Q9HQ87 - HALSA - GREMLIN Contacts

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Q9HQ87 - Uncharacterized protein

UniProt:	Q9HQ87	Sequences: MISLDDAVTARLETHGERFEVLVDPDAALEMRRDEFDGELTDVIAARDVFENASRGDRPAESDLETVFGTTEPLEIIPEVIGQGEIQITADQREAMQQRKKRSLINTISRNAINPQMDGAPHPPDRIESALDEAGFTVDPMTPADEQVDDALEALRPVIPIRFEEMTVAVQLPADYAGSGQAKLREFGELEREEWQADGSWVGVITFPAGMQDEFYGRVNEVSEGNGETSVVKDKDELKTR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	241 (228)
Sequences:	503 (331)
Seq/√Len:	21.9

HALSA - Q9HQ87
SULSO - Q7LXL4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
131_L	151_A	6.352	1.00
72_E	75_E	4.456	1.00
136_F	151_A	3.708	1.00
100_K	144_A	3.514	1.00
31_M	81_I	3.313	1.00
64_L	76_I	2.920	0.99
105_I	131_L	2.584	0.98
154_A	157_P	2.510	0.98
78_P	82_G	2.501	0.98
115_P	122_H	2.496	0.98
219_V	227_G	2.477	0.98
168_V	207_F	2.477	0.98
123_P	126_R	2.454	0.98
39_E	42_D	2.447	0.98
105_I	124_P	2.390	0.97
17_E	63_D	2.378	0.97
216_Y	229_T	2.322	0.97
131_L	155_L	2.283	0.96
204_V	232_V	2.203	0.96
79_E	83_Q	2.175	0.95
170_V	215_F	2.124	0.95
131_L	136_F	2.104	0.94
25_P	88_I	2.076	0.94
170_V	188_G	2.038	0.93
115_P	127_I	1.977	0.92
75_E	78_P	1.976	0.92
13_E	18_R	1.963	0.92
104_L	138_V	1.927	0.91
31_M	40_L	1.926	0.91
216_Y	220_N	1.816	0.89
184_L	224_E	1.810	0.88
47_R	74_L	1.802	0.88
113_I	217_G	1.748	0.87
104_L	151_A	1.708	0.85
119_G	223_S	1.698	0.85
8_V	30_E	1.674	0.84
124_P	131_L	1.582	0.80
21_V	81_I	1.546	0.79
46_A	50_F	1.535	0.78
142_T	146_E	1.531	0.78
44_I	77_I	1.517	0.77
11_R	21_V	1.514	0.77
55_R	59_P	1.513	0.77
14_T	67_V	1.509	0.77
154_A	168_V	1.499	0.77
54_S	63_D	1.479	0.76
166_M	212_Q	1.467	0.75
50_F	191_E	1.455	0.74
90_A	113_I	1.451	0.74
107_T	144_A	1.443	0.74
159_I	219_V	1.432	0.73
112_A	161_I	1.428	0.73
41_T	47_R	1.401	0.71
7_A	22_L	1.383	0.70
50_F	193_E	1.372	0.70
112_A	164_E	1.366	0.69
43_V	81_I	1.356	0.69
138_V	190_L	1.348	0.68
195_W	207_F	1.340	0.68
9_T	88_I	1.338	0.68
13_E	63_D	1.319	0.67
210_G	225_G	1.317	0.67
103_S	132_D	1.315	0.66
44_I	73_P	1.310	0.66
31_M	43_V	1.304	0.66
105_I	138_V	1.298	0.65
169_A	202_V	1.285	0.65
211_M	214_E	1.284	0.65
21_V	40_L	1.279	0.64
14_T	83_Q	1.268	0.64
108_I	151_A	1.263	0.63
11_R	87_Q	1.255	0.63
70_T	198_D	1.245	0.62
70_T	102_R	1.216	0.60
184_L	189_E	1.213	0.60
149_D	152_L	1.208	0.60
75_E	79_E	1.204	0.59
167_T	191_E	1.184	0.58
89_T	206_T	1.177	0.58
209_A	212_Q	1.164	0.57
210_G	219_V	1.148	0.56
8_V	77_I	1.146	0.56
49_V	64_L	1.145	0.56
49_V	218_R	1.145	0.56
184_L	201_W	1.142	0.55
104_L	183_K	1.140	0.55
126_R	160_P	1.130	0.55
7_A	10_A	1.125	0.54
165_E	206_T	1.122	0.54
172_L	176_Y	1.119	0.54
113_I	173_P	1.118	0.54
24_D	45_A	1.111	0.53
7_A	24_D	1.109	0.53
81_I	168_V	1.109	0.53
130_A	193_E	1.108	0.53
9_T	157_P	1.077	0.51
66_T	83_Q	1.073	0.51
159_I	187_F	1.067	0.50
19_F	67_V	1.054	0.49
109_S	159_I	1.049	0.49
151_A	159_I	1.045	0.49
179_S	195_W	1.041	0.48
16_G	156_R	1.037	0.48
142_T	153_E	1.035	0.48
