GREMLIN Database
Q9HQA4 - Phosphoesterase
UniProt: Q9HQA4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (195)
Sequences: 717 (552)
Seq/√Len: 39.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_V132_F5.7461.00
148_T198_A4.4711.00
157_A209_G4.4491.00
21_R64_D4.3551.00
22_A67_V3.4661.00
66_L98_A3.2381.00
12_A57_L3.1311.00
65_R97_P3.1201.00
69_L132_F3.0361.00
204_N207_S2.8571.00
13_A198_A2.8441.00
68_V72_V2.6351.00
136_H139_P2.5671.00
154_E199_V2.4431.00
50_R204_N2.4421.00
30_A50_R2.3971.00
15_A20_G2.3881.00
157_A169_V2.3031.00
8_L11_P2.3001.00
25_V54_L2.1080.99
65_R99_T2.0700.99
10_E60_E2.0690.99
159_R167_T1.9550.99
67_V132_F1.8760.98
32_I207_S1.8350.98
8_L61_E1.8210.98
175_R198_A1.8200.98
11_P53_R1.7050.97
148_T175_R1.6920.97
162_D166_G1.6570.96
10_E56_R1.6410.96
174_L199_V1.6350.96
53_R203_F1.6340.96
126_V147_E1.5870.95
44_E74_H1.5390.94
66_L96_V1.4980.93
24_V131_G1.4490.92
130_V148_T1.4320.92
46_R50_R1.4220.91
162_D165_G1.4180.91
148_T176_G1.3890.90
34_V75_A1.3870.90
157_A211_W1.3330.88
161_T167_T1.3020.87
66_L212_V1.2930.87
33_E46_R1.2710.86
20_G127_L1.2670.86
22_A65_R1.2610.85
58_V63_A1.2440.85
12_A25_V1.2390.84
25_V138_W1.2320.84
23_L57_L1.2310.84
32_I36_L1.2290.84
14_V61_E1.2270.84
150_C198_A1.2260.84
58_V92_D1.2170.83
158_V222_P1.2130.83
75_A107_S1.1890.82
69_L204_N1.1850.82
48_P52_R1.1770.81
83_E86_E1.1750.81
14_V21_R1.1710.81
55_R93_A1.1690.81
49_Q205_D1.1610.80
24_V69_L1.1400.79
67_V99_T1.1320.78
21_R48_P1.1250.78
24_V67_V1.1240.78
124_G131_G1.1190.78
157_A202_A1.1000.76
55_R59_R1.0970.76
85_E160_L1.0970.76
102_V112_V1.0920.76
200_F207_S1.0850.75
136_H151_I1.0850.75
33_E47_G1.0730.75
10_E173_W1.0600.74
54_L203_F1.0560.73
32_I73_G1.0550.73
101_V123_D1.0510.73
94_V98_A1.0440.73
65_R127_L1.0430.72
7_V12_A1.0310.72
176_G218_G1.0180.71
202_A207_S1.0120.70
37_R207_S1.0010.69
34_V87_L0.9940.69
196_D203_F0.9910.69
42_E206_L0.9910.69
98_A119_V0.9820.68
62_G129_D0.9800.68
36_L206_L0.9800.68
21_R56_R0.9800.68
124_G139_P0.9730.67
18_G171_R0.9710.67
140_S169_V0.9480.65
203_F206_L0.9470.65
154_E213_N0.9450.65
46_R206_L0.9410.64
76_I108_G0.9390.64
177_P226_A0.9310.64
64_D137_T0.9190.63
91_F98_A0.9160.62
32_I208_G0.9100.62
105_H153_H0.9090.62
130_V198_A0.8980.61
209_G220_L0.8960.61
133_A149_V0.8960.61
19_G167_T0.8920.60
165_G209_G0.8890.60
151_I197_L0.8810.59
81_E87_L0.8740.59
57_L61_E0.8720.59
172_A208_G0.8710.58
133_A223_F0.8690.58
204_N208_G0.8680.58
31_G100_V0.8650.58
91_F96_V0.8640.58
29_H105_H0.8600.57
118_T122_S0.8590.57
93_A200_F0.8580.57
173_W198_A0.8560.57
26_A69_L0.8560.57
135_G222_P0.8500.57
63_A177_P0.8490.56
15_A132_F0.8440.56
48_P59_R0.8420.56
19_G147_E0.8250.54
171_R211_W0.8200.54
170_Q204_N0.8180.54
99_T120_T0.8170.54
11_P175_R0.8130.53
32_I50_R0.8100.53
158_V217_Q0.8060.53
136_H222_P0.8060.53
37_R42_E0.8040.52
60_E64_D0.8010.52
60_E167_T0.7890.51
72_V170_Q0.7850.51
12_A203_F0.7850.51
50_R135_G0.7830.50
30_A68_V0.7820.50
91_F94_V0.7800.50
29_H153_H0.7760.50
36_L41_L0.7730.50
25_V217_Q0.7730.50
101_V122_S0.7730.50
69_L151_I0.7670.49
13_A26_A0.7600.48
214_V218_G0.7570.48
64_D145_E0.7560.48
126_V129_D0.7540.48
118_T121_P0.7490.47
