GREMLIN Database
Q9HQC0 - X-pro aminopeptidase homolog
UniProt: Q9HQC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (340)
Sequences: 10981 (8172)
Seq/√Len: 443.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_R380_E5.2481.00
348_A376_E4.4621.00
286_I374_V3.2861.00
151_I373_V3.1281.00
267_A363_E2.7821.00
273_A277_A2.5991.00
274_V306_H2.5601.00
163_A206_H2.5321.00
167_R202_E2.5211.00
156_E159_R2.5111.00
201_I205_R2.4411.00
281_A302_V2.4371.00
265_S268_H2.4291.00
198_E201_I2.4191.00
267_A270_E2.3741.00
293_E344_D2.3291.00
191_T231_P2.3261.00
154_V351_V2.3191.00
291_T294_A2.3121.00
266_D270_E2.3101.00
145_T347_H2.3051.00
29_S332_D2.2911.00
296_N300_I2.2681.00
280_E284_D2.2561.00
55_L97_V2.2431.00
285_A298_A2.2311.00
122_D125_R2.1731.00
301_D305_D2.1551.00
282_A299_V2.1411.00
329_V371_I2.1391.00
153_H249_S2.1201.00
17_V111_A2.0671.00
155_R159_R1.9841.00
200_E204_L1.9301.00
281_A284_D1.9101.00
171_L198_E1.8921.00
93_A96_R1.8711.00
233_P236_D1.8661.00
11_F14_D1.8291.00
57_S60_E1.8241.00
269_R273_A1.8221.00
202_E205_R1.7911.00
297_Q301_D1.7661.00
375_T380_E1.7541.00
302_V306_H1.7231.00
291_T345_E1.7181.00
277_A281_A1.7081.00
237_P268_H1.6981.00
169_E259_F1.6961.00
202_E206_H1.6921.00
277_A306_H1.6701.00
271_R364_G1.6691.00
354_I372_V1.6601.00
271_R366_V1.6461.00
191_T194_Y1.6381.00
275_T366_V1.6301.00
283_L372_V1.6091.00
276_R280_E1.6061.00
303_F358_L1.5971.00
287_E290_V1.5871.00
347_H350_N1.5601.00
215_V238_V1.5481.00
144_A350_N1.5351.00
13_E48_T1.5271.00
282_A295_V1.5091.00
197_Q201_I1.4921.00
5_F9_D1.4911.00
167_R170_E1.4911.00
47_Y50_A1.4821.00
210_L252_H1.4731.00
234_A261_N1.4661.00
245_R252_H1.4591.00
193_E230_G1.4541.00
195_V232_L1.4531.00
97_V100_E1.4511.00
166_A170_E1.4471.00
167_R206_H1.4451.00
373_V382_L1.4411.00
241_D254_D1.4311.00
11_F15_S1.4241.00
254_D369_E1.4201.00
260_A264_P1.4171.00
278_A302_V1.4141.00
162_E385_Y1.4121.00
353_T371_I1.4081.00
290_V294_A1.4081.00
174_G234_A1.3891.00
198_E202_E1.3881.00
148_E152_E1.3801.00
271_R360_E1.3671.00
32_Y250_K1.3671.00
279_F283_L1.3651.00
152_E156_E1.3531.00
277_A305_D1.3151.00
217_G232_L1.3141.00
63_R67_A1.3111.00
10_E14_D1.3001.00
288_P348_A1.2981.00
61_Y65_S1.2911.00
194_Y205_R1.2911.00
299_V325_T1.2871.00
277_A302_V1.2761.00
237_P260_A1.2621.00
196_R200_E1.2601.00
293_E297_Q1.2501.00
272_Y368_I1.2491.00
266_D269_R1.2441.00
294_A297_Q1.2441.00
195_V238_V1.2411.00
121_A125_R1.2401.00
241_D369_E1.2391.00
18_D108_E1.2261.00
217_G236_D1.2211.00
4_D147_T1.2211.00
160_A208_C1.2181.00
109_S132_E1.2121.00
232_L261_N1.2111.00
270_E306_H1.2101.00
279_F370_D1.2071.00
30_D33_Y1.2021.00
165_M255_M1.1981.00
159_R163_A1.1941.00
35_A44_F1.1861.00
346_L352_I1.1791.00
6_S10_E1.1771.00
