GREMLIN Database
AROK - Shikimate kinase
UniProt: Q9HQB0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 284 (271)
Sequences: 176 (131)
Seq/√Len: 7.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
206_D209_T5.8671.00
13_V149_V3.6420.95
97_A127_A3.4200.93
219_C248_Y3.3390.92
14_L195_A3.1210.89
34_S79_R2.9500.86
124_V133_T2.7470.82
225_P258_E2.6380.79
14_L198_V2.6040.78
17_L244_T2.5370.76
138_F146_L2.4460.74
12_T144_S2.3840.72
23_A225_P2.2390.66
29_I272_R2.1470.63
124_V132_V2.1360.63
13_V275_T2.1290.62
58_L132_V2.1170.62
13_V130_A2.1070.62
71_G274_T2.0870.61
9_A278_L1.9970.57
27_L169_A1.9790.56
13_V118_D1.9240.54
73_G151_M1.9190.54
261_S273_E1.8930.53
100_T134_V1.8260.50
122_L125_Q1.8210.50
30_D277_Q1.7980.49
216_L229_A1.7670.48
9_A248_Y1.7570.47
201_L206_D1.7500.47
10_A91_K1.7400.47
11_G25_F1.7220.46
128_R157_D1.7220.46
169_A175_P1.6910.45
142_A150_A1.6860.45
70_Y105_L1.6740.44
250_A264_W1.6420.43
21_V171_V1.6220.42
123_G132_V1.6190.42
15_N141_A1.6050.41
12_T24_A1.6010.41
83_E262_T1.5940.41
5_A102_L1.5910.41
20_G219_C1.5830.40
137_A246_P1.5530.39
62_C133_T1.5510.39
9_A48_I1.5390.39
98_N141_A1.5350.39
9_A196_E1.4910.37
166_E170_A1.4870.37
23_A151_M1.4830.37
121_R138_F1.4790.36
102_L119_A1.4730.36
171_V270_T1.4720.36
66_V118_D1.4630.36
91_K215_G1.4610.36
125_Q129_D1.4530.35
160_L199_A1.4530.35
131_G149_V1.4440.35
50_G227_A1.4440.35
241_L264_W1.4410.35
222_L250_A1.4340.35
125_Q253_D1.4000.33
9_A134_V1.3960.33
142_A247_S1.3890.33
21_V251_V1.3880.33
9_A219_C1.3830.33
128_R133_T1.3730.32
168_H275_T1.3670.32
180_S240_S1.3610.32
98_N144_S1.3610.32
7_A144_S1.3600.32
68_D87_A1.3520.32
31_T97_A1.3470.32
62_C244_T1.3370.31
94_S147_G1.3340.31
35_V159_L1.3330.31
28_D34_S1.3310.31
20_G155_R1.3240.31
36_S44_V1.3220.31
27_L273_E1.3220.31
105_L118_D1.3120.30
31_T96_A1.3090.30
31_T127_A1.3070.30
23_A88_A1.3050.30
159_L231_T1.2950.30
65_R125_Q1.2950.30
87_A180_S1.2940.30
12_T249_V1.2790.29
134_V272_R1.2790.29
11_G249_V1.2780.29
31_T138_F1.2770.29
80_T104_T1.2760.29
119_A254_E1.2750.29
30_D181_A1.2580.29
42_S45_S1.2540.28
64_S271_V1.2540.28
71_G209_T1.2520.28
25_F249_V1.2500.28
265_H271_V1.2390.28
132_V238_G1.2310.28
199_A276_T1.2240.27
255_D258_E1.2230.27
33_A96_A1.2220.27
216_L240_S1.2170.27
169_A274_T1.2120.27
126_A132_V1.2090.27
222_L247_S1.2070.27
65_R129_D1.1960.26
7_A11_G1.1860.26
116_R251_V1.1800.26
123_G142_A1.1770.26
10_A124_V1.1650.26
78_V176_E1.1630.25
15_N244_T1.1630.25
25_F188_C1.1550.25
228_P247_S1.1320.25
70_Y118_D1.1300.24
91_K211_M1.1290.24
98_N103_A1.1280.24
48_I239_V1.1280.24
124_V246_P1.1270.24
195_A244_T1.1210.24
222_L269_G1.1140.24
123_G215_G1.1130.24
67_I217_A1.1100.24
114_V177_R1.1080.24
197_H209_T1.1060.24
128_R142_A1.1000.24
231_T234_P1.0920.23
143_A241_L1.0770.23
131_G171_V1.0700.23
198_V236_A1.0670.23
189_E235_H1.0660.23
47_E79_R1.0630.22
173_T267_N1.0560.22
