GREMLIN Database
Q9HQ94 - 8-oxoguanine DNA glycosylase
UniProt: Q9HQ94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (267)
Sequences: 1234 (956)
Seq/√Len: 58.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_T250_T5.2641.00
216_T219_D5.2051.00
150_T167_A4.9661.00
80_R86_H4.7661.00
209_A212_L4.2851.00
139_E143_R3.7701.00
151_P158_T3.6891.00
99_D256_Y3.4901.00
123_L231_V3.4481.00
214_R229_D3.3141.00
18_Q31_R3.0071.00
123_L223_V3.0011.00
164_E167_A2.9081.00
213_A232_L2.7141.00
76_A80_R2.5791.00
191_T220_F2.5051.00
132_M136_R2.4071.00
133_R136_R2.3791.00
172_T175_D2.3061.00
189_Q193_A2.2721.00
214_R232_L2.2331.00
120_F124_V2.1631.00
190_R194_M2.1541.00
99_D275_L2.0911.00
210_Y238_Y2.0381.00
210_Y240_A2.0151.00
210_Y241_A2.0041.00
153_T158_T2.0041.00
116_R237_G1.9981.00
88_D91_A1.8741.00
148_Y175_D1.8681.00
247_W291_R1.8671.00
29_W41_G1.8451.00
181_L188_V1.8281.00
28_L145_R1.8140.99
127_I191_T1.8130.99
120_F165_P1.8120.99
143_R179_L1.8080.99
30_W142_E1.8040.99
140_M143_R1.7960.99
201_T204_D1.7570.99
176_L188_V1.7440.99
124_V188_V1.7300.99
169_A192_A1.6670.99
128_C140_M1.6590.99
144_L168_L1.6340.99
210_Y213_A1.6220.99
32_P36_T1.6190.99
84_G87_D1.5870.99
131_Q136_R1.5800.99
173_E186_P1.5730.98
142_E146_R1.5180.98
122_C235_S1.5010.98
210_Y232_L1.4990.98
82_A117_D1.4870.98
17_V52_V1.4750.98
276_G279_A1.4610.98
173_E177_R1.4510.97
125_S141_Q1.4480.97
213_A236_L1.4460.97
140_M181_L1.4350.97
131_Q225_N1.4090.97
136_R180_K1.3760.96
263_R266_D1.3690.96
84_G239_L1.3460.96
16_D52_V1.3320.96
14_A93_R1.3250.96
213_A238_Y1.3090.95
33_D36_T1.3040.95
87_D281_Y1.2930.95
136_R140_M1.2800.95
81_D86_H1.2630.94
249_Q253_E1.2630.94
147_E175_D1.2620.94
26_T29_W1.2550.94
143_R180_K1.2410.94
84_G89_L1.2280.93
186_P221_V1.2190.93
129_S132_M1.2180.93
169_A196_A1.2170.93
126_F230_C1.2140.93
131_Q182_G1.2000.93
173_E185_A1.1870.92
218_T225_N1.1840.92
240_A279_A1.1820.92
208_R212_L1.1700.92
129_S230_C1.1670.91
177_R185_A1.1640.91
195_V202_K1.1620.91
173_E189_Q1.1550.91
210_Y214_R1.1480.91
225_N282_T1.1410.91
92_V281_Y1.1410.91
230_C234_F1.1400.91
186_P190_R1.1330.90
148_Y171_A1.1220.90
126_F129_S1.1000.89
137_I226_K1.0990.89
124_V162_V1.0910.88
123_L220_F1.0880.88
165_P195_V1.0780.88
208_R213_A1.0750.88
214_R218_T1.0660.87
36_T49_Y1.0610.87
190_R221_V1.0500.86
174_S178_D1.0490.86
194_M199_E1.0470.86
232_L238_Y1.0440.86
29_W248_M1.0300.85
275_L282_T1.0190.85
227_V287_F1.0150.85
190_R193_A1.0110.84
81_D116_R1.0100.84
124_V191_T1.0070.84
28_L121_G1.0040.84
269_R273_E1.0020.84
247_W250_T0.9960.83
167_A192_A0.9960.83
226_K230_C0.9960.83
165_P192_A0.9940.83
140_M179_L0.9920.83
200_L220_F0.9840.83
126_F137_I0.9790.82
193_A197_S0.9770.82
136_R139_E0.9760.82
14_A88_D0.9670.82
146_R158_T0.9600.81
30_W138_F0.9570.81
127_I187_Y0.9570.81
18_Q22_E0.9550.81
32_P35_D0.9520.81
109_Y288_H0.9330.79
46_D75_A0.9300.79
208_R216_T0.9270.79
