GREMLIN Database
IF2B - Translation initiation factor 2 subunit beta
UniProt: Q9HQ97 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (118)
Sequences: 609 (361)
Seq/√Len: 33.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_H95_Y5.1691.00
60_F94_A4.3941.00
23_R108_P3.5881.00
43_F58_L3.2191.00
34_E76_R3.0851.00
43_F57_V2.9681.00
111_N124_E2.6931.00
62_Q69_A2.4571.00
112_L121_L2.2530.99
29_P89_S2.0250.98
27_P49_A1.9700.98
90_D99_Y1.9250.97
39_V76_R1.8950.97
52_R100_V1.7850.96
50_L96_V1.7740.96
51_S124_E1.7040.95
40_Y46_T1.6900.94
52_R110_T1.6810.94
114_T117_D1.6800.94
27_P45_A1.6580.94
32_R39_V1.6520.94
101_T108_P1.6070.93
66_G99_Y1.4980.90
17_V60_F1.4940.90
122_H129_R1.4790.89
97_E106_G1.4400.88
72_D76_R1.4390.88
28_D93_D1.4170.87
13_E23_R1.3920.86
123_C126_C1.3910.86
57_V100_V1.3740.85
36_N39_V1.3360.83
97_E121_L1.2960.81
14_K17_V1.2770.81
24_F108_P1.2440.79
59_K80_T1.2110.77
29_P95_Y1.2040.76
43_F71_I1.1790.75
29_P46_T1.1600.74
96_V101_T1.1550.73
93_D101_T1.1460.73
68_S80_T1.1390.72
74_S112_L1.1370.72
106_G122_H1.1290.72
63_N67_T1.1290.72
118_T128_A1.1030.70
56_H67_T1.0890.69
87_R90_D1.0810.68
47_L79_L1.0360.65
40_Y61_L1.0350.65
117_D128_A1.0130.63
31_V88_V0.9870.61
48_D113_E0.9860.61
15_P18_T0.9820.61
66_G76_R0.9820.61
20_S72_D0.9640.59
108_P127_G0.9590.59
30_N41_E0.9540.58
12_D88_V0.9510.58
60_F86_R0.9510.58
34_E104_E0.9460.58
46_T51_S0.9380.57
75_G106_G0.9300.56
116_G120_Q0.9190.56
61_L88_V0.9180.55
47_L57_V0.9100.55
16_D48_D0.9100.55
90_D94_A0.9070.55
21_E107_L0.9020.54
82_E117_D0.8950.54
43_F114_T0.8950.54
19_G22_T0.8940.53
47_L58_L0.8880.53
24_F96_V0.8810.52
27_P125_A0.8790.52
16_D19_G0.8760.52
69_A114_T0.8670.51
74_S79_L0.8580.50
77_A107_L0.8530.50
51_S111_N0.8480.50
40_Y99_Y0.8370.49
44_Q88_V0.8340.48
51_S122_H0.8330.48
12_D15_P0.8240.48
63_N128_A0.8000.46
24_F50_L0.7990.46
25_E96_V0.7970.45
49_A62_Q0.7860.44
66_G78_R0.7830.44
32_R41_E0.7810.44
71_I79_L0.7790.44
31_V85_Q0.7600.42
50_L92_L0.7560.42
111_N122_H0.7490.41
93_D97_E0.7270.40
79_L88_V0.7220.39
35_G65_V0.7210.39
14_K33_K0.7210.39
23_R109_D0.7200.39
57_V111_N0.7120.38
84_G117_D0.7060.38
64_E91_T0.7050.38
26_V93_D0.7040.38
67_T81_G0.7030.38
38_T61_L0.7020.38
60_F95_Y0.6970.37
90_D117_D0.6870.36
35_G108_P0.6860.36
104_E117_D0.6840.36
47_L80_T0.6830.36
108_P125_A0.6820.36
85_Q89_S0.6740.35
32_R80_T0.6670.35
89_S106_G0.6640.35
62_Q79_L0.6630.35
21_E95_Y0.6610.35
43_F99_Y0.6560.34
43_F103_P0.6530.34
61_L101_T0.6510.34
59_K71_I0.6500.34
65_V86_R0.6460.33
89_S122_H0.6450.33
99_Y118_T0.6390.33
13_E25_E0.6370.33
55_D71_I0.6360.33
51_S57_V0.6350.33
74_S97_E0.6300.32
46_T50_L0.6280.32
57_V74_S0.6260.32
61_L83_F0.6240.32
70_S77_A0.6230.32
78_R82_E0.6170.31
103_P128_A0.6050.30
59_K113_E0.6000.30
46_T71_I0.5970.30
86_R90_D0.5960.30
70_S79_L0.5950.30
45_A124_E0.5950.30
24_F125_A0.5910.29
82_E93_D0.5910.29
62_Q80_T0.5850.29
33_K61_L0.5840.29
15_P66_G0.5830.29
15_P69_A0.5820.29
49_A60_F0.5790.29
50_L107_L0.5780.29
72_D78_R0.5750.28
40_Y63_N0.5710.28
30_N70_S0.5700.28
46_T99_Y0.5690.28
13_E75_G0.5680.28
33_K82_E0.5680.28
86_R118_T0.5620.27
95_Y129_R0.5570.27
106_G116_G0.5540.27
117_D120_Q0.5540.27
77_A95_Y0.5540.27
115_D129_R0.5540.27
26_V60_F0.5430.26
16_D113_E0.5420.26
28_D89_S0.5410.26
33_K37_V0.5400.26
61_L111_N0.5400.26
30_N51_S0.5210.25
73_E89_S0.5180.25
17_V39_V0.5160.24
76_R95_Y0.5160.24
44_Q51_S0.5150.24
48_D120_Q0.5140.24
106_G121_L0.5140.24
45_A89_S0.5120.24
68_S125_A0.5120.24
44_Q73_E0.5030.24
27_P124_E0.5020.24
79_L103_P0.5010.24
30_N37_V0.5010.24
56_H64_E0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cw2K 1 1 100 0.048 Contact Map
1neeA 1 0.9924 100 0.057 Contact Map
2d74B 1 0.9924 100 0.065 Contact Map
3j81l 1 0.1136 100 0.072 Contact Map
2g2kA 1 0.9394 100 0.169 Contact Map
2e9hA 1 0.9394 100 0.176 Contact Map
1k8bA 1 0.3939 99.8 0.628 Contact Map
1k81A 1 0.25 99 0.755 Contact Map
4bpeF 1 0.6061 76.7 0.913 Contact Map
3k1fM 1 0.3182 66.3 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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