Q9HQC0 - HALSA - GREMLIN Contacts

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Q9HQC0 - X-pro aminopeptidase homolog

UniProt:	Q9HQC0	Sequences: MDPDFSQLDEFLEDSGVDGYAFHDDDSNSDLYYLAGFDAPDPFFAVYTPAQTGVLVSPLEYGRASKAARADVVARHSDYDLQAKREEYGPRAAKERVLAEFVADLGCESLAVGERFPVGTADALRDHEITVEPDEDNVVEDIRATKTEAEIEHVREAQRANEAAMARAEELIRGADREDGVLVRDDGQPLTSEYVRQEIEIELLRHGCALDDTIVAGGAQAADAHERGSGPLPADDPVVVDIFPRSKDSKYHSDMTRTFANGDPSDAHRERYAVTRAAFEAALDAIEPGVTGEAVNQAVIDVFDDHGYPNVFADPDTESGFIHSTGHGVGLDVHEMPAVSQGGDELHAGNVITIEPGLYEPGEGGVRIEDIVVVTEDGYENLTDYEIALTD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	391 (340)
Sequences:	10981 (8172)
Seq/√Len:	443.2

ECOLI - YPDF AMPP PEPQ MAP1
BACSU - YKVY YQHT MAP11 MAP12
HALSA - Q9HQC0 Q9HRF6 Q9HMB3 Q9HP03
SULSO - Q981D7 Q980E9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_R	380_E	5.248	1.00
348_A	376_E	4.462	1.00
286_I	374_V	3.286	1.00
151_I	373_V	3.128	1.00
267_A	363_E	2.782	1.00
273_A	277_A	2.599	1.00
274_V	306_H	2.560	1.00
163_A	206_H	2.532	1.00
167_R	202_E	2.521	1.00
156_E	159_R	2.511	1.00
201_I	205_R	2.441	1.00
281_A	302_V	2.437	1.00
265_S	268_H	2.429	1.00
198_E	201_I	2.419	1.00
267_A	270_E	2.374	1.00
293_E	344_D	2.329	1.00
191_T	231_P	2.326	1.00
154_V	351_V	2.319	1.00
291_T	294_A	2.312	1.00
266_D	270_E	2.310	1.00
145_T	347_H	2.305	1.00
29_S	332_D	2.291	1.00
296_N	300_I	2.268	1.00
280_E	284_D	2.256	1.00
55_L	97_V	2.243	1.00
285_A	298_A	2.231	1.00
122_D	125_R	2.173	1.00
301_D	305_D	2.155	1.00
282_A	299_V	2.141	1.00
329_V	371_I	2.139	1.00
153_H	249_S	2.120	1.00
17_V	111_A	2.067	1.00
155_R	159_R	1.984	1.00
200_E	204_L	1.930	1.00
281_A	284_D	1.910	1.00
171_L	198_E	1.892	1.00
93_A	96_R	1.871	1.00
233_P	236_D	1.866	1.00
11_F	14_D	1.829	1.00
57_S	60_E	1.824	1.00
269_R	273_A	1.822	1.00
202_E	205_R	1.791	1.00
297_Q	301_D	1.766	1.00
375_T	380_E	1.754	1.00
302_V	306_H	1.723	1.00
291_T	345_E	1.718	1.00
277_A	281_A	1.708	1.00
237_P	268_H	1.698	1.00
169_E	259_F	1.696	1.00
202_E	206_H	1.692	1.00
277_A	306_H	1.670	1.00
271_R	364_G	1.669	1.00
354_I	372_V	1.660	1.00
271_R	366_V	1.646	1.00
191_T	194_Y	1.638	1.00
275_T	366_V	1.630	1.00
283_L	372_V	1.609	1.00
276_R	280_E	1.606	1.00
303_F	358_L	1.597	1.00
287_E	290_V	1.587	1.00
347_H	350_N	1.560	1.00
215_V	238_V	1.548	1.00
144_A	350_N	1.535	1.00
13_E	48_T	1.527	1.00
282_A	295_V	1.509	1.00
197_Q	201_I	1.492	1.00
5_F	9_D	1.491	1.00
167_R	170_E	1.491	1.00
47_Y	50_A	1.482	1.00
210_L	252_H	1.473	1.00
234_A	261_N	1.466	1.00
245_R	252_H	1.459	1.00
193_E	230_G	1.454	1.00
195_V	232_L	1.453	1.00
97_V	100_E	1.451	1.00
166_A	170_E	1.447	1.00
167_R	206_H	1.445	1.00