104_L	152_L	1.032	0.48
121_P	128_E	1.026	0.47
168_V	215_F	1.020	0.47
156_R	159_I	1.013	0.47
100_K	139_D	1.013	0.47
116_Q	233_K	1.001	0.46
108_I	153_E	0.999	0.46
5_D	24_D	0.995	0.45
143_P	194_E	0.994	0.45
54_S	64_L	0.982	0.45
127_I	194_E	0.974	0.44
14_T	41_T	0.973	0.44
54_S	218_R	0.965	0.43
155_L	184_L	0.959	0.43
23_V	26_D	0.958	0.43
48_D	73_P	0.957	0.43
18_R	166_M	0.951	0.42
105_I	128_E	0.950	0.42
125_D	129_S	0.932	0.41
12_L	142_T	0.930	0.41
113_I	169_A	0.925	0.41
16_G	121_P	0.916	0.40
122_H	127_I	0.915	0.40
65_E	71_T	0.913	0.40
107_T	111_N	0.910	0.40
170_V	217_G	0.907	0.40
5_D	10_A	0.905	0.39
63_D	194_E	0.901	0.39
51_E	55_R	0.900	0.39
29_L	123_P	0.895	0.39
83_Q	115_P	0.893	0.39
9_T	16_G	0.890	0.38
173_P	227_G	0.889	0.38
104_L	147_Q	0.885	0.38
175_D	178_G	0.880	0.38
155_L	229_T	0.874	0.37
112_A	208_P	0.872	0.37
101_K	105_I	0.872	0.37
226_N	232_V	0.867	0.37
189_E	220_N	0.866	0.37
186_E	202_V	0.866	0.37
3_S	8_V	0.865	0.37
16_G	135_G	0.865	0.37
170_V	203_G	0.864	0.37
21_V	139_D	0.864	0.37
121_P	210_G	0.860	0.37
189_E	215_F	0.858	0.36
139_D	158_V	0.856	0.36
170_V	224_E	0.855	0.36
120_A	138_V	0.850	0.36
34_D	101_K	0.848	0.36
111_N	213_D	0.842	0.35
33_R	144_A	0.839	0.35
22_L	26_D	0.835	0.35
97_Q	138_V	0.833	0.35
7_A	45_A	0.824	0.34
79_E	125_D	0.815	0.34
16_G	103_S	0.813	0.34
101_K	132_D	0.813	0.34
12_L	38_G	0.808	0.33
194_E	212_Q	0.806	0.33
38_G	43_V	0.795	0.33
212_Q	233_K	0.794	0.32
41_T	122_H	0.794	0.32
10_A	23_V	0.794	0.32
98_Q	104_L	0.790	0.32
179_S	190_L	0.790	0.32
109_S	136_F	0.788	0.32
159_I	192_R	0.785	0.32
102_R	106_N	0.782	0.32
31_M	78_P	0.781	0.32
27_A	43_V	0.780	0.32
212_Q	229_T	0.779	0.32
40_L	47_R	0.778	0.32
31_M	60_A	0.778	0.32
25_P	29_L	0.776	0.31
106_N	207_F	0.775	0.31
174_A	219_V	0.767	0.31
191_E	206_T	0.763	0.31
5_D	104_L	0.761	0.31
182_A	220_N	0.760	0.31
80_V	104_L	0.760	0.31
108_I	157_P	0.758	0.30
123_P	162_R	0.757	0.30
101_K	128_E	0.756	0.30
50_F	145_D	0.753	0.30
135_G	146_E	0.752	0.30
63_D	111_N	0.752	0.30
25_P	90_A	0.746	0.30
112_A	180_G	0.744	0.30
17_E	90_A	0.744	0.30
114_N	161_I	0.739	0.29
10_A	28_A	0.738	0.29
86_I	175_D	0.736	0.29
178_G	195_W	0.734	0.29
60_A	96_M	0.733	0.29
42_D	149_D	0.733	0.29
40_L	67_V	0.731	0.29
40_L	53_A	0.729	0.29
190_L	224_E	0.728	0.29
134_A	139_D	0.722	0.28
26_D	31_M	0.721	0.28
119_G	180_G	0.710	0.28
13_E	17_E	0.704	0.27
62_S	94_E	0.703	0.27
16_G	137_T	0.702	0.27
188_G	195_W	0.701	0.27
52_N	63_D	0.701	0.27
113_I	161_I	0.700	0.27
82_G	95_A	0.699	0.27
4_L	63_D	0.695	0.27
113_I	186_E	0.694	0.27
134_A	158_V	0.692	0.27
172_L	177_A	0.689	0.27
14_T	170_V	0.688	0.27
195_W	210_G	0.683	0.26
40_L	111_N	0.680	0.26
178_G	193_E	0.678	0.26
30_E	89_T	0.678	0.26
99_R	105_I	0.678	0.26
177_A	196_Q	0.677	0.26
56_G	86_I	0.677	0.26
102_R	138_V	0.675	0.26
38_G	180_G	0.675	0.26
98_Q	109_S	0.674	0.26
143_P	146_E	0.674	0.26
85_E	111_N	0.672	0.26
65_E	76_I	0.667	0.25
168_V	229_T	0.666	0.25
19_F	83_Q	0.664	0.25
