GREMLIN Database
SURE - 5'-nucleotidase SurE
UniProt: Q9HQB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (230)
Sequences: 3020 (1981)
Seq/√Len: 130.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_E33_N4.8611.00
184_V233_H3.9311.00
114_A121_A3.6941.00
227_R231_D3.2711.00
28_L88_V3.2541.00
87_V114_A3.1091.00
186_T235_S3.0821.00
175_P232_G2.9461.00
182_E233_H2.8141.00
57_H202_T2.7411.00
26_D146_V2.7401.00
124_V172_A2.7041.00
228_A235_S2.6311.00
199_T207_D2.4271.00
10_V25_A2.3811.00
170_V236_V2.3171.00
124_V149_T2.2811.00
181_G233_H2.2071.00
27_G30_A2.1511.00
186_T228_A2.1211.00
7_E35_T2.1061.00
200_G208_R2.0661.00
93_E142_Y2.0551.00
31_V154_H2.0491.00
7_E82_P2.0201.00
46_T49_A1.9751.00
86_L153_A1.9401.00
54_V66_E1.9101.00
43_Q46_T1.9091.00
147_D177_A1.9021.00
229_V235_S1.8681.00
122_I170_V1.8561.00
79_A199_T1.8381.00
145_A172_A1.8121.00
97_L229_V1.8051.00
47_G109_S1.7971.00
30_A150_T1.7841.00
124_V170_V1.7781.00
40_A43_Q1.7531.00
11_T110_A1.7281.00
25_A36_V1.7241.00
19_P23_A1.7231.00
202_T206_Y1.7201.00
148_A234_V1.7051.00
27_G146_V1.6741.00
88_V124_V1.6171.00
8_I86_L1.5821.00
187_R223_G1.5491.00
58_D61_L1.5481.00
59_H62_G1.5211.00
23_A27_G1.5211.00
75_A209_L1.5031.00
148_A172_A1.5001.00
166_D245_T1.4931.00
37_V76_G1.4901.00
23_A146_V1.4791.00
95_G127_Y1.4701.00
25_A62_G1.4241.00
104_R113_E1.4141.00
115_A167_Y1.4031.00
155_D159_D1.3901.00
10_V34_V1.3641.00
170_V234_V1.3621.00
176_D179_A1.3621.00
151_H155_D1.3561.00
108_V239_L1.3551.00
150_T154_H1.3501.00
19_P93_E1.3491.00
141_D144_H1.3461.00
187_R224_T1.3241.00
89_S110_A1.3181.00
203_V210_W1.3131.00
27_G150_T1.3111.00
11_T89_S1.3071.00
18_A93_E1.3001.00
77_L119_V1.2961.00
25_A29_D1.2831.00
74_V197_A1.2421.00
188_P237_S1.2361.00
31_V150_T1.2321.00
27_G147_D1.2261.00
184_V223_G1.2261.00
111_A121_A1.2141.00
35_T63_Y1.2080.99
40_A66_E1.2050.99
181_G232_G1.2040.99
148_A180_T1.1900.99
156_A160_G1.1780.99
201_D207_D1.1590.99
10_V88_V1.1360.99
147_D151_H1.1350.99
228_A233_H1.1230.99
120_P160_G1.1210.99
240_T245_T1.1210.99
22_R26_D1.1120.99
184_V231_D1.1090.99
55_A210_W1.0980.99
10_V28_L1.0940.99
28_L31_V1.0870.99
112_V241_A1.0790.99
223_G227_R1.0730.99
97_L100_Y1.0730.99
77_L117_F1.0630.99
51_S71_D1.0620.99
128_M174_H1.0300.98
48_R109_S1.0290.98
42_N93_E1.0280.98
84_P119_V1.0050.98
11_T73_V0.9970.98
163_D166_D0.9960.98
108_V167_Y0.9880.98
153_A157_V0.9850.98
101_V108_V0.9840.98
148_A183_M0.9820.98
116_F167_Y0.9810.98
56_V66_E0.9660.98