373_V	382_L	1.441	1.00
241_D	254_D	1.431	1.00
11_F	15_S	1.424	1.00
254_D	369_E	1.420	1.00
260_A	264_P	1.417	1.00
278_A	302_V	1.414	1.00
162_E	385_Y	1.412	1.00
353_T	371_I	1.408	1.00
290_V	294_A	1.408	1.00
174_G	234_A	1.389	1.00
198_E	202_E	1.388	1.00
148_E	152_E	1.380	1.00
271_R	360_E	1.367	1.00
32_Y	250_K	1.367	1.00
279_F	283_L	1.365	1.00
152_E	156_E	1.353	1.00
277_A	305_D	1.315	1.00
217_G	232_L	1.314	1.00
63_R	67_A	1.311	1.00
10_E	14_D	1.300	1.00
288_P	348_A	1.298	1.00
61_Y	65_S	1.291	1.00
194_Y	205_R	1.291	1.00
299_V	325_T	1.287	1.00
277_A	302_V	1.276	1.00
237_P	260_A	1.262	1.00
196_R	200_E	1.260	1.00
293_E	297_Q	1.250	1.00
272_Y	368_I	1.249	1.00
266_D	269_R	1.244	1.00
294_A	297_Q	1.244	1.00
195_V	238_V	1.241	1.00
121_A	125_R	1.240	1.00
241_D	369_E	1.239	1.00
18_D	108_E	1.226	1.00
217_G	236_D	1.221	1.00
4_D	147_T	1.221	1.00
160_A	208_C	1.218	1.00
109_S	132_E	1.212	1.00
232_L	261_N	1.211	1.00
270_E	306_H	1.210	1.00
279_F	370_D	1.207	1.00
30_D	33_Y	1.202	1.00
165_M	255_M	1.198	1.00
159_R	163_A	1.194	1.00
35_A	44_F	1.186	1.00
346_L	352_I	1.179	1.00
6_S	10_E	1.177	1.00
346_L	374_V	1.177	1.00
118_V	122_D	1.172	1.00
156_E	248_D	1.166	1.00
34_L	142_I	1.166	1.00
72_V	75_R	1.165	1.00
281_A	298_A	1.163	1.00
161_N	255_M	1.163	1.00
89_G	93_A	1.158	1.00
149_A	153_H	1.154	1.00
141_D	347_H	1.153	1.00
160_A	250_K	1.150	1.00
118_V	121_A	1.147	1.00
154_V	158_Q	1.145	1.00
198_E	205_R	1.144	1.00
286_I	295_V	1.143	1.00
145_T	350_N	1.132	1.00
283_L	381_N	1.132	1.00
304_D	309_P	1.124	1.00
8_L	20_Y	1.124	1.00
216_A	226_E	1.123	1.00
237_P	258_T	1.123	1.00
218_G	236_D	1.118	1.00
200_E	213_T	1.112	1.00
190_L	194_Y	1.110	1.00
19_G	45_A	1.102	1.00
270_E	274_V	1.097	1.00
285_A	290_V	1.089	1.00
158_Q	162_E	1.089	1.00
351_V	373_V	1.076	1.00
270_E	273_A	1.075	1.00
108_E	111_A	1.065	1.00
167_R	198_E	1.062	1.00
7_Q	10_E	1.058	1.00
282_A	298_A	1.058	1.00
17_V	133_P	1.049	1.00
152_E	155_R	1.046	1.00
149_A	152_E	1.044	1.00
290_V	298_A	1.042	1.00
360_E	363_E	1.038	1.00
283_L	354_I	1.033	1.00
110_L	113_G	1.030	1.00
274_V	303_F	1.028	1.00
298_A	301_D	1.027	1.00
267_A	360_E	1.020	1.00
349_G	373_V	1.015	1.00
372_V	381_N	1.015	1.00
286_I	354_I	1.011	1.00
190_L	198_E	1.010	1.00
135_E	138_V	1.009	1.00
301_D	304_D	1.007	1.00
109_S	133_P	1.007	1.00
240_V	259_F	0.998	1.00
352_I	374_V	0.998	1.00
11_F	141_D	0.998	1.00
208_C	244_P	0.997	1.00
47_Y	52_T	0.997	1.00
296_N	325_T	0.997	1.00
278_A	303_F	0.991	1.00
12_L	17_V	0.990	1.00
220_Q	226_E	0.987	1.00
375_T	378_G	0.986	1.00
7_Q	142_I	0.980	1.00
167_R	205_R	0.977	1.00
155_R	373_V	0.973	1.00
307_G	310_N	0.973	1.00
