Q9HQ88 - HALSA - GREMLIN Contacts

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Q9HQ88 - GTP-binding protein

UniProt:	Q9HQ88	Sequences: MGLGEYDESREQDIKARISRIRDELSNIEKTEQQRRETRRESGFDLVALAGYTNAGKSTLLRRLAADVAVDENDDRHPDLDTTAESQDDLFTTLGTTTRRMELARRDVLLTDTVGFISDLPHWLVESFKSTLESVYQADLVLLVVDASEPLADIQEKLATSHDTLYERNEAPIVTVFNKTDRVEDAALAEKMEALAALAPAPVAVSARDASNLEELRERIDAALPARERERLVLPMTEDTMSVVSWVHDHAHVRTVDYGDQEVVIDFEARPTIVERSHAKASDLVAEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	288 (240)
Sequences:	8337 (6533)
Seq/√Len:	421.7

ECOLI - MNME HFLX ERA YFJP YKFA DER ENGB OBG CRFC FEOB
BACSU - HFLX ERA MNME DER YPBR ENGB OBG
HALSA - Q9HQ88 Q9HMC2 Q9HMD6 ENGB Y1111
SULSO - HFLX Q7LXR6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
219_R	222_A	3.625	1.00
142_L	176_V	3.410	1.00
126_E	129_K	3.092	1.00
48_A	138_A	2.803	1.00
180_T	204_A	2.684	1.00
147_A	177_F	2.681	1.00
145_V	175_T	2.559	1.00
174_V	219_R	2.547	1.00
104_A	221_D	2.527	1.00
63_R	213_L	2.251	1.00
201_A	219_R	2.250	1.00
219_R	223_A	2.228	1.00
144_V	178_N	2.220	1.00
203_V	219_R	2.182	1.00
59_T	207_A	2.109	1.00
63_R	210_A	2.004	1.00
88_D	122_H	1.987	1.00
176_V	203_V	1.965	1.00
242_S	246_W	1.957	1.00
98_T	109_L	1.948	1.00
100_R	107_D	1.941	1.00
46_L	109_L	1.935	1.00
47_V	108_V	1.920	1.00
45_D	224_L	1.900	1.00
50_A	135_V	1.883	1.00
177_F	204_A	1.860	1.00
194_A	198_L	1.801	1.00
218_E	222_A	1.794	1.00
49_L	61_L	1.779	1.00
29_E	248_H	1.779	1.00
129_K	133_E	1.769	1.00
212_N	215_E	1.765	1.00
195_L	199_A	1.763	1.00
164_T	168_R	1.685	1.00
245_S	249_D	1.679	1.00
176_V	216_L	1.671	1.00
273_I	276_R	1.653	1.00
249_D	253_V	1.653	1.00
196_A	199_A	1.626	1.00
147_A	183_V	1.609	1.00
96_T	111_T	1.586	1.00
140_L	174_V	1.585	1.00
26_S	29_E	1.584	1.00
237_T	240_T	1.572	1.00
157_K	160_T	1.537	1.00
178_N	207_A	1.535	1.00
140_L	220_I	1.529	1.00
142_L	216_L	1.527	1.00
216_L	220_I	1.512	1.00
63_R	207_A	1.504	1.00
89_D	121_P	1.490	1.00
104_A	218_E	1.480	1.00
60_L	144_V	1.478	1.00
53_T	90_L	1.471	1.00
247_V	251_A	1.461	1.00
156_E	160_T	1.454	1.00
156_E	159_A	1.450	1.00
133_E	137_Q	1.436	1.00
248_H	252_H	1.424	1.00
271_P	275_E	1.422	1.00
29_E	33_Q	1.407	1.00
215_E	218_E	1.403	1.00
102_E	107_D	1.390	1.00
61_L	84_A	1.389	1.00
177_F	202_P	1.385	1.00
65_A	83_T	1.383	1.00
122_H	125_V	1.379	1.00
67_D	83_T	1.366	1.00
179_K	182_R	1.341	1.00
246_W	249_D	1.335	1.00
