GREMLIN Database
Q9HQB7 - Uncharacterized protein
UniProt: Q9HQB7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (383)
Sequences: 292 (235)
Seq/√Len: 12.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
385_A390_N5.3191.00
266_A278_L5.3131.00
385_A393_G5.1031.00
390_N393_G4.1981.00
275_S345_S4.1521.00
235_V258_M4.1041.00
369_L372_A3.7170.99
384_V393_G3.6360.99
232_Y235_V3.2360.97
296_T403_S3.1860.97
385_A394_A3.1150.97
192_H195_E3.0140.96
189_V195_E2.8270.94
78_L86_V2.6610.92
165_V179_L2.6090.91
189_V192_H2.5420.90
411_C430_Y2.5140.89
266_A281_V2.4170.87
302_D311_S2.3990.87
384_V390_N2.3660.86
192_H196_P2.3570.86
387_L393_G2.3260.85
153_L348_L2.3260.85
71_P75_V2.3060.85
292_V349_L2.2710.84
312_F343_R2.2580.83
177_V206_L2.2570.83
401_R411_C2.2250.82
235_V260_A2.1390.80
385_A389_R2.1310.79
140_A341_D2.0010.75
366_L369_L2.0000.75
390_N394_A1.9730.74
292_V299_L1.9720.74
242_S268_A1.9700.74
178_G351_R1.9620.73
136_V343_R1.9180.71
56_A60_F1.9020.71
340_T351_R1.8930.70
304_R328_A1.8840.70
384_V388_S1.8700.69
320_V340_T1.8350.68
126_Y243_E1.7940.66
235_V262_G1.7910.66
389_R393_G1.7780.65
221_E228_P1.7710.65
233_D262_G1.7700.65
238_C266_A1.7660.65
369_L373_D1.7600.65
149_V265_L1.7160.62
134_Y343_R1.7130.62
384_V389_R1.6990.62
383_L394_A1.6890.61
276_T279_R1.6760.61
401_R407_Q1.6750.61
66_E69_G1.6640.60
107_L114_F1.6490.59
53_I56_A1.6390.59
296_T303_R1.6280.58
126_Y134_Y1.6170.58
384_V394_A1.6110.57
152_G156_D1.6050.57
107_L113_R1.6020.57
383_L393_G1.6010.57
52_I65_E1.5920.56
367_L370_G1.5650.55
235_V265_L1.5640.55
107_L111_I1.5630.55
108_R115_K1.5570.55
214_V217_T1.5540.55
110_T113_R1.5520.55
259_A350_R1.5480.54
390_N398_P1.5370.54
173_G286_E1.5320.54
70_P79_P1.5280.53
303_R427_A1.5230.53
303_R311_S1.5220.53
143_Y346_Y1.5050.52
62_V67_P1.5020.52
405_G413_A1.4950.52
61_V65_E1.4920.52
65_E69_G1.4870.51
238_C344_F1.4730.51
175_P236_L1.4710.50
303_R403_S1.4640.50
294_G351_R1.4560.50
75_V80_E1.4350.49
286_E303_R1.4230.48
101_G104_G1.4230.48
323_V396_A1.4050.47
148_Y342_V1.3910.46
258_M262_G1.3900.46
399_V413_A1.3860.46
274_T282_E1.3860.46
365_R370_G1.3780.46
289_P354_R1.3690.45
61_V64_P1.3620.45
91_T97_D1.3500.44
296_T311_S1.3460.44
166_L235_V1.3410.44
221_E226_F1.3400.44
152_G294_G1.3370.44
186_E189_V1.3340.44
383_L390_N1.3330.44
102_D106_S1.3250.43
388_S393_G1.3180.43
366_L372_A1.3040.42
172_V203_L1.2750.41
134_Y243_E1.2610.40
73_N77_A1.2610.40
72_F77_A1.2600.40