270_T275_T1.0520.22
123_G191_V1.0490.22
43_G156_E1.0460.22
97_A145_M1.0370.22
116_R146_L1.0370.22
46_G100_T1.0370.22
23_A150_A1.0360.22
14_L199_A1.0350.22
258_E274_T1.0330.22
160_L253_D1.0330.22
34_S83_E1.0270.21
34_S171_V1.0190.21
25_F80_T1.0150.21
200_A271_V1.0080.21
31_T146_L1.0050.21
71_G271_V1.0050.21
36_S77_H0.9970.21
139_D246_P0.9940.21
140_D246_P0.9940.21
134_V244_T0.9930.21
144_S218_F0.9890.20
55_D131_G0.9840.20
104_T221_A0.9810.20
60_E87_A0.9720.20
7_A12_T0.9690.20
233_L237_A0.9590.20
57_A130_A0.9580.20
35_V107_A0.9570.20
82_S148_G0.9550.20
24_A150_A0.9370.19
92_S214_N0.9360.19
8_P27_L0.9360.19
171_V219_C0.9330.19
47_E130_A0.9320.19
77_H262_T0.9270.19
100_T249_V0.9210.19
170_A273_E0.9200.19
10_A123_G0.9170.19
87_A223_D0.9160.19
51_H265_H0.9140.19
247_S266_E0.9100.18
206_D249_V0.9060.18
21_V84_V0.9010.18
231_T267_N0.8940.18
23_A213_V0.8920.18
184_D279_A0.8900.18
95_A144_S0.8900.18
180_S219_C0.8860.18
61_R129_D0.8810.18
71_G79_R0.8770.18
10_A211_M0.8730.18
237_A255_D0.8720.18
61_R221_A0.8680.17
28_D168_H0.8670.17
26_A120_A0.8660.17
158_D164_A0.8600.17
137_A140_D0.8550.17
114_V272_R0.8490.17
23_A38_T0.8480.17
216_L219_C0.8470.17
130_A146_L0.8460.17
160_L236_A0.8450.17
236_A278_L0.8440.17
10_A31_T0.8420.17
106_D109_G0.8410.17
170_A229_A0.8390.17
123_G174_P0.8370.17
170_A272_R0.8340.17
12_T25_F0.8340.17
54_A100_T0.8300.17
169_A272_R0.8230.16
43_G279_A0.8200.16
18_A218_F0.8190.16
26_A250_A0.8170.16
83_E242_S0.8130.16
164_A192_S0.8090.16
64_S67_I0.8060.16
51_H262_T0.8040.16
170_A241_L0.8010.16
58_L97_A0.7980.16
68_D193_G0.7920.16
213_V260_V0.7910.16
114_V207_Y0.7890.16
10_A264_W0.7830.16
8_P30_D0.7820.15
93_S99_A0.7800.15
43_G122_L0.7770.15
94_S154_N0.7740.15
146_L189_E0.7730.15
79_R262_T0.7730.15
32_E265_H0.7720.15
4_R270_T0.7700.15
26_A247_S0.7680.15
28_D274_T0.7580.15
32_E81_E0.7510.15
100_T172_W0.7480.15
21_V153_D0.7470.15
120_A171_V0.7470.15
187_R234_P0.7450.15
106_D212_T0.7430.15
188_C244_T0.7410.15
71_G265_H0.7400.15
195_A218_F0.7380.15
101_V223_D0.7330.14
24_A241_L0.7310.14
107_A241_L0.7310.14
27_L122_L0.7270.14
231_T276_T0.7270.14
39_P109_G0.7260.14
80_T207_Y0.7220.14
4_R122_L0.7210.14
63_V239_V0.7150.14
224_F247_S0.7100.14
27_L84_V0.7090.14
217_A251_V0.7080.14
159_L204_A0.7050.14
78_V203_A0.7040.14
58_L215_G0.7040.14
159_L162_R0.7030.14
34_S110_V0.7030.14
187_R212_T0.7030.14
170_A192_S0.7020.14
98_N218_F0.7000.14
27_L255_D0.6990.14
171_V206_D0.6980.14
97_A126_A0.6910.14
31_T48_I0.6890.14
17_L44_V0.6880.14
186_A231_T0.6880.14
171_V272_R0.6860.14
58_L141_A0.6810.13
254_E265_H0.6800.13
94_S214_N0.6800.13
48_I65_R0.6790.13
171_V251_V0.6780.13
72_D78_V0.6780.13
195_A267_N0.6700.13
70_Y263_R0.6690.13
20_G120_A0.6680.13
12_T211_M0.6680.13
33_A134_V0.6670.13
28_D35_V0.6670.13
20_G248_Y0.6670.13
223_D229_A0.6610.13
47_E77_H0.6590.13
11_G247_S0.6590.13
