GREMLIN Database
Q9HQB8 - Uncharacterized protein
UniProt: Q9HQB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (235)
Sequences: 3972 (2863)
Seq/√Len: 186.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_Q227_A3.7331.00
136_R148_E3.7181.00
233_D236_A3.5061.00
220_A224_D3.2821.00
4_L54_F3.2551.00
220_A227_A3.2431.00
82_V108_F2.7271.00
214_G232_G2.6711.00
150_P153_V2.6431.00
217_Q230_A2.5521.00
136_R140_A2.5031.00
24_A42_N2.3681.00
111_L158_M2.3621.00
229_A236_A2.3301.00
70_I95_M2.2741.00
122_A149_V2.2061.00
8_A27_D2.2011.00
11_V84_F2.1811.00
66_A85_T2.0921.00
32_R35_A2.0801.00
89_G93_A2.0761.00
89_G152_A2.0001.00
15_V142_A1.9501.00
36_A118_P1.9441.00
68_A72_A1.8781.00
36_A39_A1.8561.00
228_A231_A1.8361.00
18_V142_A1.8141.00
76_A79_R1.7821.00
61_V69_A1.7681.00
137_G140_A1.7621.00
5_V16_A1.7421.00
227_A230_A1.7371.00
133_D136_R1.7311.00
121_I139_L1.7061.00
63_M87_V1.6901.00
3_V19_V1.6831.00
67_G71_D1.6711.00
106_A135_L1.6661.00
92_L151_A1.6651.00
35_A39_A1.6501.00
59_V70_I1.6361.00
108_F123_V1.6351.00
19_V138_W1.6071.00
67_G94_A1.6031.00
65_A68_A1.5821.00
82_V135_L1.5651.00
95_M105_R1.5461.00
26_A53_S1.5371.00
59_V69_A1.5311.00
36_A40_T1.5281.00
80_A131_T1.5101.00
169_I199_T1.4961.00
172_F191_L1.4901.00
59_V66_A1.4821.00
43_A46_V1.4791.00
126_G129_G1.4661.00
71_D94_A1.4621.00
55_A76_A1.4541.00
67_G97_A1.4431.00
204_G238_A1.3971.00
15_V58_A1.3941.00
34_V43_A1.3891.00
139_L146_L1.3811.00
46_V49_D1.3751.00
217_Q220_A1.3731.00
235_D239_E1.3381.00
58_A82_V1.3331.00
94_A97_A1.3171.00
58_A84_F1.3131.00
238_A242_E1.2861.00
222_A225_R1.2811.00
104_E131_T1.2791.00
207_A234_G1.2721.00
30_P61_V1.2661.00
4_L50_T1.2601.00
138_W142_A1.2571.00
4_L28_T1.2571.00
61_V65_A1.2451.00
108_F121_I1.2331.00
63_M85_T1.2331.00
167_A210_Q1.2281.00
17_E40_T1.2161.00
124_T151_A1.2151.00
239_E242_E1.2101.00
211_S234_G1.2081.00
96_A126_G1.2051.00
57_V79_R1.2031.00
218_E222_A1.1751.00
87_V90_E1.1661.00
210_Q241_Y1.1511.00
35_A38_D1.1491.00
18_V22_P1.1481.00
64_R208_D1.1471.00
6_V73_H1.1411.00
6_V28_T1.1381.00
44_R50_T1.1381.00
16_A25_F1.1371.00
78_E103_V1.1371.00
51_A54_F1.1341.00
166_H206_Y1.1241.00
137_G141_D1.1231.00
153_V156_D1.1231.00
207_A238_A1.1191.00
3_V23_A1.1181.00
93_A97_A1.1111.00
158_M161_I1.1091.00
93_A96_A1.1071.00
159_E216_S1.1011.00
53_S76_A1.0931.00
92_L107_S1.0791.00
34_V45_A1.0751.00
236_A239_E1.0721.00
187_V198_V1.0611.00
121_I144_N1.0561.00
111_L185_T1.0471.00
131_T134_R1.0471.00
86_G209_I1.0251.00
125_D148_E1.0171.00
187_V191_L1.0010.99