218_I221_E1.2560.40
76_S79_P1.2510.40
64_P68_V1.2480.39
311_S403_S1.2410.39
282_E302_D1.2360.39
403_S407_Q1.2330.39
138_H142_Y1.2310.39
286_E292_V1.2290.38
285_V349_L1.2210.38
303_R313_D1.2070.37
186_E195_E1.2040.37
321_P424_G1.1990.37
279_R424_G1.1980.37
386_K391_L1.1980.37
72_F135_A1.1950.37
216_T220_R1.1890.37
246_D402_V1.1890.37
401_R430_Y1.1880.37
64_P69_G1.1850.36
255_A315_R1.1820.36
52_I55_R1.1710.36
86_V267_L1.1690.36
221_E224_E1.1670.36
398_P425_I1.1650.35
167_D171_G1.1520.35
140_A352_D1.1460.35
263_T348_L1.1450.35
271_D348_L1.1440.35
223_A254_Y1.1430.34
80_E86_V1.1410.34
385_A388_S1.1360.34
221_E225_S1.1350.34
368_A371_D1.1310.34
101_G105_D1.1290.34
366_L370_G1.1260.34
68_V371_D1.1230.34
192_H197_S1.1140.33
145_A354_R1.1070.33
166_L433_L1.1020.33
298_R328_A1.0990.33
384_V387_L1.0980.32
64_P67_P1.0950.32
54_E60_F1.0910.32
165_V234_L1.0880.32
321_P396_A1.0870.32
286_E315_R1.0850.32
383_L389_R1.0840.32
126_Y269_P1.0820.32
382_L385_A1.0800.32
217_T228_P1.0770.32
275_S279_R1.0740.31
111_I118_Y1.0730.31
373_D376_V1.0690.31
264_A290_F1.0690.31
55_R59_T1.0610.31
191_Y343_R1.0610.31
286_E302_D1.0520.30
288_D358_A1.0520.30
232_Y262_G1.0480.30
79_P82_Y1.0480.30
98_W101_G1.0470.30
325_S338_R1.0450.30
302_D407_Q1.0420.30
267_L374_D1.0380.30
415_L424_G1.0380.30
57_D67_P1.0350.30
381_D385_A1.0340.30
417_R427_A1.0330.30
162_D199_A1.0310.30
111_I115_K1.0300.30
380_A384_V1.0270.29
85_V93_A1.0270.29
130_V136_V1.0260.29
170_A174_G1.0200.29
171_G233_D1.0170.29
317_A430_Y1.0160.29
291_T299_L1.0080.29
372_A428_A1.0060.29
356_R414_V1.0040.28
398_P422_N1.0020.28
281_V426_E1.0010.28
425_I432_D0.9980.28
345_S403_S0.9930.28
375_R384_V0.9910.28
381_D390_N0.9870.28
74_G77_A0.9860.28
52_I57_D0.9840.28
417_R425_I0.9840.28
282_E286_E0.9820.28
114_F119_Y0.9800.28
71_P74_G0.9740.27
216_T221_E0.9730.27
282_E311_S0.9720.27
150_L414_V0.9680.27
317_A341_D0.9660.27
141_G340_T0.9660.27
380_A385_A0.9660.27
107_L118_Y0.9620.27
195_E240_V0.9610.27
344_F371_D0.9590.27
345_S401_R0.9590.27
222_T226_F0.9570.27
143_Y297_P0.9540.26
368_A372_A0.9530.26
300_W318_V0.9500.26
282_E313_D0.9490.26
75_V79_P0.9480.26
365_R369_L0.9450.26
258_M299_L0.9430.26
255_A313_D0.9370.26
108_R111_I0.9370.26
82_Y378_D0.9350.26
255_A430_Y0.9350.26
370_G374_D0.9320.26
370_G373_D0.9280.25
54_E65_E0.9270.25
303_R315_R0.9270.25
77_A80_E0.9220.25
302_D426_E0.9180.25
265_L428_A0.9170.25
170_A232_Y0.9130.25
364_D368_A0.9110.25
