GREMLIN Database
Q9HQ99 - Uncharacterized protein
UniProt: Q9HQ99 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 94 (87)
Sequences: 127 (81)
Seq/√Len: 8.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_L71_H3.1730.92
34_G38_A2.7980.86
16_L70_G2.6300.82
64_L68_S2.4730.78
78_A85_V2.2550.71
43_M50_D2.2020.69
16_L51_G2.0460.63
73_W93_T2.0390.63
51_G67_F1.9800.60
51_G70_G1.9590.59
50_D54_F1.8290.54
43_M54_F1.8170.53
20_L59_D1.7060.49
71_H78_A1.6730.47
10_D55_R1.5960.44
47_Y50_D1.5720.43
64_L74_L1.5540.42
36_A48_L1.5390.42
43_M47_Y1.5290.41
13_E51_G1.5200.41
54_F62_N1.3890.36
8_K83_F1.3660.35
64_L70_G1.2910.32
78_A93_T1.2620.31
67_F70_G1.2590.31
43_M59_D1.2580.31
16_L67_F1.2280.29
24_D84_D1.2200.29
7_E56_A1.2050.29
72_A76_A1.1770.28
48_L52_R1.1110.26
28_P31_S1.0920.25
44_A67_F1.0900.25
11_R68_S1.0700.24
45_E49_E1.0600.24
23_A64_L1.0480.24
11_R27_P1.0480.24
42_E74_L1.0350.23
7_E11_R1.0290.23
40_Y72_A1.0030.22
51_G64_L0.9990.22
23_A53_H0.9970.22
15_L89_G0.9960.22
9_T70_G0.9740.21
27_P72_A0.9710.21
50_D59_D0.9710.21
17_A38_A0.9680.21
21_A24_D0.9620.21
55_R66_A0.9590.21
12_Y19_A0.9530.21
39_E76_A0.9420.20
47_Y59_D0.9240.20
88_A93_T0.9050.19
37_A83_F0.8990.19
13_E16_L0.8810.19
21_A34_G0.8800.19
22_A88_A0.8710.19
27_P80_I0.8640.18
47_Y54_F0.8440.18
40_Y48_L0.8400.18
15_L64_L0.8370.18
22_A91_L0.8350.18
63_A84_D0.8340.18
32_P39_E0.8340.18
79_R82_L0.8330.18
44_A61_V0.8320.18
65_A72_A0.8280.17
28_P54_F0.8270.17
61_V71_H0.8190.17
41_F72_A0.8190.17
73_W82_L0.8170.17
12_Y79_R0.8150.17
53_H71_H0.8090.17
18_D58_D0.8060.17
13_E70_G0.7990.17
23_A58_D0.7940.17
8_K37_A0.7860.16
23_A61_V0.7860.16
29_A58_D0.7850.16
19_A75_D0.7700.16
28_P73_W0.7650.16
44_A76_A0.7620.16
6_A83_F0.7560.16
17_A49_E0.7490.16
19_A79_R0.7480.16
13_E67_F0.7480.16
75_D79_R0.7420.15
9_T16_L0.7390.15
30_G35_E0.7360.15
23_A74_L0.7350.15
51_G63_A0.7270.15
51_G68_S0.7170.15
42_E46_S0.7080.15
25_P41_F0.7070.15
35_E56_A0.7000.15
18_D76_A0.6890.14
9_T48_L0.6800.14
80_I87_A0.6800.14
78_A89_G0.6770.14
14_G34_G0.6720.14
55_R85_V0.6690.14
23_A68_S0.6680.14
14_G18_D0.6610.14
49_E78_A0.6580.14
70_G90_E0.6540.14
52_R76_A0.6520.14
7_E63_A0.6510.14
29_A45_E0.6470.13
19_A83_F0.6420.13
30_G39_E0.6270.13
41_F80_I0.6180.13
54_F73_W0.5950.12
38_A52_R0.5940.12
21_A28_P0.5920.12
20_L65_A0.5870.12
60_P70_G0.5870.12
50_D53_H0.5830.12
15_L23_A0.5770.12
11_R70_G0.5670.12
87_A93_T0.5500.12
35_E82_L0.5460.12
46_S62_N0.5390.11
82_L89_G0.5330.11
64_L67_F0.5250.11
50_D66_A0.5110.11
6_A33_L0.5100.11
47_Y53_H0.5100.11
8_K70_G0.5060.11
17_A21_A0.5030.11
44_A74_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oo2A 2 0.7979 99.9 0.37 Contact Map
4fzpA 2 0.8511 99.9 0.409 Contact Map
3u84A 2 0.9255 26 0.924 Contact Map
2x5oA 1 0.6702 22.3 0.926 Contact Map
1sf9A 1 0.6702 21.4 0.927 Contact Map
3lk7A 1 0.6809 13.9 0.933 Contact Map
3j8bE 1 0.7234 13.9 0.933 Contact Map
2yxyA 1 0.6915 13.7 0.933 Contact Map
4gq4A 1 0.766 12.9 0.934 Contact Map
4qinA 2 0.8191 12.6 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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