GREMLIN Database
Q9HQ90 - Uncharacterized protein
UniProt: Q9HQ90 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (449)
Sequences: 3517 (2776)
Seq/√Len: 131.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A115_A5.1501.00
381_L435_A4.7091.00
297_V415_A4.4721.00
297_V419_A3.9641.00
23_G55_A3.8011.00
125_P133_I3.2321.00
418_A434_A3.1611.00
26_V146_V3.0551.00
222_V419_A3.0151.00
402_T443_E2.8591.00
226_G234_P2.8441.00
20_E58_R2.8391.00
43_V136_I2.7131.00
88_L93_Y2.6911.00
400_S439_G2.5951.00
123_G126_R2.5511.00
303_G328_D2.5331.00
221_S250_R2.5201.00
325_V329_A2.4921.00
182_H185_V2.4861.00
244_A417_T2.3591.00
33_V184_H2.3191.00
331_T353_A2.3101.00
56_A146_V2.2961.00
30_V144_V2.2751.00
25_A188_A2.2691.00
369_V388_V2.2551.00
26_V56_A2.2221.00
179_L182_H2.1571.00
244_A420_A2.1521.00
27_G56_A2.1451.00
410_T458_I2.1381.00
134_E162_S2.1321.00
41_A109_P2.1031.00
54_F71_G2.1001.00
343_V418_A2.0991.00
143_T164_V2.0961.00
136_I143_T2.0821.00
405_M410_T2.0681.00
396_R432_S2.0521.00
168_R186_T2.0491.00
15_R79_R2.0241.00
136_I164_V2.0081.00
304_D331_T1.9891.00
426_P429_Q1.9871.00
39_S110_D1.9821.00
338_T342_L1.9811.00
153_D160_P1.9061.00
248_L408_G1.9041.00
169_V183_D1.8951.00
343_V422_L1.8901.00
116_L133_I1.8751.00
222_V246_A1.8561.00
31_K63_Y1.8381.00
371_G375_E1.8361.00
351_L355_G1.8281.00
238_A268_F1.8161.00
30_V111_V1.7891.00
351_L372_F1.7861.00
29_A186_T1.7851.00
127_E131_T1.7681.00
444_R465_A1.7591.00
236_L456_T1.7561.00
372_F380_L1.7501.00
44_A53_A1.7271.00
142_P167_D1.7251.00
398_N439_G1.7191.00
30_V113_V1.7151.00
42_I57_A1.7001.00
358_T361_G1.7001.00
19_M51_G1.6981.00
115_A146_V1.6851.00
29_A168_R1.6711.00
144_V168_R1.6671.00
381_L418_A1.6391.00
40_V65_V1.6181.00
175_T187_V1.6111.00
428_I432_S1.6091.00
405_M442_G1.6081.00
243_R454_L1.6071.00
33_V168_R1.5931.00
133_I137_N1.5921.00
246_A249_V1.5861.00
240_A459_C1.5831.00
214_G219_A1.5831.00
243_R457_D1.5781.00
117_L123_G1.5701.00
57_A69_L1.5651.00
170_V188_A1.5631.00
29_A170_V1.5621.00
379_T431_A1.5601.00
117_L121_I1.5561.00
9_A15_R1.5481.00
152_L163_A1.5141.00
175_T185_V1.4951.00
85_W89_Q1.4931.00
417_T434_A1.4861.00
445_A461_A1.4831.00
157_G178_G1.4811.00
265_D268_F1.4691.00
415_A419_A1.4691.00
407_V455_A1.4641.00
369_V390_S1.4511.00
163_A181_D1.4411.00
417_T462_L1.4381.00
3_A6_R1.4351.00
226_G300_P1.4301.00
298_I325_V1.4291.00
30_V56_A1.4251.00
222_V241_A1.4241.00
117_L150_S1.4211.00
425_Q430_A1.4141.00
159_T181_D1.4141.00
68_S96_T1.4121.00
130_A134_E1.4051.00
454_L457_D1.3951.00
372_F376_L1.3951.00
82_R86_D1.3921.00
42_I53_A1.3911.00
444_R461_A1.3831.00
448_A461_A1.3771.00
236_L413_V1.3731.00
24_H28_R1.3681.00
352_Q362_S1.3631.00
127_E130_A1.3611.00
442_G445_A1.3561.00
295_A419_A1.3471.00
300_P415_A1.3381.00
404_G453_L1.3381.00
324_V422_L1.3291.00
344_C380_L1.3231.00