346_L374_V1.1771.00
118_V122_D1.1721.00
156_E248_D1.1661.00
34_L142_I1.1661.00
72_V75_R1.1651.00
281_A298_A1.1631.00
161_N255_M1.1631.00
89_G93_A1.1581.00
149_A153_H1.1541.00
141_D347_H1.1531.00
160_A250_K1.1501.00
118_V121_A1.1471.00
154_V158_Q1.1451.00
198_E205_R1.1441.00
286_I295_V1.1431.00
145_T350_N1.1321.00
283_L381_N1.1321.00
304_D309_P1.1241.00
8_L20_Y1.1241.00
216_A226_E1.1231.00
237_P258_T1.1231.00
218_G236_D1.1181.00
200_E213_T1.1121.00
190_L194_Y1.1101.00
19_G45_A1.1021.00
270_E274_V1.0971.00
285_A290_V1.0891.00
158_Q162_E1.0891.00
351_V373_V1.0761.00
270_E273_A1.0751.00
108_E111_A1.0651.00
167_R198_E1.0621.00
7_Q10_E1.0581.00
282_A298_A1.0581.00
17_V133_P1.0491.00
152_E155_R1.0461.00
149_A152_E1.0441.00
290_V298_A1.0421.00
360_E363_E1.0381.00
283_L354_I1.0331.00
110_L113_G1.0301.00
274_V303_F1.0281.00
298_A301_D1.0271.00
267_A360_E1.0201.00
349_G373_V1.0151.00
372_V381_N1.0151.00
286_I354_I1.0111.00
190_L198_E1.0101.00
135_E138_V1.0091.00
301_D304_D1.0071.00
109_S133_P1.0071.00
240_V259_F0.9981.00
352_I374_V0.9981.00
11_F141_D0.9981.00
208_C244_P0.9971.00
47_Y52_T0.9971.00
296_N325_T0.9971.00
278_A303_F0.9911.00
12_L17_V0.9901.00
220_Q226_E0.9871.00
375_T378_G0.9861.00
7_Q142_I0.9801.00
167_R205_R0.9771.00
155_R373_V0.9731.00
307_G310_N0.9731.00
293_E342_G0.9721.00
19_G47_Y0.9711.00
281_A285_A0.9671.00
172_I259_F0.9551.00
42_P47_Y0.9531.00
158_Q371_I0.9511.00
290_V295_V0.9481.00
148_E375_T0.9441.00
96_R100_E0.9441.00
286_I372_V0.9411.00
274_V302_V0.9411.00
30_D140_E0.9401.00
109_S113_G0.9401.00
193_E197_Q0.9371.00
302_V305_D0.9371.00
274_V277_A0.9351.00
162_E384_D0.9341.00
166_A385_Y0.9331.00
211_D214_I0.9241.00
172_I195_V0.9231.00
203_L244_P0.9161.00
173_R190_L0.9141.00
295_V298_A0.9101.00
219_A362_G0.9091.00
292_G346_L0.9061.00
212_D227_R0.9041.00
107_C110_L0.9021.00
165_M259_F0.9001.00
122_D126_D0.8991.00
18_D109_S0.8981.00
329_V351_V0.8981.00
221_A239_V0.8961.00
288_P375_T0.8961.00
10_E13_E0.8911.00
164_A202_E0.8881.00
156_E160_A0.8871.00
285_A295_V0.8821.00
295_V346_L0.8811.00
260_A268_H0.8801.00
273_A276_R0.8791.00
167_R171_L0.8781.00
163_A166_A0.8681.00
267_A271_R0.8681.00
9_D47_Y0.8651.00
216_A221_A0.8641.00
286_I379_Y0.8621.00
88_Y93_A0.8621.00
153_H156_E0.8621.00
238_V261_N0.8601.00
6_S9_D0.8571.00
161_N253_S0.8561.00
373_V380_E0.8531.00
156_E249_S0.8501.00
174_G190_L0.8501.00
128_E131_V0.8491.00
220_Q223_D0.8481.00
119_G123_A0.8481.00
372_V379_Y0.8451.00
288_P376_E0.8401.00
9_D52_T0.8351.00
282_A354_I0.8341.00
30_D113_G0.8311.00
151_I155_R0.8271.00
12_L19_G0.8271.00
276_R368_I0.8261.00
32_Y331_L0.8241.00
328_G337_P0.8231.00
283_L379_Y0.8231.00
93_A97_V0.8221.00
18_D22_F0.8171.00
90_P93_A0.8131.00
