0.5230.89
284_D288_R0.5230.89
107_T133_L0.5230.89
168_L199_L0.5230.89
103_M119_L0.5230.89
52_L249_S0.5230.89
330_G376_V0.5220.89
82_G85_S0.5220.89
109_A137_L0.5210.88
33_H102_T0.5210.88
358_E389_D0.5200.88
28_S244_P0.5200.88
289_M337_T0.5190.88
202_A221_E0.5190.88
331_A381_T0.5180.88
25_A245_G0.5170.88
272_M275_S0.5150.88
360_L403_A0.5150.88
100_G103_M0.5140.88
133_L136_A0.5140.88
358_E361_S0.5140.88
72_A75_N0.5130.88
37_L64_V0.5130.88
292_D295_W0.5130.88
105_L108_A0.5120.88
139_G167_A0.5120.88
160_P187_T0.5100.87
132_P173_S0.5090.87
149_G152_Q0.5090.87
302_I305_Q0.5080.87
217_V238_G0.5080.87
102_T106_V0.5070.87
339_I376_V0.5070.87
25_A272_M0.5070.87
140_L162_S0.5060.87
356_M359_S0.5060.87
138_S145_R0.5060.87
33_H99_S0.5050.87
247_F283_V0.5030.87
323_L339_I0.5020.87
185_A231_G0.5010.86
206_D209_L0.5010.86
168_L226_Y0.5000.86
46_T215_F0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rmtA 4 0.9453 100 0.145 Contact Map
2pqcA 1 0.9567 100 0.16 Contact Map
3slhA 4 0.9499 100 0.177 Contact Map
1rf6A 1 0.9362 100 0.189 Contact Map
3nvsA 1 0.9522 100 0.199 Contact Map
2o0bA 1 0.9317 100 0.2 Contact Map
3zh4A 1 0.9134 100 0.288 Contact Map
4fqdA 2 0.9203 100 0.29 Contact Map
3r38A 2 0.9385 100 0.292 Contact Map
1ejdA 4 0.9271 100 0.301 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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