26_V172_F1.3191.00
396_R428_I1.3181.00
351_L382_V1.3141.00
210_R219_A1.3081.00
238_A251_L1.3021.00
61_D93_Y1.3001.00
324_V415_A1.3001.00
173_H192_I1.2991.00
201_G204_D1.2981.00
46_R123_G1.2961.00
239_Q460_D1.2941.00
224_V234_P1.2901.00
222_V295_A1.2881.00
3_A7_N1.2801.00
343_V431_A1.2681.00
267_T456_T1.2641.00
133_I150_S1.2591.00
204_D207_G1.2571.00
370_E395_T1.2531.00
24_H59_F1.2501.00
312_V332_A1.2481.00
413_V459_C1.2471.00
153_D156_T1.2471.00
388_V395_T1.2441.00
355_G372_F1.2361.00
39_S68_S1.2231.00
371_G374_A1.2191.00
159_T163_A1.2080.99
250_R269_I1.2050.99
338_T341_T1.2040.99
372_F378_Q1.2020.99
324_V434_A1.1970.99
39_S66_S1.1970.99
344_C378_Q1.1840.99
224_V237_C1.1760.99
241_A249_V1.1710.99
440_G443_E1.1700.99
41_A70_L1.1680.99
55_A58_R1.1660.99
230_Y269_I1.1650.99
173_H189_D1.1630.99
231_T262_Q1.1590.99
117_L126_R1.1550.99
305_A308_T1.1450.99
46_R75_S1.1440.99
130_A162_S1.1430.99
16_A83_A1.1420.99
239_Q265_D1.1380.99
304_D332_A1.1330.99
27_G63_Y1.1310.99
7_N10_A1.1310.99
42_I56_A1.1240.99
298_I315_F1.1220.99
348_R366_R1.1220.99
222_V423_A1.1190.99
124_P160_P1.1190.99
351_L368_A1.1160.99
379_T392_G1.1080.99
404_G443_E1.1050.99
445_A457_D1.1030.99
251_L261_V1.1030.99
367_D371_G1.0980.99
112_V136_I1.0930.99
234_P251_L1.0880.99
61_D88_L1.0840.99
436_Y440_G1.0820.99
373_A390_S1.0820.99
242_L454_L1.0810.99
128_P131_T1.0800.99
407_V410_T1.0800.99
121_I160_P1.0790.99
304_D335_D1.0740.99
29_A32_R1.0720.99
117_L129_E1.0690.99
42_I115_A1.0670.99
223_L252_A1.0590.99
14_P17_Q1.0550.99
76_I81_S1.0540.99
17_Q21_S1.0470.99
68_S109_P1.0430.99
56_A113_V1.0430.99
217_G348_R1.0420.98
152_L181_D1.0410.98
357_P361_G1.0400.98
179_L185_V1.0400.98
318_A321_G1.0390.98
253_V261_V1.0350.98
57_A67_V1.0260.98
106_L109_P1.0240.98
298_I312_V1.0170.98
5_D15_R1.0150.98
222_V297_V1.0150.98
304_D328_D1.0110.98
369_V373_A1.0100.98
171_T179_L1.0090.98
398_N435_A1.0080.98
431_A434_A1.0080.98
235_A264_F1.0020.98
373_A392_G0.9990.98
221_S248_L0.9990.98
339_D342_L0.9960.98
26_V170_V0.9910.98
422_L427_P0.9860.98
165_D180_A0.9830.98
34_A144_V0.9810.98
331_T334_P0.9810.98
445_A453_L0.9770.98
27_G60_L0.9770.98
84_N87_A0.9750.98
304_D353_A0.9740.98
44_A115_A0.9710.98
223_L296_V0.9680.98
5_D8_A0.9680.98
37_G110_D0.9670.98
31_K65_V0.9670.98
394_T428_I0.9640.98
5_D9_A0.9570.97
153_D158_A0.9550.97
436_Y439_G0.9540.97
40_V111_V0.9540.97
448_A464_A0.9530.97
223_L293_A0.9500.97
54_F88_L0.9480.97
72_R75_S0.9440.97
71_G85_W0.9430.97
408_G455_A0.9420.97
44_A54_F0.9380.97
401_G443_E0.9370.97
348_R363_Q0.9360.97
202_P207_G0.9270.97
334_P353_A0.9230.97
387_D435_A0.9220.97
391_D428_I0.9180.97
69_L93_Y0.9180.97
29_A33_V0.9160.97
343_V381_L0.9150.97
210_R404_G0.9150.97
421_M437_A0.9140.97
400_S436_Y0.9120.97
343_V379_T0.9110.96
258_A262_Q0.9070.96
200_V204_D0.9040.96
55_A84_N0.9040.96
