GREMLIN Database
Q9HQB9 - Uncharacterized protein
UniProt: Q9HQB9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 456 (364)
Sequences: 11467 (9924)
Seq/√Len: 520.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_A297_I3.9131.00
326_E358_V3.6171.00
447_G450_V3.4601.00
398_H453_P3.2801.00
377_A400_N3.1271.00
399_D403_G3.0751.00
409_Q444_V3.0521.00
431_V442_V3.0451.00
145_D237_R3.0341.00
432_Y436_R2.9481.00
387_S396_R2.9261.00
396_R453_P2.8281.00
246_S249_L2.7041.00
358_V438_T2.6781.00
275_E295_A2.5581.00
365_G435_V2.5571.00
405_P408_E2.4831.00
275_E298_Q2.4811.00
268_L301_A2.4301.00
325_T357_A2.4211.00
327_S330_D2.4191.00
115_G118_V2.3821.00
385_E398_H2.3801.00
349_V383_R2.3711.00
404_I408_E2.3591.00
152_D156_T2.3431.00
444_V454_A2.3271.00
351_T383_R2.3131.00
329_A388_V2.2701.00
389_T394_A2.2561.00
413_S442_V2.2291.00
83_V88_L2.1851.00
445_D453_P2.1511.00
118_V122_Y2.0861.00
334_T363_R2.0671.00
389_T396_R2.0341.00
351_T385_E2.0251.00
365_G434_I1.9981.00
435_V440_G1.9951.00
358_V362_L1.9901.00
387_S398_H1.9761.00
122_Y125_R1.9701.00
148_A234_W1.9671.00
377_A384_V1.9611.00
208_I243_R1.9541.00
353_E387_S1.9471.00
365_G431_V1.9191.00
163_S166_G1.9081.00
409_Q446_D1.8921.00
382_P400_N1.8671.00
133_R137_M1.8631.00
122_Y126_D1.8591.00
383_R400_N1.8551.00
377_A382_P1.8391.00
268_L302_T1.8331.00
446_D452_T1.7741.00
434_I438_T1.7631.00
404_I412_L1.7611.00
366_I395_V1.7361.00
353_E385_E1.7181.00
146_G236_C1.7121.00
213_G217_T1.7091.00
267_V301_A1.6961.00
242_R246_S1.6901.00
361_R364_L1.6881.00
406_E409_Q1.6881.00
119_A122_Y1.6821.00
274_I294_L1.6721.00
108_H111_F1.6621.00
140_L159_Y1.6601.00
275_E291_E1.6581.00
137_M141_D1.6311.00
339_V367_R1.6111.00
274_I290_H1.5821.00
436_R441_T1.5751.00
272_N298_Q1.5571.00
411_V417_E1.5331.00
323_A357_A1.5091.00
335_E363_R1.4941.00
271_A298_Q1.4921.00
405_P448_D1.4911.00
130_G133_R1.4851.00
270_R296_A1.4841.00
143_A147_I1.4691.00
270_R293_D1.4671.00
446_D450_V1.4541.00
222_E237_R1.4491.00
126_D130_G1.4451.00
340_R344_A1.4411.00
148_A157_V1.4351.00
196_A200_G1.4231.00
162_A166_G1.4191.00
222_E242_R1.4171.00
176_Q180_S1.4051.00
245_H248_R1.4031.00
245_H249_L1.3961.00
132_S135_R1.3881.00
112_G115_G1.3871.00
371_S375_E1.3731.00
413_S444_V1.3611.00
378_P382_P1.3591.00
412_L444_V1.3481.00
213_G219_Y1.3451.00
244_D248_R1.3381.00
408_E411_V1.3081.00
414_G417_E1.3081.00
343_H374_A1.3061.00
160_A165_T1.2991.00
104_V108_H1.2931.00
404_I444_V1.2921.00
169_D172_R1.2801.00
244_D247_Q1.2751.00
168_T214_A1.2641.00
361_R434_I1.2631.00
267_V297_I1.2611.00
331_I335_E1.2601.00
266_V300_A1.2561.00
238_D242_R1.2501.00
111_F115_G1.2471.00
446_D449_I1.2431.00
91_V94_G1.2411.00
165_T170_A1.2391.00
404_I452_T1.2141.00
362_L438_T1.2131.00
305_L309_E1.2111.00
223_L236_C1.2081.00
239_V243_R1.2041.00
333_R352_V1.2011.00
271_A301_A1.1991.00
329_A333_R1.1871.00
99_I102_Q1.1781.00
130_G134_A1.1721.00
148_A164_F1.1701.00
361_R437_Q1.1641.00
