Q9HQB8 - HALSA - GREMLIN Contacts

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Q9HQB8 - Uncharacterized protein

UniProt:	Q9HQB8	Sequences: MEVLVVGAGAVGRWVAEVVAAPAAFADTDPQRAVAAADATENARAVAVDTAASFAVVAVAVPMRAAGAAIDAHAAAAERAIVDFTGVMGEPLAAMAAAGPPGVERASFHPLFAPAHAPGRIAVTDGDGGPTVDRLRGWLADAGNELVEVPAAVHDDAMETIQGRTHAAILAFALAADDVPDALATPVYEELSRLADRVTGGTPGVYADIQSTFGGSQEVAAAADRIAAAAAGDGDAFAEVYEDAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	245 (235)
Sequences:	3972 (2863)
Seq/√Len:	186.8

ECOLI - TYRA
BACSU - TYRA
HALSA - Q9HQB8
SULSO - Q980J1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
217_Q	227_A	3.733	1.00
136_R	148_E	3.718	1.00
233_D	236_A	3.506	1.00
220_A	224_D	3.282	1.00
4_L	54_F	3.255	1.00
220_A	227_A	3.243	1.00
82_V	108_F	2.727	1.00
214_G	232_G	2.671	1.00
150_P	153_V	2.643	1.00
217_Q	230_A	2.552	1.00
136_R	140_A	2.503	1.00
24_A	42_N	2.368	1.00
111_L	158_M	2.362	1.00
229_A	236_A	2.330	1.00
70_I	95_M	2.274	1.00
122_A	149_V	2.206	1.00
8_A	27_D	2.201	1.00
11_V	84_F	2.181	1.00
66_A	85_T	2.092	1.00
32_R	35_A	2.080	1.00
89_G	93_A	2.076	1.00
89_G	152_A	2.000	1.00
15_V	142_A	1.950	1.00
36_A	118_P	1.944	1.00
68_A	72_A	1.878	1.00
36_A	39_A	1.856	1.00
228_A	231_A	1.836	1.00
18_V	142_A	1.814	1.00
76_A	79_R	1.782	1.00
61_V	69_A	1.768	1.00
137_G	140_A	1.762	1.00
5_V	16_A	1.742	1.00
227_A	230_A	1.737	1.00
133_D	136_R	1.731	1.00
121_I	139_L	1.706	1.00
63_M	87_V	1.690	1.00
3_V	19_V	1.683	1.00
67_G	71_D	1.671	1.00
106_A	135_L	1.666	1.00
92_L	151_A	1.665	1.00
35_A	39_A	1.650	1.00
59_V	70_I	1.636	1.00
108_F	123_V	1.635	1.00
19_V	138_W	1.607	1.00
67_G	94_A	1.603	1.00
65_A	68_A	1.582	1.00
82_V	135_L	1.565	1.00
95_M	105_R	1.546	1.00
26_A	53_S	1.537	1.00
59_V	69_A	1.531	1.00
36_A	40_T	1.528	1.00
80_A	131_T	1.510	1.00
169_I	199_T	1.496	1.00
172_F	191_L	1.490	1.00
59_V	66_A	1.482	1.00
43_A	46_V	1.479	1.00
126_G	129_G	1.466	1.00
71_D	94_A	1.462	1.00
55_A	76_A	1.454	1.00
67_G	97_A	1.443	1.00
204_G	238_A	1.397	1.00
15_V	58_A	1.394	1.00
34_V	43_A	1.389	1.00
139_L	146_L	1.381	1.00
46_V	49_D	1.375	1.00
217_Q	220_A	1.373	1.00
235_D	239_E	1.338	1.00
58_A	82_V	1.333	1.00
94_A	97_A	1.317	1.00
58_A	84_F	1.313	1.00
238_A	242_E	1.286	1.00
222_A	225_R	1.281	1.00
104_E	131_T	1.279	1.00
207_A	234_G	1.272	1.00