381_L431_A0.9030.96
253_V257_V0.9020.96
398_N436_Y0.9020.96
366_R382_V0.8940.96
193_P196_A0.8900.96
133_I164_V0.8880.96
87_A90_A0.8880.96
30_V33_V0.8870.96
26_V30_V0.8860.96
171_T187_V0.8860.96
369_V382_V0.8850.96
316_L323_A0.8830.96
246_A420_A0.8790.96
73_P76_I0.8780.96
461_A464_A0.8780.96
148_V154_A0.8770.96
437_A465_A0.8760.96
309_Q335_D0.8760.96
54_F81_S0.8690.95
237_C297_V0.8680.95
221_S294_D0.8660.95
420_A424_T0.8650.95
30_V34_A0.8640.95
172_F188_A0.8630.95
38_A110_D0.8600.95
141_A167_D0.8590.95
363_Q366_R0.8590.95
26_V144_V0.8580.95
205_L433_A0.8540.95
349_G352_Q0.8540.95
16_A55_A0.8530.95
200_V207_G0.8520.95
29_A188_A0.8520.95
390_S395_T0.8500.95
69_L88_L0.8500.95
328_D331_T0.8490.95
359_V363_Q0.8450.95
228_G305_A0.8400.94
252_A273_V0.8390.94
168_R184_H0.8340.94
114_D150_S0.8310.94
260_E263_G0.8300.94
180_A211_D0.8290.94
131_T134_E0.8280.94
366_R384_G0.8270.94
27_G30_V0.8230.94
230_Y248_L0.8220.94
143_T167_D0.8220.94
86_D89_Q0.8190.94
413_V417_T0.8190.94
298_I329_A0.8160.94
407_V454_L0.8150.94
387_D431_A0.8120.93
116_L129_E0.8120.93
258_A270_V0.8110.93
137_N164_V0.8100.93
221_S292_D0.8100.93
351_L362_S0.8090.93
124_P130_A0.8090.93
352_Q359_V0.8060.93
145_A164_V0.8060.93
441_A445_A0.8060.93
248_L269_I0.8040.93
323_A342_L0.8020.93
295_A422_L0.8020.93
226_G237_C0.8010.93
145_A166_A0.8010.93
379_T391_D0.8010.93
405_M443_E0.8000.93
20_E55_A0.8000.93
27_G59_F0.7970.93
76_I85_W0.7920.93
221_S269_I0.7910.93
442_G453_L0.7890.92
111_V144_V0.7880.92
250_R271_D0.7860.92
322_R422_L0.7840.92
405_M458_I0.7830.92
46_R117_L0.7800.92
202_P205_L0.7770.92
222_V249_V0.7770.92
325_V342_L0.7770.92
21_S59_F0.7760.92
84_N88_L0.7760.92
35_D65_V0.7750.92
54_F69_L0.7740.92
224_V249_V0.7740.92
369_V380_L0.7720.92
342_L378_Q0.7720.92
180_A213_H0.7710.92
202_P206_L0.7710.92
165_D181_D0.7700.91
235_A262_Q0.7660.91
239_Q459_C0.7660.91
2_A155_D0.7650.91
116_L125_P0.7640.91
413_V455_A0.7630.91
389_L396_R0.7630.91
244_A462_L0.7610.91
58_R84_N0.7600.91
111_V142_P0.7590.91
243_R460_D0.7580.91
153_D178_G0.7580.91
250_R292_D0.7560.91
117_L125_P0.7560.91
388_V397_V0.7530.91
352_Q358_T0.7530.91
77_N81_S0.7530.91
37_G65_V0.7510.90
7_N11_L0.7490.90
312_V333_V0.7490.90
125_P160_P0.7490.90
348_R359_V0.7470.90
137_N165_D0.7470.90
440_G444_R0.7450.90
308_T332_A0.7440.90
146_V172_F0.7400.90
152_L159_T0.7380.90
309_Q332_A0.7360.90
30_V65_V0.7340.89
365_S368_A0.7330.89
425_Q431_A0.7310.89
38_A65_V0.7300.89
195_A198_T0.7300.89
452_G463_P0.7290.89
42_I113_V0.7280.89
16_A87_A0.7280.89
400_S443_E0.7250.89
16_A84_N0.7250.89
355_G362_S0.7220.89
389_L435_A0.7210.89
9_A13_V0.7210.89
387_D438_T0.7180.88
189_D193_P0.7170.88
379_T427_P0.7170.88
231_T257_V0.7170.88
441_A461_A0.7150.88
246_A423_A0.7130.88
173_H190_I0.7120.88
329_A333_V0.7120.88
366_R386_R0.7120.88
