GREMLIN Database
Y1264 - UPF0212 protein VNG_1264C
UniProt: Q9HQ95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (113)
Sequences: 119 (36)
Seq/√Len: 3.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_A13_V3.4030.64
75_M94_I3.3160.62
9_A73_L3.0080.54
11_V29_K2.6780.45
80_V89_I2.6010.43
50_C53_C2.4580.39
8_E15_D2.3070.35
37_D61_F2.0370.29
40_Y76_T1.9830.28
23_V97_R1.9310.27
39_N77_V1.9260.27
24_R92_K1.8850.26
30_T33_M1.8460.25
2_D55_T1.7900.24
33_M71_L1.7890.24
8_E20_D1.6820.22
36_P75_M1.6540.22
11_V30_T1.6450.21
25_I43_I1.6390.21
29_K33_M1.6310.21
12_P63_A1.6290.21
42_E57_T1.6060.21
2_D77_V1.5910.20
21_E32_E1.5260.19
42_E74_S1.5100.19
30_T71_L1.4940.19
37_D93_E1.4490.18
8_E104_A1.4200.18
18_S36_P1.4120.18
9_A99_A1.4110.17
2_D6_V1.4070.17
75_M83_D1.4050.17
9_A57_T1.3920.17
18_S61_F1.3600.17
55_T58_E1.3280.16
6_V79_N1.2920.16
97_R101_I1.2600.15
27_I81_E1.2540.15
7_V78_F1.2350.15
25_I38_L1.2220.15
88_R98_L1.2080.15
11_V33_M1.1970.14
8_E44_E1.1770.14
38_L77_V1.1660.14
15_D28_S1.1650.14
28_S92_K1.1430.14
25_I36_P1.1240.14
62_V65_D1.1180.13
38_L79_N1.1170.13
21_E29_K1.0960.13
66_E101_I1.0860.13
24_R28_S1.0800.13
40_Y79_N1.0610.13
67_S108_V1.0610.13
42_E99_A1.0470.13
71_L99_A1.0420.13
69_V84_E1.0390.12
19_T44_E1.0240.12
24_R96_Q1.0220.12
33_M42_E0.9920.12
38_L108_V0.9860.12
15_D20_D0.9860.12
94_I109_D0.9790.12
17_Q71_L0.9660.12
47_S81_E0.9610.12
2_D25_I0.9610.12
17_Q37_D0.9560.12
57_T111_V0.9530.12
16_V101_I0.9510.11
55_T64_A0.9490.11
65_D94_I0.9480.11
60_A68_L0.9380.11
25_I39_N0.9330.11
88_R102_P0.9260.11
65_D93_E0.9220.11
35_N82_R0.9070.11
13_V54_G0.9050.11
10_A64_A0.9040.11
62_V107_E0.9020.11
14_Y25_I0.8920.11
12_P92_K0.8820.11
76_T89_I0.8790.11
25_I75_M0.8690.11
73_L99_A0.8470.10
7_V96_Q0.8460.10
71_L93_E0.8370.10
45_M64_A0.8340.10
44_E89_I0.8270.10
14_Y70_A0.8220.10
76_T96_Q0.8200.10
66_E70_A0.8180.10
31_G67_S0.8000.10
13_V38_L0.7800.10
41_V51_P0.7790.10
36_P77_V0.7780.10
15_D44_E0.7630.10
44_E106_L0.7590.10
50_C107_E0.7550.10
14_Y43_I0.7510.09
17_Q73_L0.7390.09
27_I60_A0.7370.09
42_E71_L0.7290.09
28_S44_E0.7270.09
25_I56_D0.7140.09
15_D60_A0.7140.09
28_S58_E0.7140.09
79_N105_V0.7140.09
60_A73_L0.7120.09
62_V73_L0.6910.09
77_V94_I0.6900.09
54_G61_F0.6870.09
48_R56_D0.6800.09
21_E53_C0.6780.09
3_C70_A0.6730.09
38_L75_M0.6580.09
13_V45_M0.6530.09
38_L56_D0.6510.09
50_C91_R0.6460.09
15_D92_K0.6410.09
43_I56_D0.6400.09
20_D47_S0.6320.08
16_V23_V0.6250.08
53_C107_E0.6240.08
21_E66_E0.6240.08
33_M43_I0.6190.08
46_G102_P0.6090.08
87_A107_E0.6070.08
21_E30_T0.6030.08
35_N40_Y0.5930.08
33_M99_A0.5910.08
3_C50_C0.5890.08
30_T99_A0.5870.08
37_D67_S0.5870.08
21_E91_R0.5820.08
53_C91_R0.5790.08
56_D79_N0.5780.08
41_V46_G0.5740.08
36_P76_T0.5690.08
30_T39_N0.5690.08
19_T45_M0.5680.08
48_R106_L0.5660.08
40_Y81_E0.5640.08
81_E99_A0.5640.08
21_E50_C0.5630.08
58_E93_E0.5620.08
68_L84_E0.5620.08
11_V21_E0.5540.08
4_R39_N0.5530.08
3_C80_V0.5520.08
12_P43_I0.5520.08
40_Y93_E0.5410.08
7_V19_T0.5390.08
10_A87_A0.5390.08
60_A72_E0.5360.08
70_A91_R0.5320.08
43_I97_R0.5300.08
7_V34_L0.5280.08
55_T93_E0.5280.08
101_I104_A0.5230.08
8_E101_I0.5200.08
93_E96_Q0.5140.08
61_F74_S0.5130.08
32_E113_D0.5090.08
46_G107_E0.5030.07
24_R81_E0.5030.07
76_T80_V0.5020.07
42_E83_D0.5020.07
25_I58_E0.5000.07
20_D83_D0.5000.07
13_V39_N0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mwaA 4 0.2913 29.3 0.945 Contact Map
2i5oA 1 0.2283 17.8 0.95 Contact Map
1zvfA 2 0.4724 16.8 0.951 Contact Map
4l2nA 2 0.4882 12.5 0.954 Contact Map
3vpbE 1 0.4331 12.3 0.954 Contact Map
3ga8A 1 0.4409 9.8 0.956 Contact Map
1tfeA 2 0.3622 9.6 0.956 Contact Map
1h7bA 2 0.4094 9.1 0.957 Contact Map
4u3eA 2 0.7008 8.5 0.957 Contact Map
3q87A 1 0.5748 7.8 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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