GREMLIN Database
Q9HQA1 - Riboflavin-specific deaminase
UniProt: Q9HQA1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (205)
Sequences: 4649 (3719)
Seq/√Len: 259.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_L138_A3.5871.00
4_V41_V3.4181.00
124_T145_R3.3211.00
152_V162_L2.8771.00
141_A145_R2.6541.00
55_D94_R2.4881.00
105_L141_A2.4421.00
43_A81_V2.4291.00
141_A144_S2.3961.00
48_V52_L2.3451.00
33_R174_F2.3251.00
49_G53_A2.2231.00
79_A103_Y2.2111.00
3_V139_L2.2061.00
5_V159_I2.1601.00
178_Q200_T2.1271.00
83_A158_L2.1121.00
57_S94_R2.0261.00
52_L88_R2.0251.00
172_S214_L2.0061.00
46_V154_G1.9761.00
135_L167_L1.9551.00
79_A147_V1.9451.00
27_G211_D1.9081.00
162_L167_L1.8821.00
115_R127_V1.8411.00
9_M175_V1.8231.00
46_V51_V1.8201.00
15_L156_G1.8111.00
5_V168_V1.7781.00
37_L151_M1.7741.00
139_L162_L1.7401.00
10_S180_I1.7291.00
178_Q198_F1.7201.00
205_G216_A1.7101.00
45_M162_L1.6581.00
170_E216_A1.6541.00
115_R119_E1.5881.00
101_E124_T1.5841.00
174_F214_L1.5781.00
12_D181_G1.5641.00
84_D88_R1.5511.00
7_A159_I1.5491.00
52_L90_P1.5481.00
87_A106_V1.5151.00
48_V89_T1.5141.00
45_M158_L1.5001.00
37_L172_S1.4981.00
51_V95_L1.4971.00
33_R214_L1.4831.00
48_V88_R1.4771.00
2_H170_E1.4651.00
39_A60_L1.4451.00
42_D148_D1.4331.00
135_L162_L1.4311.00
4_V172_S1.4171.00
43_A150_L1.4111.00
203_L215_L1.4091.00
27_G212_G1.3971.00
137_S141_A1.3781.00
29_A210_D1.3751.00
24_T31_F1.3661.00
7_A173_V1.3561.00
82_V95_L1.3491.00
106_V125_V1.3341.00
27_G30_D1.3291.00
81_V142_L1.3261.00
83_A138_A1.3101.00
175_V215_L1.3101.00
91_P117_S1.2791.00
126_V141_A1.2751.00
41_V149_R1.2441.00
105_L126_V1.2441.00
21_E195_V1.2291.00
95_L102_T1.2141.00
43_A147_V1.2001.00
9_M173_V1.1941.00
45_M83_A1.1931.00
85_S107_A1.1921.00
10_S178_Q1.1821.00
147_V150_L1.1681.00
208_R211_D1.1601.00
116_E120_A1.1531.00
26_S30_D1.1501.00
206_V213_V1.1401.00
180_I195_V1.1381.00
10_S25_L1.1241.00
21_E196_A1.0911.00
166_E199_P1.0711.00
30_D174_F1.0701.00
5_V163_F1.0661.00
140_D144_S1.0591.00
82_V89_T1.0531.00
48_V96_L1.0461.00
134_D137_S1.0461.00
5_V152_V1.0441.00
116_E119_E1.0411.00
136_P165_E1.0401.00
160_F164_A1.0321.00
52_L84_D1.0291.00
89_T104_V1.0281.00
152_V158_L1.0241.00
143_E148_D1.0111.00
25_L176_A1.0071.00
9_M188_L1.0001.00
51_V89_T0.9981.00
124_T127_V0.9911.00
48_V85_S0.9891.00
135_L139_L0.9811.00
45_M147_V0.9781.00
156_G190_D0.9711.00
87_A110_E0.9671.00
159_I168_V0.9581.00
135_L165_E0.9571.00
107_A133_V0.9551.00
109_A127_V0.9551.00
85_S133_V0.9521.00
51_V93_A0.9441.00
38_R153_E0.9401.00
90_P93_A0.9251.00
107_A110_E0.9231.00
33_R36_E0.9191.00
59_T100_A0.9171.00
208_R213_V0.9101.00
48_V84_D0.9091.00
137_S140_D0.9051.00
80_R102_T0.8991.00
4_V170_E0.8961.00
93_A96_L0.8921.00
33_R207_D0.8911.00
36_E40_S0.8791.00
135_L138_A0.8751.00
28_D32_E0.8741.00
6_N30_D0.8701.00
133_V138_A0.8681.00
103_Y126_V0.8671.00
85_S132_R0.8671.00
207_D216_A0.8661.00
4_V149_R0.8631.00
89_T96_L0.8551.00
103_Y145_R0.8480.99
46_V82_V0.8470.99
87_A114_H0.8410.99
45_M150_L0.8410.99
96_L123_A0.8340.99
3_V152_V0.8330.99
163_F168_V0.8230.99
41_V151_M0.8220.99
30_D212_G0.8170.99
106_V127_V0.8150.99
128_A133_V0.8140.99
33_R172_S0.8120.99
179_L201_F0.8110.99
33_R37_L0.8070.99
6_N34_V0.8040.99
60_L77_H0.8000.99
94_R97_D0.7980.99
158_L162_L0.7950.99
47_G154_G0.7950.99
108_E127_V0.7930.99
42_D149_R0.7880.99
157_E161_S0.7820.99