35_S81_E0.7470.47
133_A202_A0.7460.47
26_A60_E0.7400.47
26_A100_V0.7390.46
54_L90_L0.7370.46
44_E218_G0.7360.46
85_E95_D0.7330.46
31_G87_L0.7310.46
80_E98_A0.7300.46
34_V127_L0.7280.45
111_D119_V0.7280.45
32_I170_Q0.7250.45
92_D216_G0.7230.45
33_E87_L0.7230.45
31_G72_V0.7230.45
35_S107_S0.7200.45
115_A160_L0.7180.45
88_A97_P0.7160.44
101_V198_A0.7160.44
150_C200_F0.7160.44
73_G83_E0.7110.44
7_V30_A0.7090.44
35_S83_E0.7080.44
58_V94_V0.7070.44
43_V80_E0.7060.44
44_E97_P0.6980.43
46_R72_V0.6960.43
25_V150_C0.6950.43
66_L172_A0.6910.42
86_E214_V0.6900.42
154_E158_V0.6880.42
43_V210_T0.6870.42
60_E101_V0.6870.42
127_L215_D0.6820.41
97_P118_T0.6810.41
10_E53_R0.6800.41
46_R83_E0.6790.41
48_P177_P0.6790.41
64_D92_D0.6750.41
139_P144_L0.6720.40
10_E57_L0.6680.40
13_A92_D0.6620.40
154_E210_T0.6570.39
87_L91_F0.6530.39
62_G200_F0.6530.39
53_R205_D0.6520.39
24_V101_V0.6520.39
50_R207_S0.6440.38
61_E81_E0.6410.38
38_R172_A0.6360.37
59_R216_G0.6350.37
104_N153_H0.6330.37
93_A98_A0.6320.37
25_V44_E0.6250.36
171_R206_L0.6230.36
82_A86_E0.6210.36
135_G139_P0.6200.36
21_R118_T0.6150.36
158_V202_A0.6120.35
62_G226_A0.6110.35
170_Q173_W0.6100.35
87_L223_F0.6090.35
69_L150_C0.6080.35
209_G212_V0.6050.35
35_S75_A0.6030.35
35_S176_G0.6010.34
174_L218_G0.6010.34
164_V207_S0.6000.34
66_L114_P0.5980.34
29_H104_N0.5970.34
213_N219_F0.5940.34
55_R89_A0.5910.34
68_V137_T0.5910.34
174_L212_V0.5910.34
25_V48_P0.5910.34
34_V37_R0.5890.33
38_R125_A0.5890.33
30_A204_N0.5870.33
46_R86_E0.5850.33
134_H155_H0.5830.33
70_G134_H0.5830.33
70_G155_H0.5830.33
71_D155_H0.5830.33
71_D134_H0.5830.33
80_E172_A0.5790.33
107_S136_H0.5750.32
25_V97_P0.5730.32
46_R75_A0.5700.32
79_P165_G0.5700.32
34_V47_G0.5690.32
26_A72_V0.5650.32
78_A120_T0.5640.31
128_G176_G0.5630.31
66_L77_G0.5630.31
140_S145_E0.5610.31
14_V58_V0.5610.31
161_T213_N0.5590.31
65_R130_V0.5570.31
99_T114_P0.5550.31
24_V51_R0.5540.31
73_G87_L0.5520.31
63_A114_P0.5470.30
94_V199_V0.5450.30
24_V150_C0.5440.30
86_E159_R0.5430.30
35_S45_G0.5430.30
75_A210_T0.5400.30
208_G220_L0.5390.30
25_V117_V0.5390.30
24_V95_D0.5320.29
148_T212_V0.5300.29
13_A205_D0.5300.29
57_L203_F0.5290.29
25_V68_V0.5280.29
76_I209_G0.5270.29
25_V203_F0.5260.29
171_R200_F0.5250.28
18_G129_D0.5250.28
11_P204_N0.5240.28
74_H200_F0.5190.28
52_R59_R0.5180.28
80_E83_E0.5170.28
31_G158_V0.5160.28
58_V62_G0.5140.28
23_L104_N0.5140.28
36_L77_G0.5140.28
101_V177_P0.5140.28
83_E172_A0.5140.28
19_G86_E0.5130.28
129_D147_E0.5080.27
25_V140_S0.5070.27
70_G103_G0.5040.27
103_G134_H0.5040.27
103_G155_H0.5040.27
71_D103_G0.5040.27
159_R211_W0.5030.27
35_S50_R0.5030.27
22_A146_A0.5000.27
128_G225_P0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xm7A 1 0.664 99.5 0.794 Contact Map
1su1A 3 0.6964 99.4 0.804 Contact Map
1z2wA 2 0.6883 99.2 0.819 Contact Map
1s3lA 1 0.6154 99.2 0.819 Contact Map
4nzvA 1 0.9109 99.2 0.821 Contact Map
3thoB 2 0.8543 99.2 0.824 Contact Map
2a22A 1 0.7652 99.2 0.825 Contact Map
3d03A 5 0.8097 99.1 0.83 Contact Map
3t1iA 2 0.8502 99.1 0.831 Contact Map
2kknA 1 0.5951 99 0.837 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.