GREMLIN Database
MOAC - Probable cyclic pyranopterin monophosphate synthase accessory protein
UniProt: Q9HQ89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (151)
Sequences: 2892 (1670)
Seq/√Len: 135.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_H76_E5.2991.00
102_L126_L2.9331.00
104_V121_G2.8291.00
48_A136_A2.6651.00
36_S148_A2.6491.00
37_G145_P2.4971.00
13_T17_D2.4541.00
149_I157_K2.4431.00
36_S101_V2.3241.00
40_H143_Q2.2401.00
37_G122_V2.1761.00
47_D51_D2.0681.00
28_D111_K2.0561.00
30_A107_E1.8951.00
67_A125_G1.8911.00
96_R99_R1.8101.00
36_S146_G1.7341.00
151_N157_K1.7111.00
34_V105_A1.6881.00
77_T124_T1.6771.00
38_D101_V1.6771.00
32_R105_A1.6571.00
130_W147_T1.6361.00
46_I95_V1.6301.00
42_A45_T1.6191.00
123_T145_P1.6131.00
39_L126_L1.5871.00
43_E47_D1.5791.00
96_R101_V1.5751.00
28_D109_T1.5411.00
40_H141_D1.5391.00
71_V121_G1.5001.00
93_F100_V1.4911.00
139_D158_E1.4871.00
49_V133_V1.4641.00
138_K155_D1.4541.00
32_R151_N1.4541.00
41_L45_T1.4491.00
50_R97_D1.4491.00
133_V140_A1.4391.00
95_V100_V1.4191.00
50_R95_V1.4111.00
37_G126_L1.4091.00
38_D144_Y1.4041.00
85_P110_G1.3661.00
32_R107_E1.3641.00
36_S103_E1.3281.00
58_N61_A1.2971.00
77_T120_E1.2571.00
65_V80_M1.2411.00
61_A64_R1.2351.00
86_I106_V1.2351.00
67_A91_T1.2291.00
85_P108_T1.2281.00
39_L140_A1.2111.00
48_A53_G1.1971.00
104_V122_V1.1961.00
54_I59_V1.1941.00
24_G87_T1.1850.99
94_D101_V1.1790.99
22_D107_E1.1590.99
94_D103_E1.1580.99
88_N107_E1.1540.99
141_D144_Y1.1490.99
119_L127_N1.1460.99
18_A61_A1.1440.99
122_V145_P1.1310.99
34_V103_E1.1210.99
12_T62_T1.1200.99
87_T111_K1.1150.99
67_A104_V1.1020.99
100_V129_V1.0940.99
42_A137_E1.0910.99
71_V86_I1.0870.99
38_D99_R1.0860.99
48_A54_I1.0820.99
126_L142_G1.0810.99
34_V149_I1.0430.99
54_I133_V1.0370.99
123_T142_G1.0220.98
17_D64_R1.0060.98
62_T65_V0.9950.98
34_V104_V0.9740.98
71_V89_V0.9690.98
84_I108_T0.9640.98
24_G30_A0.9580.98
32_R149_I0.9580.98
86_I114_C0.9570.98
54_I136_A0.9510.98
39_L129_V0.9460.97
142_G145_P0.9450.97
64_R92_T0.9430.97
59_V129_V0.9400.97
65_V69_Q0.9270.97
92_T103_E0.9270.97
41_L46_I0.9260.97
18_A64_R0.9180.97
24_G107_E0.8990.97
28_D110_G0.8830.96
106_V114_C0.8690.96
36_S144_Y0.8600.96
41_L140_A0.8420.95
75_W83_Q0.8410.95
103_E148_A0.8330.95
44_S47_D0.8330.95
123_T126_L0.8300.95
137_E140_A0.8290.95
29_T152_V0.8220.94
30_A109_T0.8210.94
91_T125_G0.8190.94
39_L102_L0.8150.94
63_A128_V0.8140.94
70_A124_T0.8090.94
38_D143_Q0.8070.94
13_T19_Q0.8000.94
85_P111_K0.7960.93
58_N62_T0.7950.93
60_L100_V0.7940.93
66_G128_V0.7930.93
