GREMLIN Database
Q9HQ87 - Uncharacterized protein
UniProt: Q9HQ87 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (228)
Sequences: 503 (331)
Seq/√Len: 21.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_L151_A6.3521.00
72_E75_E4.4561.00
136_F151_A3.7081.00
100_K144_A3.5141.00
31_M81_I3.3131.00
64_L76_I2.9200.99
105_I131_L2.5840.98
154_A157_P2.5100.98
78_P82_G2.5010.98
115_P122_H2.4960.98
219_V227_G2.4770.98
168_V207_F2.4770.98
123_P126_R2.4540.98
39_E42_D2.4470.98
105_I124_P2.3900.97
17_E63_D2.3780.97
216_Y229_T2.3220.97
131_L155_L2.2830.96
204_V232_V2.2030.96
79_E83_Q2.1750.95
170_V215_F2.1240.95
131_L136_F2.1040.94
25_P88_I2.0760.94
170_V188_G2.0380.93
115_P127_I1.9770.92
75_E78_P1.9760.92
13_E18_R1.9630.92
104_L138_V1.9270.91
31_M40_L1.9260.91
216_Y220_N1.8160.89
184_L224_E1.8100.88
47_R74_L1.8020.88
113_I217_G1.7480.87
104_L151_A1.7080.85
119_G223_S1.6980.85
8_V30_E1.6740.84
124_P131_L1.5820.80
21_V81_I1.5460.79
46_A50_F1.5350.78
142_T146_E1.5310.78
44_I77_I1.5170.77
11_R21_V1.5140.77
55_R59_P1.5130.77
14_T67_V1.5090.77
154_A168_V1.4990.77
54_S63_D1.4790.76
166_M212_Q1.4670.75
50_F191_E1.4550.74
90_A113_I1.4510.74
107_T144_A1.4430.74
159_I219_V1.4320.73
112_A161_I1.4280.73
41_T47_R1.4010.71
7_A22_L1.3830.70
50_F193_E1.3720.70
112_A164_E1.3660.69
43_V81_I1.3560.69
138_V190_L1.3480.68
195_W207_F1.3400.68
9_T88_I1.3380.68
13_E63_D1.3190.67
210_G225_G1.3170.67
103_S132_D1.3150.66
44_I73_P1.3100.66
31_M43_V1.3040.66
105_I138_V1.2980.65
169_A202_V1.2850.65
211_M214_E1.2840.65
21_V40_L1.2790.64
14_T83_Q1.2680.64
108_I151_A1.2630.63
11_R87_Q1.2550.63
70_T198_D1.2450.62
70_T102_R1.2160.60
184_L189_E1.2130.60
149_D152_L1.2080.60
75_E79_E1.2040.59
167_T191_E1.1840.58
89_T206_T1.1770.58
209_A212_Q1.1640.57
210_G219_V1.1480.56
8_V77_I1.1460.56
49_V64_L1.1450.56
49_V218_R1.1450.56
184_L201_W1.1420.55
104_L183_K1.1400.55
126_R160_P1.1300.55
7_A10_A1.1250.54
165_E206_T1.1220.54
172_L176_Y1.1190.54
113_I173_P1.1180.54
24_D45_A1.1110.53
7_A24_D1.1090.53
81_I168_V1.1090.53
130_A193_E1.1080.53
9_T157_P1.0770.51
66_T83_Q1.0730.51
159_I187_F1.0670.50
19_F67_V1.0540.49
109_S159_I1.0490.49
151_A159_I1.0450.49
179_S195_W1.0410.48
16_G156_R1.0370.48
142_T153_E1.0350.48
104_L152_L1.0320.48
121_P128_E1.0260.47
168_V215_F1.0200.47
156_R159_I1.0130.47
100_K139_D1.0130.47
116_Q233_K1.0010.46
108_I153_E0.9990.46
5_D24_D0.9950.45
143_P194_E0.9940.45
54_S64_L0.9820.45
127_I194_E0.9740.44