141_A250_A0.6580.13
27_L149_V0.6570.13
36_S79_R0.6570.13
8_P12_T0.6570.13
57_A196_E0.6560.13
9_A84_V0.6550.13
62_C101_V0.6530.13
125_Q159_L0.6490.13
37_V86_L0.6480.13
55_D80_T0.6480.13
177_R194_L0.6470.13
228_P232_A0.6460.13
128_R276_T0.6430.13
163_D187_R0.6420.13
242_S269_G0.6420.13
66_V251_V0.6390.13
18_A196_E0.6370.13
43_G76_G0.6270.12
31_T82_S0.6260.12
199_A240_S0.6260.12
38_T113_E0.6230.12
6_V34_S0.6230.12
84_V173_T0.6190.12
46_G59_V0.6170.12
50_G160_L0.6160.12
9_A79_R0.6160.12
14_L70_Y0.6160.12
265_H279_A0.6150.12
233_L248_Y0.6130.12
104_T151_M0.6130.12
4_R115_D0.6130.12
259_E267_N0.6090.12
168_H186_A0.6090.12
91_K124_V0.6080.12
144_S174_P0.6050.12
160_L176_E0.6040.12
160_L265_H0.6030.12
35_V103_A0.6020.12
33_A99_A0.5990.12
132_V152_T0.5990.12
218_F241_L0.5940.12
17_L198_V0.5930.12
138_F142_A0.5910.12
31_T107_A0.5900.12
254_E273_E0.5900.12
58_L99_A0.5890.12
252_G257_I0.5860.12
149_V171_V0.5820.12
180_S248_Y0.5820.12
69_R109_G0.5810.12
105_L192_S0.5800.12
63_V104_T0.5790.12
179_Y229_A0.5790.12
55_D228_P0.5780.12
159_L213_V0.5770.12
34_S226_T0.5760.12
90_L135_T0.5710.11
135_T245_G0.5710.11
89_G245_G0.5710.11
136_G243_G0.5710.11
136_G245_G0.5710.11
89_G243_G0.5710.11
89_G136_G0.5710.11
89_G135_T0.5710.11
90_L245_G0.5710.11
135_T243_G0.5710.11
90_L243_G0.5710.11
90_L136_G0.5710.11
166_E196_E0.5710.11
115_D125_Q0.5700.11
51_H84_V0.5680.11
163_D207_Y0.5660.11
98_N241_L0.5650.11
104_T224_F0.5610.11
74_Q115_D0.5610.11
153_D197_H0.5610.11
148_G250_A0.5600.11
131_G203_A0.5600.11
34_S43_G0.5540.11
13_V65_R0.5520.11
54_A78_V0.5510.11
63_V81_E0.5490.11
34_S200_A0.5490.11
79_R205_G0.5470.11
15_N31_T0.5440.11
29_I275_T0.5440.11
26_A130_A0.5400.11
119_A192_S0.5390.11
77_H229_A0.5370.11
38_T225_P0.5350.11
18_A169_A0.5340.11
29_I236_A0.5320.11
104_T129_D0.5300.11
107_A143_A0.5300.11
76_G172_W0.5280.11
17_L150_A0.5280.11
170_A252_G0.5260.11
20_G188_C0.5230.11
183_A211_M0.5230.11
13_V271_V0.5230.11
44_V73_G0.5220.11
68_D271_V0.5210.11
23_A128_R0.5210.11
99_A246_P0.5200.11
172_W276_T0.5190.11
147_G214_N0.5190.11
34_S266_E0.5190.11
68_D208_G0.5180.11
42_S74_Q0.5160.11
153_D270_T0.5150.11
179_Y260_V0.5150.11
152_T215_G0.5140.11
80_T244_T0.5140.11
84_V262_T0.5120.11
44_V229_A0.5120.11
45_S72_D0.5110.11
26_A277_Q0.5100.11
7_A46_G0.5100.11
106_D207_Y0.5060.10
81_E266_E0.5040.10
47_E256_G0.5040.10
28_D107_A0.5010.10
227_A256_G0.5010.10
7_A129_D0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n3oA 2 0.9718 100 0.738 Contact Map
1h72C 2 0.9648 100 0.74 Contact Map
4p52A 2 0.9683 100 0.74 Contact Map
4hacA 2 0.9542 100 0.744 Contact Map
3hulA 4 0.8908 100 0.745 Contact Map
3qt5A 2 0.9542 100 0.746 Contact Map
3k85A 3 0.9085 100 0.747 Contact Map
3pyfA 1 0.9261 99.9 0.75 Contact Map
1kkhA 1 0.9577 99.9 0.753 Contact Map
2hfsA 1 0.9683 99.9 0.755 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.