25_S30_A0.7930.93
18_A58_N0.7890.93
102_L125_G0.7830.93
78_I128_V0.7780.93
19_Q88_N0.7760.93
47_D50_R0.7750.92
13_T90_D0.7710.92
93_F129_V0.7690.92
84_I106_V0.7590.92
49_V59_V0.7500.91
68_I80_M0.7420.91
46_I97_D0.7340.90
130_W133_V0.7310.90
45_T137_E0.7310.90
141_D146_G0.7280.90
12_T52_D0.7260.90
12_T55_G0.7250.90
87_T109_T0.7120.89
8_A14_A0.7050.88
19_Q80_M0.7040.88
89_V106_V0.7030.88
27_P111_K0.6980.88
92_T105_A0.6950.88
22_D88_N0.6940.88
93_F102_L0.6870.87
62_T80_M0.6850.87
138_K154_V0.6840.87
19_Q90_D0.6780.86
130_W140_A0.6750.86
130_W138_K0.6730.86
42_A139_D0.6660.85
9_L133_V0.6630.85
64_R90_D0.6620.85
90_D105_A0.6600.85
139_D147_T0.6600.85
46_I50_R0.6560.85
140_A147_T0.6500.84
42_A46_I0.6460.84
70_A75_W0.6450.84
52_D58_N0.6420.83
49_V100_V0.6390.83
120_E124_T0.6380.83
75_W85_P0.6290.82
102_L122_V0.6270.82
60_L93_F0.6260.82
78_I135_A0.6190.81
55_G136_A0.6110.80
49_V54_I0.6100.80
46_I49_V0.6060.80
138_K157_K0.6060.80
75_W84_I0.6050.80
16_G58_N0.6050.80
47_D97_D0.5960.79
70_A120_E0.5900.78
55_G129_V0.5880.78
15_D92_T0.5870.77
138_K151_N0.5870.77
86_I89_V0.5850.77
35_A122_V0.5840.77
45_T49_V0.5820.77
138_K156_T0.5800.77
38_D96_R0.5780.76
18_A93_F0.5770.76
21_V135_A0.5750.76
52_D61_A0.5740.76
23_V111_K0.5710.76
45_T136_A0.5700.75
87_T108_T0.5660.75
69_Q74_T0.5660.75
24_G109_T0.5640.75
41_L137_E0.5630.75
12_T61_A0.5620.74
41_L49_V0.5560.74
58_N64_R0.5540.73
106_V118_A0.5540.73
106_V147_T0.5520.73
66_G114_C0.5510.73
71_V104_V0.5510.73
18_A62_T0.5500.73
9_L48_A0.5490.73
9_L135_A0.5490.73
83_Q86_I0.5430.72
39_L142_G0.5430.72
59_V110_G0.5420.72
71_V106_V0.5410.72
64_R86_I0.5390.71
91_T104_V0.5370.71
20_M23_V0.5370.71
120_E127_N0.5360.71
25_S28_D0.5350.71
79_P128_V0.5320.70
67_A71_V0.5310.70
73_H77_T0.5300.70
116_M119_L0.5280.70
68_I89_V0.5280.70
83_Q108_T0.5260.69
27_P156_T0.5250.69
62_T69_Q0.5230.69
8_A48_A0.5200.69
45_T133_V0.5190.68
49_V53_G0.5170.68
87_T110_G0.5160.68
143_Q146_G0.5140.68
50_R100_V0.5120.67
69_Q75_W0.5040.66
25_S109_T0.5010.66
64_R93_F0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eeyA 5 0.9571 100 0.05 Contact Map
4pyaA 3 0.7485 100 0.054 Contact Map
4fdfA 5 0.865 100 0.063 Contact Map
2iihA 4 0.8834 100 0.08 Contact Map
2eknA 5 0.8528 100 0.106 Contact Map
2ohdA 5 0.8405 100 0.142 Contact Map
2ia9A 2 0.319 7.6 0.965 Contact Map
3eirA 1 0.3313 7 0.965 Contact Map
2i9zA 2 0.3006 6.1 0.966 Contact Map
1ccwB 2 0.362 5.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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