GREMLIN Database
Q9HQ88 - GTP-binding protein
UniProt: Q9HQ88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (240)
Sequences: 8337 (6533)
Seq/√Len: 421.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_R222_A3.6251.00
142_L176_V3.4101.00
126_E129_K3.0921.00
48_A138_A2.8031.00
180_T204_A2.6841.00
147_A177_F2.6811.00
145_V175_T2.5591.00
174_V219_R2.5471.00
104_A221_D2.5271.00
63_R213_L2.2511.00
201_A219_R2.2501.00
219_R223_A2.2281.00
144_V178_N2.2201.00
203_V219_R2.1821.00
59_T207_A2.1091.00
63_R210_A2.0041.00
88_D122_H1.9871.00
176_V203_V1.9651.00
242_S246_W1.9571.00
98_T109_L1.9481.00
100_R107_D1.9411.00
46_L109_L1.9351.00
47_V108_V1.9201.00
45_D224_L1.9001.00
50_A135_V1.8831.00
177_F204_A1.8601.00
194_A198_L1.8011.00
218_E222_A1.7941.00
49_L61_L1.7791.00
29_E248_H1.7791.00
129_K133_E1.7691.00
212_N215_E1.7651.00
195_L199_A1.7631.00
164_T168_R1.6851.00
245_S249_D1.6791.00
176_V216_L1.6711.00
273_I276_R1.6531.00
249_D253_V1.6531.00
196_A199_A1.6261.00
147_A183_V1.6091.00
96_T111_T1.5861.00
140_L174_V1.5851.00
26_S29_E1.5841.00
237_T240_T1.5721.00
157_K160_T1.5371.00
178_N207_A1.5351.00
140_L220_I1.5291.00
142_L216_L1.5271.00
216_L220_I1.5121.00
63_R207_A1.5041.00
89_D121_P1.4901.00
104_A218_E1.4801.00
60_L144_V1.4781.00
53_T90_L1.4711.00
247_V251_A1.4611.00
156_E160_T1.4541.00
156_E159_A1.4501.00
133_E137_Q1.4361.00
248_H252_H1.4241.00
271_P275_E1.4221.00
29_E33_Q1.4071.00
215_E218_E1.4031.00
102_E107_D1.3901.00
61_L84_A1.3891.00
177_F202_P1.3851.00
65_A83_T1.3831.00
122_H125_V1.3791.00
67_D83_T1.3661.00
179_K182_R1.3411.00
246_W249_D1.3351.00
209_D212_N1.3031.00
24_E31_T1.2851.00
157_K161_S1.2731.00
25_L28_I1.2571.00
22_R26_S1.2421.00
62_R86_S1.2411.00
19_S22_R1.2381.00
106_R221_D1.2251.00
98_T111_T1.2221.00
194_A197_A1.2151.00
149_E152_A1.2051.00
111_T134_S1.2031.00
134_S137_Q1.2011.00
158_L164_T1.1981.00
130_S133_E1.1911.00
50_A141_V1.1871.00
84_A97_T1.1841.00
241_M245_S1.1781.00
145_V177_F1.1761.00
84_A87_Q1.1691.00
275_E278_H1.1661.00
66_A217_R1.1661.00
255_T259_G1.1641.00
174_V223_A1.1541.00
247_V254_R1.1521.00
214_E217_R1.1411.00
254_R257_D1.1321.00
100_R109_L1.1271.00
201_A204_A1.1271.00
93_T98_T1.1251.00
103_L108_V1.1201.00
165_L168_R1.1171.00
234_L237_T1.1051.00
246_W250_H1.1051.00
201_A223_A1.0961.00
24_E29_E1.0871.00
245_S248_H1.0831.00
19_S23_D1.0821.00
262_E266_D1.0781.00
265_I269_A1.0781.00
96_T134_S1.0781.00
143_L173_I1.0671.00
269_A273_I1.0671.00
162_H168_R1.0631.00
162_H165_L1.0591.00
64_L217_R1.0541.00
238_E241_M1.0461.00
25_L29_E1.0421.00
146_D149_E1.0411.00
158_L162_H1.0401.00
123_W126_E1.0351.00