265_L372_A0.9110.25
158_L435_S0.9100.25
62_V69_G0.9100.25
315_R397_N0.9100.25
283_R287_D0.9090.25
417_R439_A0.9090.25
59_T64_P0.9080.25
387_L390_N0.9080.25
275_S401_R0.9080.25
306_T323_V0.9070.25
243_E269_P0.9070.25
274_T302_D0.9060.25
55_R60_F0.9030.25
350_R355_R0.9010.24
77_A83_E0.8930.24
381_D388_S0.8880.24
383_L386_K0.8850.24
367_L379_R0.8840.24
260_A351_R0.8760.24
252_R318_V0.8730.23
422_N425_I0.8730.23
227_Q285_V0.8670.23
90_L136_V0.8600.23
167_D264_A0.8590.23
274_T311_S0.8560.23
130_V134_Y0.8560.23
156_D432_D0.8540.23
419_T427_A0.8530.23
103_T106_S0.8530.23
114_F117_D0.8530.23
302_D403_S0.8520.23
299_L412_Y0.8490.23
255_A302_D0.8450.22
397_N432_D0.8440.22
397_N418_P0.8310.22
56_A69_G0.8290.22
152_G268_A0.8270.22
100_R258_M0.8240.22
156_D302_D0.8230.22
296_T302_D0.8200.22
108_R114_F0.8200.22
76_S344_F0.8180.22
72_F75_V0.8150.21
149_V312_F0.8150.21
417_R432_D0.8150.21
156_D255_A0.8140.21
251_L387_L0.8120.21
304_R320_V0.8110.21
112_R408_T0.8090.21
249_S362_S0.8090.21
170_A292_V0.8080.21
292_V315_R0.8080.21
282_E303_R0.8060.21
199_A277_H0.8000.21
246_D252_R0.7990.21
255_A311_S0.7980.21
110_T114_F0.7950.21
128_R161_H0.7940.21
367_L373_D0.7920.21
91_T142_Y0.7910.21
408_T428_A0.7880.21
255_A317_A0.7860.20
203_L270_A0.7860.20
69_G409_T0.7860.20
134_Y148_Y0.7850.20
373_D379_R0.7830.20
207_L210_T0.7830.20
166_L254_Y0.7820.20
297_P313_D0.7770.20
62_V65_E0.7760.20
117_D133_G0.7750.20
63_P66_E0.7750.20
61_V68_V0.7750.20
400_F428_A0.7710.20
223_A226_F0.7680.20
255_A401_R0.7650.20
268_A296_T0.7640.20
174_G199_A0.7630.20
391_L394_A0.7620.20
399_V416_V0.7590.20
112_R116_D0.7560.19
282_E296_T0.7550.19
162_D344_F0.7530.19
296_T313_D0.7520.19
155_R189_V0.7500.19
358_A362_S0.7470.19
194_V197_S0.7460.19
131_A343_R0.7450.19
81_R344_F0.7450.19
162_D298_R0.7430.19
367_L372_A0.7430.19
432_D439_A0.7380.19
56_A67_P0.7340.19
74_G80_E0.7330.19
225_S229_A0.7330.19
345_S407_Q0.7330.19
299_L327_L0.7320.19
314_E411_C0.7310.19
267_L406_S0.7300.19
60_F65_E0.7290.19
397_N427_A0.7280.19
135_A184_P0.7280.19
55_R58_G0.7250.19
132_L279_R0.7230.18
384_V395_D0.7210.18
100_R106_S0.7210.18
153_L289_P0.7200.18
197_S343_R0.7190.18
89_E323_V0.7170.18
164_R219_H0.7080.18
69_G314_E0.7050.18
172_V199_A0.7050.18
86_V358_A0.7050.18
136_V340_T0.7040.18
110_T350_R0.7030.18
58_G61_V0.7010.18
216_T219_H0.7010.18
232_Y330_A0.7000.18
303_R407_Q0.7000.18
264_A426_E0.6990.18
166_L233_D0.6930.18
111_I114_F0.6920.18
163_L233_D0.6910.18
