GREMLIN Database
Q9HQA2 - Uncharacterized protein
UniProt: Q9HQA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 460 (374)
Sequences: 803 (548)
Seq/√Len: 28.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_L184_V5.5861.00
135_G154_L4.9011.00
155_E158_D4.8881.00
390_T393_D4.2891.00
99_I113_A3.6971.00
226_T233_E3.6741.00
337_C340_C3.4821.00
367_L376_A3.2161.00
324_V386_V3.1881.00
267_I270_V3.1601.00
307_R311_A3.0321.00
202_D205_A3.0071.00
123_I132_I2.9001.00
167_V176_L2.8981.00
125_Y128_D2.8721.00
396_E400_E2.8711.00
146_Y178_F2.6631.00
113_A137_L2.6260.99
202_D244_E2.4940.99
137_L146_Y2.4420.99
451_A455_L2.4310.99
217_A241_L2.3860.99
348_Q353_G2.3640.99
267_I287_S2.3620.99
320_L367_L2.3140.99
365_A378_L2.2710.98
238_S249_P2.2680.98
121_R132_I2.2140.98
137_L162_I2.2120.98
380_R384_A2.2100.98
99_I144_I2.1880.98
178_F182_A2.1660.98
446_D449_A2.1570.98
340_C349_C2.1440.98
389_G393_D2.1330.98
333_L359_D2.1110.97
304_M309_A2.1060.97
171_E199_G2.1060.97
337_C352_H2.0810.97
273_R280_S2.0660.97
220_T242_G2.0530.97
158_D186_S2.0440.97
135_G148_A2.0050.97
340_C352_H1.9790.96
198_G217_A1.9280.96
81_R86_D1.9150.95
325_I368_D1.9040.95
79_L82_K1.8810.95
81_R85_D1.8650.95
130_H149_W1.8530.95
337_C349_C1.8420.94
79_L83_Y1.8280.94
363_V387_Y1.8210.94
309_A429_D1.8190.94
304_M308_D1.8140.94
305_A310_V1.8010.94
162_I178_F1.7630.93
82_K85_D1.7440.93
283_V287_S1.7430.93
206_L248_L1.7420.93
335_K347_G1.7410.92
80_R84_G1.7150.92
162_I327_I1.7060.92
81_R84_G1.7000.92
146_Y182_A1.6820.91
79_L85_D1.6770.91
200_D266_R1.6680.91
218_V264_S1.6660.91
328_R375_T1.6610.91
83_Y86_D1.6310.90
306_I310_V1.6280.90
115_V137_L1.6020.89
308_D442_E1.5980.89
251_T277_G1.5880.88
376_A424_G1.5680.88
157_G227_I1.5660.88
200_D214_N1.5640.88
215_V445_D1.5510.87
229_G232_G1.5410.87
414_D418_R1.5370.87
287_S306_I1.5350.87
346_T355_V1.5230.86
80_R83_Y1.5180.86
397_Q406_V1.4730.84
417_G427_S1.4680.84
224_E431_Y1.4560.84
297_E442_E1.4430.83
313_G316_Y1.4430.83
206_L213_R1.4420.83
301_P310_V1.4370.83
305_A308_D1.4360.83
308_D372_D1.3920.81
142_G284_S1.3750.80
240_V247_R1.3660.79
78_S85_D1.3660.79
448_A451_A1.3640.79
321_V450_R1.3640.79
105_D109_V1.3610.79
78_S82_K1.3520.79
121_R158_D1.3510.79
78_S81_R1.3500.79
303_R310_V1.3480.79
132_I149_W1.3480.79
80_R86_D1.3450.78
198_G290_E1.3430.78
384_A418_R1.3420.78
113_A162_I1.3330.78
78_S90_P1.3290.78
332_G411_I1.3220.77
317_D425_H1.3190.77
403_D406_V1.3160.77
136_E145_S1.3130.77
358_E392_A1.3100.77
241_L381_E1.3030.76
143_R268_E1.2840.75
135_G146_Y1.2790.75
274_E278_V1.2720.74
363_V383_T1.2720.74
219_V222_V1.2590.74
308_D311_A1.2460.73
423_R440_F1.2400.72
127_G137_L1.2380.72
100_A193_M1.2240.71
145_S175_E1.2220.71
286_F458_V1.2190.71
248_L350_R1.2100.71
424_G439_A1.2040.70
140_E206_L1.2030.70
85_D90_P1.1980.70
306_I372_D1.1890.69
304_M310_V1.1850.69
429_D438_I1.1840.69
377_I424_G1.1840.69
378_L386_V1.1710.68
82_K90_P1.1680.68
83_Y90_P1.1620.67
267_I289_V1.1610.67
165_A176_L1.1470.66
158_D386_V1.1350.65