288_A291_E0.7110.88
224_V297_V0.7110.88
239_Q264_F0.7100.88
14_P83_A0.7090.88
142_P168_R0.7080.88
427_P430_A0.7070.88
355_G368_A0.7060.88
296_V315_F0.7060.88
86_D90_A0.7060.88
401_G439_G0.7060.88
258_A272_S0.7040.87
123_G160_P0.7040.87
261_V265_D0.7000.87
315_F323_A0.7000.87
121_I161_G0.6990.87
287_L290_A0.6980.87
386_R397_V0.6980.87
228_G254_P0.6980.87
25_A28_R0.6930.87
199_V399_R0.6930.87
391_D394_T0.6920.87
13_V193_P0.6920.87
396_R429_Q0.6910.86
78_D82_R0.6910.86
30_V40_V0.6900.86
214_G218_D0.6890.86
32_R186_T0.6880.86
294_D423_A0.6870.86
256_A275_G0.6850.86
235_A265_D0.6850.86
173_H197_E0.6850.86
445_A459_C0.6850.86
16_A20_E0.6820.86
298_I302_L0.6810.86
214_G406_T0.6800.86
21_S24_H0.6770.85
83_A86_D0.6770.85
251_L268_F0.6770.85
40_V60_L0.6760.85
370_E374_A0.6760.85
352_Q357_P0.6760.85
310_A313_A0.6740.85
54_F85_W0.6710.85
33_V144_V0.6700.85
229_P269_I0.6690.85
240_A417_T0.6690.85
325_V333_V0.6680.85
8_A193_P0.6670.84
418_A430_A0.6660.84
400_S440_G0.6650.84
180_A212_P0.6640.84
458_I461_A0.6630.84
16_A79_R0.6620.84
200_V205_L0.6620.84
158_A364_P0.6610.84
355_G376_L0.6600.84
429_Q432_S0.6590.84
71_G76_I0.6560.83
368_A372_F0.6560.83
20_E84_N0.6550.83
408_G454_L0.6540.83
297_V300_P0.6500.83
357_P362_S0.6490.83
358_T362_S0.6490.83
42_I67_V0.6480.83
17_Q87_A0.6470.83
149_P166_A0.6460.83
5_D119_T0.6450.82
444_R464_A0.6440.82
253_V270_V0.6420.82
224_V419_A0.6420.82
87_A91_G0.6410.82
140_D143_T0.6400.82
440_G465_A0.6390.82
421_M430_A0.6370.82
313_A317_A0.6360.82
398_N443_E0.6360.82
437_A466_I0.6350.81
420_A423_A0.6340.81
421_M434_A0.6340.81
34_A168_R0.6340.81
5_D77_N0.6330.81
424_T451_H0.6330.81
308_T311_A0.6270.81
201_G206_L0.6260.81
348_R384_G0.6260.81
250_R293_A0.6230.80
295_A322_R0.6210.80
125_P161_G0.6190.80
149_P179_L0.6180.80
237_C415_A0.6180.80
9_A16_A0.6120.79
2_A119_T0.6100.79
402_T405_M0.6100.79
242_L249_V0.6050.78
359_V362_S0.6050.78
117_L133_I0.6040.78
112_V141_A0.6020.78
40_V56_A0.6020.78
83_A87_A0.6020.78
88_L91_G0.6010.78
212_P403_P0.6010.78
41_A106_L0.6010.78
351_L380_L0.6000.78
194_E198_T0.5990.78
349_G359_V0.5990.78
327_A331_T0.5970.77
225_I298_I0.5960.77
106_L135_R0.5960.77
310_A314_A0.5960.77
132_A135_R0.5960.77
225_I302_L0.5950.77
156_T178_G0.5950.77
127_E133_I0.5950.77
242_L269_I0.5940.77
26_V29_A0.5940.77
200_V206_L0.5930.77
444_R447_E0.5900.77
135_R139_T0.5890.76
314_A318_A0.5890.76
302_L308_T0.5870.76
170_V186_T0.5860.76
317_A337_E0.5840.76
235_A239_Q0.5830.76
264_F268_F0.5820.76
87_A93_Y0.5800.75
428_I431_A0.5800.75
401_G405_M0.5800.75
57_A93_Y0.5790.75
152_L182_H0.5790.75
211_D214_G0.5790.75
58_R87_A0.5770.75
427_P431_A0.5770.75
28_R188_A0.5760.75
240_A408_G0.5760.75
6_R10_A0.5750.75
166_A183_D0.5750.75
449_R463_P0.5730.74
373_A378_Q0.5730.74
44_A69_L0.5700.74
247_D438_T0.5700.74
262_Q266_E0.5690.74