27_G149_T0.9590.97
154_H158_T0.9560.97
48_R113_E0.9500.97
81_G84_P0.9470.97
100_Y191_A0.9430.97
124_V153_A0.9410.97
197_A211_E0.9310.97
149_T153_A0.9290.97
21_I38_A0.9050.96
220_D223_G0.9020.96
83_Y119_V0.9020.96
222_D227_R0.9000.96
204_T210_W0.8980.96
175_P180_T0.8970.96
16_I64_A0.8950.96
58_D62_G0.8900.96
100_Y104_R0.8870.96
31_V153_A0.8860.96
10_V21_I0.8830.96
183_M236_V0.8790.96
199_T209_L0.8780.96
87_V121_A0.8780.96
127_Y229_V0.8740.96
175_P179_A0.8650.95
112_V167_Y0.8520.95
37_V80_L0.8520.95
23_A26_D0.8520.95
33_N82_P0.8480.95
126_M145_A0.8470.95
202_T205_L0.8440.95
8_I32_G0.8430.95
126_M142_Y0.8350.94
238_P244_S0.8350.94
162_F166_D0.8280.94
96_N107_T0.8240.94
43_Q65_V0.8110.93
28_L153_A0.8060.93
221_P224_T0.8050.93
35_T84_P0.8030.93
35_T82_P0.8020.93
144_H177_A0.8020.93
57_H208_R0.7970.93
115_A121_A0.7860.92
18_A21_I0.7850.92
45_A52_Q0.7800.92
6_P157_V0.7790.92
13_D96_N0.7790.92
98_G235_S0.7780.92
128_M131_E0.7780.92
22_R25_A0.7760.92
146_V150_T0.7750.92
16_I62_G0.7680.91
29_D60_D0.7660.91
108_V123_A0.7660.91
185_V236_V0.7640.91
149_T170_V0.7640.91
20_G91_V0.7630.91
98_G189_S0.7620.91
145_A149_T0.7580.91
25_A34_V0.7570.91
31_V146_V0.7550.91
152_L183_M0.7530.91
73_V87_V0.7510.90
220_D230_L0.7500.90
9_L76_G0.7490.90
42_N45_A0.7470.90
7_E85_D0.7430.90
175_P181_G0.7410.90
43_Q68_T0.7310.89
26_D143_E0.7290.89
155_D158_T0.7290.89
152_L170_V0.7250.89
48_R112_V0.7210.89
231_D235_S0.7190.88
13_D107_T0.7180.88
53_E204_T0.7170.88
30_A34_V0.7100.88
159_D164_T0.7090.88
202_T210_W0.7080.88
151_H154_H0.7070.88
109_S240_T0.7060.87
127_Y186_T0.7000.87
30_A146_V0.6980.87
112_V243_H0.6940.87
70_A112_V0.6900.86
21_I36_V0.6880.86
162_F168_L0.6880.86
28_L32_G0.6870.86
76_G79_A0.6860.86
97_L226_R0.6850.86
48_R104_R0.6840.86
41_D66_E0.6810.86
88_V122_I0.6800.85
45_A109_S0.6740.85
170_V183_M0.6700.85
75_A79_A0.6700.85
160_G170_V0.6700.85
51_S55_A0.6670.84
204_T208_R0.6670.84
42_N53_E0.6660.84
79_A209_L0.6650.84
123_A237_S0.6620.84
8_I28_L0.6570.83
50_M70_A0.6510.83
228_A231_D0.6500.83
179_A232_G0.6500.83
115_A165_A0.6470.83
88_V149_T0.6460.82
144_H175_P0.6440.82
183_M234_V0.6440.82
100_Y113_E0.6430.82
144_H148_A0.6430.82
55_A203_V0.6410.82
19_P22_R0.6410.82
32_G157_V0.6400.82
28_L124_V0.6400.82
101_V239_L0.6400.82
70_A241_A0.6390.82
98_G226_R0.6380.82
141_D176_D0.6370.82
91_V149_T0.6350.81
86_L122_I0.6330.81
52_Q100_Y0.6300.81
6_P85_D0.6240.80
72_C104_R0.6240.80
35_T81_G0.6230.80
167_Y239_L0.6220.80
141_D174_H0.6180.80