204_T216_A0.7820.99
136_P140_D0.7760.99
114_H117_S0.7690.99
129_G134_D0.7630.99
17_T180_I0.7620.99
6_N174_F0.7610.99
4_V37_L0.7600.99
103_Y106_V0.7590.99
14_K183_R0.7540.99
209_L214_L0.7540.99
43_A79_A0.7520.99
103_Y124_T0.7440.99
139_L150_L0.7430.99
17_T21_E0.7350.99
84_D87_A0.7340.98
203_L206_V0.7340.98
29_A211_D0.7340.98
203_L213_V0.7310.98
201_F215_L0.7300.98
14_K186_P0.7280.98
114_H118_L0.7240.98
119_E122_G0.7220.98
187_T190_D0.7180.98
25_L195_V0.7180.98
80_R100_A0.7120.98
154_G159_I0.7100.98
49_G88_R0.7090.98
22_Q31_F0.7080.98
158_L161_S0.7050.98
97_D100_A0.7030.98
128_A137_S0.7010.98
10_S17_T0.6970.98
134_D165_E0.6940.98
176_A212_G0.6860.98
4_V151_M0.6840.98
55_D93_A0.6830.98
81_V105_L0.6820.98
118_L123_A0.6780.97
206_V215_L0.6770.97
175_V213_V0.6770.97
83_A105_L0.6710.97
118_L122_G0.6700.97
161_S165_E0.6650.97
135_L158_L0.6620.97
35_D60_L0.6620.97
140_D143_E0.6610.97
8_A26_S0.6600.97
14_K184_D0.6580.97
195_V198_F0.6570.97
126_V145_R0.6560.97
183_R186_P0.6530.97
171_L179_L0.6520.97
115_R118_L0.6500.97
32_E36_E0.6500.97
182_G189_A0.6490.97
79_A101_E0.6490.97
6_N26_S0.6470.97
89_T95_L0.6430.97
33_R209_L0.6360.96
46_V56_P0.6340.96
119_E124_T0.6340.96
170_E203_L0.6310.96
54_D58_L0.6300.96
34_V151_M0.6300.96
7_A171_L0.6280.96
30_D209_L0.6280.96
45_M152_V0.6260.96
11_A175_V0.6220.96
46_V58_L0.6210.96
21_E25_L0.6180.96
172_S216_A0.6140.96
16_S20_R0.6140.96
26_S34_V0.6130.95
59_T80_R0.6120.95
37_L174_F0.6100.95
105_L133_V0.6090.95
200_T211_D0.6060.95
97_D121_A0.6060.95
37_L41_V0.6050.95
45_M139_L0.6050.95
29_A32_E0.6040.95
101_E145_R0.6030.95
157_E183_R0.6020.95
14_K187_T0.6010.95
182_G186_P0.6000.95
44_V77_H0.5990.95
57_S98_G0.5990.95
50_T154_G0.5990.95
73_G77_H0.5990.95
31_F174_F0.5970.95
128_A141_A0.5960.95
51_V82_V0.5940.95
89_T118_L0.5920.95
26_S31_F0.5910.95
83_A162_L0.5900.94
132_R157_E0.5880.94
163_F171_L0.5880.94
87_A104_V0.5870.94
106_V110_E0.5820.94
45_M81_V0.5800.94
30_D33_R0.5790.94
14_K182_G0.5780.94
152_V159_I0.5770.94
52_L89_T0.5760.94
55_D92_D0.5760.94
119_E125_V0.5760.94
162_L168_V0.5740.94
40_S149_R0.5710.93
110_E115_R0.5710.93
83_A135_L0.5690.93
96_L118_L0.5680.93
135_L161_S0.5660.93
202_E211_D0.5610.93
49_G157_E0.5610.93
38_R54_D0.5590.93
182_G187_T0.5570.93
16_S24_T0.5570.93
48_V93_A0.5550.92
49_G52_L0.5540.92
54_D80_R0.5540.92
96_L121_A0.5520.92
168_V171_L0.5480.92
205_G208_R0.5390.91
104_V118_L0.5380.91
89_T93_A0.5330.91
7_A15_L0.5320.91
189_A192_D0.5320.91
187_T191_G0.5310.91
37_L40_S0.5290.91
115_R125_V0.5280.91
39_A76_P0.5260.90
41_V172_S0.5250.90
77_H98_G0.5240.90
96_L102_T0.5240.90
111_P115_R0.5240.90
60_L78_P0.5220.90
183_R192_D0.5220.90
34_V195_V0.5220.90
128_A138_A0.5100.89
7_A188_L0.5080.89
89_T114_H0.5040.88
11_A201_F0.5020.88
17_T22_Q0.5010.88
86_H109_A0.5000.88
207_D214_L0.5000.88
54_D153_E0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3zA 3 0.9591 100 0.234 Contact Map
2aznA 2 0.9545 100 0.242 Contact Map
2g6vA 2 0.9727 100 0.256 Contact Map
2p4gA 2 0.9864 100 0.261 Contact Map
4ha7A 2 0.85 100 0.293 Contact Map
3zpgA 2 0.9182 100 0.309 Contact Map
2hxvA 2 0.8864 100 0.334 Contact Map
2gd9A 2 0.7545 100 0.484 Contact Map
3jtwA 2 0.7773 100 0.504 Contact Map
1cz3A 2 0.7364 100 0.515 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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