209_D	212_N	1.303	1.00
24_E	31_T	1.285	1.00
157_K	161_S	1.273	1.00
25_L	28_I	1.257	1.00
22_R	26_S	1.242	1.00
62_R	86_S	1.241	1.00
19_S	22_R	1.238	1.00
106_R	221_D	1.225	1.00
98_T	111_T	1.222	1.00
194_A	197_A	1.215	1.00
149_E	152_A	1.205	1.00
111_T	134_S	1.203	1.00
134_S	137_Q	1.201	1.00
158_L	164_T	1.198	1.00
130_S	133_E	1.191	1.00
50_A	141_V	1.187	1.00
84_A	97_T	1.184	1.00
241_M	245_S	1.178	1.00
145_V	177_F	1.176	1.00
84_A	87_Q	1.169	1.00
275_E	278_H	1.166	1.00
66_A	217_R	1.166	1.00
255_T	259_G	1.164	1.00
174_V	223_A	1.154	1.00
247_V	254_R	1.152	1.00
214_E	217_R	1.141	1.00
254_R	257_D	1.132	1.00
100_R	109_L	1.127	1.00
201_A	204_A	1.127	1.00
93_T	98_T	1.125	1.00
103_L	108_V	1.120	1.00
165_L	168_R	1.117	1.00
234_L	237_T	1.105	1.00
246_W	250_H	1.105	1.00
201_A	223_A	1.096	1.00
24_E	29_E	1.087	1.00
245_S	248_H	1.083	1.00
19_S	23_D	1.082	1.00
262_E	266_D	1.078	1.00
265_I	269_A	1.078	1.00
96_T	134_S	1.078	1.00
143_L	173_I	1.067	1.00
269_A	273_I	1.067	1.00
162_H	168_R	1.063	1.00
162_H	165_L	1.059	1.00
64_L	217_R	1.054	1.00
238_E	241_M	1.046	1.00
25_L	29_E	1.042	1.00
146_D	149_E	1.041	1.00
158_L	162_H	1.040	1.00
123_W	126_E	1.035	1.00
214_E	218_E	1.035	1.00
141_V	173_I	1.032	1.00
236_M	240_T	1.031	1.00
60_L	216_L	1.031	1.00
238_E	242_S	1.030	1.00
266_D	270_R	1.024	1.00
133_E	136_Y	1.022	1.00
147_A	180_T	1.021	1.00
83_T	99_R	1.020	1.00
20_R	24_E	1.011	1.00
38_T	41_E	1.004	1.00
176_V	205_V	1.002	1.00
246_W	276_R	1.002	1.00
242_S	245_S	0.995	1.00
275_E	279_A	0.993	1.00
254_R	258_Y	0.987	1.00
251_A	254_R	0.987	1.00
127_S	130_S	0.986	1.00
248_H	251_A	0.986	1.00
235_P	240_T	0.985	1.00
121_P	124_L	0.981	1.00
30_K	34_Q	0.974	1.00
236_M	241_M	0.974	1.00
264_V	268_E	0.955	1.00
85_E	89_D	0.949	1.00
247_V	250_H	0.948	1.00
271_P	278_H	0.943	1.00
265_I	268_E	0.942	1.00
175_T	202_P	0.939	1.00
47_V	140_L	0.934	1.00
25_L	31_T	0.934	1.00
58_S	84_A	0.933	1.00
125_V	129_K	0.932	1.00
261_Q	265_I	0.932	1.00
119_D	128_F	0.930	1.00
102_E	105_R	0.928	1.00
221_D	225_P	0.925	1.00
26_S	30_K	0.922	1.00
85_E	92_T	0.921	1.00
195_L	198_L	0.919	1.00
240_T	247_V	0.913	1.00
240_T	243_V	0.909	1.00
20_R	23_D	0.907	1.00
184_E	187_A	0.906	1.00
215_E	219_R	0.905	1.00
46_L	139_D	0.899	1.00
252_H	255_T	0.899	1.00
183_V	188_L	0.899	1.00
174_V	203_V	0.897	1.00
250_H	269_A	0.892	1.00
158_L	161_S	0.886	1.00
218_E	221_D	0.885	1.00
65_A	99_R	0.882	1.00