30_P	61_V	1.266	1.00
4_L	50_T	1.260	1.00
138_W	142_A	1.257	1.00
4_L	28_T	1.257	1.00
61_V	65_A	1.245	1.00
108_F	121_I	1.233	1.00
63_M	85_T	1.233	1.00
167_A	210_Q	1.228	1.00
17_E	40_T	1.216	1.00
124_T	151_A	1.215	1.00
239_E	242_E	1.210	1.00
211_S	234_G	1.208	1.00
96_A	126_G	1.205	1.00
57_V	79_R	1.203	1.00
218_E	222_A	1.175	1.00
87_V	90_E	1.166	1.00
210_Q	241_Y	1.151	1.00
35_A	38_D	1.149	1.00
18_V	22_P	1.148	1.00
64_R	208_D	1.147	1.00
6_V	73_H	1.141	1.00
6_V	28_T	1.138	1.00
44_R	50_T	1.138	1.00
16_A	25_F	1.137	1.00
78_E	103_V	1.137	1.00
51_A	54_F	1.134	1.00
166_H	206_Y	1.124	1.00
137_G	141_D	1.123	1.00
153_V	156_D	1.123	1.00
207_A	238_A	1.119	1.00
3_V	23_A	1.118	1.00
93_A	97_A	1.111	1.00
158_M	161_I	1.109	1.00
93_A	96_A	1.107	1.00
159_E	216_S	1.101	1.00
53_S	76_A	1.093	1.00
92_L	107_S	1.079	1.00
34_V	45_A	1.075	1.00
236_A	239_E	1.072	1.00
187_V	198_V	1.061	1.00
121_I	144_N	1.056	1.00
111_L	185_T	1.047	1.00
131_T	134_R	1.047	1.00
86_G	209_I	1.025	1.00
125_D	148_E	1.017	1.00
187_V	191_L	1.001	0.99
201_G	241_Y	0.993	0.99
56_V	80_A	0.986	0.99
80_A	135_L	0.982	0.99
224_D	228_A	0.982	0.99
90_E	93_A	0.976	0.99
48_V	72_A	0.974	0.99
167_A	226_I	0.973	0.99
68_A	71_D	0.972	0.99
96_A	127_D	0.948	0.99
78_E	104_E	0.945	0.99
80_A	134_R	0.943	0.99
71_D	98_A	0.943	0.99
161_I	186_P	0.940	0.99
220_A	226_I	0.939	0.99
122_A	183_L	0.935	0.99
123_V	139_L	0.933	0.99
234_G	238_A	0.927	0.99
133_D	137_G	0.927	0.99
8_A	29_D	0.927	0.99
160_T	179_V	0.925	0.99
90_E	212_T	0.923	0.99
80_A	106_A	0.920	0.99
5_V	12_G	0.916	0.99
17_E	21_A	0.911	0.99
3_V	56_V	0.904	0.99
157_A	183_L	0.896	0.99
51_A	73_H	0.889	0.99
170_L	201_G	0.888	0.99
73_H	86_G	0.886	0.99
71_D	75_A	0.885	0.99
94_A	98_A	0.884	0.99
42_N	46_V	0.884	0.99
6_V	69_A	0.884	0.99
89_G	215_G	0.883	0.99
108_F	139_L	0.882	0.99
56_V	138_W	0.881	0.99
149_V	157_A	0.879	0.99
135_L	139_L	0.875	0.99
201_G	206_Y	0.872	0.99
190_E	196_D	0.869	0.98
106_A	131_T	0.860	0.98
123_V	136_R	0.859	0.98
129_G	132_V	0.854	0.98
16_A	27_D	0.854	0.98
187_V	201_G	0.854	0.98
82_V	106_A	0.853	0.98
13_R	17_E	0.851	0.98
70_I	74_A	0.848	0.98
168_A	219_V	0.840	0.98
56_V	135_L	0.835	0.98
107_S	124_T	0.833	0.98
20_A	25_F	0.833	0.98
134_R	137_G	0.825	0.98
166_H	198_V	0.819	0.98
15_V	138_W	0.818	0.98