214_E218_E1.0351.00
141_V173_I1.0321.00
236_M240_T1.0311.00
60_L216_L1.0311.00
238_E242_S1.0301.00
266_D270_R1.0241.00
133_E136_Y1.0221.00
147_A180_T1.0211.00
83_T99_R1.0201.00
20_R24_E1.0111.00
38_T41_E1.0041.00
176_V205_V1.0021.00
246_W276_R1.0021.00
242_S245_S0.9951.00
275_E279_A0.9931.00
254_R258_Y0.9871.00
251_A254_R0.9871.00
127_S130_S0.9861.00
248_H251_A0.9861.00
235_P240_T0.9851.00
121_P124_L0.9811.00
30_K34_Q0.9741.00
236_M241_M0.9741.00
264_V268_E0.9551.00
85_E89_D0.9491.00
247_V250_H0.9481.00
271_P278_H0.9431.00
265_I268_E0.9421.00
175_T202_P0.9391.00
47_V140_L0.9341.00
25_L31_T0.9341.00
58_S84_A0.9331.00
125_V129_K0.9321.00
261_Q265_I0.9321.00
119_D128_F0.9301.00
102_E105_R0.9281.00
221_D225_P0.9251.00
26_S30_K0.9221.00
85_E92_T0.9211.00
195_L198_L0.9191.00
240_T247_V0.9131.00
240_T243_V0.9091.00
20_R23_D0.9071.00
184_E187_A0.9061.00
215_E219_R0.9051.00
46_L139_D0.8991.00
252_H255_T0.8991.00
183_V188_L0.8991.00
174_V203_V0.8971.00
250_H269_A0.8921.00
158_L161_S0.8861.00
218_E221_D0.8851.00
65_A99_R0.8821.00
48_A111_T0.8781.00
164_T167_E0.8761.00
232_L235_P0.8761.00
31_T34_Q0.8751.00
252_H256_V0.8721.00
249_D252_H0.8671.00
146_D179_K0.8671.00
243_V246_W0.8611.00
153_D156_E0.8601.00
146_D178_N0.8561.00
159_A162_H0.8531.00
196_A200_P0.8531.00
46_L134_S0.8411.00
217_R221_D0.8401.00
128_F131_T0.8371.00
120_L125_V0.8351.00
23_D27_N0.8261.00
236_M239_D0.8201.00
46_L111_T0.8171.00
233_V236_M0.8161.00
84_A92_T0.8141.00
185_D188_L0.8131.00
203_V206_S0.8111.00
38_T42_S0.8091.00
135_V141_V0.8091.00
246_W273_I0.8091.00
25_L252_H0.8061.00
19_S29_E0.8031.00
205_V213_L0.8031.00
27_N30_K0.7951.00
160_T164_T0.7901.00
143_L175_T0.7891.00
49_L142_L0.7881.00
253_V256_V0.7881.00
127_S131_T0.7861.00
21_I25_L0.7821.00
153_D157_K0.7761.00
213_L217_R0.7591.00
93_T99_R0.7591.00
159_A163_D0.7581.00
104_A217_R0.7551.00
34_Q37_E0.7531.00
122_H126_E0.7461.00
161_S164_T0.7431.00
188_L204_A0.7401.00
30_K33_Q0.7351.00
59_T205_V0.7311.00
253_V266_D0.7311.00
231_R236_M0.7291.00
143_L158_L0.7291.00
39_R43_G0.7291.00
25_L255_T0.7261.00
243_V273_I0.7261.00
185_D189_A0.7241.00
194_A199_A0.7211.00
45_D108_V0.7191.00
22_R25_L0.7191.00
202_P205_V0.7181.00
250_H253_V0.7161.00
235_P239_D0.7061.00
48_A113_T0.7051.00
102_E106_R0.7051.00
60_L205_V0.7051.00
128_F132_L0.7021.00
266_D269_A0.7011.00
262_E268_E0.7001.00
54_N88_D0.6961.00
183_V204_A0.6921.00
260_D263_V0.6891.00
272_T276_R0.6791.00
147_A184_E0.6781.00
52_Y55_A0.6771.00
223_A227_R0.6721.00
157_K164_T0.6721.00
31_T38_T0.6701.00
158_L168_R0.6691.00
250_H254_R0.6681.00
253_V257_D0.6660.99
130_S134_S0.6660.99