48_A	111_T	0.878	1.00
164_T	167_E	0.876	1.00
232_L	235_P	0.876	1.00
31_T	34_Q	0.875	1.00
252_H	256_V	0.872	1.00
249_D	252_H	0.867	1.00
146_D	179_K	0.867	1.00
243_V	246_W	0.861	1.00
153_D	156_E	0.860	1.00
146_D	178_N	0.856	1.00
159_A	162_H	0.853	1.00
196_A	200_P	0.853	1.00
46_L	134_S	0.841	1.00
217_R	221_D	0.840	1.00
128_F	131_T	0.837	1.00
120_L	125_V	0.835	1.00
23_D	27_N	0.826	1.00
236_M	239_D	0.820	1.00
46_L	111_T	0.817	1.00
233_V	236_M	0.816	1.00
84_A	92_T	0.814	1.00
185_D	188_L	0.813	1.00
203_V	206_S	0.811	1.00
38_T	42_S	0.809	1.00
135_V	141_V	0.809	1.00
246_W	273_I	0.809	1.00
25_L	252_H	0.806	1.00
19_S	29_E	0.803	1.00
205_V	213_L	0.803	1.00
27_N	30_K	0.795	1.00
160_T	164_T	0.790	1.00
143_L	175_T	0.789	1.00
49_L	142_L	0.788	1.00
253_V	256_V	0.788	1.00
127_S	131_T	0.786	1.00
21_I	25_L	0.782	1.00
153_D	157_K	0.776	1.00
213_L	217_R	0.759	1.00
93_T	99_R	0.759	1.00
159_A	163_D	0.758	1.00
104_A	217_R	0.755	1.00
34_Q	37_E	0.753	1.00
122_H	126_E	0.746	1.00
161_S	164_T	0.743	1.00
188_L	204_A	0.740	1.00
30_K	33_Q	0.735	1.00
59_T	205_V	0.731	1.00
253_V	266_D	0.731	1.00
231_R	236_M	0.729	1.00
143_L	158_L	0.729	1.00
39_R	43_G	0.729	1.00
25_L	255_T	0.726	1.00
243_V	273_I	0.726	1.00
185_D	189_A	0.724	1.00
194_A	199_A	0.721	1.00
45_D	108_V	0.719	1.00
22_R	25_L	0.719	1.00
202_P	205_V	0.718	1.00
250_H	253_V	0.716	1.00
235_P	239_D	0.706	1.00
48_A	113_T	0.705	1.00
102_E	106_R	0.705	1.00
60_L	205_V	0.705	1.00
128_F	132_L	0.702	1.00
266_D	269_A	0.701	1.00
262_E	268_E	0.700	1.00
54_N	88_D	0.696	1.00
183_V	204_A	0.692	1.00
260_D	263_V	0.689	1.00
272_T	276_R	0.679	1.00
147_A	184_E	0.678	1.00
52_Y	55_A	0.677	1.00
223_A	227_R	0.672	1.00
157_K	164_T	0.672	1.00
31_T	38_T	0.670	1.00
158_L	168_R	0.669	1.00
250_H	254_R	0.668	1.00
253_V	257_D	0.666	0.99
130_S	134_S	0.666	0.99
93_T	100_R	0.665	0.99
96_T	99_R	0.664	0.99
147_A	152_A	0.663	0.99
101_M	108_V	0.663	0.99
106_R	224_L	0.662	0.99
205_V	208_R	0.661	0.99
168_R	173_I	0.658	0.99
257_D	266_D	0.656	0.99
131_T	135_V	0.655	0.99
46_L	137_Q	0.653	0.99
98_T	134_S	0.653	0.99
126_E	130_S	0.651	0.99
25_L	30_K	0.649	0.99
101_M	110_L	0.648	0.99
269_A	272_T	0.647	0.99
164_T	169_N	0.645	0.99
28_I	31_T	0.644	0.99
91_F	95_G	0.640	0.99
254_R	263_V	0.639	0.99
48_A	134_S	0.638	0.99
140_L	223_A	0.637	0.99
247_V	253_V	0.637	0.99
195_L	200_P	0.636	0.99
124_L	128_F	0.633	0.99
207_A	213_L	0.632	0.99