9_D46_V0.8101.00
340_S343_G0.8091.00
9_D48_T0.8081.00
374_V379_Y0.8071.00
298_A302_V0.8071.00
291_T344_D0.8041.00
20_Y135_E0.8011.00
339_V352_I0.8001.00
170_E174_G0.7991.00
360_E364_G0.7981.00
51_Q72_V0.7971.00
138_V141_D0.7961.00
13_E49_P0.7961.00
210_L213_T0.7921.00
195_V215_V0.7911.00
123_A126_D0.7901.00
69_R73_V0.7901.00
158_Q383_T0.7901.00
281_A299_V0.7881.00
272_Y276_R0.7861.00
22_F34_L0.7791.00
153_H248_D0.7791.00
271_R308_Y0.7751.00
144_A347_H0.7731.00
160_A206_H0.7721.00
22_F139_V0.7721.00
278_A282_A0.7711.00
199_I240_V0.7711.00
95_E99_A0.7691.00
224_A323_H0.7681.00
53_G89_G0.7661.00
254_D327_H0.7641.00
164_A203_L0.7641.00
235_D263_D0.7601.00
257_R370_D0.7571.00
174_G261_N0.7561.00
150_E251_Y0.7561.00
329_V353_T0.7561.00
192_S220_Q0.7531.00
159_R162_E0.7531.00
111_A135_E0.7521.00
162_E166_A0.7521.00
287_E379_Y0.7501.00
7_Q11_F0.7491.00
29_S331_L0.7471.00
299_V321_F0.7471.00
47_Y53_G0.7411.00
9_D12_L0.7391.00
96_R99_A0.7381.00
215_V240_V0.7351.00
278_A298_A0.7341.00
168_A240_V0.7341.00
68_A72_V0.7331.00
355_E369_E0.7301.00
264_P269_R0.7261.00
68_A71_D0.7241.00
158_Q253_S0.7231.00
288_P347_H0.7221.00
223_D226_E0.7221.00
285_A288_P0.7211.00
199_I242_I0.7201.00
44_F47_Y0.7171.00
12_L20_Y0.7151.00
54_V64_A0.7151.00
294_A298_A0.7131.00
271_R274_V0.7121.00
171_L202_E0.7121.00
241_D355_E0.7091.00
168_A195_V0.7091.00
221_A365_G0.7091.00
244_P253_S0.7071.00
32_Y44_F0.7061.00
190_L195_V0.6991.00
199_I203_L0.6981.00
200_E209_A0.6981.00
328_G335_E0.6981.00
24_D29_S0.6971.00
99_A102_V0.6961.00
161_N164_A0.6961.00
211_D243_F0.6941.00
288_P379_Y0.6921.00
160_A248_D0.6911.00
221_A237_P0.6911.00
359_Y367_R0.6901.00
9_D13_E0.6881.00
71_D74_A0.6871.00
237_P264_P0.6851.00
89_G97_V0.6851.00
56_V61_Y0.6831.00
327_H369_E0.6821.00
8_L34_L0.6821.00
158_Q382_L0.6791.00
18_D48_T0.6781.00
164_A199_I0.6761.00
201_I204_L0.6741.00
8_L142_I0.6701.00
109_S112_V0.6691.00
114_E117_P0.6671.00
304_D310_N0.6651.00
235_D261_N0.6651.00
175_A190_L0.6651.00
168_A198_E0.6631.00
225_H334_H0.6631.00
282_A285_A0.6601.00
303_F308_Y0.6601.00
97_V101_F0.6591.00
345_E348_A0.6591.00
252_H333_V0.6581.00
264_P268_H0.6581.00
8_L46_V0.6571.00
234_A262_G0.6561.00
280_E283_L0.6551.00
279_F354_I0.6521.00
60_E63_R0.6511.00
357_G367_R0.6501.00
288_P374_V0.6501.00
19_G22_F0.6460.99
281_A301_D0.6430.99
254_D355_E0.6420.99
11_F138_V0.6400.99
100_E103_A0.6370.99
11_F142_I0.6360.99
158_Q255_M0.6350.99
274_V308_Y0.6340.99
300_I321_F0.6340.99
348_A375_T0.6340.99
265_S363_E0.6320.99
31_L42_P0.6310.99
90_P94_K0.6300.99
194_Y197_Q0.6290.99
94_K102_V0.6270.99
335_E339_V0.6260.99
160_A244_P0.6230.99
234_A263_D0.6210.99
165_M242_I0.6210.99
31_L44_F0.6170.99
64_A68_A0.6170.99