201_G241_Y0.9930.99
56_V80_A0.9860.99
80_A135_L0.9820.99
224_D228_A0.9820.99
90_E93_A0.9760.99
48_V72_A0.9740.99
167_A226_I0.9730.99
68_A71_D0.9720.99
96_A127_D0.9480.99
78_E104_E0.9450.99
80_A134_R0.9430.99
71_D98_A0.9430.99
161_I186_P0.9400.99
220_A226_I0.9390.99
122_A183_L0.9350.99
123_V139_L0.9330.99
234_G238_A0.9270.99
133_D137_G0.9270.99
8_A29_D0.9270.99
160_T179_V0.9250.99
90_E212_T0.9230.99
80_A106_A0.9200.99
5_V12_G0.9160.99
17_E21_A0.9110.99
3_V56_V0.9040.99
157_A183_L0.8960.99
51_A73_H0.8890.99
170_L201_G0.8880.99
73_H86_G0.8860.99
71_D75_A0.8850.99
94_A98_A0.8840.99
42_N46_V0.8840.99
6_V69_A0.8840.99
89_G215_G0.8830.99
108_F139_L0.8820.99
56_V138_W0.8810.99
149_V157_A0.8790.99
135_L139_L0.8750.99
201_G206_Y0.8720.99
190_E196_D0.8690.98
106_A131_T0.8600.98
123_V136_R0.8590.98
129_G132_V0.8540.98
16_A27_D0.8540.98
187_V201_G0.8540.98
82_V106_A0.8530.98
13_R17_E0.8510.98
70_I74_A0.8480.98
168_A219_V0.8400.98
56_V135_L0.8350.98
107_S124_T0.8330.98
20_A25_F0.8330.98
134_R137_G0.8250.98
166_H198_V0.8190.98
15_V138_W0.8180.98
23_A141_D0.8160.98
191_L200_G0.7990.97
22_P141_D0.7960.97
92_L126_G0.7950.97
91_P105_R0.7920.97
224_D227_A0.7910.97
106_A132_V0.7900.97
206_Y209_I0.7890.97
90_E94_A0.7880.97
26_A42_N0.7790.97
111_L191_L0.7780.97
109_H113_A0.7780.97
226_I240_V0.7780.97
11_V112_F0.7780.97
162_Q197_R0.7760.97
168_A172_F0.7710.97
48_V52_A0.7670.97
174_L240_V0.7640.97
219_V223_A0.7620.97
50_T54_F0.7480.96
147_V182_A0.7390.96
229_A240_V0.7320.96
29_D34_V0.7320.96
222_A240_V0.7250.95
81_I95_M0.7230.95
29_D33_A0.7230.95
44_R49_D0.7140.95
222_A226_I0.7130.95
99_G103_V0.7130.95
49_D52_A0.7130.95
111_L139_L0.7120.95
186_P198_V0.7110.95
120_R189_E0.7100.95
65_A69_A0.7090.95
161_I183_L0.7000.94
33_A36_A0.6980.94
175_A222_A0.6980.94
122_A146_L0.6970.94
92_L105_R0.6970.94
133_D140_A0.6940.94
111_L186_P0.6940.94
152_A156_D0.6910.94
51_A57_V0.6910.94
15_V19_V0.6910.94
99_G102_G0.6880.94
96_A128_G0.6870.94
4_L26_A0.6860.94
107_S120_R0.6840.94
89_G151_A0.6830.94
81_I99_G0.6810.94
159_E213_F0.6780.94
53_S78_E0.6770.93
162_Q185_T0.6750.93
173_A199_T0.6740.93
161_I176_A0.6740.93
136_R146_L0.6710.93
207_A211_S0.6700.93
170_L241_Y0.6680.93
61_V66_A0.6650.93
168_A171_A0.6630.93
30_P65_A0.6620.93
47_A50_T0.6600.93
14_W162_Q0.6580.92
178_D222_A0.6570.92
163_G187_V0.6560.92
32_R45_A0.6550.92
42_N53_S0.6530.92
187_V190_E0.6520.92
166_H201_G0.6510.92
14_W18_V0.6500.92
86_G163_G0.6460.92
147_V183_L0.6410.91
12_G29_D0.6410.91
228_A236_A0.6380.91
198_V201_G0.6370.91