293_E	342_G	0.972	1.00
19_G	47_Y	0.971	1.00
281_A	285_A	0.967	1.00
172_I	259_F	0.955	1.00
42_P	47_Y	0.953	1.00
158_Q	371_I	0.951	1.00
290_V	295_V	0.948	1.00
148_E	375_T	0.944	1.00
96_R	100_E	0.944	1.00
286_I	372_V	0.941	1.00
274_V	302_V	0.941	1.00
30_D	140_E	0.940	1.00
109_S	113_G	0.940	1.00
193_E	197_Q	0.937	1.00
302_V	305_D	0.937	1.00
274_V	277_A	0.935	1.00
162_E	384_D	0.934	1.00
166_A	385_Y	0.933	1.00
211_D	214_I	0.924	1.00
172_I	195_V	0.923	1.00
203_L	244_P	0.916	1.00
173_R	190_L	0.914	1.00
295_V	298_A	0.910	1.00
219_A	362_G	0.909	1.00
292_G	346_L	0.906	1.00
212_D	227_R	0.904	1.00
107_C	110_L	0.902	1.00
165_M	259_F	0.900	1.00
122_D	126_D	0.899	1.00
18_D	109_S	0.898	1.00
329_V	351_V	0.898	1.00
221_A	239_V	0.896	1.00
288_P	375_T	0.896	1.00
10_E	13_E	0.891	1.00
164_A	202_E	0.888	1.00
156_E	160_A	0.887	1.00
285_A	295_V	0.882	1.00
295_V	346_L	0.881	1.00
260_A	268_H	0.880	1.00
273_A	276_R	0.879	1.00
167_R	171_L	0.878	1.00
163_A	166_A	0.868	1.00
267_A	271_R	0.868	1.00
9_D	47_Y	0.865	1.00
216_A	221_A	0.864	1.00
286_I	379_Y	0.862	1.00
88_Y	93_A	0.862	1.00
153_H	156_E	0.862	1.00
238_V	261_N	0.860	1.00
6_S	9_D	0.857	1.00
161_N	253_S	0.856	1.00
373_V	380_E	0.853	1.00
156_E	249_S	0.850	1.00
174_G	190_L	0.850	1.00
128_E	131_V	0.849	1.00
220_Q	223_D	0.848	1.00
119_G	123_A	0.848	1.00
372_V	379_Y	0.845	1.00
288_P	376_E	0.840	1.00
9_D	52_T	0.835	1.00
282_A	354_I	0.834	1.00
30_D	113_G	0.831	1.00
151_I	155_R	0.827	1.00
12_L	19_G	0.827	1.00
276_R	368_I	0.826	1.00
32_Y	331_L	0.824	1.00
328_G	337_P	0.823	1.00
283_L	379_Y	0.823	1.00
93_A	97_V	0.822	1.00
18_D	22_F	0.817	1.00
90_P	93_A	0.813	1.00
9_D	46_V	0.810	1.00
340_S	343_G	0.809	1.00
9_D	48_T	0.808	1.00
374_V	379_Y	0.807	1.00
298_A	302_V	0.807	1.00
291_T	344_D	0.804	1.00
20_Y	135_E	0.801	1.00
339_V	352_I	0.800	1.00
170_E	174_G	0.799	1.00
360_E	364_G	0.798	1.00
51_Q	72_V	0.797	1.00
138_V	141_D	0.796	1.00
13_E	49_P	0.796	1.00
210_L	213_T	0.792	1.00
195_V	215_V	0.791	1.00
123_A	126_D	0.790	1.00
69_R	73_V	0.790	1.00
158_Q	383_T	0.790	1.00
281_A	299_V	0.788	1.00
272_Y	276_R	0.786	1.00
22_F	34_L	0.779	1.00
153_H	248_D	0.779	1.00
271_R	308_Y	0.775	1.00
144_A	347_H	0.773	1.00
160_A	206_H	0.772	1.00
22_F	139_V	0.772	1.00
278_A	282_A	0.771	1.00
199_I	240_V	0.771	1.00
95_E	99_A	0.769	1.00
224_A	323_H	0.768	1.00
53_G	89_G	0.766	1.00
254_D	327_H	0.764	1.00
164_A	203_L	0.764	1.00
235_D	263_D	0.760	1.00
257_R	370_D	0.757	1.00
174_G	261_N	0.756	1.00
150_E	251_Y	0.756	1.00
329_V	353_T	0.756	1.00
192_S	220_Q	0.753	1.00
159_R	162_E	0.753	1.00
111_A	135_E	0.752	1.00
162_E	166_A	0.752	1.00
287_E	379_Y	0.750	1.00