243_R247_Q1.1631.00
295_A299_D1.1621.00
411_V414_G1.1511.00
129_R133_R1.1511.00
105_V108_H1.1461.00
298_Q302_T1.1381.00
364_L434_I1.1301.00
408_E417_E1.1291.00
306_E360_E1.1261.00
291_E295_A1.1191.00
419_P422_H1.1151.00
210_T220_P1.1151.00
209_V223_L1.1041.00
136_L140_L1.1021.00
195_V199_D1.1011.00
259_D262_N1.0951.00
404_I409_Q1.0901.00
296_A300_A1.0861.00
392_P441_T1.0791.00
210_T218_T1.0771.00
165_T169_D1.0771.00
271_A275_E1.0761.00
183_P186_S1.0741.00
115_G119_A1.0651.00
271_A294_L1.0621.00
125_R129_R1.0601.00
150_I234_W1.0541.00
220_P243_R1.0511.00
339_V370_L1.0451.00
435_V442_V1.0371.00
300_A303_G1.0361.00
177_S180_S1.0251.00
241_D244_D1.0251.00
402_P421_K1.0221.00
243_R246_S1.0211.00
323_A358_V1.0131.00
260_T304_L1.0121.00
323_A438_T1.0111.00
255_V415_Q1.0091.00
88_L91_V1.0001.00
239_V242_R0.9991.00
88_L92_L0.9981.00
328_V395_V0.9971.00
206_Q222_E0.9961.00
87_D90_A0.9961.00
332_V386_V0.9961.00
268_L305_L0.9941.00
129_R132_S0.9931.00
343_H350_V0.9901.00
160_A164_F0.9881.00
292_P296_A0.9811.00
278_L290_H0.9811.00
262_N266_V0.9721.00
328_V393_L0.9721.00
146_G164_F0.9721.00
336_A352_V0.9681.00
277_R290_H0.9631.00
386_V397_V0.9631.00
279_G290_H0.9621.00
335_E339_V0.9571.00
97_G102_Q0.9541.00
92_L95_A0.9481.00
126_D129_R0.9471.00
149_M233_V0.9451.00
444_V452_T0.9441.00
125_R128_W0.9381.00
141_D162_A0.9371.00
257_R262_N0.9361.00
375_E420_L0.9361.00
87_D91_V0.9331.00
342_A345_E0.9321.00
266_V270_R0.9291.00
283_D290_H0.9251.00
259_D300_A0.9231.00
336_A350_V0.9221.00
225_M232_Y0.9211.00
135_R149_M0.9201.00
338_A367_R0.9191.00
332_V366_I0.9151.00
108_H112_G0.9141.00
124_E128_W0.9121.00
310_K361_R0.9081.00
399_D451_I0.9051.00
333_R337_T0.9051.00
426_V430_V0.9041.00
385_E400_N0.9001.00
337_T340_R0.8991.00
150_I157_V0.8971.00
102_Q108_H0.8901.00
121_T124_E0.8831.00
270_R300_A0.8811.00
366_I397_V0.8811.00
282_D290_H0.8801.00
361_R438_T0.8801.00
256_L311_S0.8801.00
373_A384_V0.8791.00
192_D196_A0.8761.00
206_Q224_T0.8751.00
369_L431_V0.8731.00
415_Q433_W0.8731.00
162_A165_T0.8661.00
165_T173_V0.8551.00
326_E331_I0.8531.00
331_I358_V0.8531.00
327_S355_D0.8511.00
382_P388_V0.8511.00
412_L454_A0.8501.00
186_S210_T0.8501.00
339_V374_A0.8481.00
323_A439_G0.8481.00
346_T350_V0.8471.00
212_C218_T0.8461.00
226_T233_V0.8441.00
259_D263_A0.8431.00
261_R305_L0.8421.00
369_L454_A0.8411.00
112_G118_V0.8401.00
147_I161_N0.8381.00
109_A115_G0.8371.00
95_A105_V0.8311.00
266_V296_A0.8281.00
136_L139_A0.8251.00
257_R261_R0.8211.00
191_A195_V0.8211.00
369_L397_V0.8201.00
156_T177_S0.8181.00
418_T421_K0.8161.00
299_D334_T0.8141.00
297_I301_A0.8131.00
97_G100_T0.8101.00
219_Y238_D0.8101.00
84_L89_W0.8091.00
378_P402_P0.8071.00
251_V415_Q0.8071.00
366_I370_L0.8031.00
112_G116_G0.8021.00
100_T104_V0.7971.00
220_P240_T0.7971.00
376_H420_L0.7951.00
344_A347_A0.7941.00
343_H384_V0.7941.00
160_A173_V0.7921.00
135_R159_Y0.7891.00
402_P446_D0.7881.00
168_T172_R0.7881.00