42_L47_A0.9250.79
129_S226_K0.9190.78
210_Y229_D0.9160.78
72_T76_A0.9150.78
59_D62_Q0.9140.78
271_F275_L0.9120.78
199_E219_D0.9120.78
32_P49_Y0.9120.78
89_L93_R0.9080.77
129_S137_I0.9070.77
147_E178_D0.9040.77
211_E215_E0.9030.77
153_T156_G0.9030.77
268_S272_R0.9000.77
148_Y168_L0.8990.77
185_A189_Q0.8990.77
176_L181_L0.8980.77
183_Y187_Y0.8950.76
129_S287_F0.8900.76
233_L280_G0.8900.76
171_A175_D0.8890.76
21_L26_T0.8890.76
16_D19_A0.8870.76
179_L275_L0.8850.75
134_V230_C0.8820.75
31_R36_T0.8770.75
129_S227_V0.8770.75
122_C125_S0.8730.74
205_I236_L0.8690.74
132_M247_W0.8670.74
53_I59_D0.8660.74
192_A196_A0.8620.74
44_G118_P0.8570.73
147_E179_L0.8520.73
194_M197_S0.8460.72
87_D237_G0.8450.72
128_C141_Q0.8440.72
120_F192_A0.8430.72
123_L202_K0.8420.72
136_R182_G0.8400.72
23_S112_L0.8360.71
43_S46_D0.8330.71
251_A286_L0.8230.70
234_F284_T0.8190.70
27_Y137_I0.8170.69
233_L283_Q0.8160.69
226_K247_W0.8150.69
248_M286_L0.8150.69
242_V291_R0.8090.69
229_D264_Y0.8070.69
104_A207_G0.8010.68
119_F238_Y0.8000.68
280_G287_F0.8000.68
149_G161_S0.8000.68
137_I227_V0.7990.68
82_A115_V0.7990.68
264_Y268_S0.7960.67
31_R35_D0.7960.67
133_R180_K0.7930.67
152_I161_S0.7910.67
16_D23_S0.7900.67
190_R220_F0.7890.67
143_R146_R0.7840.66
183_Y227_V0.7780.66
15_V26_T0.7730.65
284_T288_H0.7670.65
117_D284_T0.7660.64
58_I62_Q0.7660.64
195_V220_F0.7650.64
125_S138_F0.7640.64
114_I280_G0.7620.64
115_V126_F0.7600.64
242_V252_I0.7540.63
36_T51_T0.7530.63
280_G283_Q0.7520.63
220_F223_V0.7480.63
214_R225_N0.7480.63
24_G27_Y0.7480.63
129_S134_V0.7480.63
238_Y241_A0.7470.63
132_M227_V0.7470.63
200_L223_V0.7410.62
198_G201_T0.7370.61
31_R81_D0.7370.61
150_T161_S0.7360.61
31_R37_Y0.7350.61
119_F236_L0.7330.61
122_C234_F0.7310.61
119_F185_A0.7270.60
81_D237_G0.7260.60
143_R147_E0.7230.60
26_T82_A0.7200.60
22_E31_R0.7200.60
126_F284_T0.7200.60
239_L281_Y0.7180.59
21_L282_T0.7140.59
42_L110_D0.7140.59
128_C181_L0.7110.59
230_C233_L0.7080.58
90_D94_G0.7070.58
93_R109_Y0.7070.58
194_M220_F0.7070.58
18_Q32_P0.7050.58
231_V248_M0.7010.58
230_C256_Y0.7000.58
229_D272_R0.6990.57
126_F226_K0.6960.57
26_T130_A0.6950.57
168_L172_T0.6930.57
134_V242_V0.6930.57
129_S283_Q0.6820.56
48_W225_N0.6710.54
19_A93_R0.6690.54
29_W47_A0.6670.54
139_E188_V0.6670.54
283_Q287_F0.6660.54
132_M226_K0.6660.54
166_S196_A0.6650.54
226_K287_F0.6640.54
136_R227_V0.6630.53
212_L215_E0.6610.53
99_D102_I0.6580.53
242_V271_F0.6570.53
137_I233_L0.6560.53
119_F202_K0.6550.53
252_I271_F0.6520.52
80_R167_A0.6510.52
132_M141_Q0.6500.52
112_L122_C0.6500.52
137_I280_G0.6490.52
125_S184_R0.6470.52
81_D235_S0.6460.52
94_G100_P0.6420.51
104_A166_S0.6420.51
126_F234_F0.6390.51
122_C231_V0.6380.51
130_A140_M0.6370.51
137_I230_C0.6360.50
131_Q226_K0.6320.50
115_V137_I0.6310.50
57_V60_V0.6300.50
136_R183_Y0.6300.50
181_L185_A0.6280.50
192_A195_V0.6260.49
45_G78_I0.6260.49
82_A145_R0.6250.49