14_T41_T0.9730.44
54_S218_R0.9650.43
155_L184_L0.9590.43
23_V26_D0.9580.43
48_D73_P0.9570.43
18_R166_M0.9510.42
105_I128_E0.9500.42
125_D129_S0.9320.41
12_L142_T0.9300.41
113_I169_A0.9250.41
16_G121_P0.9160.40
122_H127_I0.9150.40
65_E71_T0.9130.40
107_T111_N0.9100.40
170_V217_G0.9070.40
5_D10_A0.9050.39
63_D194_E0.9010.39
51_E55_R0.9000.39
29_L123_P0.8950.39
83_Q115_P0.8930.39
9_T16_G0.8900.38
173_P227_G0.8890.38
104_L147_Q0.8850.38
175_D178_G0.8800.38
155_L229_T0.8740.37
112_A208_P0.8720.37
101_K105_I0.8720.37
226_N232_V0.8670.37
189_E220_N0.8660.37
186_E202_V0.8660.37
3_S8_V0.8650.37
16_G135_G0.8650.37
170_V203_G0.8640.37
21_V139_D0.8640.37
121_P210_G0.8600.37
189_E215_F0.8580.36
139_D158_V0.8560.36
170_V224_E0.8550.36
120_A138_V0.8500.36
34_D101_K0.8480.36
111_N213_D0.8420.35
33_R144_A0.8390.35
22_L26_D0.8350.35
97_Q138_V0.8330.35
7_A45_A0.8240.34
79_E125_D0.8150.34
16_G103_S0.8130.34
101_K132_D0.8130.34
12_L38_G0.8080.33
194_E212_Q0.8060.33
38_G43_V0.7950.33
212_Q233_K0.7940.32
41_T122_H0.7940.32
10_A23_V0.7940.32
98_Q104_L0.7900.32
179_S190_L0.7900.32
109_S136_F0.7880.32
159_I192_R0.7850.32
102_R106_N0.7820.32
31_M78_P0.7810.32
27_A43_V0.7800.32
212_Q229_T0.7790.32
40_L47_R0.7780.32
31_M60_A0.7780.32
25_P29_L0.7760.31
106_N207_F0.7750.31
174_A219_V0.7670.31
191_E206_T0.7630.31
5_D104_L0.7610.31
182_A220_N0.7600.31
80_V104_L0.7600.31
108_I157_P0.7580.30
123_P162_R0.7570.30
101_K128_E0.7560.30
50_F145_D0.7530.30
135_G146_E0.7520.30
63_D111_N0.7520.30
25_P90_A0.7460.30
112_A180_G0.7440.30
17_E90_A0.7440.30
114_N161_I0.7390.29
10_A28_A0.7380.29
86_I175_D0.7360.29
178_G195_W0.7340.29
60_A96_M0.7330.29
42_D149_D0.7330.29
40_L67_V0.7310.29
40_L53_A0.7290.29
190_L224_E0.7280.29
134_A139_D0.7220.28
26_D31_M0.7210.28
119_G180_G0.7100.28
13_E17_E0.7040.27
62_S94_E0.7030.27
16_G137_T0.7020.27
188_G195_W0.7010.27
52_N63_D0.7010.27
113_I161_I0.7000.27
82_G95_A0.6990.27
4_L63_D0.6950.27
113_I186_E0.6940.27
134_A158_V0.6920.27
172_L177_A0.6890.27
14_T170_V0.6880.27
195_W210_G0.6830.26
40_L111_N0.6800.26
178_G193_E0.6780.26
30_E89_T0.6780.26
99_R105_I0.6780.26
177_A196_Q0.6770.26
56_G86_I0.6770.26
102_R138_V0.6750.26
38_G180_G0.6750.26
98_Q109_S0.6740.26
143_P146_E0.6740.26
85_E111_N0.6720.26
65_E76_I0.6670.25
168_V229_T0.6660.25
19_F83_Q0.6640.25
29_L86_I0.6630.25
157_P178_G0.6620.25
88_I147_Q0.6590.25
123_P225_G0.6520.25
39_E55_R0.6490.25
147_Q151_A0.6480.24
94_E139_D0.6470.24