7_Q	11_F	0.749	1.00
29_S	331_L	0.747	1.00
299_V	321_F	0.747	1.00
47_Y	53_G	0.741	1.00
9_D	12_L	0.739	1.00
96_R	99_A	0.738	1.00
215_V	240_V	0.735	1.00
278_A	298_A	0.734	1.00
168_A	240_V	0.734	1.00
68_A	72_V	0.733	1.00
355_E	369_E	0.730	1.00
264_P	269_R	0.726	1.00
68_A	71_D	0.724	1.00
158_Q	253_S	0.723	1.00
288_P	347_H	0.722	1.00
223_D	226_E	0.722	1.00
285_A	288_P	0.721	1.00
199_I	242_I	0.720	1.00
44_F	47_Y	0.717	1.00
12_L	20_Y	0.715	1.00
54_V	64_A	0.715	1.00
294_A	298_A	0.713	1.00
271_R	274_V	0.712	1.00
171_L	202_E	0.712	1.00
241_D	355_E	0.709	1.00
168_A	195_V	0.709	1.00
221_A	365_G	0.709	1.00
244_P	253_S	0.707	1.00
32_Y	44_F	0.706	1.00
190_L	195_V	0.699	1.00
199_I	203_L	0.698	1.00
200_E	209_A	0.698	1.00
328_G	335_E	0.698	1.00
24_D	29_S	0.697	1.00
99_A	102_V	0.696	1.00
161_N	164_A	0.696	1.00
211_D	243_F	0.694	1.00
288_P	379_Y	0.692	1.00
160_A	248_D	0.691	1.00
221_A	237_P	0.691	1.00
359_Y	367_R	0.690	1.00
9_D	13_E	0.688	1.00
71_D	74_A	0.687	1.00
237_P	264_P	0.685	1.00
89_G	97_V	0.685	1.00
56_V	61_Y	0.683	1.00
327_H	369_E	0.682	1.00
8_L	34_L	0.682	1.00
158_Q	382_L	0.679	1.00
18_D	48_T	0.678	1.00
164_A	199_I	0.676	1.00
201_I	204_L	0.674	1.00
8_L	142_I	0.670	1.00
109_S	112_V	0.669	1.00
114_E	117_P	0.667	1.00
304_D	310_N	0.665	1.00
235_D	261_N	0.665	1.00
175_A	190_L	0.665	1.00
168_A	198_E	0.663	1.00
225_H	334_H	0.663	1.00
282_A	285_A	0.660	1.00
303_F	308_Y	0.660	1.00
97_V	101_F	0.659	1.00
345_E	348_A	0.659	1.00
252_H	333_V	0.658	1.00
264_P	268_H	0.658	1.00
8_L	46_V	0.657	1.00
234_A	262_G	0.656	1.00
280_E	283_L	0.655	1.00
279_F	354_I	0.652	1.00
60_E	63_R	0.651	1.00
357_G	367_R	0.650	1.00
288_P	374_V	0.650	1.00
19_G	22_F	0.646	0.99
281_A	301_D	0.643	0.99
254_D	355_E	0.642	0.99
11_F	138_V	0.640	0.99
100_E	103_A	0.637	0.99
11_F	142_I	0.636	0.99
158_Q	255_M	0.635	0.99
274_V	308_Y	0.634	0.99
300_I	321_F	0.634	0.99
348_A	375_T	0.634	0.99
265_S	363_E	0.632	0.99
31_L	42_P	0.631	0.99
90_P	94_K	0.630	0.99
194_Y	197_Q	0.629	0.99
94_K	102_V	0.627	0.99
335_E	339_V	0.626	0.99
160_A	244_P	0.623	0.99
234_A	263_D	0.621	0.99
165_M	242_I	0.621	0.99
31_L	44_F	0.617	0.99
64_A	68_A	0.617	0.99
268_H	363_E	0.615	0.99
9_D	49_P	0.615	0.99
295_V	325_T	0.614	0.99
47_Y	51_Q	0.614	0.99
112_V	118_V	0.613	0.99
195_V	240_V	0.611	0.99
289_G	345_E	0.610	0.99
193_E	209_A	0.610	0.99
108_E	113_G	0.610	0.99
289_G	347_H	0.610	0.99
359_Y	365_G	0.609	0.99
165_M	168_A	0.607	0.99
375_T	379_Y	0.607	0.99
172_I	238_V	0.606	0.99
278_A	299_V	0.603	0.99
282_A	325_T	0.602	0.99
236_D	268_H	0.601	0.99
335_E	338_A	0.598	0.99
287_E	377_D	0.597	0.99
161_N	242_I	0.596	0.99