241_A280_G0.6240.49
116_R230_C0.6230.49
235_S238_Y0.6230.49
244_L248_M0.6190.49
133_R179_L0.6190.49
93_R290_L0.6150.48
183_Y229_D0.6120.48
253_E257_P0.6110.48
53_I57_V0.6110.48
96_A106_W0.6100.48
206_D209_A0.6090.47
18_Q30_W0.6070.47
179_L271_F0.6070.47
18_Q36_T0.6050.47
105_A289_Y0.6040.47
78_I82_A0.6020.47
244_L264_Y0.6000.46
96_A102_I0.5990.46
76_A86_H0.5990.46
144_L181_L0.5980.46
200_L203_R0.5980.46
86_H91_A0.5960.46
75_A79_V0.5930.46
287_F291_R0.5930.46
259_C264_Y0.5900.45
14_A251_A0.5860.45
152_I198_G0.5850.45
259_C262_G0.5850.45
183_Y287_F0.5850.45
119_F237_G0.5850.45
125_S129_S0.5840.45
173_E218_T0.5840.45
45_G49_Y0.5830.45
136_R185_A0.5830.45
155_D203_R0.5830.45
74_D77_P0.5830.45
169_A193_A0.5820.44
33_D42_L0.5820.44
194_M221_V0.5810.44
134_V226_K0.5810.44
130_A187_Y0.5810.44
89_L278_H0.5790.44
143_R270_A0.5780.44
226_K283_Q0.5730.44
255_H275_L0.5700.43
87_D239_L0.5690.43
182_G283_Q0.5670.43
154_F157_Q0.5650.43
270_A274_H0.5650.43
110_D143_R0.5640.43
165_P196_A0.5640.43
32_P212_L0.5580.42
282_T286_L0.5580.42
281_Y286_L0.5570.42
44_G78_I0.5570.42
183_Y226_K0.5570.42
172_T192_A0.5570.42
112_L284_T0.5570.42
44_G81_D0.5550.42
120_F256_Y0.5550.42
226_K280_G0.5550.42
254_D290_L0.5530.41
87_D92_V0.5510.41
131_Q227_V0.5510.41
232_L240_A0.5500.41
91_A169_A0.5500.41
31_R34_G0.5460.41
150_T160_Y0.5460.41
31_R42_L0.5440.40
260_E263_R0.5430.40
133_R139_E0.5410.40
83_L127_I0.5410.40
126_F280_G0.5410.40
276_G280_G0.5400.40
22_E37_Y0.5400.40
120_F144_L0.5390.40
182_G226_K0.5380.40
41_G49_Y0.5380.40
233_L245_D0.5370.40
127_I140_M0.5360.40
100_P166_S0.5350.39
247_W251_A0.5350.39
251_A280_G0.5340.39
144_L160_Y0.5330.39
51_T61_R0.5330.39
58_I155_D0.5330.39
47_A159_V0.5320.39
51_T147_E0.5310.39
194_M219_D0.5310.39
23_S284_T0.5300.39
247_W290_L0.5280.39
103_T107_D0.5270.39
129_S136_R0.5230.38
248_M284_T0.5230.38
132_M229_D0.5220.38
61_R107_D0.5190.38
17_V51_T0.5190.38
140_M185_A0.5170.38
29_W286_L0.5170.38
137_I283_Q0.5150.37
76_A94_G0.5140.37
131_Q247_W0.5140.37
197_S273_E0.5140.37
73_T77_P0.5130.37
132_M137_I0.5130.37
204_D208_R0.5130.37
144_L179_L0.5120.37
124_V184_R0.5120.37
153_T166_S0.5110.37
123_L191_T0.5090.37
32_P157_Q0.5070.37
180_K255_H0.5070.37
194_M200_L0.5060.36
171_A178_D0.5050.36
87_D278_H0.5040.36
137_I247_W0.5030.36
168_L171_A0.5030.36
286_L289_Y0.5020.36
134_V283_Q0.5010.36
251_A256_Y0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xhiA 1 0.9635 100 0.254 Contact Map
3i0wA 1 0.9402 100 0.274 Contact Map
4ejyA 1 0.9369 100 0.286 Contact Map
2jhnA 1 0.9169 100 0.427 Contact Map
1mpgA 1 0.9037 100 0.465 Contact Map
4b21A 2 0.6645 100 0.469 Contact Map
2yg9A 1 0.6744 100 0.52 Contact Map
2h56A 1 0.6944 100 0.525 Contact Map
3s6iA 1 0.6611 100 0.54 Contact Map
3fhgA 2 0.6346 100 0.653 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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