115_K118_Y0.6910.18
302_D315_R0.6880.17
149_V426_E0.6880.17
159_L364_D0.6880.17
276_T320_V0.6850.17
162_D328_A0.6850.17
153_L263_T0.6800.17
53_I59_T0.6800.17
214_V228_P0.6770.17
112_R117_D0.6770.17
226_F229_A0.6760.17
255_A411_C0.6760.17
371_D378_D0.6740.17
166_L261_D0.6740.17
241_L417_R0.6740.17
177_V183_L0.6740.17
365_R372_A0.6730.17
250_V357_H0.6730.17
93_A101_G0.6720.17
298_R303_R0.6700.17
182_F267_L0.6700.17
95_G98_W0.6690.17
372_A378_D0.6680.17
317_A411_C0.6680.17
238_C251_L0.6660.17
89_E93_A0.6660.17
144_A408_T0.6630.17
165_V428_A0.6630.17
178_G426_E0.6630.17
184_P355_R0.6630.17
294_G303_R0.6560.17
396_A438_D0.6560.17
108_R117_D0.6550.16
128_R380_A0.6540.16
131_A144_A0.6530.16
96_P180_F0.6520.16
193_A242_S0.6510.16
165_V409_T0.6490.16
134_Y141_G0.6470.16
152_G433_L0.6470.16
102_D351_R0.6460.16
302_D417_R0.6440.16
157_G263_T0.6430.16
161_H344_F0.6420.16
68_V362_S0.6420.16
274_T303_R0.6400.16
267_L363_G0.6390.16
385_A426_E0.6390.16
109_E113_R0.6390.16
157_G341_D0.6380.16
409_T416_V0.6380.16
70_P80_E0.6370.16
154_A421_L0.6370.16
387_L394_A0.6360.16
225_S360_E0.6360.16
398_P426_E0.6340.16
195_E202_V0.6320.16
248_A340_T0.6310.16
382_L390_N0.6310.16
266_A318_V0.6310.16
156_D303_R0.6300.16
397_N413_A0.6300.16
311_S347_S0.6300.16
198_A252_R0.6290.16
136_V249_S0.6280.16
137_Y271_D0.6270.16
320_V323_V0.6270.16
87_E111_I0.6270.16
411_C416_V0.6270.16
128_R292_V0.6260.16
365_R368_A0.6260.16
213_N344_F0.6250.16
169_G243_E0.6250.16
191_Y195_E0.6240.16
90_L102_D0.6240.16
160_G199_A0.6200.16
145_A206_L0.6190.16
346_Y398_P0.6190.16
280_A356_R0.6170.15
270_A340_T0.6160.15
358_A387_L0.6160.15
52_I56_A0.6150.15
424_G439_A0.6140.15
70_P265_L0.6120.15
96_P104_G0.6120.15
168_L254_Y0.6110.15
107_L112_R0.6100.15
83_E86_V0.6100.15
222_T227_Q0.6090.15
141_G195_E0.6090.15
130_V272_K0.6080.15
286_E311_S0.6080.15
362_S369_L0.6060.15
54_E57_D0.6030.15
114_F147_Q0.6000.15
56_A65_E0.6000.15
401_R426_E0.6000.15
344_F434_V0.5990.15
255_A296_T0.5990.15
56_A68_V0.5960.15
165_V349_L0.5960.15
130_V400_F0.5950.15
302_D425_I0.5940.15
128_R365_R0.5940.15
90_L341_D0.5930.15
156_D162_D0.5930.15
54_E66_E0.5920.15
79_P317_A0.5920.15
216_T229_A0.5900.15
417_R426_E0.5900.15
62_V68_V0.5890.15
248_A251_L0.5880.15
182_F433_L0.5880.15
170_A324_Q0.5870.15
300_W335_G0.5840.15
310_W391_L0.5810.15
299_L354_R0.5800.15
162_D168_L0.5790.14
403_S427_A0.5780.14
427_A432_D0.5780.14
79_P83_E0.5770.14