150_D229_T0.6450.24
19_F55_R0.6440.24
50_F152_L0.6370.24
23_V27_A0.6360.24
66_T207_F0.6360.24
51_E57_D0.6340.24
60_A140_P0.6300.24
39_E60_A0.6290.24
70_T158_V0.6290.24
8_V23_V0.6290.24
133_E207_F0.6280.23
11_R18_R0.6280.23
22_L53_A0.6270.23
72_E136_F0.6210.23
146_E181_Q0.6190.23
152_L182_A0.6120.23
205_I215_F0.6110.23
147_Q152_L0.6040.22
13_E31_M0.6040.22
50_F166_M0.6040.22
43_V92_Q0.6010.22
17_E66_T0.5980.22
47_R231_V0.5950.22
77_I89_T0.5940.22
25_P156_R0.5940.22
24_D27_A0.5910.22
87_Q127_I0.5900.22
168_V205_I0.5900.22
126_R212_Q0.5890.22
10_A24_D0.5890.22
123_P133_E0.5890.22
10_A81_I0.5890.22
8_V29_L0.5890.22
105_I135_G0.5880.22
22_L92_Q0.5880.22
201_W205_I0.5860.21
32_R49_V0.5850.21
90_A109_S0.5830.21
70_T138_V0.5830.21
23_V92_Q0.5830.21
134_A159_I0.5810.21
50_F231_V0.5810.21
27_A30_E0.5800.21
143_P181_Q0.5780.21
12_L218_R0.5780.21
166_M209_A0.5770.21
159_I196_Q0.5770.21
94_E102_R0.5730.21
25_P166_M0.5720.21
59_P63_D0.5710.21
149_D155_L0.5710.21
34_D82_G0.5690.21
87_Q107_T0.5680.21
25_P89_T0.5680.21
28_A101_K0.5680.21
177_A215_F0.5670.21
19_F39_E0.5670.21
75_E102_R0.5660.21
161_I164_E0.5590.20
170_V195_W0.5580.20
5_D81_I0.5550.20
179_S192_R0.5540.20
210_G223_S0.5520.20
52_N209_A0.5510.20
167_T204_V0.5510.20
29_L33_R0.5450.20
190_L219_V0.5450.20
175_D185_R0.5420.20
6_D18_R0.5420.20
43_V54_S0.5400.19
197_A222_V0.5400.19
24_D92_Q0.5370.19
148_V163_F0.5350.19
64_L83_Q0.5340.19
174_A177_A0.5330.19
62_S119_G0.5330.19
22_L145_D0.5330.19
18_R53_A0.5320.19
91_D129_S0.5310.19
43_V148_V0.5250.19
26_D41_T0.5240.19
99_R131_L0.5220.19
107_T231_V0.5180.19
145_D149_D0.5180.19
70_T73_P0.5150.18
98_Q132_D0.5140.18
177_A222_V0.5120.18
11_R68_F0.5120.18
177_A195_W0.5110.18
168_V186_E0.5100.18
52_N86_I0.5080.18
107_T149_D0.5070.18
107_T221_E0.5060.18
88_I169_A0.5060.18
41_T164_E0.5050.18
138_V148_V0.5030.18
165_E173_P0.5020.18
65_E184_L0.5020.18
122_H212_Q0.5010.18
27_A31_M0.5000.18
12_L49_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wbmA 1 0.9627 100 0.091 Contact Map
2kdoA 1 0.9834 100 0.1 Contact Map
1t95A 1 0.9544 100 0.108 Contact Map
1nynA 1 0.4191 100 0.639 Contact Map
3lh2S 2 0.2822 91.4 0.937 Contact Map
2cveA 1 0.6556 82.3 0.945 Contact Map
1jeyB 1 0.5851 25.4 0.963 Contact Map
1vi7A 1 0.6846 19.9 0.965 Contact Map
2yweA 1 0.9502 19.5 0.965 Contact Map
4zciA 1 0.5726 18 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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