22_R	255_T	0.630	0.99
244_V	248_H	0.625	0.99
136_Y	171_A	0.625	0.99
114_V	127_S	0.621	0.99
248_H	256_V	0.621	0.99
248_H	255_T	0.619	0.99
124_L	127_S	0.617	0.99
94_L	97_T	0.615	0.99
91_F	94_L	0.613	0.99
27_N	31_T	0.611	0.99
205_V	216_L	0.611	0.99
89_D	122_H	0.606	0.99
261_Q	266_D	0.605	0.99
270_R	273_I	0.603	0.99
106_R	225_P	0.601	0.99
151_L	156_E	0.600	0.99
19_S	24_E	0.600	0.99
162_H	167_E	0.598	0.99
186_A	189_A	0.597	0.99
231_R	235_P	0.596	0.99
262_E	265_I	0.594	0.99
231_R	234_L	0.594	0.99
37_E	41_E	0.593	0.99
266_D	271_P	0.589	0.99
23_D	26_S	0.588	0.99
61_L	97_T	0.577	0.99
32_E	36_R	0.577	0.99
93_T	97_T	0.574	0.99
60_L	176_V	0.573	0.98
239_D	242_S	0.572	0.98
39_R	67_D	0.571	0.98
268_E	271_P	0.569	0.98
179_K	206_S	0.568	0.98
148_S	182_R	0.567	0.98
54_N	179_K	0.564	0.98
183_V	186_A	0.564	0.98
119_D	122_H	0.563	0.98
254_R	259_G	0.561	0.98
31_T	35_R	0.561	0.98
250_H	266_D	0.560	0.98
222_A	226_A	0.558	0.98
180_T	211_S	0.558	0.98
40_R	137_Q	0.554	0.98
95_G	114_V	0.554	0.98
29_E	252_H	0.554	0.98
47_V	110_L	0.553	0.98
32_E	241_M	0.552	0.98
28_I	244_V	0.552	0.98
160_T	163_D	0.545	0.98
272_T	275_E	0.542	0.98
132_L	164_T	0.540	0.98
21_I	24_E	0.540	0.98
253_V	269_A	0.538	0.98
89_D	92_T	0.537	0.98
48_A	141_V	0.534	0.98
201_A	205_V	0.533	0.98
231_R	239_D	0.533	0.98
39_R	139_D	0.532	0.98
188_L	196_A	0.532	0.98
35_R	39_R	0.531	0.98
25_L	248_H	0.531	0.98
24_E	27_N	0.530	0.98
184_E	188_L	0.528	0.97
145_V	186_A	0.527	0.97
52_Y	149_E	0.526	0.97
276_R	279_A	0.526	0.97
87_Q	90_L	0.526	0.97
103_L	217_R	0.523	0.97
194_A	200_P	0.523	0.97
243_V	250_H	0.521	0.97
29_E	32_E	0.520	0.97
250_H	256_V	0.515	0.97
172_P	223_A	0.514	0.97
202_P	219_R	0.508	0.97
244_V	247_V	0.508	0.97
184_E	189_A	0.507	0.97
60_L	207_A	0.504	0.97
85_E	95_G	0.503	0.97
159_A	164_T	0.502	0.97
207_A	210_A	0.501	0.97
141_V	171_A	0.501	0.97
20_R	31_T	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3geeA	2	0.7917	100	0.442	Contact Map
3gehA	2	0.8438	100	0.449	Contact Map
1xzpA	4	0.9167	100	0.456	Contact Map
2qtfA	1	0.625	100	0.468	Contact Map
2j69A	1	0.9167	100	0.476	Contact Map
3ievA	1	0.8021	100	0.494	Contact Map
1mkyA	1	0.8785	100	0.498	Contact Map
3j65o	1	0.7465	100	0.501	Contact Map
2e87A	1	0.8021	100	0.505	Contact Map
4aurA	1	0.9167	100	0.505	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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