214_V218_I0.5770.14
291_T416_V0.5760.14
62_V66_E0.5760.14
103_T405_G0.5730.14
385_A395_D0.5730.14
132_L202_V0.5730.14
282_E298_R0.5720.14
377_T382_L0.5720.14
196_P324_Q0.5690.14
191_Y409_T0.5690.14
177_V239_S0.5650.14
383_L387_L0.5650.14
166_L292_V0.5620.14
255_A303_R0.5620.14
137_Y339_H0.5620.14
125_E227_Q0.5610.14
133_G197_S0.5600.14
70_P81_R0.5590.14
96_P101_G0.5590.14
149_V259_A0.5590.14
215_H219_H0.5570.14
176_A347_S0.5560.14
276_T321_P0.5560.14
56_A64_P0.5550.14
415_L418_P0.5550.14
82_Y86_V0.5550.14
276_T412_Y0.5530.14
145_A267_L0.5520.14
91_T95_G0.5510.14
346_Y425_I0.5490.14
329_D435_S0.5470.14
72_F361_L0.5470.14
160_G298_R0.5460.14
269_P281_V0.5460.14
294_G313_D0.5460.14
382_L387_L0.5450.14
214_V221_E0.5430.14
184_P415_L0.5430.14
61_V69_G0.5430.14
252_R424_G0.5420.14
303_R425_I0.5420.14
232_Y258_M0.5410.14
424_G427_A0.5410.14
86_V121_R0.5400.14
315_R430_Y0.5400.14
294_G320_V0.5390.14
71_P77_A0.5390.14
247_A430_Y0.5390.14
141_G183_L0.5390.14
56_A59_T0.5380.13
193_A196_P0.5360.13
161_H185_D0.5360.13
73_N313_D0.5350.13
133_G283_R0.5330.13
197_S201_D0.5320.13
303_R398_P0.5310.13
65_E134_Y0.5290.13
77_A84_R0.5280.13
177_V271_D0.5280.13
78_L154_A0.5270.13
396_A427_A0.5260.13
52_I109_E0.5250.13
189_V197_S0.5250.13
115_K233_D0.5250.13
142_Y406_S0.5240.13
210_T217_T0.5240.13
127_D155_R0.5240.13
204_D325_S0.5220.13
415_L439_A0.5220.13
272_K400_F0.5190.13
235_V264_A0.5190.13
166_L232_Y0.5180.13
62_V337_F0.5160.13
304_R318_V0.5160.13
234_L377_T0.5140.13
79_P90_L0.5130.13
282_E403_S0.5130.13
282_E315_R0.5130.13
192_H397_N0.5120.13
91_T312_F0.5110.13
207_L410_D0.5100.13
390_N426_E0.5100.13
313_D432_D0.5070.13
137_Y312_F0.5070.13
188_L229_A0.5060.13
402_V410_D0.5050.13
286_E427_A0.5050.13
265_L396_A0.5050.13
251_L408_T0.5050.13
52_I62_V0.5040.13
351_R424_G0.5040.13
150_L195_E0.5030.13
134_Y173_G0.5020.13
309_G404_D0.5010.13
401_R440_L0.5010.13
192_H418_P0.5000.13
270_A343_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ssoA 4 0.6933 99.7 0.875 Contact Map
5bp7A 3 0.4816 99.4 0.9 Contact Map
4kdcA 1 0.4341 99.4 0.901 Contact Map
2p7iA 6 0.4276 99.4 0.903 Contact Map
2o57A 2 0.5205 99.3 0.904 Contact Map
2aotA 1 0.5076 99.3 0.904 Contact Map
4krgA 1 0.689 99.3 0.905 Contact Map
2p35A 2 0.4773 99.3 0.905 Contact Map
4gekA 2 0.4795 99.3 0.905 Contact Map
3g5lA 3 0.3801 99.3 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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