134_E145_S1.1330.65
101_D203_L1.1210.65
452_A455_L1.1180.64
121_R226_T1.1160.64
312_R316_Y1.1110.64
321_V421_R1.1060.63
264_S325_I1.0990.63
215_V281_V1.0880.62
388_G431_Y1.0850.62
177_N314_G1.0820.62
148_A162_I1.0820.62
378_L439_A1.0800.62
300_G305_A1.0780.61
162_I393_D1.0780.61
270_V283_V1.0740.61
270_V281_V1.0580.60
137_L154_L1.0500.59
250_F267_I1.0480.59
84_G90_P1.0440.59
223_E240_V1.0400.59
84_G92_G1.0390.59
78_S86_D1.0380.58
79_L407_V1.0330.58
182_A380_R1.0300.58
407_V446_D1.0300.58
303_R309_A1.0290.58
453_A456_A1.0290.58
224_E308_D1.0280.58
298_V306_I1.0270.58
334_I343_V1.0240.57
245_T420_F1.0240.57
157_G222_V1.0240.57
86_D90_P1.0130.57
160_V186_S1.0000.56
386_V397_Q0.9980.55
123_I130_H0.9950.55
114_T194_A0.9940.55
90_P297_E0.9890.55
447_P451_A0.9890.55
360_D379_D0.9870.55
361_L387_Y0.9870.55
343_V391_L0.9870.55
104_T174_P0.9800.54
403_D411_I0.9800.54
150_E210_D0.9760.54
227_I234_T0.9760.54
311_A390_T0.9750.54
298_V309_A0.9730.54
137_L144_I0.9730.54
317_D339_D0.9720.53
335_K357_A0.9720.53
349_C352_H0.9660.53
121_R238_S0.9630.53
239_G254_D0.9620.53
296_V309_A0.9610.53
336_R347_G0.9580.52
324_V354_A0.9540.52
306_I309_A0.9520.52
82_K86_D0.9480.52
339_D381_E0.9460.51
226_T235_E0.9450.51
251_T254_D0.9370.51
86_D458_V0.9360.51
361_L391_L0.9350.51
178_F291_R0.9290.50
204_A245_T0.9260.50
387_Y411_I0.9200.49
214_N334_I0.9180.49
215_V223_E0.9170.49
301_P306_I0.9160.49
79_L84_G0.9130.49
165_A170_W0.9110.49
80_R85_D0.9010.48
121_R413_E0.8990.48
334_I379_D0.8980.48
129_D215_V0.8980.48
333_L395_R0.8940.47
338_P381_E0.8890.47
98_D101_D0.8890.47
301_P309_A0.8880.47
357_A450_R0.8870.47
161_T173_S0.8860.47
348_Q373_S0.8780.46
357_A395_R0.8770.46
362_R381_E0.8770.46
79_L86_D0.8760.46
84_G307_R0.8740.46
206_L423_R0.8700.46
100_A426_L0.8660.45
239_G378_L0.8620.45
110_T167_V0.8620.45
179_G270_V0.8620.45
133_G175_E0.8500.44
121_R441_A0.8460.44
363_V417_G0.8460.44
302_T411_I0.8440.44
193_M222_V0.8430.44
298_V310_V0.8420.43
176_L438_I0.8400.43
222_V255_P0.8380.43
155_E160_V0.8380.43
320_L372_D0.8370.43
78_S84_G0.8360.43
290_E373_S0.8360.43
135_G178_F0.8360.43
434_N442_E0.8340.43
294_H436_E0.8320.43
97_V101_D0.8310.43
144_I167_V0.8290.42
99_I427_S0.8280.42
306_I444_D0.8280.42
311_A374_V0.8270.42
232_G235_E0.8250.42
120_K203_L0.8240.42
191_I200_D0.8210.42
198_G398_A0.8180.42
376_A439_A0.8160.41
81_R90_P0.8150.41
136_E219_V0.8150.41
133_G153_G0.8100.41
149_W268_E0.8070.41
119_G134_E0.8050.41
116_L138_A0.8010.40
384_A387_Y0.7980.40
119_G169_E0.7960.40
98_D140_E0.7950.40
376_A443_R0.7930.40
321_V441_A0.7900.40
208_A211_R0.7890.39
397_Q410_T0.7890.39
266_R269_D0.7880.39
344_V357_A0.7880.39
148_A275_F0.7850.39
248_L281_V0.7810.39
148_A165_A0.7790.39
109_V174_P0.7780.39
367_L424_G0.7760.39
365_A382_L0.7750.38
383_T418_R0.7740.38
202_D382_L0.7730.38
181_S325_I0.7730.38
356_E392_A0.7690.38
298_V301_P0.7680.38
124_R294_H0.7660.38
318_V426_L0.7650.38
319_E423_R0.7650.38
324_V456_A0.7650.38
79_L92_G0.7630.38
213_R456_A0.7590.37
155_E294_H0.7570.37
