GREMLIN Database
Q9HQB6 - Uncharacterized protein
UniProt: Q9HQB6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 160 (137)
Sequences: 13564 (8694)
Seq/√Len: 742.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_A32_E2.8991.00
48_E56_Y2.8001.00
76_T134_V2.5051.00
105_T136_D2.4611.00
97_R111_F2.3151.00
115_A119_D2.2621.00
26_S44_I2.1841.00
46_R50_R2.0511.00
92_V126_D2.0291.00
63_E118_D2.0191.00
16_A23_S2.0051.00
54_T61_D1.9621.00
10_D43_R1.9201.00
70_Y111_F1.8731.00
78_P133_E1.8501.00
72_L99_E1.7961.00
96_V113_V1.7711.00
54_T59_D1.7691.00
9_L35_V1.7201.00
16_A19_R1.6561.00
74_V138_D1.6361.00
92_V123_I1.6341.00
45_G49_E1.6241.00
35_V39_T1.6211.00
27_Q31_D1.5901.00
23_S32_E1.5321.00
116_D119_D1.5171.00
28_D31_D1.5111.00
27_Q37_A1.4981.00
119_D122_R1.4891.00
88_A130_L1.4731.00
88_A91_D1.4571.00
36_S39_T1.4421.00
35_V40_V1.4381.00
13_I29_I1.4051.00
26_S41_R1.4001.00
85_L89_A1.3971.00
86_A90_V1.3921.00
81_Q84_E1.3891.00
94_G119_D1.3721.00
74_V106_E1.3531.00
76_T105_T1.3471.00
75_C110_V1.3431.00
22_R56_Y1.3341.00
8_D12_T1.3181.00
33_A40_V1.3131.00
83_E87_A1.3111.00
73_I112_A1.2811.00
23_S29_I1.2701.00
69_L117_S1.2671.00
76_T133_E1.2521.00
122_R125_R1.2511.00
67_Y115_A1.2461.00
28_D32_E1.2371.00
17_L44_I1.2271.00
9_L12_T1.2271.00
77_A85_L1.2031.00
94_G126_D1.1961.00
86_A142_S1.1811.00
20_D32_E1.1671.00
45_G48_E1.1531.00
19_R32_E1.1461.00
121_S142_S1.1421.00
16_A29_I1.1151.00
70_Y113_V1.1041.00
55_G59_D1.0891.00
7_D43_R1.0741.00
9_L33_A1.0631.00
12_T15_H1.0431.00
95_V112_A1.0411.00
12_T16_A1.0161.00
114_G119_D1.0151.00
98_V110_V1.0121.00
74_V136_D1.0041.00
86_A108_I0.9981.00
84_E88_A0.9901.00
23_S28_D0.9861.00
26_S30_A0.9811.00
72_L109_H0.9741.00
22_R48_E0.9741.00
41_R45_G0.9661.00
12_T33_A0.9631.00
30_A40_V0.9601.00
61_D64_Q0.9541.00
15_H19_R0.9511.00
21_A56_Y0.9471.00
87_A90_V0.9451.00
72_L111_F0.9341.00
99_E111_F0.9341.00
37_A41_R0.9191.00
114_G120_L0.9171.00
112_A123_I0.9061.00
114_G123_I0.8961.00
30_A35_V0.8781.00
105_T134_V0.8761.00
26_S37_A0.8741.00
68_Q116_D0.8731.00
27_Q41_R0.8721.00
78_P81_Q0.8651.00
6_L11_R0.8641.00
87_A91_D0.8591.00
62_Y113_V0.8561.00
21_A28_D0.8521.00
47_L52_I0.8471.00
95_V98_V0.8371.00
10_D46_R0.8261.00
74_V109_H0.8241.00
88_A92_V0.8231.00
38_S42_N0.8201.00
83_E86_A0.8191.00
11_R15_H0.8171.00
95_V110_V0.7971.00
99_E140_I0.7931.00
6_L52_I0.7901.00
20_D23_S0.7801.00
75_C85_L0.7771.00
122_R126_D0.7691.00
7_D10_D0.7691.00
29_I44_I0.7671.00
29_I40_V0.7651.00
13_I40_V0.7521.00
124_G137_E0.7511.00
84_E87_A0.7491.00
99_E143_V0.7411.00
16_A20_D0.7371.00
72_L140_I0.7351.00
103_T139_L0.7341.00
21_A58_A0.7331.00
89_A98_V0.7271.00
126_D130_L0.7211.00
8_D11_R0.7191.00
94_G123_I0.7131.00
86_A144_H0.7101.00
13_I43_R0.7081.00
106_E136_D0.7051.00
76_T106_E0.7051.00
118_D121_S0.6981.00
67_Y94_G0.6971.00
84_E131_G0.6911.00
82_R108_I0.6891.00
67_Y113_V0.6801.00
42_N46_R0.6781.00
70_Y143_V0.6761.00
30_A37_A0.6761.00
118_D122_R0.6731.00
74_V105_T0.6731.00
38_S41_R0.6691.00
14_L47_L0.6601.00
89_A110_V0.6591.00
71_T120_L0.6581.00
117_S139_L0.6551.00
43_R47_L0.6511.00
13_I16_A0.6491.00
73_I110_V0.6451.00
70_Y140_I0.6431.00
85_L108_I0.6431.00
42_N45_G0.6411.00
124_G135_A0.6411.00
71_T139_L0.6401.00
52_I64_Q0.6401.00
21_A55_G0.6401.00
94_G115_A0.6371.00
78_P131_G0.6291.00
10_D47_L0.6281.00
13_I23_S0.6241.00
92_V130_L0.6191.00
51_G54_T0.6191.00
128_D135_A0.6191.00
101_V109_H0.6181.00
13_I44_I0.6151.00
119_D123_I0.6091.00
27_Q30_A0.6031.00
75_C132_L0.6001.00
83_E129_E0.5901.00
73_I135_A0.5901.00
61_D65_A0.5891.00
100_E108_I0.5831.00
83_E125_R0.5821.00
13_I47_L0.5811.00
60_V65_A0.5791.00
71_T137_E0.5761.00
76_T136_D0.5711.00
59_D62_Y0.5691.00
26_S40_V0.5651.00
77_A107_N0.5591.00
18_Q57_H0.5581.00
70_Y99_E0.5481.00
53_L56_Y0.5451.00
124_G141_R0.5431.00
82_R128_D0.5401.00
9_L39_T0.5381.00
46_R49_E0.5361.00
71_T114_G0.5331.00
33_A39_T0.5291.00
20_D28_D0.5271.00
96_V111_F0.5251.00
15_H18_Q0.5211.00
117_S141_R0.5201.00
101_V106_E0.5171.00
123_I127_L0.5161.00
79_V133_E0.5151.00
121_S125_R0.5151.00
10_D50_R0.5131.00
89_A127_L0.5121.00
100_E103_T0.5021.00
16_A33_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9437 100 0.172 Contact Map
4un1B 1 0.9375 100 0.222 Contact Map
4un1A 1 0.8812 100 0.248 Contact Map
4pcqA 2 0.9125 100 0.257 Contact Map
2e1cA 1 0.9125 100 0.261 Contact Map
2p5vA 5 0.9625 100 0.262 Contact Map
2ia0A 2 0.9187 100 0.27 Contact Map
2cg4A 6 0.9125 99.9 0.281 Contact Map
3i4pA 5 0.9313 99.9 0.288 Contact Map
2pn6A 5 0.9125 99.9 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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