394_A443_S0.7861.00
332_V388_V0.7841.00
133_R136_L0.7831.00
406_E447_G0.7831.00
92_L109_A0.7791.00
161_N238_D0.7791.00
189_P192_D0.7781.00
119_A123_A0.7781.00
83_V87_D0.7751.00
120_G124_E0.7731.00
277_R280_D0.7681.00
300_A304_L0.7661.00
262_N269_G0.7621.00
433_W436_R0.7621.00
260_T263_A0.7581.00
119_A125_R0.7561.00
89_W92_L0.7531.00
275_E294_L0.7501.00
115_G122_Y0.7491.00
89_W104_V0.7481.00
114_L117_A0.7471.00
123_A127_R0.7431.00
363_R367_R0.7401.00
109_A112_G0.7381.00
238_D243_R0.7371.00
303_G363_R0.7341.00
127_R131_R0.7331.00
396_R445_D0.7321.00
368_E431_V0.7311.00
293_D297_I0.7301.00
104_V107_Q0.7301.00
128_W132_S0.7291.00
113_A117_A0.7271.00
188_G192_D0.7251.00
343_H348_V0.7241.00
404_I410_R0.7231.00
250_R255_V0.7221.00
402_P452_T0.7221.00
265_N269_G0.7211.00
335_E370_L0.7211.00
279_G291_E0.7211.00
111_F114_L0.7201.00
91_V95_A0.7191.00
119_A126_D0.7181.00
227_A232_Y0.7171.00
261_R312_R0.7171.00
102_Q105_V0.7151.00
335_E367_R0.7141.00
101_V105_V0.7141.00
149_M159_Y0.7111.00
131_R135_R0.7111.00
302_T305_L0.7111.00
301_A305_L0.7051.00
150_I178_W0.7031.00
97_G101_V0.7021.00
139_A149_M0.7011.00
252_L255_V0.7001.00
105_V112_G0.7001.00
83_V91_V0.6981.00
313_A361_R0.6981.00
292_P295_A0.6981.00
314_L429_W0.6941.00
362_L366_I0.6931.00
132_S136_L0.6921.00
336_A340_R0.6921.00
368_E424_S0.6911.00
348_V377_A0.6901.00
261_R309_E0.6891.00
150_I225_M0.6871.00
266_V269_G0.6861.00
269_G273_R0.6851.00
259_D307_T0.6841.00
263_A304_L0.6821.00
259_D364_L0.6811.00
404_I446_D0.6801.00
273_R293_D0.6801.00
326_E362_L0.6781.00
197_L232_Y0.6781.00
316_D424_S0.6761.00
97_G105_V0.6751.00
274_I297_I0.6721.00
87_D94_G0.6711.00
134_A138_A0.6661.00
406_E410_R0.6631.00
331_I363_R0.6631.00
251_V255_V0.6621.00
377_A380_D0.6621.00
413_S454_A0.6591.00
322_D359_D0.6591.00
146_G161_N0.6591.00
172_R214_A0.6581.00
161_N164_F0.6581.00
188_G191_A0.6571.00
84_L104_V0.6541.00
416_A429_W0.6521.00
225_M234_W0.6521.00
190_I193_A0.6511.00
255_V262_N0.6501.00
84_L88_L0.6491.00
259_D304_L0.6481.00
261_R304_L0.6481.00
259_D430_V0.6471.00
84_L87_D0.6451.00
112_G119_A0.6441.00
253_R256_L0.6421.00
296_A299_D0.6401.00
152_D158_Q0.6381.00
241_D245_H0.6371.00
231_G234_W0.6361.00
162_A170_A0.6361.00
184_S187_H0.6351.00
98_A102_Q0.6351.00
348_V382_P0.6331.00
431_V435_V0.6321.00
302_T306_E0.6321.00
376_H402_P0.6321.00
388_V395_V0.6301.00
146_G149_M0.6301.00
83_V86_L0.6261.00
114_L118_V0.6251.00
416_A426_V0.6241.00
332_V395_V0.6231.00
258_H262_N0.6221.00
309_E313_A0.6211.00
101_V104_V0.6201.00
268_L272_N0.6191.00
268_L298_Q0.6191.00
118_V125_R0.6181.00
270_R297_I0.6181.00
280_D290_H0.6171.00
338_A363_R0.6171.00
267_V300_A0.6161.00
258_H368_E0.6161.00
260_T308_S0.6161.00
314_L415_Q0.6121.00
150_I194_L0.6101.00
348_V374_A0.6101.00
105_V109_A0.6101.00
170_A174_R0.6091.00
259_D368_E0.6071.00
85_A91_V0.6071.00
253_R257_R0.6061.00
86_L89_W0.6061.00
111_F118_V0.6061.00
89_W100_T0.6061.00
123_A126_D0.6061.00