86_L121_A0.6180.80
84_P118_G0.6170.79
151_H177_A0.6100.79
239_L243_H0.6090.79
29_D32_G0.6090.79
26_D178_D0.6080.78
33_N62_G0.6070.78
14_D96_N0.6070.78
49_A68_T0.6060.78
172_A180_T0.6060.78
121_A167_Y0.6030.78
20_G142_Y0.6030.78
154_H170_V0.6020.78
165_A190_H0.6010.78
102_L241_A0.5990.77
73_V77_L0.5940.77
224_T227_R0.5930.77
95_G126_M0.5930.77
37_V72_C0.5870.76
162_F165_A0.5850.76
147_D158_T0.5830.76
149_T152_L0.5830.76
158_T164_T0.5830.76
10_V91_V0.5820.75
144_H176_D0.5790.75
74_V113_E0.5780.75
102_L112_V0.5760.75
48_R70_A0.5750.75
67_G71_D0.5740.74
202_T208_R0.5730.74
99_M193_D0.5730.74
72_C113_E0.5710.74
92_N96_N0.5710.74
74_V99_M0.5690.74
18_A128_M0.5680.74
167_Y241_A0.5680.74
102_L243_H0.5670.74
20_G38_A0.5670.74
16_I38_A0.5640.73
152_L236_V0.5630.73
147_D178_D0.5630.73
143_E147_D0.5620.73
65_V75_A0.5610.73
184_V228_A0.5610.73
35_T61_L0.5610.73
209_L214_A0.5590.72
20_G24_L0.5540.72
65_V72_C0.5520.72
101_V197_A0.5520.72
218_I230_L0.5510.71
56_V65_V0.5510.71
209_L213_M0.5490.71
99_M191_A0.5490.71
45_A53_E0.5480.71
7_E84_P0.5460.71
203_V206_Y0.5460.71
45_A101_V0.5450.71
7_E81_G0.5450.71
27_G88_V0.5440.70
10_V36_V0.5430.70
183_M233_H0.5410.70
40_A64_A0.5400.70
97_L191_A0.5390.70
31_V157_V0.5370.69
73_V114_A0.5360.69
140_A164_T0.5360.69
144_H153_A0.5350.69
144_H147_D0.5340.69
56_V72_C0.5340.69
185_V238_P0.5330.69
93_E128_M0.5330.69
43_Q49_A0.5310.69
201_D206_Y0.5300.69
37_V65_V0.5300.69
222_D231_D0.5290.68
9_L114_A0.5290.68
17_D40_A0.5280.68
43_Q66_E0.5260.68
48_R116_F0.5260.68
194_M214_A0.5210.67
24_L149_T0.5210.67
200_G210_W0.5200.67
188_P244_S0.5200.67
144_H180_T0.5180.67
229_V232_G0.5180.67
109_S243_H0.5160.66
42_N74_V0.5150.66
148_A151_H0.5140.66
240_T243_H0.5110.66
49_A70_A0.5110.66
203_V213_M0.5090.65
148_A177_A0.5070.65
154_H157_V0.5060.65
20_G71_D0.5040.65
120_P168_L0.5040.65
47_G104_R0.5040.65
25_A28_L0.5040.65
71_D100_Y0.5030.65
87_V119_V0.5030.65
128_M140_A0.5010.64
92_N107_T0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wqkA 3 0.9341 100 0.103 Contact Map
3ty2A 2 0.938 100 0.106 Contact Map
4zg5D 3 0.9535 100 0.11 Contact Map
1j9jA 3 0.9225 100 0.114 Contact Map
1l5xA 4 0.9612 100 0.115 Contact Map
2v4nA 2 0.9302 100 0.122 Contact Map
2e6cA 4 0.8992 100 0.124 Contact Map
3otiA 2 0.8682 85.7 0.939 Contact Map
3h4tA 1 0.7984 80.1 0.943 Contact Map
3ot5A 2 0.876 76.1 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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