317_D440_F0.7570.37
227_I296_V0.7570.37
367_L422_V0.7560.37
165_A438_I0.7510.37
244_E410_T0.7510.37
172_G338_P0.7490.37
157_G317_D0.7460.36
291_R296_V0.7440.36
341_G360_D0.7360.36
364_K375_T0.7340.35
271_Y293_D0.7330.35
153_G282_N0.7320.35
157_G290_E0.7290.35
386_V442_E0.7280.35
90_P93_G0.7270.35
137_L455_L0.7250.35
102_V345_Q0.7250.35
250_F270_V0.7240.35
132_I242_G0.7240.35
121_R178_F0.7220.35
446_D452_A0.7220.35
264_S292_L0.7220.35
165_A434_N0.7180.34
423_R441_A0.7170.34
327_I409_D0.7110.34
400_E458_V0.7110.34
358_E383_T0.7110.34
252_D334_I0.7110.34
294_H311_A0.7100.34
119_G411_I0.7080.34
242_G426_L0.7080.34
193_M344_V0.7070.34
104_T215_V0.7040.33
132_I175_E0.7030.33
448_A452_A0.6980.33
416_V422_V0.6980.33
224_E232_G0.6970.33
168_R203_L0.6970.33
320_L324_V0.6950.33
215_V241_L0.6950.33
188_D265_V0.6930.33
123_I140_E0.6920.33
187_A287_S0.6900.32
222_V263_A0.6880.32
117_T156_P0.6880.32
200_D217_A0.6870.32
201_R448_A0.6860.32
241_L365_A0.6830.32
451_A458_V0.6830.32
265_V289_V0.6820.32
153_G173_S0.6780.32
301_P313_G0.6750.31
225_R238_S0.6750.31
409_D414_D0.6740.31
78_S83_Y0.6720.31
107_G164_N0.6710.31
264_S280_S0.6700.31
80_R90_P0.6700.31
305_A371_T0.6690.31
114_T198_G0.6670.31
173_S324_V0.6670.31
231_D235_E0.6660.31
137_L178_F0.6640.31
85_D457_E0.6640.31
429_D436_E0.6640.31
258_E318_V0.6640.31
386_V415_V0.6630.31
333_L361_L0.6600.30
258_E287_S0.6600.30
143_R149_W0.6590.30
365_A439_A0.6590.30
334_I360_D0.6590.30
152_F180_E0.6580.30
90_P309_A0.6580.30
161_T187_A0.6570.30
453_A457_E0.6570.30
300_G310_V0.6560.30
109_V347_G0.6560.30
213_R421_R0.6550.30
303_R306_I0.6550.30
126_Q429_D0.6540.30
222_V405_S0.6530.30
330_G437_T0.6520.30
292_L432_G0.6520.30
448_A453_A0.6520.30
133_G194_A0.6500.30
115_V300_G0.6490.30
307_R310_V0.6480.30
238_S242_G0.6480.30
111_V129_D0.6470.30
118_A352_H0.6450.29
109_V144_I0.6450.29
334_I342_R0.6440.29
447_P450_R0.6440.29
81_R418_R0.6440.29
124_R129_D0.6430.29
300_G303_R0.6420.29
136_E165_A0.6380.29
224_E443_R0.6380.29
358_E384_A0.6370.29
184_V338_P0.6360.29
332_G335_K0.6340.29
205_A408_A0.6330.29
256_H287_S0.6320.29
282_N367_L0.6310.29
185_T265_V0.6290.28
220_T294_H0.6280.28
269_D426_L0.6260.28
131_V150_E0.6250.28
102_V111_V0.6240.28
336_R360_D0.6230.28
267_I271_Y0.6210.28
374_V437_T0.6200.28
175_E230_R0.6200.28
173_S350_R0.6170.28
366_V373_S0.6170.28
205_A397_Q0.6150.28
86_D410_T0.6120.27
200_D268_E0.6110.27
157_G195_A0.6100.27
116_L189_G0.6090.27
111_V144_I0.6090.27
90_P250_F0.6090.27
329_D411_I0.6080.27
190_D319_E0.6080.27
113_A135_G0.6080.27
180_E376_A0.6080.27
117_T121_R0.6080.27
391_L425_H0.6070.27
238_S394_A0.6050.27
115_V340_C0.6040.27
115_V432_G0.6030.27
141_T193_M0.6020.27
269_D286_F0.6020.27
121_R289_V0.6010.27
303_R308_D0.6000.27
120_K154_L0.6000.27
343_V351_Q0.5990.27
332_G377_I0.5970.26
176_L203_L0.5960.26
113_A163_G0.5960.26
356_E396_E0.5960.26
335_K359_D0.5950.26
306_I374_V0.5940.26
127_G255_P0.5940.26
142_G254_D0.5920.26
250_F408_A0.5920.26
129_D200_D0.5910.26
219_V233_E0.5900.26