412_L429_W0.6051.00
254_R259_D0.6051.00
193_A196_A0.6041.00
164_F236_C0.6041.00
372_N427_G0.6041.00
312_R316_D0.6041.00
238_D246_S0.6021.00
89_W108_H0.5991.00
83_V89_W0.5970.99
104_V109_A0.5960.99
117_A121_T0.5950.99
90_A94_G0.5920.99
342_A371_S0.5920.99
369_L442_V0.5920.99
196_A201_D0.5880.99
339_V371_S0.5880.99
98_A105_V0.5880.99
336_A370_L0.5840.99
433_W437_Q0.5830.99
348_V400_N0.5830.99
385_E388_V0.5830.99
159_Y170_A0.5780.99
294_L298_Q0.5760.99
346_T374_A0.5760.99
136_L233_V0.5730.99
312_R315_A0.5730.99
260_T307_T0.5720.99
311_S315_A0.5720.99
304_L307_T0.5700.99
83_V92_L0.5690.99
160_A163_S0.5680.99
100_T111_F0.5680.99
312_R424_S0.5660.99
365_G438_T0.5650.99
292_P337_T0.5630.99
182_Y187_H0.5630.99
415_Q426_V0.5620.99
376_H400_N0.5610.99
372_N403_G0.5610.99
189_P193_A0.5600.99
83_V95_A0.5570.99
220_P224_T0.5560.99
179_Q187_H0.5550.99
404_I454_A0.5540.99
197_L225_M0.5530.99
409_Q412_L0.5520.99
224_T227_A0.5520.99
161_N240_T0.5490.99
250_R254_R0.5480.99
242_R249_L0.5470.99
109_A113_A0.5470.99
89_W95_A0.5470.99
183_P210_T0.5460.99
404_I428_L0.5460.99
100_T105_V0.5450.99
341_D344_A0.5450.99
149_M161_N0.5450.99
100_T108_H0.5440.99
140_L233_V0.5440.99
250_R314_L0.5440.99
295_A298_Q0.5430.99
428_L454_A0.5430.99
306_E310_K0.5420.99
332_V335_E0.5420.99
100_T107_Q0.5420.99
250_R318_L0.5410.99
128_W131_R0.5400.99
373_A397_V0.5390.99
269_G300_A0.5390.99
382_P386_V0.5380.99
107_Q111_F0.5370.99
148_A236_C0.5350.99
372_N399_D0.5340.99
384_V397_V0.5340.99
95_A100_T0.5340.99
257_R263_A0.5340.99
250_R260_T0.5330.99
262_N312_R0.5320.99
145_D149_M0.5300.99
252_L311_S0.5290.99
192_D195_V0.5280.99
135_R140_L0.5280.99
396_R443_S0.5270.99
403_G451_I0.5270.99
408_E412_L0.5270.99
409_Q413_S0.5260.99
280_D283_D0.5250.99
383_R398_H0.5240.99
330_D334_T0.5230.99
273_R277_R0.5220.99
370_L386_V0.5210.99
262_N376_H0.5200.99
134_A137_M0.5200.99
179_Q191_A0.5190.99
326_E357_A0.5190.99
310_K430_V0.5180.99
256_L260_T0.5180.99
364_L368_E0.5170.99
94_G98_A0.5170.99
98_A104_V0.5160.99
127_R130_G0.5160.99
346_T377_A0.5150.99
312_R416_A0.5150.99
343_H346_T0.5150.99
277_R293_D0.5140.98
364_L430_V0.5130.98
332_V352_V0.5130.98
415_Q429_W0.5130.98
83_V104_V0.5130.98
108_H114_L0.5070.98
149_M158_Q0.5070.98
269_G301_A0.5070.98
85_A88_L0.5060.98
85_A89_W0.5040.98
254_R257_R0.5040.98
147_I235_V0.5030.98
316_D368_E0.5030.98
95_A101_V0.5030.98
330_D333_R0.5020.98
293_D300_A0.5010.98
256_L300_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gczA 2 0.7237 100 0.443 Contact Map
4i5sA 2 0.8004 100 0.46 Contact Map
3a0rA 2 0.6535 100 0.473 Contact Map
4r3aA 1 0.636 100 0.548 Contact Map
3jz3A 2 0.3246 100 0.593 Contact Map
3d36A 2 0.4561 100 0.602 Contact Map
2c2aA 2 0.4693 100 0.606 Contact Map
4q20A 2 0.4693 100 0.61 Contact Map
2q8gA 2 0.6053 100 0.612 Contact Map
4mpcA 2 0.6118 100 0.613 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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