151_I	351_V	0.596	0.99
331_L	334_H	0.593	0.99
157_A	161_N	0.592	0.99
381_N	384_D	0.592	0.99
148_E	349_G	0.591	0.99
286_I	346_L	0.591	0.99
274_V	358_L	0.590	0.99
89_G	92_A	0.590	0.99
16_G	109_S	0.589	0.99
165_M	169_E	0.585	0.99
88_Y	91_R	0.584	0.99
50_A	53_G	0.582	0.99
117_P	120_T	0.581	0.99
32_Y	38_D	0.581	0.99
221_A	224_A	0.580	0.99
351_V	371_I	0.579	0.99
9_D	50_A	0.578	0.99
168_A	171_L	0.576	0.99
5_F	46_V	0.575	0.99
21_A	45_A	0.575	0.99
288_P	378_G	0.572	0.99
141_D	144_A	0.571	0.99
338_A	352_I	0.571	0.99
56_V	60_E	0.571	0.99
327_H	355_E	0.567	0.99
172_I	261_N	0.561	0.99
197_Q	204_L	0.560	0.99
58_P	61_Y	0.558	0.98
277_A	280_E	0.557	0.98
297_Q	341_Q	0.557	0.98
241_D	327_H	0.556	0.98
62_G	66_K	0.555	0.98
217_G	233_P	0.555	0.98
148_E	348_A	0.555	0.98
71_D	75_R	0.551	0.98
297_Q	304_D	0.549	0.98
271_R	358_L	0.549	0.98
303_F	309_P	0.549	0.98
256_T	369_E	0.546	0.98
255_M	371_I	0.545	0.98
120_T	123_A	0.544	0.98
54_V	57_S	0.543	0.98
168_A	199_I	0.542	0.98
152_E	159_R	0.542	0.98
31_L	35_A	0.540	0.98
292_G	326_G	0.539	0.98
217_G	261_N	0.539	0.98
299_V	302_V	0.537	0.98
65_S	68_A	0.536	0.98
260_A	265_S	0.534	0.98
62_G	65_S	0.532	0.98
217_G	220_Q	0.532	0.98
8_L	31_L	0.531	0.98
293_E	343_G	0.530	0.98
146_K	150_E	0.530	0.98
278_A	281_A	0.529	0.98
58_P	322_I	0.528	0.98
34_L	139_V	0.526	0.98
63_R	66_K	0.526	0.98
357_G	365_G	0.525	0.98
140_E	336_M	0.524	0.98
5_F	52_T	0.524	0.98
97_V	102_V	0.523	0.98
322_I	361_P	0.523	0.98
58_P	90_P	0.522	0.98
60_E	64_A	0.521	0.98
213_T	242_I	0.520	0.98
161_N	244_P	0.520	0.98
116_F	121_A	0.515	0.97
197_Q	205_R	0.515	0.97
219_A	222_A	0.514	0.97
91_R	94_K	0.514	0.97
61_Y	64_A	0.514	0.97
145_T	348_A	0.513	0.97
64_A	67_A	0.512	0.97
174_G	233_P	0.512	0.97
292_G	339_V	0.511	0.97
92_A	95_E	0.511	0.97
70_A	73_V	0.510	0.97
108_E	112_V	0.510	0.97
163_A	202_E	0.507	0.97
162_E	383_T	0.506	0.97
12_L	16_G	0.505	0.97
191_T	230_G	0.505	0.97
171_L	190_L	0.503	0.97
210_L	214_I	0.502	0.97
303_F	306_H	0.502	0.97
371_I	383_T	0.501	0.97
296_N	321_F	0.500	0.97
194_Y	231_P	0.500	0.97
161_N	243_F	0.500	0.97
99_A	103_A	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fkcA	2	0.8977	100	0.214	Contact Map
3q6dA	1	0.89	100	0.224	Contact Map
2zsgA	2	0.8875	100	0.226	Contact Map
4r60A	2	0.9079	100	0.226	Contact Map
1wy2A	2	0.8721	100	0.228	Contact Map
1wn1A	2	0.8824	100	0.229	Contact Map
4egeA	2	0.8977	100	0.239	Contact Map
3ig4A	4	0.9386	100	0.253	Contact Map
1kp0A	2	0.798	100	0.263	Contact Map
2v3zA	3	0.9437	100	0.265	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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