29_L	86_I	0.663	0.25
157_P	178_G	0.662	0.25
88_I	147_Q	0.659	0.25
123_P	225_G	0.652	0.25
39_E	55_R	0.649	0.25
147_Q	151_A	0.648	0.24
94_E	139_D	0.647	0.24
150_D	229_T	0.645	0.24
19_F	55_R	0.644	0.24
50_F	152_L	0.637	0.24
23_V	27_A	0.636	0.24
66_T	207_F	0.636	0.24
51_E	57_D	0.634	0.24
60_A	140_P	0.630	0.24
39_E	60_A	0.629	0.24
70_T	158_V	0.629	0.24
8_V	23_V	0.629	0.24
133_E	207_F	0.628	0.23
11_R	18_R	0.628	0.23
22_L	53_A	0.627	0.23
72_E	136_F	0.621	0.23
146_E	181_Q	0.619	0.23
152_L	182_A	0.612	0.23
205_I	215_F	0.611	0.23
147_Q	152_L	0.604	0.22
13_E	31_M	0.604	0.22
50_F	166_M	0.604	0.22
43_V	92_Q	0.601	0.22
17_E	66_T	0.598	0.22
47_R	231_V	0.595	0.22
77_I	89_T	0.594	0.22
25_P	156_R	0.594	0.22
24_D	27_A	0.591	0.22
87_Q	127_I	0.590	0.22
168_V	205_I	0.590	0.22
126_R	212_Q	0.589	0.22
10_A	24_D	0.589	0.22
123_P	133_E	0.589	0.22
10_A	81_I	0.589	0.22
8_V	29_L	0.589	0.22
105_I	135_G	0.588	0.22
22_L	92_Q	0.588	0.22
201_W	205_I	0.586	0.21
32_R	49_V	0.585	0.21
90_A	109_S	0.583	0.21
70_T	138_V	0.583	0.21
23_V	92_Q	0.583	0.21
134_A	159_I	0.581	0.21
50_F	231_V	0.581	0.21
27_A	30_E	0.580	0.21
143_P	181_Q	0.578	0.21
12_L	218_R	0.578	0.21
166_M	209_A	0.577	0.21
159_I	196_Q	0.577	0.21
94_E	102_R	0.573	0.21
25_P	166_M	0.572	0.21
59_P	63_D	0.571	0.21
149_D	155_L	0.571	0.21
34_D	82_G	0.569	0.21
87_Q	107_T	0.568	0.21
25_P	89_T	0.568	0.21
28_A	101_K	0.568	0.21
177_A	215_F	0.567	0.21
19_F	39_E	0.567	0.21
75_E	102_R	0.566	0.21
161_I	164_E	0.559	0.20
170_V	195_W	0.558	0.20
5_D	81_I	0.555	0.20
179_S	192_R	0.554	0.20
210_G	223_S	0.552	0.20
52_N	209_A	0.551	0.20
167_T	204_V	0.551	0.20
29_L	33_R	0.545	0.20
190_L	219_V	0.545	0.20
175_D	185_R	0.542	0.20
6_D	18_R	0.542	0.20
43_V	54_S	0.540	0.19
197_A	222_V	0.540	0.19
24_D	92_Q	0.537	0.19
148_V	163_F	0.535	0.19
64_L	83_Q	0.534	0.19
174_A	177_A	0.533	0.19
62_S	119_G	0.533	0.19
22_L	145_D	0.533	0.19
18_R	53_A	0.532	0.19
91_D	129_S	0.531	0.19
43_V	148_V	0.525	0.19
26_D	41_T	0.524	0.19
99_R	131_L	0.522	0.19
107_T	231_V	0.518	0.19
145_D	149_D	0.518	0.19
70_T	73_P	0.515	0.18
98_Q	132_D	0.514	0.18
177_A	222_V	0.512	0.18
11_R	68_F	0.512	0.18
177_A	195_W	0.511	0.18
168_V	186_E	0.510	0.18
52_N	86_I	0.508	0.18
107_T	149_D	0.507	0.18
107_T	221_E	0.506	0.18
88_I	169_A	0.506	0.18
41_T	164_E	0.505	0.18
138_V	148_V	0.503	0.18
165_E	173_P	0.502	0.18
65_E	184_L	0.502	0.18
122_H	212_Q	0.501	0.18
27_A	31_M	0.500	0.18
12_L	49_V	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wbmA	1	0.9627	100	0.091	Contact Map
2kdoA	1	0.9834	100	0.1	Contact Map
1t95A	1	0.9544	100	0.108	Contact Map
1nynA	1	0.4191	100	0.639	Contact Map
3lh2S	2	0.2822	91.4	0.937	Contact Map
2cveA	1	0.6556	82.3	0.945	Contact Map
1jeyB	1	0.5851	25.4	0.963	Contact Map
1vi7A	1	0.6846	19.9	0.965	Contact Map
2yweA	1	0.9502	19.5	0.965	Contact Map
4zciA	1	0.5726	18	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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