2_A5_D0.5680.74
333_V344_C0.5680.74
221_S293_A0.5670.74
456_T459_C0.5670.74
122_S153_D0.5670.74
225_I315_F0.5670.74
41_A112_V0.5660.74
249_V419_A0.5650.73
267_T407_V0.5650.73
302_L312_V0.5640.73
407_V442_G0.5630.73
257_V262_Q0.5630.73
201_G205_L0.5620.73
294_D321_G0.5600.73
250_R289_R0.5600.73
231_T266_E0.5580.72
269_I408_G0.5580.72
373_A377_G0.5580.72
71_G81_S0.5560.72
139_T143_T0.5560.72
381_L434_A0.5550.72
408_G458_I0.5550.72
369_V381_L0.5540.72
11_L21_S0.5530.72
34_A111_V0.5530.72
163_A178_G0.5520.72
221_S230_Y0.5520.72
445_A465_A0.5520.72
421_M424_T0.5510.72
453_L457_D0.5500.71
459_C462_L0.5500.71
324_V343_V0.5480.71
462_L466_I0.5470.71
56_A144_V0.5470.71
379_T428_I0.5460.71
78_D81_S0.5460.71
200_V432_S0.5440.71
285_D288_A0.5440.71
121_I150_S0.5430.70
72_R76_I0.5420.70
320_E339_D0.5420.70
8_A192_I0.5410.70
20_E59_F0.5410.70
200_V389_L0.5410.70
217_G248_L0.5400.70
237_C300_P0.5400.70
449_R460_D0.5380.70
20_E87_A0.5380.70
351_L390_S0.5380.70
306_D310_A0.5380.70
320_E338_T0.5370.70
154_A178_G0.5360.69
27_G31_K0.5360.69
137_N143_T0.5340.69
5_D14_P0.5340.69
199_V205_L0.5330.69
379_T387_D0.5330.69
155_D177_P0.5330.69
28_R63_Y0.5310.69
242_L267_T0.5290.68
226_G233_A0.5290.68
362_S382_V0.5290.68
134_E138_A0.5270.68
437_A462_L0.5270.68
84_N91_G0.5270.68
54_F84_N0.5260.68
255_D272_S0.5250.68
62_D91_G0.5240.68
4_V196_A0.5240.68
5_D193_P0.5220.67
51_G84_N0.5220.67
441_A465_A0.5210.67
374_A393_D0.5210.67
231_T260_E0.5200.67
112_V139_T0.5200.67
121_I125_P0.5190.67
133_I143_T0.5190.67
306_D309_Q0.5180.67
223_L286_L0.5170.67
81_S84_N0.5170.67
119_T154_A0.5170.67
248_L292_D0.5170.67
70_L96_T0.5170.67
398_N425_Q0.5160.67
5_D17_Q0.5160.67
217_G221_S0.5150.66
247_D387_D0.5150.66
123_G127_E0.5150.66
51_G79_R0.5140.66
177_P388_V0.5140.66
69_L95_T0.5130.66
305_A332_A0.5130.66
369_V395_T0.5120.66
362_S368_A0.5120.66
320_E341_T0.5110.66
239_Q456_T0.5110.66
201_G207_G0.5110.66
300_P403_P0.5100.66
59_F62_D0.5070.65
122_S126_R0.5070.65
5_D18_L0.5070.65
341_T422_L0.5070.65
399_R436_Y0.5060.65
139_T164_V0.5060.65
249_V268_F0.5060.65
398_N401_G0.5060.65
330_L372_F0.5060.65
125_P130_A0.5050.65
33_V186_T0.5040.65
213_H363_Q0.5040.65
329_A332_A0.5040.65
267_T455_A0.5020.64
452_G466_I0.5020.64
6_R325_V0.5020.64
15_R119_T0.5010.64
121_I127_E0.5010.64
355_G380_L0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rssA 4 0.9873 100 0.27 Contact Map
3k5wA 4 0.9131 100 0.294 Contact Map
3bgkA 3 0.5593 100 0.651 Contact Map
2o8nA 2 0.4407 100 0.654 Contact Map
1jztA 2 0.4555 100 0.655 Contact Map
3d3kA 2 0.428 100 0.671 Contact Map
3d3jA 2 0.4258 100 0.672 Contact Map
3rpzA 3 0.5699 100 0.675 Contact Map
2r3bA 3 0.5805 100 0.675 Contact Map
3nl6A 4 0.8877 100 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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