23_A	141_D	0.816	0.98
191_L	200_G	0.799	0.97
22_P	141_D	0.796	0.97
92_L	126_G	0.795	0.97
91_P	105_R	0.792	0.97
224_D	227_A	0.791	0.97
106_A	132_V	0.790	0.97
206_Y	209_I	0.789	0.97
90_E	94_A	0.788	0.97
26_A	42_N	0.779	0.97
111_L	191_L	0.778	0.97
109_H	113_A	0.778	0.97
226_I	240_V	0.778	0.97
11_V	112_F	0.778	0.97
162_Q	197_R	0.776	0.97
168_A	172_F	0.771	0.97
48_V	52_A	0.767	0.97
174_L	240_V	0.764	0.97
219_V	223_A	0.762	0.97
50_T	54_F	0.748	0.96
147_V	182_A	0.739	0.96
229_A	240_V	0.732	0.96
29_D	34_V	0.732	0.96
222_A	240_V	0.725	0.95
81_I	95_M	0.723	0.95
29_D	33_A	0.723	0.95
44_R	49_D	0.714	0.95
222_A	226_I	0.713	0.95
99_G	103_V	0.713	0.95
49_D	52_A	0.713	0.95
111_L	139_L	0.712	0.95
186_P	198_V	0.711	0.95
120_R	189_E	0.710	0.95
65_A	69_A	0.709	0.95
161_I	183_L	0.700	0.94
33_A	36_A	0.698	0.94
175_A	222_A	0.698	0.94
122_A	146_L	0.697	0.94
92_L	105_R	0.697	0.94
133_D	140_A	0.694	0.94
111_L	186_P	0.694	0.94
152_A	156_D	0.691	0.94
51_A	57_V	0.691	0.94
15_V	19_V	0.691	0.94
99_G	102_G	0.688	0.94
96_A	128_G	0.687	0.94
4_L	26_A	0.686	0.94
107_S	120_R	0.684	0.94
89_G	151_A	0.683	0.94
81_I	99_G	0.681	0.94
159_E	213_F	0.678	0.94
53_S	78_E	0.677	0.93
162_Q	185_T	0.675	0.93
173_A	199_T	0.674	0.93
161_I	176_A	0.674	0.93
136_R	146_L	0.671	0.93
207_A	211_S	0.670	0.93
170_L	241_Y	0.668	0.93
61_V	66_A	0.665	0.93
168_A	171_A	0.663	0.93
30_P	65_A	0.662	0.93
47_A	50_T	0.660	0.93
14_W	162_Q	0.658	0.92
178_D	222_A	0.657	0.92
163_G	187_V	0.656	0.92
32_R	45_A	0.655	0.92
42_N	53_S	0.653	0.92
187_V	190_E	0.652	0.92
166_H	201_G	0.651	0.92
14_W	18_V	0.650	0.92
86_G	163_G	0.646	0.92
147_V	183_L	0.641	0.91
12_G	29_D	0.641	0.91
228_A	236_A	0.638	0.91
198_V	201_G	0.637	0.91
185_T	196_D	0.637	0.91
229_A	233_D	0.633	0.91
152_A	215_G	0.631	0.91
160_T	176_A	0.629	0.91
4_L	51_A	0.627	0.91
15_V	84_F	0.625	0.90
67_G	91_P	0.622	0.90
220_A	223_A	0.620	0.90
56_V	82_V	0.619	0.90
217_Q	224_D	0.618	0.90
171_A	222_A	0.616	0.90
163_G	209_I	0.615	0.90
235_D	238_A	0.611	0.89
211_S	237_F	0.610	0.89
17_E	20_A	0.606	0.89
162_Q	169_I	0.606	0.89
176_A	188_Y	0.605	0.89
10_A	162_Q	0.605	0.89
162_Q	190_E	0.605	0.89
106_A	129_G	0.603	0.89
225_R	229_A	0.602	0.89
83_D	110_P	0.594	0.88
111_L	122_A	0.593	0.88
10_A	13_R	0.591	0.88
46_V	50_T	0.591	0.88