264_S399_R0.5900.26
96_A245_T0.5890.26
134_E149_W0.5880.26
145_S172_G0.5860.26
356_E411_I0.5850.26
201_R267_I0.5850.26
229_G234_T0.5850.26
132_I229_G0.5840.26
292_L378_L0.5830.26
160_V170_W0.5820.26
237_L274_E0.5820.26
131_V375_T0.5810.26
377_I380_R0.5780.25
339_D363_V0.5760.25
241_L250_F0.5740.25
382_L446_D0.5730.25
365_A432_G0.5730.25
122_S129_D0.5730.25
239_G403_D0.5730.25
121_R176_L0.5720.25
167_V203_L0.5700.25
273_R382_L0.5690.25
265_V275_F0.5660.25
331_S383_T0.5660.25
134_E409_D0.5660.25
302_T307_R0.5660.25
275_F280_S0.5650.25
239_G324_V0.5650.25
176_L333_L0.5640.25
154_L325_I0.5620.24
139_D349_C0.5620.24
373_S429_D0.5580.24
106_S140_E0.5570.24
178_F320_L0.5560.24
103_D229_G0.5560.24
284_S287_S0.5540.24
361_L383_T0.5540.24
306_I320_L0.5530.24
120_K183_T0.5520.24
304_M371_T0.5510.24
205_A218_V0.5490.24
149_W328_R0.5490.24
109_V343_V0.5480.24
219_V262_G0.5480.24
338_P355_V0.5480.24
241_L418_R0.5460.24
314_G411_I0.5460.24
199_G365_A0.5450.23
183_T456_A0.5450.23
127_G431_Y0.5440.23
158_D260_E0.5440.23
223_E451_A0.5430.23
184_V193_M0.5420.23
327_I372_D0.5420.23
152_F178_F0.5420.23
90_P414_D0.5400.23
216_E411_I0.5390.23
94_P328_R0.5380.23
119_G132_I0.5380.23
219_V378_L0.5370.23
192_E351_Q0.5370.23
157_G198_G0.5360.23
270_V311_A0.5360.23
322_G422_V0.5360.23
170_W174_P0.5360.23
297_E397_Q0.5350.23
192_E307_R0.5330.23
304_M370_G0.5330.23
376_A417_G0.5300.23
91_S451_A0.5290.23
165_A179_G0.5280.23
91_S155_E0.5280.23
155_E260_E0.5270.22
100_A184_V0.5260.22
317_D423_R0.5260.22
227_I295_E0.5250.22
219_V234_T0.5230.22
198_G292_L0.5230.22
133_G145_S0.5230.22
148_A182_A0.5220.22
85_D371_T0.5220.22
219_V317_D0.5220.22
103_D179_G0.5210.22
320_L442_E0.5190.22
192_E363_V0.5170.22
311_A456_A0.5170.22
160_V214_N0.5170.22
139_D369_D0.5170.22
347_G352_H0.5160.22
297_E306_I0.5160.22
221_E415_V0.5160.22
124_R455_L0.5160.22
86_D93_G0.5160.22
171_E306_I0.5160.22
303_R450_R0.5150.22
172_G352_H0.5150.22
270_V374_V0.5140.22
241_L280_S0.5120.22
117_T132_I0.5120.22
124_R187_A0.5110.22
388_G423_R0.5110.22
233_E287_S0.5110.22
109_V165_A0.5100.22
117_T457_E0.5090.22
184_V194_A0.5090.22
145_S149_W0.5080.21
390_T446_D0.5080.21
221_E240_V0.5080.21
235_E308_D0.5070.21
452_A456_A0.5070.21
82_K223_E0.5060.21
206_L225_R0.5060.21
382_L385_D0.5060.21
146_Y335_K0.5050.21
79_L409_D0.5050.21
191_I386_V0.5030.21
112_T334_I0.5030.21
134_E175_E0.5030.21
325_I410_T0.5010.21
235_E318_V0.5010.21
174_P387_Y0.5010.21
295_E439_A0.5010.21
206_L299_G0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gnxC 1 0.7848 100 0.337 Contact Map
1jmcA 1 0.4674 100 0.635 Contact Map
1l1oC 2 0.3348 100 0.693 Contact Map
3u50C 1 0.3065 100 0.721 Contact Map
1ynxA 1 0.2174 99.9 0.802 Contact Map
2k75A 1 0.2304 99.8 0.842 Contact Map
1wjjA 1 0.2848 99.7 0.85 Contact Map
2kbnA 1 0.2304 99.7 0.854 Contact Map
3dm3A 4 0.2 99.6 0.866 Contact Map
1o7iA 1 0.2435 99.5 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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