185_T196_D0.6370.91
229_A233_D0.6330.91
152_A215_G0.6310.91
160_T176_A0.6290.91
4_L51_A0.6270.91
15_V84_F0.6250.90
67_G91_P0.6220.90
220_A223_A0.6200.90
56_V82_V0.6190.90
217_Q224_D0.6180.90
171_A222_A0.6160.90
163_G209_I0.6150.90
235_D238_A0.6110.89
211_S237_F0.6100.89
17_E20_A0.6060.89
162_Q169_I0.6060.89
176_A188_Y0.6050.89
10_A162_Q0.6050.89
162_Q190_E0.6050.89
106_A129_G0.6030.89
225_R229_A0.6020.89
83_D110_P0.5940.88
111_L122_A0.5930.88
10_A13_R0.5910.88
46_V50_T0.5910.88
125_D132_V0.5900.88
190_E197_R0.5840.87
164_R219_V0.5830.87
204_G207_A0.5820.87
91_P107_S0.5820.87
166_H170_L0.5810.87
223_A227_A0.5800.87
132_V136_R0.5790.87
162_Q187_V0.5780.87
185_T206_Y0.5740.86
111_L183_L0.5730.86
87_V212_T0.5720.86
120_R186_P0.5720.86
10_A163_G0.5720.86
175_A219_V0.5710.86
161_I184_A0.5710.86
188_Y191_L0.5670.86
83_D88_M0.5660.86
82_V121_I0.5660.86
217_Q221_A0.5660.86
63_M212_T0.5640.85
67_G90_E0.5640.85
114_P117_A0.5630.85
218_E225_R0.5620.85
71_D97_A0.5610.85
162_Q206_Y0.5610.85
96_A102_G0.5600.85
153_V181_D0.5600.85
164_R172_F0.5570.85
68_A231_A0.5570.85
69_A73_H0.5550.84
158_M183_L0.5530.84
42_N45_A0.5520.84
13_R27_D0.5520.84
28_T51_A0.5520.84
162_Q196_D0.5520.84
130_P133_D0.5520.84
43_A49_D0.5500.84
153_V157_A0.5490.84
54_F57_V0.5490.84
219_V226_I0.5450.83
58_A138_W0.5450.83
186_P201_G0.5440.83
14_W163_G0.5430.83
10_A199_T0.5420.83
26_A50_T0.5410.83
198_V206_Y0.5400.83
93_A152_A0.5380.83
219_V222_A0.5370.82
70_I98_A0.5350.82
48_V51_A0.5350.82
197_R201_G0.5320.82
231_A239_E0.5280.81
206_Y210_Q0.5280.81
179_V218_E0.5270.81
123_V132_V0.5260.81
112_F162_Q0.5250.81
203_P242_E0.5250.81
228_A242_E0.5230.81
62_P86_G0.5220.81
91_P95_M0.5210.81
157_A161_I0.5200.80
89_G216_S0.5190.80
221_A224_D0.5190.80
170_L199_T0.5180.80
173_A188_Y0.5170.80
166_H209_I0.5150.80
163_G201_G0.5140.80
235_D242_E0.5100.79
111_L170_L0.5100.79
160_T169_I0.5090.79
4_L57_V0.5090.79
162_Q166_H0.5070.79
156_D160_T0.5040.78
165_T191_L0.5030.78
10_A14_W0.5010.78
70_I81_I0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pv7A 2 0.9469 100 0.424 Contact Map
3b1fA 2 0.9673 100 0.437 Contact Map
3ktdA 2 0.9755 100 0.443 Contact Map
3ggoA 2 0.9755 100 0.463 Contact Map
2g5cA 2 0.9755 100 0.468 Contact Map
4wjiA 2 0.9837 100 0.471 Contact Map
2f1kA 2 0.9673 100 0.498 Contact Map
3triA 2 0.9592 99.9 0.648 Contact Map
2izzA 5 0.9673 99.9 0.649 Contact Map
2rcyA 5 0.9347 99.9 0.665 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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