125_D	132_V	0.590	0.88
190_E	197_R	0.584	0.87
164_R	219_V	0.583	0.87
204_G	207_A	0.582	0.87
91_P	107_S	0.582	0.87
166_H	170_L	0.581	0.87
223_A	227_A	0.580	0.87
132_V	136_R	0.579	0.87
162_Q	187_V	0.578	0.87
185_T	206_Y	0.574	0.86
111_L	183_L	0.573	0.86
87_V	212_T	0.572	0.86
120_R	186_P	0.572	0.86
10_A	163_G	0.572	0.86
175_A	219_V	0.571	0.86
161_I	184_A	0.571	0.86
188_Y	191_L	0.567	0.86
83_D	88_M	0.566	0.86
82_V	121_I	0.566	0.86
217_Q	221_A	0.566	0.86
63_M	212_T	0.564	0.85
67_G	90_E	0.564	0.85
114_P	117_A	0.563	0.85
218_E	225_R	0.562	0.85
71_D	97_A	0.561	0.85
162_Q	206_Y	0.561	0.85
96_A	102_G	0.560	0.85
153_V	181_D	0.560	0.85
164_R	172_F	0.557	0.85
68_A	231_A	0.557	0.85
69_A	73_H	0.555	0.84
158_M	183_L	0.553	0.84
42_N	45_A	0.552	0.84
13_R	27_D	0.552	0.84
28_T	51_A	0.552	0.84
162_Q	196_D	0.552	0.84
130_P	133_D	0.552	0.84
43_A	49_D	0.550	0.84
153_V	157_A	0.549	0.84
54_F	57_V	0.549	0.84
219_V	226_I	0.545	0.83
58_A	138_W	0.545	0.83
186_P	201_G	0.544	0.83
14_W	163_G	0.543	0.83
10_A	199_T	0.542	0.83
26_A	50_T	0.541	0.83
198_V	206_Y	0.540	0.83
93_A	152_A	0.538	0.83
219_V	222_A	0.537	0.82
70_I	98_A	0.535	0.82
48_V	51_A	0.535	0.82
197_R	201_G	0.532	0.82
231_A	239_E	0.528	0.81
206_Y	210_Q	0.528	0.81
179_V	218_E	0.527	0.81
123_V	132_V	0.526	0.81
112_F	162_Q	0.525	0.81
203_P	242_E	0.525	0.81
228_A	242_E	0.523	0.81
62_P	86_G	0.522	0.81
91_P	95_M	0.521	0.81
157_A	161_I	0.520	0.80
89_G	216_S	0.519	0.80
221_A	224_D	0.519	0.80
170_L	199_T	0.518	0.80
173_A	188_Y	0.517	0.80
166_H	209_I	0.515	0.80
163_G	201_G	0.514	0.80
235_D	242_E	0.510	0.79
111_L	170_L	0.510	0.79
160_T	169_I	0.509	0.79
4_L	57_V	0.509	0.79
162_Q	166_H	0.507	0.79
156_D	160_T	0.504	0.78
165_T	191_L	0.503	0.78
10_A	14_W	0.501	0.78
70_I	81_I	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2pv7A	2	0.9469	100	0.424	Contact Map
3b1fA	2	0.9673	100	0.437	Contact Map
3ktdA	2	0.9755	100	0.443	Contact Map
3ggoA	2	0.9755	100	0.463	Contact Map
2g5cA	2	0.9755	100	0.468	Contact Map
4wjiA	2	0.9837	100	0.471	Contact Map
2f1kA	2	0.9673	100	0.498	Contact Map
3triA	2	0.9592	99.9	0.648	Contact Map
2izzA	5	0.9673	99.9	0.649	Contact Map
2rcyA	5	0.9347	99.9	0.665	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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