268_H363_E0.6150.99
9_D49_P0.6150.99
295_V325_T0.6140.99
47_Y51_Q0.6140.99
112_V118_V0.6130.99
195_V240_V0.6110.99
289_G345_E0.6100.99
193_E209_A0.6100.99
108_E113_G0.6100.99
289_G347_H0.6100.99
359_Y365_G0.6090.99
165_M168_A0.6070.99
375_T379_Y0.6070.99
172_I238_V0.6060.99
278_A299_V0.6030.99
282_A325_T0.6020.99
236_D268_H0.6010.99
335_E338_A0.5980.99
287_E377_D0.5970.99
161_N242_I0.5960.99
151_I351_V0.5960.99
331_L334_H0.5930.99
157_A161_N0.5920.99
381_N384_D0.5920.99
148_E349_G0.5910.99
286_I346_L0.5910.99
274_V358_L0.5900.99
89_G92_A0.5900.99
16_G109_S0.5890.99
165_M169_E0.5850.99
88_Y91_R0.5840.99
50_A53_G0.5820.99
117_P120_T0.5810.99
32_Y38_D0.5810.99
221_A224_A0.5800.99
351_V371_I0.5790.99
9_D50_A0.5780.99
168_A171_L0.5760.99
5_F46_V0.5750.99
21_A45_A0.5750.99
288_P378_G0.5720.99
141_D144_A0.5710.99
338_A352_I0.5710.99
56_V60_E0.5710.99
327_H355_E0.5670.99
172_I261_N0.5610.99
197_Q204_L0.5600.99
58_P61_Y0.5580.98
277_A280_E0.5570.98
297_Q341_Q0.5570.98
241_D327_H0.5560.98
62_G66_K0.5550.98
217_G233_P0.5550.98
148_E348_A0.5550.98
71_D75_R0.5510.98
297_Q304_D0.5490.98
271_R358_L0.5490.98
303_F309_P0.5490.98
256_T369_E0.5460.98
255_M371_I0.5450.98
120_T123_A0.5440.98
54_V57_S0.5430.98
168_A199_I0.5420.98
152_E159_R0.5420.98
31_L35_A0.5400.98
292_G326_G0.5390.98
217_G261_N0.5390.98
299_V302_V0.5370.98
65_S68_A0.5360.98
260_A265_S0.5340.98
62_G65_S0.5320.98
217_G220_Q0.5320.98
8_L31_L0.5310.98
293_E343_G0.5300.98
146_K150_E0.5300.98
278_A281_A0.5290.98
58_P322_I0.5280.98
34_L139_V0.5260.98
63_R66_K0.5260.98
357_G365_G0.5250.98
140_E336_M0.5240.98
5_F52_T0.5240.98
97_V102_V0.5230.98
322_I361_P0.5230.98
58_P90_P0.5220.98
60_E64_A0.5210.98
213_T242_I0.5200.98
161_N244_P0.5200.98
116_F121_A0.5150.97
197_Q205_R0.5150.97
219_A222_A0.5140.97
91_R94_K0.5140.97
61_Y64_A0.5140.97
145_T348_A0.5130.97
64_A67_A0.5120.97
174_G233_P0.5120.97
292_G339_V0.5110.97
92_A95_E0.5110.97
70_A73_V0.5100.97
108_E112_V0.5100.97
163_A202_E0.5070.97
162_E383_T0.5060.97
12_L16_G0.5050.97
191_T230_G0.5050.97
171_L190_L0.5030.97
210_L214_I0.5020.97
303_F306_H0.5020.97
371_I383_T0.5010.97
296_N321_F0.5000.97
194_Y231_P0.5000.97
161_N243_F0.5000.97
99_A103_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fkcA 2 0.8977 100 0.214 Contact Map
3q6dA 1 0.89 100 0.224 Contact Map
2zsgA 2 0.8875 100 0.226 Contact Map
4r60A 2 0.9079 100 0.226 Contact Map
1wy2A 2 0.8721 100 0.228 Contact Map
1wn1A 2 0.8824 100 0.229 Contact Map
4egeA 2 0.8977 100 0.239 Contact Map
3ig4A 4 0.9386 100 0.253 Contact Map
1kp0A 2 0.798 100 0.263 Contact Map
2v3zA 3 0.9437 100 0.265 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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