93_T100_R0.6650.99
96_T99_R0.6640.99
147_A152_A0.6630.99
101_M108_V0.6630.99
106_R224_L0.6620.99
205_V208_R0.6610.99
168_R173_I0.6580.99
257_D266_D0.6560.99
131_T135_V0.6550.99
46_L137_Q0.6530.99
98_T134_S0.6530.99
126_E130_S0.6510.99
25_L30_K0.6490.99
101_M110_L0.6480.99
269_A272_T0.6470.99
164_T169_N0.6450.99
28_I31_T0.6440.99
91_F95_G0.6400.99
254_R263_V0.6390.99
48_A134_S0.6380.99
140_L223_A0.6370.99
247_V253_V0.6370.99
195_L200_P0.6360.99
124_L128_F0.6330.99
207_A213_L0.6320.99
22_R255_T0.6300.99
244_V248_H0.6250.99
136_Y171_A0.6250.99
114_V127_S0.6210.99
248_H256_V0.6210.99
248_H255_T0.6190.99
124_L127_S0.6170.99
94_L97_T0.6150.99
91_F94_L0.6130.99
27_N31_T0.6110.99
205_V216_L0.6110.99
89_D122_H0.6060.99
261_Q266_D0.6050.99
270_R273_I0.6030.99
106_R225_P0.6010.99
151_L156_E0.6000.99
19_S24_E0.6000.99
162_H167_E0.5980.99
186_A189_A0.5970.99
231_R235_P0.5960.99
262_E265_I0.5940.99
231_R234_L0.5940.99
37_E41_E0.5930.99
266_D271_P0.5890.99
23_D26_S0.5880.99
61_L97_T0.5770.99
32_E36_R0.5770.99
93_T97_T0.5740.99
60_L176_V0.5730.98
239_D242_S0.5720.98
39_R67_D0.5710.98
268_E271_P0.5690.98
179_K206_S0.5680.98
148_S182_R0.5670.98
54_N179_K0.5640.98
183_V186_A0.5640.98
119_D122_H0.5630.98
254_R259_G0.5610.98
31_T35_R0.5610.98
250_H266_D0.5600.98
222_A226_A0.5580.98
180_T211_S0.5580.98
40_R137_Q0.5540.98
95_G114_V0.5540.98
29_E252_H0.5540.98
47_V110_L0.5530.98
32_E241_M0.5520.98
28_I244_V0.5520.98
160_T163_D0.5450.98
272_T275_E0.5420.98
132_L164_T0.5400.98
21_I24_E0.5400.98
253_V269_A0.5380.98
89_D92_T0.5370.98
48_A141_V0.5340.98
201_A205_V0.5330.98
231_R239_D0.5330.98
39_R139_D0.5320.98
188_L196_A0.5320.98
35_R39_R0.5310.98
25_L248_H0.5310.98
24_E27_N0.5300.98
184_E188_L0.5280.97
145_V186_A0.5270.97
52_Y149_E0.5260.97
276_R279_A0.5260.97
87_Q90_L0.5260.97
103_L217_R0.5230.97
194_A200_P0.5230.97
243_V250_H0.5210.97
29_E32_E0.5200.97
250_H256_V0.5150.97
172_P223_A0.5140.97
202_P219_R0.5080.97
244_V247_V0.5080.97
184_E189_A0.5070.97
60_L207_A0.5040.97
85_E95_G0.5030.97
159_A164_T0.5020.97
207_A210_A0.5010.97
141_V171_A0.5010.97
20_R31_T0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3geeA 2 0.7917 100 0.442 Contact Map
3gehA 2 0.8438 100 0.449 Contact Map
1xzpA 4 0.9167 100 0.456 Contact Map
2qtfA 1 0.625 100 0.468 Contact Map
2j69A 1 0.9167 100 0.476 Contact Map
3ievA 1 0.8021 100 0.494 Contact Map
1mkyA 1 0.8785 100 0.498 Contact Map
3j65o 1 0.7465 100 0.501 Contact Map
2e87A 1 0.8021 100 0.505 Contact Map
4aurA 1 0.9167 100 0.505 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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